PROFESSIONAL CURRICULUM VITAE

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1 PROFESSIONAL CURRICULUM VITAE Steven K. Malin, Ph.D. Assistant Professor Director: Applied Metabolism and Physiology (AMP) Laboratory Co-Director: Exercise Physiology Graduate Program Department of Kinesiology Curry School of Education Division of Endocrinology & Metabolism School of Medicine Robert M. Berne Cardiovascular Research Center (CVRC) University of Virginia 210 Memorial Gymnasium Room 225A Charlottesville, VA Work: Fax: EDUCATION PhD, University of Massachusetts, Department of Kinesiology, Amherst, MA, 2011 Designed, implemented and presented results of human (clinical) research studies assessing the interaction of metformin with exercise and diet interventions on energy metabolism, insulin resistance, inflammation, and cardiometabolic risk factors in healthy as well as overweight men and women with prediabetes and metabolic syndrome. MS, University of Delaware, Department of Nutrition, Newark, DE, 2006 Designed, implemented and presented results of human (clinical) research studies assessing the interaction of dietary supplements with exercise capacity and muscle strength in men and women with multiple sclerosis. BSc, King s College, Department of Neuroscience, Wilkes-Barre, PA, 2004 Major: Neuroscience (1 st ) and Psychology (2 nd ) PROFESSIONAL EXPERIENCE Assistant Professor, Department of Kinesiology, University of Virginia, Charlottesville, VA, 2014-Present. Director of Applied Metabolism and Physiology Laboratory Co-director of Exercise Physiology Graduate Program. Assistant Professor, Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, VA, 2014-Present. Assistant Professor, Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, 2014-Present. Postdoctoral Research Fellow, Cleveland Clinic, Cleveland, OH, Design, implement and present results of human (clinical) research studies assessing bariatric surgery, exercise and diet interventions on energy metabolism, insulin resistance, beta-cell function, incretins, appetite hormones, oxidative stress, inflammation, and cardiometabolic risk factors in overweight men and women with: prediabetes, metabolic syndrome, fatty liver disease and type 2 diabetes. Project manager for Nestle Sponsored Research on Whole-Grains and Metabolic health, and NIH funded investigation on mechanisms related to bariatric surgery and diabetes remission. Coordinator for the Cleveland Clinic Heart Transplant Team, Create schedules for heart research team, coordinate with medical fellows, dissect heart for experimental procedures. Judge, American College of Sports Medicine Nutrition Group Student Research Award, 2010-present Reviewed several applications regarding nutrition, exercise and health or athletic performance for quality, research design, writing quality and overall relativity to advancing the field of nutrition and exercise. 1

2 Chair, American College of Sports Medicine Free Communication Session, Metabolic adaptations to Exercise, 2015 Co-Coordinator, Baystate-Umass Collaborative Biomedical Research Program, Amherst, Served as a mentor to undergraduate students on graduate level research. Helped students design presentations, develop note taking skills as well as design studies. Was responsible for orientating students to the Umass Amherst campus, assisted students in receiving scholarship money as well as set up presentations from faculty throughout Umass to our students. Fitness Assessment Instructor, Cardio-Kinetics, Newark, DE, Communicated with individuals suffering from heart disease and diabetes about general nutrition as well as exercise importance. Coordinated specific exercise plans for elderly adults. Assessed blood pressure, heart rate, VO2max, metabolic assessments, musculoskeletal assessments and flexibility. CURRENT RESEARCH INTERSTS Understanding how to optimize the exercise effect on metabolic health with use of pharmacology and diet. Determining the effects of bariatric surgery on glycemic control, insulin action, and cardiovascular health. Exploring the roles of endocrine related inflammation and substrate metabolism during rest, exercise and meal intake in the pathogenesis of insulin resistance. Use of dietary supplements as a tool for improving athletic and functional performance. TEACHING EXPERIENCE Instructor (onsite), KINE 5490 Energy Metabolism, University of Virginia, present Instructor (onsite), KINE 5470 Metabolic Adaptations to Exercise, University of Virginia, present Instructor (onsite), KINE 3410 Exercise Physiology, University of Virginia, present Instructor (onsite), KIN 355 Seminar in Writing for Kinesiology, University of Massachusetts, Spring 2011 Instructor (onsite), KIN 110 Human Performance and Nutrition, University of Massachusetts, Fall 2010 Instructor (online), KIN 380 Diet, supplements and athletic performance, University of Massachusetts, Instructor (online), KIN 110 Human Performance and Nutrition, University of Massachusetts, ADVISING EXPERIENCE Laura Thistle, B.S. in Kinesiology, University of Massachusetts, Amherst, MA, Graduated 2010 Thesis: The effects of combining exercise training and metformin on body weight and food intake in individuals with pre-diabetes. Responsibilities: Assist in project development, perform data collection, entry and analysis for food intake, steps per day, perceived appetite and anthropometric measures. Oleg Kamentsky, B.S. in Kinesiology, University of Massachusetts, Amherst, MA, Graduated 2010 Thesis: The effects of combining exercise training and metformin on cardio-metabolic health in individuals with pre-diabetes. Responsibilities: Assist in project development, perform data collection, entry and analysis for blood lipids, anthropometric measures, and conduct lab protocol for blood pressure and cholesterol analysis. 2

3 Sarah Casey, B.S. in Kinesiology, University of Massachusetts, Amherst, MA, Graduated 2010 Project: The effect of metformin and exercise training on aerobic fitness in men and women with pre-diabetes. Responsibilities: Assist in project development, perform data collection, entry and analysis for blood lipids, anthropometric measures, and conduct lab protocol for blood pressure and cholesterol analysis. Corianne Oliver, B.S. in Biology, University of Massachusetts, Amherst, MA, Graduated 2011 Thesis: The role of thermal stress during exercise on appetite regulation in recreationally active men and women. Responsibilities: Independently develop project, perform data collection, entry and analysis, conduct lab protocol for submaximal exercise tests, hormonal analysis, blood glucose and insulin analysis. Joy Nightingale, B.S. in Kinesiology, University of Massachusetts, Amherst, MA, Graduated 2011 Thesis: The effects of exercise training and metformin on reducing cardiometabolic disease risk factors individuals with the metabolic syndrome. Responsibilities: Assist in project development, perform data collection, entry and analysis, conduct lab protocol for blood lipid, glucose, hormonal analysis. Nicole Nemi, B.S. in Exercise Science, Cleveland State University, Cleveland, OH, Graduated 2013 Project: Effect of exercise training with a low glycemic index diets in older men and women with the metabolic syndrome. Responsibilities: Assist in data acquisition, perform data entry and calculations. Stephen Finnegan, High School Student, Cleveland, OH, Graduated 2013 Project: Exercise dose: Is there a critical threshold for improving β-cell function in older adults? Responsibilities: Assist in data acquisition, perform data entry and calculations. Michelle Elkadi, MS, Cleveland Clinic Dietetic Intern, Cleveland, OH, Project: Role of Dietary Fats During Exercise Training in Obese Adults with Prediabetes. Responsibilities: Data analysis, data organization, literature review, propose study and develop a paper/manuscript. Cortney Staruch, BS, Cleveland Clinic Dietetic Intern, Cleveland, OH, Project: Exercise Responsiveness for Glucose Regulation following 7-days of Exercise Responsibilities: Data analysis, data organization, literature review, propose study and develop a paper/manuscript. Sarah Skinner, M.Ed, University of Virginia, Charlottesville, VA, Project: Variations in dietary fat during exercise training influences insulin sensitivity, blood lipids and appetite responses in adults with prediabetes. Responsibilities: Literature review, propose study, protocol development, data collection, subject recruitment, and data analysis. TECHNICAL SKILLS Stable isotope analysis (6,6-2H glucose) via high performance liquid chromatography/mass spectrometry. Hyperinsulinemic-euglycemic and hyperglycemic clamp technique Dual-tracer (6,6-2H glucose + 13C) approach to study glucose uptake, endogenous glucose production, exogenous glucose meal appearance and blood glucose oxidation. 13-C Leucine and glycine for determination of whole-body protein synthesis/breakdown. Oral glucose tolerance test and mixed-meal tolerance test. Glucose Analox (GL-5 model) for glucose, lactate and cholesterol measures. 3

4 True Max 2400 for peak oxygen consumption (VO 2 peak) and resting metabolism tests Experienced in placing catheters and butterfly needles Insulin, Free Fatty Acid, C-reactive protein, Fetuin-A, DPP-4, and Triglyceride Assays Biodex Multi-Joint Dynamometer Diet Analysis Plus/ ESHA Food Processor DEXA, Bodpod, InBody, Body Mass Index Scores, Waist circumference measures 1055R Exer-3R Open Treadmill for Rats with Shocker (6-100 M/m) R Statistical Software, Microsoft Package (Word, Power-Point, Excel), and Blackboard Course Designer GRANT/ABSTRACT REVIEWER Health Research Awards (HRA-2013-HSR-259) Ireland Funding Agency 2013 (Grant) American Diabetes Associations 74 th Scientific Sessions, June 13-17, 2014 (Abstract) Clinical & Translational Science Collaborative (CTSC) - Case Western Reserve University 2014 (Grant) INVITED MANUSCRIPT REVIEWER Applied Physiology, Nutrition, & Metabolism Obesity Journal of Applied Physiology European Journal of Applied Physiology PLoS One Journal of Pediatric Endocrinology and Metabolism Diabetes, Obesity & Metabolism Endocrine Nutrition Research Diabetic Medicine Journal of Diabetes Research The American Journal of Medicine Obesity Research & Clinical Practice Microcirculation Medicine & Science and Sports & Exercise Scientific Reports Diabetology & Metabolic Syndrome Journal of Caffeine Research Diabetologia Cytokine Surgery for Obesity Related Disorders Journal of Diabetes Science and Technology PEER REVIEWED PUBLICATIONS 1. Malin SK and Cotguna N. Creatine Supplementation Enhances Endurance Performance in Trained Rats. Journal of Dietary Supplements. 2008, 5(2), Malin SK, Cotguna N, Fang C. Short term Creatine supplementation does not enhance work capacity in individuals with Multiple Sclerosis. Journal of Dietary Supplements. 2008, 5(1), Malin SK, Stephens BR, Hagobian TA, Sharoff CG, Chipkin SR, and Braun B Metformin s effect on exercise and post-exercise substrate oxidation. International Journal of Sports Nutrition and Exercise Metabolism; 2010, 20(1): Sharoff CG, Hagobian TA, Malin SK, Chipkin SR, Yu H, Hirshman M, Goodyear L, and Braun B. Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulin resistant individuals. American Journal of Physiology, Endocrinology and Metabolism; 2010, 298(4): E

5 5. Malin SK, Gerber R, Chipkin SR, and Braun, B. Combining metformin with exercise does not produce additive effects on whole body insulin sensitivity in individuals with prediabetes. Diabetes Care; 2012, 35(1) Granados K, Stephens BR, Malin SK, Zderic T, Hamilton M, and Braun B. Effects of inactivity and energy status on appetite regulation in men and women. Applied Physiology, Nutrition and Metabolism, 2012; 37(2): Malin SK and Kirwan JP. Fasting hyperglycemia blunts the reversal of impaired glucose tolerance after exercise training in obese older adults. Diabetes, Obesity, and Metabolism, 2012, 14(9): Malin SK, Nightingale J, Choi S, Chipkin SR, and Braun B. Metformin modifies the exercise training effects on risk factors for cardiovascular disease in impaired glucose tolerant adults. Obesity, 2013; 21(1): Malin SK, Niemi N, Solomon TPS, Haus JM, Kelly KR, Filion J, Rocco M, Kashyap SR, Barkoukis H, and Kirwan JP. Exercise training with weight loss and a high or low glycemic diet reduces metabolic syndrome severity in older adults. Annals of Nutrition & Metabolism, 2012; 61(2): Glass C, Hipskind P, Tsien C, Malin SK, Kasumov T, Kirwan JP, Dasarathy S. Hospitalized Cirrhotic patients have a non-physiological respiratory quotient compared to healthy controls. Journal of Applied Physiology, 2013, 114(5): Malin SK and Braun B. Effects of metformin on substrate utilization after exercise training in adults with impaired glucose tolerance. Applied Physiology, Nutrition and Metabolism, 2012, 38(4): Samat A, Malin SK, Huang H, Schauer PR, Kirwan JP, Kashyap, SR. Ghrelin suppression is associated with weight loss and insulin action following gastric bypass surgery at 12 months in obese adults with type 2 diabetes. Diabetes, Obesity, and Metabolism, 2013, 15(10) Solomon TJP, Malin SK, Karstoft K, Haus JM, and Kirwan JP. The influence of hyperglycemia on the therapeutic effect of exercise on glycemic control in patients with type 2 diabetes mellitus. Journal of American Medical Association, 2013, 173(19): Malin SK, Viskochil R, Oliver C, and Braun B. Fasting hyperglycemia shifts fuel reliance to fat during exercise in adults with impaired glucose tolerance. Journal of Applied Physiology, 2013, 115(1): Malin SK, Huang H, Kashyap SR, and Kirwan JP. Lower Dipeptidyl peptidase-4 following exercise training is related to increased insulin sensitivity in adults with metabolic syndrome. Peptides, 2013, 47: Malin SK, Fealy C, Haus JM, Pagadala M, Scelsi AR, Huang H, Lu L, McCullough AJ, Flask CA, and Kirwan JP. Decreased fetuin-a correlates with improved glucose tolerance after short-term exercise training in adults with NAFLD. Journal of Applied Physiology, 2013, 115(7): Solomon TJP, Malin SK, Karstoft K, Haus JM, Kashyap SR, and Kirwan JP. Pancreatic beta-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than peripheral insulin sensitivity. Journal of Clinical Endocrinology and Metabolism, 2013, 98(10): Malin SK, Finnegan S, Fealy C, Filion J, Rocco M, and Kirwan, JP. β-cell dysfunction is associated with metabolic syndrome severity in older obese adults. Metabolic Syndrome and Related Disorders, 2014, 12(2): Malin SK, Solomon TPS, Finnegan S, Blaszczak A, Filion J, and Kirwan, JP. Pancreatic beta-cell function increases in a linear dose-response manner following exercise training in adults with prediabetes. American Journal of Physiology: Endocrinology and Metabolism, 2013, 15(305): E1248-E Malin SK* Hinnerichs* KR, Echtenkamp BG, Evetovich TK, and Engebretsen BJ. Effect of adiposity on insulin action after resistance exercise in non-diabetic women. European Journal of Applied Physiology, 2013, 113(12): *Shared first author responsibility 5

6 21. Malin SK, Navaneethan SD, Muyla A, Huang H, and Kirwan, JP. Exercise-induced lowering of chemerin is associated with reduced cardiometabolic risk and glucose-stimulated insulin secretion in older adults. Journal of Health, Aging and Nutrition, 2014, 18(6): Malin SK, Samat A, Wolski K, Abood B, Pothier C, Bhat DL, Nissen S, Brethauer SA, Schauer PR, Kirwan JP, and Kashyap SR. Improved acylated ghrelin suppression at 2 years: effects of bariatric surgery versus standard medical therapy in type 2 diabetics. International Journal of Obesity, 2014, 38(3): Malin SK, Haus JM, Solomon TPS, Blaszczak A, and Kirwan JP. Insulin sensitivity and metabolic flexibility after exercise training among different obese insulin resistant phenotypes. American Journal of Physiology: Endocrinology and Metabolism, 2013, 15(305): E1292-E Malin SK, Kirwan JP, Ling-Sia C, Gonzalez F. Pancreatic beta-cell function is inversely related to glucoseinduced oxidative stress in polycystic ovarian syndrome (PCOS). Journal of Clinical Endocrinology & Metabolism, 2014, 99(1): Malin SK*, del Rincon JP*, Haung H, and Kirwan JP. Exercise-induced lowering of fetuin-a may relate to improved hepatic insulin sensitivity (Accepted: Medicine and Science in Sports and Exercise, 2014). *Shared first author responsibility 26. Malin SK and Kashyap SR. Effects of metformin on weight loss: potential mechanisms. (Accepted: Current Opinion in Endocrinology, Diabetes and Obesity, 2014). 27. Malin SK, Kashyap SR, Hammel J, Miyazaki Y, DeFronzo RA and Kirwan JP. Adjusting glucose-stimulated insulin secretion for adipose insulin resistance: a novel index of beta-cell function (Accepted: Diabetes Care, 2013). 28. Malin SK, Bena J, Abood B, Pothier C, Bhat DL, Nissen S, Brethauer SA, Schauer PR, Kirwan JP, and Kashyap SR. Attenuated improvements in adiponectin and fat loss characterize type 2 diabetes nonremission status 2 years following bariatric surgery. (Accepted: Diabetes, Obesity & Metabolism, 2014). 