PEDIATRIC SEIZURES. Illinois Emergency Medical Services for Children 4th Edition November 2018

Transcription

1 PEDIATRIC SEIZURES Illinois Emergency Medical Services for Children 4th Edition November 2018 This educational module is eligible for 1.5 CEs.

2 ILLINOIS EMERGENCY MEDICAL SERVICES FOR CHILDREN (EMSC) Illinois EMSC is a collaborative program between the Illinois Department of Public Health and Ann & Robert H. Lurie Children s Hospital of Chicago aimed at improving pediatric emergency care within our state. Since 1994, the Illinois EMSC Advisory Board and several committees, organizations and individuals within EMS and pediatric communities have worked to enhance and integrate the following pediatric specific components into our state emergency care system: Education Practice standards Injury prevention Data initiatives Disaster preparedness 2

3 PROGRAM GOAL The goal of Illinois EMSC is to ensure that appropriate emergency medical care is available for ill and injured children at every point along the continuum of care. This educational activity is being presented without bias or conflict of interest from the planners and presenters. 3

4 Acknowledgements Illinois EMSC Facility Recognition & Quality Improvement Committee The Illinois EMSC Advisory Board gratefully acknowledges the commitment and dedication of the EMSC Facility Recognition & Quality Improvement Committee for their assistance with this module which was originally published in June This 4 th Edition underwent committee review in 2018 to assure that it is consistent with current practice standards. The contributions of this committee have led to this valuable resource and assists Illinois EMSC in striving toward the goal of improving pediatric emergency care within our state. Note: nothing in this module should be considered a replacement for prudent and cautious judgment of the health care provider treating the child. Every situation is unique and requires individualized care and independent treatment options. 4

5 PURPOSE The purpose of this educational module is to enhance the care of pediatric patients who present with seizures through appropriate Assessment Management Prevention of complications, and Disposition (including patient and parent/caregiver education) Suggested Citation: Illinois Emergency Medical Services for Children (EMSC), Pediatric Seizures, 4 th Edition November

6 EXCLUSIONS Management of post traumatic seizures is beyond the scope of this module and will not be addressed. Neonatal seizures are not addressed in the body of this module. However, information can be found in Appendix C. 6

7 PEDIATRIC SEIZURES Few health care problems elicit more distress than witnessing a child having a seizure. It is terrifying to many. When the victim is a child, and the observer is a parent or caregiver, that terror can become panic. This module seeks to aid you in minimizing that distress and maximizing the outcome for your patient with evidence-based guidelines. 7

8 OBJECTIVES At the conclusion of this module, you will be able to: Manage the child with a seizure in the prehospital and Emergency Department (ED) settings Identify the distinguishing characteristics between types of seizures in the pediatric patient Explain the rationale for specific diagnostic testing Provide educational information related to care of a child with seizures NOTE: Hyperlinks are provided throughout the module to offer additional information 8

9 TABLE OF CONTENTS 1. Introduction and Background 2. Febrile Seizure 3. First Unprovoked Seizure 4. Status Epilepticus 5. References 6. Resources 7. Appendices APPENDIX A EMSC Prehospital Protocols APPENDIX B Sample Emergency Department Guidelines APPENDIX C Neonatal Seizures 9

10 INTRODUCTION AND BACKGROUND Return to Table of Contents 10

11 U.S. DEMOGRAPHICS 1,2 3.4 million people in the U.S. have active epilepsy 3 million are adults (age 18 years and older) 470,000 are children (age 0-17 years) General Epilepsy Population costs 3 The direct health costs of epilepsy in the U.S. range from $10,192 to $47,869 per person annually. 11

12 INCIDENCE IN ILLINOIS 4 In 2014, 10,027 children age 0-17 years in Illinois were seen in the emergency department with the principle diagnosis of epilepsy/convulsions. 12

13 ILLINOIS EMSC STATEWIDE PEDIATRIC SEIZURE QI PROJECT 5 In , Illinois EMSC conducted a statewide survey of Emergency Department practice patterns (including medical record reviews) related to children presenting with: Simple Febrile Seizure (SFS) Unprovoked Seizures (UnS), and Status Epilepticus (SE) 13

