Pharmacokinetics and bioavailability derived from various body fluids. Saliva samples instead of plasma samples
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1 Pharmacokinetics and bioavailability derived from various body fluids Saliva samples instead of plasma samples Willi Cawello, Schwarz BioSciences, Monheim am Rhein 1
2 Overview Introduction Sampling tissues/fluids to characterize PK Model of saliva sampling Examples Discussion, Conclusion / Perspectives 2
3 Definitions Regulatory Definition (21 CFR 320.1(a)): Bioavailability means the rate and extent to which the active ingredient or active moiety is absorbed from a drug product and becomes available at the site of action. Regulatory Definition (21 CFR 320.1(e)): Bioequivalence means the absence of a significant difference in the rate and extent to which the active ingredient or active moiety in pharmaceutical equivalents or pharmaceutical alternatives becomes available at the site of drug action when administered at the same molar dose under similar conditions in an appropriately designed study. Collected from a presentation of Kofi A. Kumi, Office of Clinical Pharmacology and Biopharmaceutics Division of Pharmaceutical Evaluation III, ACPS 7/20/2001 3
4 Definitions 21 CFR The following in vivo and in vitro approaches, in descending order of accuracy, sensitivity, and reproducibility, are acceptable for determining the bioavailability or bioequivalence of a drug product: Blood/plasma/serum drug conc. measurement in humans Urinary excretion in humans In vivo pharmacological effect Well-controlled clinical trials In-vitro test Any other approach deemed adequate by FDA 4 Collected from a presentation of Kofi A. Kumi, Office of Clinical Pharmacology and Biopharmaceutics Division of Pharmaceutical Evaluation III, ACPS 7/20/2001
5 Pharmacokinetics Pharmacodynamics peripheral tissue distribution dose absorption blood/plasma site of action elimination interaction with receptor stimulus excretory comp. effect movement of molecules cascade to the effect 5
6 Excretion excretory comp. metabolism renal elimination salivatory comp. 6
7 VENOUS BLOOD ARTERIAL BLOOD Q LU Q MU LU MU Q LU Q MU Q LI Q AD Q SK Q SA Q HT Q BR Q TE LI AD SK SA HT BR TE Q ST Q LI Q SP C LINT Q AD Q SK Q SA Q HT Q BR Q TE ST Q PA PA Q PA Q GU SP GU Q S T Q SP Q GU Tissues MU SA SK TE GU ST SP LI PA LU HT BR AD KI musculature salivatory gland skin testis thin intestine stomach spleen liver pancreas lung heart brain fat tissue kidney Q KI KI QKI 7 DUMMY
8 Pharmacokinetics in saliva 50mL/min salivatory gland 50mL/min 1-4mL/min saliva Mass of saliva glands: 30-50g Approximated Blood flow: mL/min 8
9 Pharmacokinetics in saliva What about mass balance during extraction to saliva? Having a 1:1 extraction: Concentration in plasma and in saliva is the same. Plasma Before extraction 5µg/mL After extraction 4.902µg/mL Saliva Concentration 4.902µg/mL 50mL/min =5*50/(50+1) =5*50/(50+1) Total Amount in Plasma (central circulation) Before: 12.5mg (2500ml * 5µg/mL) After: mg = 4.998µg/mL salivatory gland saliva 1-4mL/min 50mL/min 9
10 Prediction of extraction into saliva Ratio of saliva vs. plasma concentrations R ph saliva pka = ph pka plasma f u, plasma f u, saliva ph plasma is almost constant, f u =fraction unbound, f u,saliva is 1 for most drugs, pka is the negative logarithm of acid dissociation constant 10 Equation derived from: a) Kozjek F, et al, Biopharm Drug Dispos 20: (1999) b) Drobitch RK and Svensson CK, Clin Pharmacokinet 23: (1992)
11 Elimination by saliva Examples of drug elimination by saliva (ratios collected from the literature) drug ratio of saliva conc vs plasma conc protein binding % Aminophenazon 0.79 >99 Amphetamin 2.76 Antipyrin Carbamazepine Coffein 0.55 <10 Diazepam Digoxin Isoniazid Levetiracetam 1.3 <10 Lithium Paracetamol Penicillin >80 Phenacetin Phenobarbital Phenytoin Sulfanilamid Theophyllin
12 12 Examples of saliva sampling for PK evaluation
13 Examples of saliva sampling for PK evaluation Conc saliva 0.423*conc plasma, r= Ohmori N., et al, Int J Clin Pharmacol Therapy and Toxicol, (1986) 24:
14 Examples of saliva sampling for PK evaluation 14 Ohmori N., et al, Int J Clin Pharmacol Therapy and Toxicol, (1986) 24:
15 Examples of saliva sampling for PK evaluation conc saliva =-0.51+/ /-0.066*conc plasma 15 Published by: Fontain N.B., et al, Epilepsy Research 2007, in press
16 Examples of saliva sampling for PK evaluation Levetiracetam concentration (µg/ml) 16 Concentrations after single oral dose of 750mg Levetiracetam (three 250mg tablets) Extract from: Lins RL, et al. IntJClinPharmacol&Thera; 45(1), 2007, 47-54