29. Solomon TPJ, Malin SK, Karstoft K, Knudsen SH, Haus JM, Laye MJ, Pederson M, Pedersen BK, Kirwan JP. The oral glucose tolerance test: A simple tool for assessing pancreatic beta-cell compensation for changing insulin sensitivity. (Accepted: American Journal of Physiology: Endocrinology and Metabolism, 2014). 30. Navaneethan S, Malin SK, Kirwan JP, Kashyap SR, Schauer PR. Improvements in insulin resistance, adipokines and kidney function following bariatric surgery (Accepted: American Journal of Kidney Disease, 2014). 31. Malin SK and Kashayp SR. Differences in weight loss and gut hormones: role of Rouen-Y Gastric bypass and sleeve gastrectomy surgery. (Accepted: Current Obesity Reports, 2014). 32. Khanna V*, Malin SK*, Bena J, Abood B, Pothier, C, Bhat DL, Nissen S, Brethauer SA, Schauer PR, Kirwan JP, Kashyap SR. Long duration type 2 diabetics have blunted glycemic control and β-cell function responses to bariatric surgery (Accepted: Obesity, 2014). *Shared first author responsibility 33. Solomon TPJ, Malin SK, Karstoft K, Knudsen SH, Haus JM, Laye MJ, Kirwan JP. The association between cardiorespiratory fitness and the determinants of glycemic control across the entire glucose tolerance continuum. (Accepted: Diabetes Care, 2015). 34. Malin SK, Kirwan JP, Ling-Sia C, Gonzalez F. Pancreatic beta-cell function is linked to glucose-stimulated monocyte inflammation in polycystic ovarian syndrome. (Accepted: American Journal of Physiology: Endocrinology and Metabolism, 2015). ***Picked as APSselect June 2015*** 35. Rynders CA, Weltman JY, Malin SK, Jiang B, Breton M, Barrett EJ, Weltman A. Evaluating the validity of surrogate indices of insulin sensitivity against the oral minimal model following exercise different intensities of exercise. (Accepted, Medicine and Science in Sports and Exercise, 2015). 6

7 36. Malin SK and Braun B. Metformin plus exercise: is it better than exercise alone to lower type 2 diabetes risk. (Submitted: Exercise and Science and Sports and Review, 2015). 37. Malin SK, Rynders CA, Weltman JY, Barrett EJ, Weltman A. Exercise intensity modulates glucosestimulated insulin secretion adjusted for hepatic, adipose and skeletal muscle insulin resistance. (Submitted, PLoS One, 2015). 38. Muyla A, Malin SK, Haus JM, Solomon TPS, Kelly KR, and Kirwan JP. PGC-1 alpha and fat metabolism are upregulated after both high and low glycemic index diets and exercise training in older adults. (Submitted: Obesity, 2015). 39. Navaneethan, S, Fealy CE, Scelsi AR, Huang H, Malin, SK, Kirwan, JP. Benefits of lifestyle modification in obese chronic kidney disease patients. (in preparation: Obesity, 2014). 40. Brandauer J, Malin SK, Berardinelli DM, Viskochil R, Chipkin SR, Braun B. Metformin blunts reductions in serum retinol binding protein 4 following exercise training. (in preparation: Metabolism, 2015) 41. Malin SK, Krishanan RK, Marchetti CM, Willimson DL, and Kirwan JP. Free fatty acid-induced peripheral and hepatic insulin resistance is exaggerated in old compared to young adults (in preparation: Journal of Applied Physiology, 2015). 42. Malin SK, Huang H, Kirwan JP. RAGE is associated with blunted glycemic benefit following exercise training in adults with impaired glucose metabolism (in preparation: Medicine and Science & Sports and Exercise, 2015). 43. Malin SK, Rynders CA, Weltman JY, Barrett EJ, Weltman A. Exercise intensity modulates vascular insulin resistance in relation to oxidative stress. (in preparation: Medicine and Science in Sports and Exercise, 2015). 44. Skinner SC, Choi SE, Chipkin SR, Braun B, Malin SK. Variations in dietary fat associate with insulin sensitivity and appetite following exercise in IGT adults. (in preparation Annals of Nutrition & Metabolism, 2015). 45. Kirwan JP, Malin SK, Scelsi AR, Kullman EL, Haus JM, Filion J, Godin J-P, Kochhar S, Ross AB. A Whole Grain Diet Reduces Blood Pressure in Overweight/Obese Adults A Randomized Control Trial. (in preparation American Journal of Clinical Nutrition, 2015). 46. Viskochil, R, Malin, SK, Blankenship J, Braun, B. Exercise training with metformin, but not exercise alone, lowers fasting proinsulin concentrations in women and men with prediabetes (in preparation Applied Physiology, Metabolism and Nutrition, 2015). TEXTBOOK CHAPTERS 1. Malin SK and Kashyap SR. Role of bariatric surgery in the treatment of type 2 diabetes. (Therapy for Diabetes Mellitus and Related Disorders. 6 th ed. Umpierrez GE, Ed. Alexandria, VA, American Diabetes Association, 2014, p ). 2. Malin SK and Kirwan JP. Understanding the benefits of bariatric surgery on gut physiology: implications for obesity, type 2 diabetes and cardiovascular disease. (Accepted: Metabolomics and Gut Microbiota in Nutrition and Disease, 2014). ABSTRACTS 1. Malin SK, Kodra C. Creatine Supplementation Enhances Rat s Endurance in a Treadmill Performance Test. (2006). American College of Sports Medicine, Denver, CO. 7