14 PEDIATRIC SEIZURE QI PROJECT 5 Opportunities for improvement: Less than half of responding facilities had a protocol/policy/guideline/clinical pathway that addressed the clinical management of seizures (44%) or clinical management of SE in particular (19%) In the prehospital management of pediatric seizures, blood glucose assessments were documented in only 34% of SFS patients and slightly over half of UnS/SE patients For UnS/SE patients, seizure precautions were either not taken or not documented in more than 1/3 of the cases 14

15 A SEIZURE IS: Abnormal neuronal activity A sudden biochemical imbalance at the cell membrane Repeated abnormal electrical discharges Seen clinically as changes in motor control, sensory perception and/or autonomic function 6 15

16 CLINICAL PRESENTATION: MOTOR CHANGES Parents/caregivers may report seeing: Repetitive non-purposeful movements Staring Lip-smacking Falling down without cause Stiffening of any or all extremities Rhythmic shaking of any or all extremities Seizure activity cannot be interrupted with verbal or physical stimulation 7 16

17 CLINICAL PRESENTATION: SENSORY AND AUTONOMIC Parents/caregivers may report the child is: Feeling nauseated Feeling odd or peculiar Losing control of bowel or bladder Feeling numbness, tingling Experiencing odd smells or sounds 17

18 CLINICAL PRESENTATION: CONSCIOUSNESS Consciousness is the usual alertness or responsiveness the child demonstrates. Parents/caregivers may report or you may observe the child to have: Baseline alertness Diminished level of consciousness Unresponsive and unconscious 18

19 CLINICAL PRESENTATION: EVENTS THAT MIMIC SEIZURES Apnea Breath Holding Dizziness Myoclonus Pseudoseizures Psychogenic Seizures Rigors Shuddering Syncope Tics Transient Ischemic Attacks 19

20 SEIZURE CLASSIFICATIONS Generalized Involves BOTH hemispheres of the brain Always involves loss of consciousness Complex Involves motor* or autonomic # symptoms with altered level of consciousness May start in one muscle group and spread Partial Simple Can involve motor,* autonomic # or somatosensory + symptoms May start in one muscle group and spread Types: Tonic or clonic movements or combination (grand mal) Absence (petit mal) Myoclonic Atonic (e.g., drop attacks) Infantile spasms Types of symptoms: 1) Motor* - head/eye deviation, jerking, stiffening 2) Autonomic # - pupillary dilatation, drooling, pallor, change in heart rate or respiratory rate 3) Somatosensory + - smells, alteration of perception (déjà vu) 20

21 GENERALIZED SEIZURE CLASSIFICATION: DESCRIPTIONS 1 Absence Abrupt lapses of consciousness lasting a few seconds Atonic Abrupt, unexpected loss of muscle tone Myoclonic Rapid short contractions of one or all extremities 21

22 Return to Table of Contents 22

23 FEBRILE SEIZURE 8,9 Febrile seizures are the most common seizure disorder in childhood, affecting 2-4% of children between the ages of 6 months and 5 years. 23

24 FEBRILE SEIZURE 10 Caused by the increase in the core body temperature greater than o F or 38 o C Threshold of temperature which may trigger seizures is unique to each individual Can occur within the first 24 hours of an illness Can be the first sign of illness in 25-50% of patients 24

25 Are benign FEBRILE SEIZURE: CHARACTERISTICS Occurrence: between 6 months to 5 years of age May be either simple or complex type seizure Seizure accompanied by fever (before, during or after) WITHOUT ANY Central nervous system infection Metabolic disturbance History of previous seizure disorder 25

26 FEBRILE SEIZURE: TWO TYPES 8 Simple Febrile 6 months 5 years of age Febrile before, during or after seizure Includes all of the following Seizure lasting less than 15 minutes Generalized seizure Occurs once in a 24-hour period Complex Febrile 6 months 5 years of age Febrile before, during or after seizure One or more of the following Prolonged (lasting more than 15 minutes) Focal seizure Occurs more than once in 24 hours 26

