REGISTER OF INTERESTS SIGN guideline 154: Pharmacological management of glycaemic control in people with type 2 diabetes Published: 29 November 2017

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1 CHAIR John Petrie, Professor of Diabetic Medicine Financial Non-financial Non-personal Last updated Specific Non-Specific Specific Non- Specific Professor of Diabetic Medicine, University of Glasgow Academic. Honorary Consultant Physician/ Diabetologist NHS GGC Healthcare. Applied Clinical Intelligence Adjudication Committee for Boehringer Ingelheim trials of empagliflozin in type 1 diabetes. Diabetologia European diabetes journal (advisory board). Clinical Trial Committees (steering/adjudication /Glycemia) Novo Nordisk, Sanofi, Shareholder Lecht Ski Company. Trustee of Novo Nordisk UK Research Foundation ( ). Chair Complications Clinical Studies Group, Diabetes UK ( ). None Donation of medication for REMOVAL clinical trial (metformin in type 1 diabetes) of which I am Chief Investigator Merck KGaA (Germany). Donation of reading services for endothelial function in REMOVAL trial (ENDOPAT) Itamar Medical (Israel). Research Fellowship for Rachel Livingstone ( ) Novo Nordisk UK Research Foundation. Support for annual meeting of European Group for the study of Insulin Resistance Novo Nordisk. RISC study 12 year follow-up grant to Action Agreed to not be allocated to questions on liraglutide or lixisenatide due to work on LEADER and ELIXA trials. 1

2 Roche/Genentech, Quintiles/Janssen approx. once monthly. Including membership of LEADER trial Global Expert Panel ( , Novo Nordisk) and ELIXA trial UK coordinator ( , Sanofi). These are the recent cardiovascular outcome trials with liraglutide and lixisenatide. University of Pisa ( ) Janssen Pharmaceuticals. Grantholder: investigator-sponsored trial of empagliflozin in patients with diabetes and heart failure, Chief Investigator N Sattar ( ) Boehringer-Ingelheim. Consultancy Novo Nordisk, Servier, Lilly approx. once every two months. Speaker Novo Nordisk, Lilly, Boehringer approx. once every two months. Now adjudication committee membership May 2

3 2017 Boehringer EMPEROR trials. Pfizer. GUIDELINE DEVELOPMENT GROUP MEMBER Allan Cairns, (Patient Representative) None I am retired, no employer. None None None None No action Samantha Carmichael, (Lead Pharmacist) Lead Pharmacist Clinical Trials/R&D NHS Greater Glasgow and Clyde. Samantha Carmichael selfemployed locum pharmacist. Travel and accommodation paid for participation in international meetings regarding clinical trials site perspectives Fisher Clinical Services, 2 3 times per year. None None None No action Chair of clinical Trials Specialist Interest Group for pharmacists & technicians in Scotland. Member of The National Pharmacy 3

4 Gemma Currie, (Clinical Lecturer) Andrea Llano, (ST5 in Clinical Pharmacology and Therapeutics) David McGrane, (Consultant Physician) Clinical Lecturer, University of Glasgow academic/clinical ST5 in Clinical Pharmacology and Therapeutics, Department of Diabetes, Endocrinology & Clinical Pharmacology, Glasgow Royal Infirmary, Glasgow. Consultant Physician, GGC Health Board Provision of clinical expertise and management of patients within my Clinical Trials Advisory Group (Royal Pharmaceutical Society Network). Member of the Guild of Hospital Pharmacists. None None None None No action None None None None No action None None Member, Scottish South Asian Health Foundation None No clear conflict with individual products linked to guideline therefore no action. 4

5 Gerard McKay, (Honorary Clinical Associate Professor) role as a Consultant Physician. Northview Consultancy Ltd provision of advice and consultancy to pharmaceutical companies once monthly. Advisory work, speaker at meetings, providing education AZ, Boehringer Ingelheim, Janssen, Lilly, MSD, NAPP, Novo Novodisk, Sanofi, Takeda, Sunovion on average once or twice monthly in total. Consultant Physician NHS GG&C, Glasgow Royal Infirmary health care provision including management of patients with diabetes. None None None None Declaration of potential conflict (SGLT2 inhibitors). Discussion with all group members and agreement to continued work on this question in partnership with second group 5

6 G McKay Medical Advisory Ltd medical advisory, consultancy work (intermittently for companies including Novo Nordisk, BoehringerIngleheim, Sanofi, AZ, MSD, and Eli Lilly) This includes advising on a submission to SMC (Boehringer Ingleheim). self and partner. member. Independent review of pivotal decisions by HIS researcher with follow up to resolve queries revealed no anomalous decision. May Millward, (Patient Representative) Project Officer, Scottish Mediation Network Professional body for accredited mediators in Scotland. None Chair of West Lothian Diabetes Scotland Group. None None No action Chris Schofield, (Consultant Physician) Consultant Physician, NHS Tayside. Fee for travel, accommodation & conference Alexion Pharmaceuticals, Single episode. None Site PI for Alexion Pharmaceuticals database for the study of hereditary hypohosphatatsia None None No clear conflict with individual products linked to guideline therefore no action. 6

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