8 2. Malin SK, Cotguna N, Fang C. Short term Creatine supplementation does not enhance work capacity in individuals with Multiple Sclerosis. (2006). American College of Sports Medicine Conference on Integrative Physiology of Exercise. Indianapolis, IN. 3. Malin SK, Stephens BR, Sharoff CG, Chipkin SR, Braun B. Metformin treatment decreases fat utilization after exercise (2008). APS Intersociety Meeting: Integrative Biology of Exercise V. Hilton Head, South Carolina. 4. Stephens BR, Granados K, Malin SK, Zderic T, Hamilton M, Braun B. Effects of inactivity and energy status on appetite regulation in men and women. (2008). APS Intersociety Meeting: Integrative Biology of Exercise V. Hilton Head, South Carolina. 5. Granados K, Stephens BR, Malin SK, Zderic T, Hamilton M, Braun B. Detrimental effects of inactivity on insulin action: role of energy surplus. (2008). APS Intersociety Meeting: Integrative Biology of Exercise V. Hilton Head, South Carolina. 6. Hinnerichs K., Echtenkamp B, Malin SK, Evetovich T, Conley D, Braun B, Engebretsen, B. Insulin sensitivity increases in lean but not obese young women after 7 weeks of progressive resistance training. (2008). APS Intersociety Meeting: Integrative Biology of Exercise V. Hilton Head, South Carolina. 7. Sharoff CG, Malin SK, Hagobian TA, Chipkin SR, Braun B. The combined effects of metformin and exercise on metabolic flexibility and substrate utilization during exercise and insulin stimulation in insulin resistant individuals. (2008). American College of Sports Medicine, Indianapolis, IN. 8. Sharoff CG, Malin SK, Hagobian TA, Chipkin SR, Yu H, Hirshman M, Goodyear LJ, Braun B. Combining shortterm metformin treatment and acute exercise does not improve insulin sensitivity. (2008). American Diabetes Association San Francisco, CA. 9. Granados K, Stephens BR, Malin SK, Zderic T, Hamilton M, Braun B. Effects of inactivity and energy status on appetite regulation in men and women. (2009). American College of Sports Medicine. Seattle, Washington. 10. Stephens BR, Granados K, Malin SK, Zderic T, Hamilton M, Braun B. Detrimental effects of inactivity on insulin action: role of energy surplus. (2009). American College of Sports Medicine. Seattle, Washington. 11. Nightingale, J, Malin, SK, Braun, B. Effects of adding metformin to exercise training to reduce risk factors for the metabolic syndrome. (2010). New England Chapter of the American College of Sports Medicine, Providence, RI. 12. Malin, SK, Gerber, R, Chipkin, S, Braun, B. Effect of Exercise Training with and without Metformin on Insulin Sensitivity in Individuals with Prediabetes. (2010). Integrative Physiology of Exercise Conference. Miami, FL. 13. Oliver, C, Malin, SK, Chipkin, S, Braun, B. Exercise Training, with and without metformin, improves markers of cardiometabolic health in Adults with Prediabetes. (2010). Integrative Physiology of Exercise Conference. Miami, FL. 14. Viskochil, R, Malin, SK, Gerber, R, Chipkin, S, Braun, B. Metformin Enhances the Effects of Exercise Training on Fasting insulin Secretion in Adults with Prediabetes. (2010). Integrative Physiology of Exercise Conference. Miami, FL. 15. Granados K, Stephens BR, Malin SK, Zderic T, Hamilton M, Braun B. Sex Differences in Appetite Regulation With 24 hours of Imposed Sitting. (2010). Integrative Physiology of Exercise Conference. Miami, FL. 16. Malin, SK, Choi, S, Thistle, LJ, Braun, B. The Effects of Exercise Training and/or Metformin for 12 weeks on Body weight and Energy Intake in Individuals with Prediabetes. (2010). American Dietetics Association. Boston, MA. 17. Kamenetsky, OA, Malin, SK, Braun, B. Combining Metformin and/or Exercise Improves Cardiovascular Health in Men and Women with Prediabetes. (2010). Massachusetts Undergraduate conference, Amherst, MA. 18. Casey, S, Malin, SK, Braun, B. Effect of Metformin and Exercise Training on Aerobic Fitness in Men and Women with Prediabetes. (2010). Massachusetts Undergraduate conference, Amherst, MA. 8

9 19. Thistle, LJ, Malin, SK, Choi, S, Braun, B. The Effects of Exercise Training and/or Metformin on Body weight and Food Intake in Individuals with Prediabetes. (2010). Massachusetts Undergraduate conference, Amherst, MA. 20. Choi, S, Malin SK, Braun B. Effects of exercise training and/or metformin treatment on body weight and food intake in individuals with prediabetes. (2010). Massachusetts Dietetic Association Conference, MA. 21. Gerber R, Malin SK, Chipkin SR, Freedson P, Braun B. Relationship between habitual physical activity and whole-body insulin sensitivity in individuals with prediabetes. (2010). American College of Sports Medicine, Baltimore, MD. 22. Oliver, C, Malin, SK, Braun, B. Suppression of Appetite after Exercise: Role of Elevated body temperature. (2011). Massachusetts Undergraduate conference, Amherst, MA. 23. Malin, SK, Granados K, Viskochil R, Chipkin SR, Braun, B. Adding metformin to exercise training alters insulin resistance and risk factors for the metabolic syndrome. (2011). American College of Sports Medicine, Denver, CO. 24. Granados K, Stephens BR, Malin SK, Zderic T, Hamilton M, Braun B. Insulin secretion is not effected by acute physical inactivity or energy surplus. (2011). American College of Sports Medicine, Denver, CO 25. Malin, SK, Niemi, N, Solomon, TPS, Haus, JM, Kelly, KR, Filion, J, Rocco, M, Kashyap, SR, Barkoukis, H, Kirwan, JP Effects of low and high glycemic index diets with exercise training in older adults with the metabolic syndrome. (2011). Cleveland Clinic Obesity Submit, Cleveland, OH. 26. Malin, SK, and Kirwan, JP. Fasting hyperglycemia blunts the regression of impaired glucose tolerance after lifestyle modification in older adults. (2012). Experimental Biology, San Diego, CA. 27. Samat A, Malin, SK, Huang, H, Schauer, PS, Kirwan, JP, Kashyap, SR Suppression of Ghrelin after Gastric Bypass Surgery is Associated with Weight Loss in Super Obese Patients with T2DM. (2012). American Diabetes Association Annual Conference, Philadelphia, PA. 28. Muyla, A, Haus, JM, Solomon, TPJ, Kelley, KR, Malin, SK, Kirwan JP. Upregulation of PGC-1α and fat transport/oxidation genes in skeletal muscle is linked to improved insulin