27 Assess the A,B,Cs FEBRILE SEIZURE: PREHOSPITAL ASSESSMENT Assess neurological status (D = Disability using AVPU) Obtain seizure history from a dependable witness: How long was the seizure? What did it look like (movements, eye deviation)? History of previous seizures (child and family)? Does the child have a current illness/fever? Any indications of trauma or abuse? Length of postictal phase? List current medications Include any antipyretics given (time and dose) 27

28 AVPU The AVPU scale (Alert, Voice, Pain, Unresponsive) is a system by which a healthcare professional can measure and record a child s level of consciousness. The AVPU scale should be assessed using these identifiable traits, looking for the best response of each: A V P U Alert t he infant is active, responsive to parent s and interacts appropr iately with s urroundings ; t he child is lucid and fully responsive, can answer questions and s ee what you're doing. Voice t he child or infant is not looking around; responds to your voice, but may be drowsy, keeps eyes closed and may not speak coherently, or make s ounds. Pain t he child or infant is not alert and does not respond to your voice. Responds to a painful stimulus (e.g., s haking t he shoulders or possibly applying nail bed pressure). Unresponsive t he child or infant is unresponsive to any of t he above; unconscious. 28

29 FEBRILE SEIZURE: PREHOSPITAL MANAGEMENT Monitor the A, B, C, Ds Position with spinal motion restriction (if trauma) Follow seizure and aspiration precautions (per EMS System protocol) Physical exam Check blood glucose If blood glucose < 60 mg/dl, treat as appropriate Refer to the EMSC Seizure protocols (Appendix A) 29

30 FEBRILE SEIZURE: ED ASSESSMENT Baseline assessment Vital signs (including temperature) Assess the A, B, C, Ds Continue providing and documenting seizure and aspiration precautions 30

31 FEBRILE SEIZURE: ED ASSESSMENT (CONT.) Full History Obtain seizure history from a dependable witness: When did the seizure occur? How long was the seizure and what did it look like? How was the child acting immediately before the seizure? History of previous seizures (child and family)? History of developmental delay/recent loss of milestones? Does the child have a current illness/fever? Any indications of trauma or abuse? Length of postictal state? Immunization history? List current medications Include any antipyretics given (time and dose) 31

32 FEBRILE SEIZURE: ED MANAGEMENT 11 If still having a seizure, follow Status Epilepticus protocol Complete physical exam to identify the source of fever Lab testing No routine lab tests are necessary for the diagnosis of simple febrile seizures Direct lab testing toward identifying the source of fever 32

33 SIMPLE FEBRILE SEIZURE: LUMBAR PUNCTURE Evidence-based recommendations from the 2011 American Academy of Pediatrics (AAP) Subcommittee on Febrile Seizures 12 are as follows: A lumbar puncture should be performed in any child who presents with a seizure and a fever and has meningeal signs and symptoms (e.g., neck stiffness, Kernig and/or Brudzinski signs) or in any child whose history or examination suggests the presence of meningitis or intracranial infection. Current data does not support routine lumbar puncture in well-appearing, fully immunized children who present with a simple febrile seizure. 33

34 SIMPLE FEBRILE SEIZURE: LUMBAR PUNCTURE (CONT.) Additional evidence-based recommendations from the 2011 AAP Subcommittee on Febrile Seizures 12 are as follows: In any infant between 6 and 12 months of age who presents with a seizure and fever, a lumbar puncture is an option when: - the child is considered deficient in Haemophilus influenza type b (Hib) or Streptococcus pneumoniae immunizations (i.e., has not received scheduled immunizations as recommended) or - when the immunization status cannot be determined because of an increased risk of bacterial meningitis. A lumbar puncture is an option in the child who presents with a seizure and fever and is pretreated with antibiotics, because antibiotic treatment can mask the signs and symptoms of meningitis. 34