17 Examples of saliva sampling for PK evaluation Example: drug RED 17
18 Comparison of plasma PK and saliva PK 8 Concentrations of RED 7 saliva concentration (µg/ml) y = x R 2 = plasma concentration (µg/ml) 18
19 Comparison of plasma PK and saliva PK 0.8 Concentrations of RED metabolite saliva concentration (µg/ml) y = x R 2 = plasma concentration (µg/ml) 19
20 Parameters of pharmacokinetics evaluation of bioequivalence Treatment drug AUC Plasma AUC Saliva BE % plasma BE % saliva 90%CI plasma 90%CI saliva A RED 86.4/ / B RED 85.1/ /18.6 A metabolite 10.05/ / B metabolite 9.98/ /4.45 Arithmetic mean/sd, n=16, BE and 90% CI after log transformation 20
21 Model dependent PK with plasma or saliva samples c_p treatno=1 c_s c_p treatno=2 c_s c_p treatno=4 c_s t t t 100 c_p treatno=3 c_s c_p treatno=4 c_s c_p treatno=6 c_s t t t
22 PK Parameters of RED One compartment model with first order absorption and first order elimination (Bateman function with parameters k a, k e, dose, and V d ) Saliva samples k e = h -1 t 1/2 = 11 h t lag = h V/f= 42.2 L Plasma samples k e = h -1 t 1/2 = 11 h t lag = h V/f= 49.6 L 22
23 Comparison of plasma PK and saliva PK Data from saliva samples are sufficient to characterize PK profile, model dependent PK and useful for BE evaluation. Rate constant of elimination resp. t 1/2 is the same. Approximation of the volume of distribution using saliva samples results in about 15% lower values corresponding to 15% higher concentrations in saliva than in plasma. Similar results for the metabolite of RED. Pharmacokinetics of RED in saliva is a good approximation (a surrogate) for the pharmacokinetics in plasma. 23
24 Examples of saliva sampling for PK evaluation Example: drug BLUE 24
25 Correlation between BLUE concentrations in saliva and plasma 12 y = 0.681x R = concentration in saliva (ng/ml) concentration in plasma (ng/ml)
26 Correlation between BLUE concentrations in saliva and plasma Individual factor for correlation between plasma and saliva concentration C saliva = intercept + factor * C plasma parameter intercept factor arithmetic mean SD range
27 Correlation between BLUE concentrations in saliva and plasma (after individual correction) corrected concentration in saliva (ng/ml) y = x R = concentration in plasma (ng/ml)
28 Results of BE evaluation Parameter Medium 8mg BLUE - reference 8mg BLUE - test C max Plasma Saliva 3.69(45.1) 3.17(63.5) 4.16(43.7) 3.47(65.2) AUC (0-tz) Plasma Saliva 44.9(43.8) 33.3(65.2) 47.5(41.5) 34.4(63.0) t max Plasma Saliva 5(3-6) 5(3-8) C max and AUC (0-tz) : Mean (CV), t max : range 5(3-6) 5(3-8) 28
29 Results of BE evaluation Parameter Saliva Plasma point estimate 90% CI point estimate 90% CI C max AUC(0-tz) ANOVA results relative bioavailability 29
30 PK modelling 10.0 plasma 10.0 saliva conc. [ng/ml] 1.0 conc. [ng/ml] time [h] time [h] 30
31 PK modelling PK model: one compartment model with first order absorption and elimination (Bateman function) k e (1/h) treatment A (n=33) treatment B (n=33) plasma / / saliva / /
32 Comparison of plasma PK and saliva PK Saliva samples are a good surrogate for model independent PK and PK modelling (for drug BLUE in plasma). BE evaluation based on the saliva samples fit with the results of the evaluation based on plasma samples (especially after normalization using individual factors). 32 Use saliva samples instead of plasma samples for characterization of BLUE PK (after validation of the correlation and characterization of variability and maybe use of individual value of R estimeted with 1 or 2 plasma samples).
33 Discussion and Conclusion - Using saliva samples instead of / in addition to plasma samples was shown to be a feasible tool to characterize the PK of a drug in plasma. - Using a drug specific ratio for saliva over plasma concentrations can result in useful values for model dependent and model independent parameters of PK and BE testing. - The BE evaluation based on saliva samples fits with the results based on plasma samples (especially after normalization using individual factors). 33
34 Discussion and Conclusion Future perspectives - Saliva samples not only for therapeutic drug monitoring but for PK / poppk evaluation - Decreased costs for sample collection - Increased explanatory power of Population PK with possible (more) sampling out of clinics (at more relevant time points after admin.) - Increased acceptance for studies in children (by patients, parents, ethics committees, and authorities) - Increased comfort for the patients/subjects by non-invasive sampling 34
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