sensitivity following a lifestyle intervention in obese humans. (2012). American Diabetes Association, Philadelphia, PA. 29. Malin, SK, Huang, H, Muyula A, Kashyap, SR, Kirwan, JP. DPP-4 may mediate reduced insulin resistance after exercise training induced weight loss in adults with metabolic syndrome. (2013). American College of Sports Medicine, Indianapolis, IN. 30. Viskochil, R, Kozey-Keadle, S, Malin, SK, Chipkin, SR, Freedson, PS, Braun, B. Exercise training combined with metformin lowers circulating proinsulin concentrations in adults with prediabetes (2013). American College of Sports Medicine, Indianapolis, IN. 31. Malin, SK, Samat, A, Wolski, K, Abood, B, Pothier, C, Bhat, DL, Nissen, S, Brethauer, SA, Schauer, PR, Kirwan, JP, Kashyap SR. Gastric bypass surgery enhances ghrelin suppression in parallel with improved beta-cell function and central adiposity at 24 months in adults with type 2 diabetes. (2013). American Diabetes Association, Chicago, IL. 32. Mahmoud, AM, Somal V, Solomon, TPJ, Kasumov, T, Fealy CE, Malin, SK, Kirwan, JP, Haus, JM. RAGE Expression in Human Skeletal Muscle is Normalized Following Aerobic Exercise Training. (2013). American Diabetes Association, Chicago, IL. 33. Nadolski, LE, Solomon, TPJ, Fealy, CE, Malin, SK, Kirwan, JP, Haus, JM. Diminished Glyoxalase I Activity in Skeletal Muscle of Older Obese Individuals is Associated with Determinants of Metabolic Health. (2013). American Diabetes Association, Chicago, IL. 34. Malin, SK, Kirwan, JP, Ling-Sia, C, Gonzalez F. Pancreatic beta-cell function is inversely related to glucose-induce oxidative stress in polycystic ovarian syndrome (PCOS). (2013). Endocrinology. San Francisco, CA. 9

10 35. del Rincon, JP, Malin, SK, Kirwan, JP. Circulating fetuin-a decreases following exercise-induced weight loss in older prediabetic adults in association with reduced hepatic insulin resistance. (2013). Endocrinology. San Francisco, CA. 36. Mahmoud, AM, Mey, JT, Solomon, TPJ, Fealy, CE, Malin, SK, Kirwan, JP, Haus, JM. Glycoxalase 1 protein expression in human insulin resistant skeletal muscle. (2013). Biochemical Society: Glyoxalase Centennial: 100 Years of Glyoxalase Research and Emergence of Dicarbonyl Stress, UK 37. Navaneethan, S, Malin, SK, Kirwan, JP, Schauer, PR. Changes in insulin resistance, adipokines and kidney function following bariatric surgery. (2013). American Society of Nephrology. Atlanta, GA. 38. Kirwan JP, Malin SK, Scelsi AR, Kullman EL, Haus JM, Filion J, Godin J-P, Kochhar S, Ross AB. A Whole Grain Diet Reduces Blood Pressure in Overweight/Obese Adults A Randomized Control Trial. (2014). Experimental Biology, San Diego, CA. 39. Malin, SK, Kashyap, SR, Hammel, J, Miyazaki, Y, Kirwan, JP, DeFronzo RA. Adjusting glucose-stimulated insulin secretion for adipose insulin resistance: role of exercise on novel β-cell function index. (2014). American College of Sports Medicine. Orlando, FL. 40. Viskochil, R, Blankenship, J, Malin, SK, Braun, B. Similar phenotypic variability following 12-weeks of exercise training with/without metformin in adults with prediabetes. (2014). American College of Sports Medicine. Orlando, FL. 41. Gonzalez F, Malin SK, Kirwan, JP, Ling-Sia, C. Pancreatic beta-cell function is linked to glucose-stimulated monocyte inflammation in polycystic ovarian syndrome (PCOS). (2014). American Diabetes Association, San Francisco, CA. 42. Kirwan JP, Malin SK, Kullman, EL, del Rincon, JP, Scelsi, AR, Brethauer, SA, Kashyap SR, Schauer, PR. Early diabetes remission after gastric bypass surgery is explained by exclusion of the foregut. (2014). American Diabetes Association, San Francisco, CA. 43. Malin SK, Bena J, Abood B, Pothier, C, Bhat DL, Nissen S, Brethauer SA, Schauer PR, Kirwan JP, Kashyap SR. Attenuated improvements in adiponectin and fat loss characterizes type 2 diabetes nonremission status 2 years following bariatric surgery. (2014). American Diabetes Association, San Francisco, CA. (selected for Audio Tour). 44. Mahmoud AM, Blackburn BK, Coleman K, Mey JT, Somal VS, Solomon TPJ, Fealy CE, Malin SK, Kirwan JP, Haus JM. Aerobic Exercise Induces RAGE Shedding via ADAM10 in Human Skeletal Muscle. (2014). Advances in Skeletal Muscle Biology In Health & Disease Conference, Orlando, FL. 45. Khanna V, Malin SK, Bena J, Abood B, Pothier, C, Bhat DL, Nissen S, Brethauer SA, Schauer PR, Kirwan JP, Kashyap SR. Long duration type 2 diabetics have blunted glycemic control and β-cell function responses to bariatric surgery (2014). American Diabetes Association, San Francisco, CA. 46. Navaneethan, S, Fealy CE, Scelsi AR, Huang H, Malin, SK, Kirwan, JP. Benefits of lifestyle modification in obese chronic kidney disease patients. (2014). American Society of Nephrology. Philadelphia, PA. 47. del Rincon, JP, Malin SK, Kullman, EL, Ratycz M, Scelsi, AR, Kasumov T, Kashyap SR, Schauer, PR, Kirwan JP. Taurocholic acid increases in oral vs. gastrostomy tube mixed meal feeding early after Roux-n- Y gastric bypass surgery in adults with type 2 diabetes (2014). Obesity Society, Boston, MA. 48. Viskochil R, Laurin J, Malin SK, Blankenship JM, Braun B. Metformin may blunt beneficial effects of exercise training on cancer-related adipokines in women with prediabetes. (2015). American College of Sports Medicine, San Diego, CA. 49. Malin, SK, Navaneethan, S, Fealy CE, Scelsi AR, Huang H, Kirwan, JP. Lifestyle-intervention lowers RAGE and improves insulin sensitivity in chronic kidney disease. (2015). American College of Sports Medicine, San Diego, CA. **Thematic Poster** 10

11 50. Skinner SC, Choi SE, Chipkin SR, Braun B, Malin SK. Variations in dietary fat associate with insulin sensitivity and appetite following exercise in IGT adults. (2015). American College of Sports Medicine, San Diego, CA. **Thematic Poster** 51. Brandauer J, Malin SK, Berardinelli DM, Viskochil R, Chipkin SR, Braun B. Metformin blunts reductions in serum retinol binding protein 4 following exercise training. (2015). Experimental Biology, Boston, MA. 52. Heresi GA, Malin SK, Barnes JW, Tian L, Tonelli AR, Kirwan JP, Dweik RA.. Beta Cell Dysfunction and Energy Wasting are Associated with Inflammation and Markers of Vascular Dysfunction in Idiopathic Pulmonary Arterial Hypertension (2015). American Thoracic Society International Conference, Denver, CO. 53. Heresi GA, Malin SK, Barnes JW, Tian L, Dweik RA, Kirwan JP. Glucose Metabolism Dysregulation and Energy Wasting in Idiopathic Pulmonary Arterial Hypertension. (2015). American Thoracic Society International Conference, Denver, CO. 54. Malin SK, Huang H, Kirwan JP. RAGE is associated with blunted glycemic benefit following exercise training in adults with impaired glucose metabolism. (2015). American Diabetes Association, Boston, MA. 55. Malin SK, Bena J, Abood B, Pothier, C, Bhat DL, Nissen S, Brethauer SA, Schauer PR, Kirwan JP, and Kashyap SR. Bariatric surgery improves metabolic syndrome severity in relation to changes in insulin secretion relative to multi-tissue insulin resistance. (2015). American Diabetes Association, Boston, MA. 56. Weltman A, Rynders CA, Weltman JY, Liu Z, Roberts J, Nadler J, Barrett EJ, Malin SK (lead author). Effects of exercise intensity on vascular insulin action and oxidative stress in adults with prediabetes. (2015). American Diabetes Association, Boston, MA. 57. Nieuwoudt S, Fealy CE, Scelsi AR, Malin SK, Foucher JA, Navaneethan SD, Li M, Rocco M, Burguera B, Kirwan JP. High intensity CrossFit exercise attenuates cardiometabolic risk factors in adults with type 2 diabetes. (2015). American Diabetes Association, Boston, MA. 58. Fealy CE, Nieuwoudt S, Scelsi AR, Malin SK, Foucher JA, Pagadala M, Li M, Rocco M, Burguera B, Kirwan JP. High Intensity CrossFit Exercise Increases β-cell Function and Insulin Sensitivity in Adults with Type 2 Diabetes. (2015). American Diabetes Association, Boston, MA. CONFERENCE PRESENTATIONS 1. Malin SK, Kodra C, O Brien M, Dunley, J. Effect of creatine supplementation on run performance in rats. King s College, Neuroscience Research Day, University of Delaware, Annual Teaching Assistant Conference 2005, Guest Lecture on Assessment Tools Used in the Classroom and Panelist for Discussion on the Life of a TA 3. Malin, SK. Creatine supplementation does not enhance muscle capacity in individuals with multiple sclerosis. (2006) New England Chapter of the American College of Sports Medicine, Providence, RI. 4. Malin SK, Stephens BR, Hagobian TA, Sharoff CG, Chipkin SR, and Braun B. Metformin alters substrate oxidation during submaximal exercise. (2007). New England Chapter of the American College of Sports Medicine, Providence, RI. 5. Malin SK, Stephens BR, Hagobian TA, Sharoff CG, Chipkin SR, and Braun B Metformin alters substrate oxidation and perception of effort during exercise. (2008). American College of Sports Medicine, Indianapolis, IN. 6. Malin SK, Howe C, Braun, B., and Freedson P. Substrate utilization differences during submaximal exercise between lean, overweight and obese children. (2009). American College of Sports Medicine, Seattle, Washington. 7. Malin SK and Braun B. Effects of exercise training and metformin on substrate utilization in individuals with prediabetes. (2010). American College of Sports Medicine, Baltimore, MD. 11

12 8. Malin, SK, Gerber, R, Chipkin, SR, and Braun, B. Adding metformin to exercise attenuates gains in insulin sensitivity in individuals with prediabtetes. (2010). New England Chapter of the American College of Sports Medicine, Providence, RI. 9. Malin, SK, Fealy, CE, Haus, JM, Pagadala, M, Scelsi, AR, Huang, H, Lu, L, McCullough, AJ, Flask, CA, and Kirwan, JP. Decreased fetuin-a correlates with glucose tolerance following short-term exercise training in adults with NAFLD. (2012). American Diabetes Association, Philadelphia, PA. 10. Malin, SK, Fealy, CE, Haus, JM, Pagadala, M, Scelsi, AR, Huang, H, Lu, L, McCullough, AJ, Flask, CA, and Kirwan, JP. Exercise reduces fetuin-a levels in conjunction with glucose control after 7-days of exercise in adults with NAFLD. (2012). Obesity Submit Cleveland Clinic, Cleveland, OH. 11. Malin SK, Samat A, Wolski K, Abood B, Pothier C, Bhat DL, Nissen S, Brethauer SA, Schauer PR, Kirwan JP, and Kashyap SR. Ghrelin regulation may contribute to diabetes remission after bariatric surgery (2013). Obesity Submit Cleveland Clinic, Cleveland, OH. 12. Malin, SK, Kullman, EL, Scelsi, AR, Haus, JM, Filion, J, Godin, J-P, Kochhar, S, Ross, AB, Kirwan JP. A Whole Grain Diet Improves Glucose Tolerance and Peripheral Insulin Resistance in Obese Prediabetic Adults. (2014). American Diabetes Association, San Francisco, CA. 13. Malin SK, Bena J, Abood B, Pothier, C, Bhat DL, Nissen S, Brethauer SA, Schauer PR, Kirwan JP, and Kashyap SR. Attenuated rises in adiponectin and fat loss characterizes type 2 diabetes non-remission status 2 years following bariatric surgery. (2014). Endocrinology & Metabolic Institute Research Day, Cleveland, OH. 14. Malin, SK, Navaneethan, S, Fealy CE, Scelsi AR, Huang H, Kirwan, JP. Lifestyle-intervention lowers RAGE and improves insulin sensitivity in chronic kidney disease. (2015). Southeast American College of Sports Medicine, Jacksonville, FL. 15. Weltman A, Rynders CA, Weltman JY, Barrett EJ, Malin SK (lead author). Exercise intensity modulates glucose-stimulated insulin secretion adjusted for hepatic, adipose and skeletal muscle insulin resistance. (2015). American College of Sports Medicine, San Diego, CA. INVITED TALKS 1. Guest Lecture in Molecular Medicine, Cleveland Clinic, Cleveland OH Title: Glucose metabolism during exercise and the metabolic syndrome. 2. Guest lecture in Nutrition 577, University of Massachusetts, Amherst, MA Title: Role of exercise in preventing type 2 diabetes. 3. Seminar Talk in Nutrition, University of Delaware, Newark, DE Title: Combining exercise with metformin: is it beneficial for metabolic health? 4. Seminar Talk in Kinesiology, University of Virginia, Charlottesville, VA Title: Optimizing lifestyle modification and bariatric surgery strategies to lower type 2 diabetes risk. 5. Seminar Talk in Nutrition, University of Michigan, Ann Arbor, MI Title: Maximizing the use of physical activity and nutrition to prevent type 2 diabetes. 6. Seminar Talk in Kinesiology, Kent State University, Kent, OH Title: Optimizing lifestyle modification and bariatric surgery strategies to lower type 2 diabetes risk. 7. Seminar Talk in Diabetes Center, University of Virginia, Charlottesville, VA Title: Combining metformin with exercise: is it optimal for type 2 diabetes prevention? 8. Seminar Talk in Department of Human Nutrition, Foods and Exercise, Virginia Tech Title: Individual responsiveness to exercise for glycemic control in adults at risk for type 2 diabetes 12

13 RESEARCH GRANTS $50,000: University of Virginia School of Medicine Thelma R. Swortzel Award. Role of pre-operative exercise and nutrition therapy on immunometabolism for patients undergoing bariatric surgery. Role contact PI, (Funded). $600,000; Clinical & Translational Research Award American Diabetes Association. Rescuing vascular insulin resistance in prediabetes by exercise. Role: PI, (Not Funded). $1,900,000: RO1 NIH Study. Exercise and metformin Improve vascular health in adults with metabolic syndrome. Role PI, 2015 (Not Funded). $9,980; Young Investigator ACSM Research Endowment Award. Rescuing vascular insulin resistance in prediabetes. Role: PI, (Not founded). $187,250; Educational Trust Fund, University of Virginia. Role Co-PI (Co-PI Weltman), (Funded). $1,700,00; Esiai Investigator Initiated Study. Effect of Lorcascerin on the prevention of weight regain and obesity-related comorbidities post-bariatric surgery, Role: Co-investigator (PI: Kashayp) (Funded but closed due to company financial constraints). $10,000; Young Investigator ACSM Research Endowment Award. Effect of short-term exercise training on meal appearance in prediabetic men and women. Role: PI, (Not funded). $45,000 National Institutes of Health T32 Postdoctoral Training Grant, National Heart, Lung and Blood Institute (HL ). Heart-Lung Physiology: Molecular-Systemic Integration. T32 DK Role: Postdoctoral Trainee, $5,000; American College of Sports Medicine Doctoral Grant, Effect of drug on fat metabolism before and after exercise in insulin resistant adults. Role: Co-PI (Co-PI: Braun), 2008 (Funded). $7,000 King s College Undergraduate Neuroscience Program Grant, Effect of Creatine Supplementation on Endurance Performance in Rats. Role: PI, 2003 (Funded) PROFESSIONAL MEMBERSHIP American College of Sports Medicine, 2005-present Southeast American College of Sports Medicine, 2014-present American Diabetes Association, 2014-present American Physiological Society, 2010-present Obesity Society, 2011-present Alpha Epsilon Delta Member (Professional Medical-Health Society), 2003-present Psi Chi Member (Psychology Society), 2004-present VOLUNTEER WORK Cups and Conversation Session Moderator: Role of Scaffolding in Scientific Writing, University of Virginia, 2014 Boot camp for Dads ; new dad support counselor, University of Delaware student representative for Nutrition Graduate Students, University of Delaware Employee Wellness Center Screening for Diabetes, High Blood Pressure and Cholesterol,

14 American Red Cross, Blood Runner, King s College Treist Hall, Home for mentally handicapped individuals, St. James Elementary School Track & Field/ Basketball coach, HONORS & SCHOLARSHIPS Cleveland Clinic Endocrinology & Metabolism Institute Research Day Oral Presentation Award, 2014 Cleveland Clinic Scientist of the Month for the Department of Pathobiology (November), 2013 Cleveland Clinic Postdoctoral Research Award for the Department of Pathobiology, 2013 Cleveland Clinic Caregiver Appreciation Award, 2012, 2013 American Kinesiology Association Doctoral Student Award, American Kinesiology Association, 2011 Michael Polluck Clinical Research Award, American College of Sports Medicine, 2011 David N. Camaione Doctoral Scholarship Award, New England Chapter of ACSM, Doctoral Student Investigator Award, New England Chapter of the ACSM, First Place Scholar Research Award for School of Public Health University of Massachusetts, 2008 $300 Travel Grant from University of Massachusetts, 2008 $300 Travel Grant from University of Delaware Graduate Studies Office, 2006 $850 Travel Grant from University of Delaware, Nutrition Department, 2006 $250 University of Delaware Graduate Research Grant, 2005 Graduate Research Assistantship, $30000, University of Massachusetts, Graduate Teaching Assistantship, $28000, University of Delaware, Moreau Scholarship, $10000, King s College, J. Wood Platt Caddie Scholarship $8200, Philadelphia Golf Association, New Economic & Technology Scholarship, $9000, State of Pennsylvania, Scholar Athlete Award, Bishop McDevitt High School, Philadelphia Catholic League Football MVP,