Why manage type 2 diabetes when you can reverse it? Type 2 Diabetes at Purdue University. March 27, 2018

Transcription

1 Why manage type 2 diabetes when you can reverse it? Type 2 Diabetes at Purdue University March 27, 2018

2 Hello. Bill Snyder, MBA Enterprise Partnership Lead

3 FOR TODAY Challenge Solution Outcomes

4 The Challenge: Diabetes at Purdue (2015) 10% of employees & dependents were diabetic in 2015 $13.6k Average medical + pharmacy costs per diabetic person

5 The Challenge: Purdue Diabetes Costs 2015 Calendar year $8,236,097 Overall Pharmacy Spend (excluding medical) $16,166,564 Medical spend (excluding pharmacy) $2,928,902 Diabetes Pharmacy Spend (excluding medical) $13,587 Average per-person annual medical & pharmacy costs

6 The Challenge: Purdue Diabetes Burden High absenteeism Low productivity Low morale

7 FOR TODAY Challenge Solution Outcomes

8 Online Diabetes Reversal Clinic

9 The Solution: Virta Online Diabetes Clinic Video will play in presentation version

10 A multi-channel Confidential marketing approach delivers Info Sessions (onsite & web) All-hands & targeted s Brochures Posters Direct mailers Grocers & restaurants

11 Two Sources of Virta Innovation Continuous Remote Care Telemedicine tech platform allowing 24x7 individualized physician and coach support Individualized Patient Protocol Nutrition core focused on reversing insulin resistance with individualized carbohydrate restriction

12 Patient Intake Process 1: Application 2: Intake Call 3: Labs & Screening 4: Virta Physician Visit

13 Starter Kit Starter Booklet Wireless Scale Kitchen Scale Glucose/Ketone Meter Blood Glucose Test Strips Ketone Test Strips Lancets Bouillon Cubes Magnesium

14 Virta s Continuous Remote Care Platform

15 Two Sources of Virta Innovation Continuous Remote Care Telemedicine tech platform allowing 24x7 individualized physician and coach support Individualized Patient Protocol Nutrition core focused on reversing insulin resistance with individualized carbohydrate restriction

16 Virta s Nutrition Approach Highly Individualized carb restriction (low-carb, high fat) Eat delicious, real foods until satisfied Behavior Change (no food delivery)

17 Integration with Existing Providers Additive to patient s care ecosystem Virta is a Metabolic Health Expert doing work PCPs and Endos don t have time/access to do Physician to physician discussions/consultations Reports Virta PCP every 3-4 months

18 Confidential Onsite clinics leverage existing partnerships Most screening through existing clinics and partnership Partnership with onsite clinical staff Flyers/ brochures on site Referrals

19 Application Momentum from patient success Volume s (x30) 700+ applications Webinars (x6) 100+ applications On-site Events (x6) 150+ applications Other (posters and mailers) 50+ applications

20 Virta Deployments in the Purdue Population Indiana Clinical Trial August Total of 378 patients in Virta trial A couple dozen Purdue employees 1+ years of data available Purdue Deployment April ~337 patients enrolled thus far 0 9 months of data available

21 Virta s results thus far have been spectacular. Based on that, we are making Virta available to all individuals with type 2 diabetes in our employee and dependent populations in Denny Darrow VP for Human Resources, Purdue University

22 FOR TODAY Challenge Solution Outcomes

23 The Outcomes: Virta Clinic Impact 60% 54% of patients with subdiabetic blood sugar and no meds 1 of diabetic medications 2 de-prescribed 1 year results from Virta clinical trial among individuals living with type 2 diabetes 1 Except metformin 2 Script volume; excludes metformin Source: IU Health Arnett - Virta Clinical Trial Data, Interim Analysis (Hallberg et al., ADA 2017), n = 111

24 Peer-reviewed and Published Virta Results

25 HbA1c reduced profoundly, 7.6 avg diabetes reversed in a majority Virta Usual Care 6.3 avg Source: IU Health Arnett - Virta Clinical Trial Data, n=204 Virta, n=72 Usual Care - all with diagnosed T2 diabetes Note: Prospective observational study with independently recruited Virta Clinic and usual care arms without randomization. Study arms were recruited from the same geography and have similar baseline characteristics including starting A1c and duration of diabetes.

26 Majority of diabetes drug prescriptions (54%) are discontinued... n=53 n=63 n=23 n=5 n=31 n=42 n=172 Source: IU Health Arnett - Virta Clinical Trial Data, n=218

27 Profound Cost Savings on Diabetes Medications IU Health Arnett - Virta Clinical Trial Data, internal interim analysis GoodRX

28 Better adherence than taking a pill and lasting results One Year Retention 83% Sustained one year weight loss at -12% Source: IU Health Arnett - Virta Clinical Trial Data

29 Purdue Patient Demographics (Purdue deployment) Average age: 53 Age range: % female, 31% male Average BMI: 38.5 BMI range:

30 Purdue Biomarkers Tracking Toward Long-Term Success (Clinical Trial & Purdue deployment) IU Health Arnett - Virta Clinical Trial Data, 1 year completers (Hallberg et al., 2018), n= 218 Purdue Deployment, n ranging from , time shifted to match change in length of patient preparation (6 days) Confidential & Unpublished

31 Purdue Body Weight Tracking Toward Long-Term Success (Clinical Trial & Purdue deployment) IU Health Arnett - Virta Clinical Trial Data, 1 year completers (Hallberg et al., 2018), n= 218 Purdue Deployment, n ranging from , time shifted to match change in length of patient preparation (6 days) Confidential & Unpublished

32 Virta Value Medications ER/Hospital Visits Specialist Visits Medical Equipment Workplace Absenteeism Workers Comp Claims

33 PERFORMANCE-BASED PRICING At Virta, we get paid for real results.

34 Select early feedback from Purdue patients 90 days or so in, I'm off two out of three drugs (metformin only now), have lost 30 lbs, and feel so much better! This has been a life changer for me. Knowing others are going through this and succeeding has been super helpful. PURDUE PATIENT With regards to inflammation, I was diagnosed with herniated discs in my lower back well over 10 years ago. They would flare up all the time. Since Virta? Noticeable difference. Big noticeable difference. PURDUE PATIENT "For the first time since I was diagnosed with diabetes I feel like someone is listening to how I feel. This feels like there is plan and a way to achieve it." PURDUE PATIENT

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36 Thank you!

37 APPENDIX

38 The level of support that Virta provides is really something that I can t. It s that constant contact with the patient. I find that referring patients to the Virta Clinic has saved me quite a bit of time. DR. MARK SAVANT Internal Medicine, Private Practice

39 Successful Enrollment at Purdue University (Purdue-specific deployment) Total Enrolled 337 % Diabetic Population 1 ~11% 1 Enrolled diabetics as a % of diagnosed beneficiaries with valid contact information

40 Leverage early success to build momentum