Dye dilution method. densitometry Fox 1761 Haller. = I / D 60 (L/min) Hamilton Stewart. Bloomfield 2) ( ) pulse dye

Transcription

1 Dye dilution method 1. D(secmg/L) I(mg) CO = I / D 60 (L/min) 2 1) Bloomfield 2) ( ) pulse dye 1 densitometry Fox 1761 Haller 3) Stewart 4) Kinsman Hamilton Stewart 5) 1

2 52 Dye dilution method 2 Kinsman, Hamilton Kinsman et al: Amer J Physiol, 1929, 5) 2 I B D 1948 Hamilton Evans blue Fick 6) Hamilton Millikan oximeter Wood Oximetry, Medical Physics Vol2, ) CO 1950 Wood oximeter 2.2 Millikan oximeter Wood oximeter oximeter dye densitometer Densitometer Millikan oximeter Wood oximeter Millikan ear oximeter 4

3 green filter I red filter R Wood 7) nm Millikan green filter 750 nm 600 nm 800 nm red filter nm RHb O 2 Hb Millikan oximeter Wood 5 5 A C Io In Lambert-Beer A A R = A IR = log Io R In R = E R Hb D (1) log Io IR In IR = E IR Hb D (2) R IR E Hb D (1) (2) 5 Wood oximeter Wood et al J Lab Clin Med ) 6 Wood SaO 2 Wood et al: J Lab Clin Med, ) = A R A IR = E R E IR (3) E Wood 5 white subject 5 dark subject 6 8) 2.4 Wood densitometer Wood oximeter densitometer Wood densitometer pulse oxmetory ( 7) Wood oximeter O 2 Hb RHb

4 54 Dye dilution method 7 Wood densitometer Hb 4 5 Hb A 8 Evans blue, ICG, O 2 Hb, RHb A 1 = log Io 1 In 1 = Eh 1 Hb D + Ed 1 Cd D (4) A 2 = log Io 2 In 2 = Eh 2 Hb D + Ed 2 Cd D (5) Io In nm nm Eh Ed ICG Hb Cd ICG D ICG nm ICG Ed 2 =0 (5) A 2 = log Io 2 In 2 = Eh 2 Hb D (6) (4) (6) = A 1 A 2 = E h1 E h2 + Ed 1 Ed 2 Cd Hb (7) E Hb Cd 2.5 Indocyanine green ICG Stewart, Hamilton Evans 9 Evans blue ICG Fox et al: Proc Staff Meet Mayo Clin, ) blue Evans blue 625 nm Evans blue 1956 Fox ICG 9) ICG Evans blue O 2 Hb RHb 8 ICG 805 nm 805 nm O 2 Hb RHb SO 2 9 Evans Blue ICG 2 right ventricle Evans blue ICG 10) ICG ICG angiography

5 ICG Obana et al: Am J Ophthalmol, (11) Obana ICG angiography ICG 11) ICG test 3774 ICG mg 2 ( 2) ICG 2.6 pulse oximetry pulse oximetry ) pulse oximetry Wood densitometer Wood densitometer 10 densitometer (1) a. b. (7) 2 Wood densitometer pulse oximetry pulse oximetry 10 :, 1966.(1) 3 Wood oximeter pulse oximeter Wood oximetry Wood oximetry D pulse oximetry D Wood oximetry pulse oximetry systolic phase Is diastolic phase Id Lambert-Beer A R = A IR = = log Id R Is R = E R Hb D (8) log Id IR = E IR Hb D (9) Is IR A R = E R (10) A IR E IR (10) SaO 2 SaO 2

6 56 Dye dilution method 11 pulse dye densitometry pulse oximetry Wood oximetry pulse dye densitometry 1974 pulse oximetry pulse dye densitometry (PDD) PDD pulse oximetry pulse spectrophotometry Pulse oximeter O 2 Hb RHb PDD Hb 13,14,15) pulse dye densitometer Wood Hb PDD Pulse oximeter Wood PDD Wood 11 1 early phase 12 Iijima T et al: J Anesth, 2005[16] 6 late phase PDD PDD ICU 16) [1]

7 ) 2) 1) Stewart Hamilton Wood oximetry Aoyagi pulse oximetry 2) Wood oximeter Wood method dye densitometer ICG Pulse oximeter Pulse dye densitometer Wood dye densitometer Pulse oximetory Pulse oximeter 1997 Pulse dye densitometer 1. :,, Bloomfield DA; Dye Curves: The theory and practice of indicator dilution., HM + M, Fox IJ: History and development aspects of the indicator-dilution technic. Circul Res 10:381, Stewart MA: Research on the circulation time in organs and on the influences which affect it. I. Preliminary paper. Proc. Physiol.Soc.Nov.8th, Kinsman JM, Moore JW, Hamilton WF: Studies on the circuration. Injection method: Physical and mathematical considerations. Amer.J.Physiol. 89: , Hamilton WF, Riley RL, et al.: Comparison of the Fick and dye injection methods of measuring the cardiac output in man., Am J Physiol. 1;153: , Wood EH: Oximetry, Medical Physics Vol2, , The Year Book Publishers Inc Wood EH, Geraci JE: Photoelectric determination of arterial oxygen saturation in man. J Lab Clin Med., 34: , Fox IJ,Brooker LGS, Heseltine DW, Wood EH: A new dye for continuous recording of dilution curves in whole blood independent of variations in blood oxygen saturation., Circulation 14, 937-8, Abstracts of the 29th scientific session, Fox IJ, Wood EH: Applications of dilution curves recorded from the right side of the heart or venous circulation with the aid of a new indicator dye. Proc Staff Meet Mayo Clin. 18;32:541-50, Obana A, Miki T, Hayashi K. et al., Survey of complications of indocyanine green angiography in Japan., Am J Ophthalmol. Dec 15;118: ME, 90-1, M.Fuse, T.Aoyagi, M.Kanemoto, C.Xie, H.Hosaka, M.Katayama, K.Miyasaka Dye dilution curve measurement using the principle of pulse oximetry. Medical and Biological Engineering & Computing 29 Suppl. 853, Iijima T, Aoyagi T, Iwao Y, Masuda J, Fuse

8 58 Dye dilution method M, Kobayashi N, Sankawa H: Cardiac output and circulating blood volume analysis by pulse dye-densitometry. J Clin Monit, 13:81-9, ?5: , Iijima T, Ueyama H et al: Determination of the standard value of circulating blood volume during anesthesia using pulse dyedensitometry: a multicenter study in Japan. J Anesth. 19: