University of Groningen. Revealing the genetic roots of obesity and type 2 diabetes Ostaptchouk, Jana
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1 University of Groningen Revealing the genetic roots of obesity and type 2 diabetes Ostaptchouk, Jana IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2010 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Vliet-Ostaptchouk, J. V. V. (2010). Revealing the genetic roots of obesity and type 2 diabetes Groningen: s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date:
2 Revealing the genetic roots of obesity and type 2 diabetes Jana van Vliet-Ostaptchouk
3 Funding The studies described in this thesis were financially supported by IOP Genomics (grant IGE05012), a programme by NL Innovatie. Printing of this thesis was financially supported by University Medical Center Groningen, Rijksuniversiteit Groningen, Research Institute SHARE, Diabetesfonds Nederland, Roche Diagnostics Nederland BV. Colofon Cover painting: Maternity by Fernando Botero (Oil on canvas 123 x 94 cm 2003) Reproduced with the kind permission of Robinsons Art Gallery Zeedijk 757A, 8300 Knokke-Zoute, Belgium info@robinsons-artgallery.com About Fernando Botero Fernando Botero was born in Medellín, Colombia, in Botero s work includes still-lifes and landscapes, but he tends to primarily focus on situational portraiture. His paintings and sculptures are united by their proportionally exaggerated, obese, or fat figures, as he once referred to them. Botero is an indispensable figure on many international art and social scenes in at least three continents. His persona might be compared to that of one of the 17th Century artists he so much admires, Peter Paul Rubens. Rubens represents the epitome of the standard notions of the Baroque. His own fleshy, eroticized figures, exist in a world exuberance and plenitude in both the realms of the sacred and the profane. Though he currently spends only one month a year in Colombia, he considers himself the most Colombian artist living due to his insulation from the international trends of the art world. Copyright 2010 J.V. van Vliet-Ostaptchouk Design by Legatron Electronic Publishing, Rotterdam, The Netherlands Printed by Ipskamp Drukkers B.V., Enschede, The Netherlands ISBN/EAN
4 Revealing the genetic roots of obesity and type 2 diabetes Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op woensdag 7 juli 2010 om 16:15 uur door Jana Vladimirovna van Vliet-Ostaptchouk geboren op 8 juni 1973 te Krasnovodsk, Turkmenistan SSR, former USSR
5 Promotores: Prof. dr. M. H. Hofker Prof. dr. C. Wijmenga Beoordelingscommissie: Prof. dr. A. K. Groen Prof. dr. H. Snieder Prof. dr. Y. T. van der Schouw ISBN
6 Look at every path closely and deliberately, then ask ourselves this crucial question: Does this path have a heart? If it does, then the path is good. If it doesn t, it is of no use. Carlos Castaneda DON T PANIC 1 Douglas Adams 1 Arthur C. Clarke said Douglas Adams use of don t panic was perhaps the best advice that could be given to humanity [and to all PhD students].
7 Paranimfen: Marijke Schreurs Alexandra Zhernakova
8 Table of contents Chapter 1 General introduction: The genetics of obesity and type 2 diabetes 9 Chapter 2 Genetic variation in the hypothalamic pathways and 41 its role on obesity, review Chapter 3 Identification of TUB as a novel candidate gene influencing 73 body weight in humans Chapter 4 Polymorphisms of the TUB gene are associated with body 87 composition and eating behavior in middle-aged women Chapter 5 Association of variants of transcription factor 7- like 2 (TCF7L2) 107 with susceptibility to type 2 diabetes in the Dutch Breda cohort Chapter 6 HHEX gene polymorphisms are associated with type diabetes in the Dutch Breda cohort Chapter 7 General discussion 127 Summaries 143 Samenvatting 147 Краткое содержание 151 Acknowledgments 155 List of abbreviations 163 List of publications 165 Curriculum Vitae 169
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