35 SIMPLE FEBRILE SEIZURE: DIAGNOSTIC TESTING 8,12 Simple Febrile Seizure EEG Should not be performed in a neurologically healthy child. Results are not predictive of recurrence or development of epilepsy CT/MRI Not indicated There are no current national guidelines addressing diagnostic testing recommendations for complex febrile seizures. 35

36 SIMPLE FEBRILE SEIZURE: ED ONGOING MANAGEMENT Reassess temperature Consider giving antipyretic if not previously administered As source of fever is identified, treat appropriately 36

37 SIMPLE FEBRILE SEIZURE: FAMILY EDUCATION 8,12,13 Here are some frequently asked questions parents/caregivers may have prior to discharge: Is my child brain damaged? There is no evidence of impact on learning abilities after seizure from SFS. Will this happen again? If child is under 12 months of age at time of first seizure, recurrence rate is 50% If child is greater than 12 months of age at time of first seizure, recurrence rate is 30% Most recurrences occur within 6-12 months of the initial febrile seizure 37

38 SIMPLE FEBRILE SEIZURE: FAMILY EDUCATION (CONT.) 8,12,13 Will my child get epilepsy? For simple febrile seizures, there is no increased risk of epilepsy Why not treat for possible seizures or fever? Anticonvulsants can reduce recurrence. However potential side effects of medications outweigh the minor risk of recurrence Prophylactic use of antipyretics does not have impact on recurrence For complex febrile seizures, there is a slight increase in the risk of epilepsy. 38

39 SIMPLE FEBRILE SEIZURE: FAMILY EDUCATION (CONT.) 12 Instruct parent/caregivers to prevent injury during a seizure: Position child while seizing in a side-lying position Protect head from injury Loosen tight clothing about the neck Prevent injury from falls Reassure child during event Do not place anything in the child s mouth 39

40 SIMPLE FEBRILE SEIZURE: Prior to discharge home DISPOSITION Educate regarding use of: Thermometer Antipyretics for fever management When to contact or ambulance Call after 5 minutes of seizure activity Identify a Primary Care Provider for follow-up appointment and stress importance of follow-up Provide developmentally appropriate explanation of event for child and family members 40

41 FEBRILE SEIZURE: TEST YOURSELF 1. Simple Febrile Seizures: A. Indicate an underlying neurological condition B. Require anticonvulsant medication C. Occur in children 6 months to 5 years of age D. Frequently lead to epilepsy 2. Which of the following are important history questions? A. Was there trauma? B. What did the seizure look like? C. Medications and herbal supplements? D. All of the above 3. Diagnostic workup in the ED is based on suspicions of: A. Meningitis B. Trauma C. Unknown immunization status D. All of the above 4. Discharge education should include instructing parents on which of the following? A. Scheduling an EEG B. Actions to take to protect the child from injury during a seizure C. Importance of a follow up MRI D. Anticonvulsant medications Proceed to next slide for answers 41

42 FEBRILE SEIZURE: TEST YOURSELF: ANSWER KEY 1. Simple Febrile Seizures: C. Occur in children 6 months to 5 years of age 3. Diagnostic workup in the ED is based on suspicions of: D. All of the above 2. Which of the following are important history questions? D. All of the above 4. Discharge education should include which of the following? B. Actions to take to protect the child from injury during a seizure 42

43 Return to Table of Contents 43

44 FIRST UNPROVOKED SEIZURE 14 This is a first seizure that occurs without an immediate precipitating event. Etiology may be: Remote symptomatic (related to a pre-existing brain abnormality/insult) Cryptogenic or idiopathic (no known cause) 44

45 FIRST UNPROVOKED SEIZURE: Parents/caregivers may describe symptoms consistent with the following: Partial seizure Generalized onset, tonic-clonic seizure Tonic seizure PRESENTATION Remember: this is a seizure that occurs without an immediate precipitating event. 45

46 FIRST UNPROVOKED SEIZURE: PREHOSPITAL ASSESSMENT Assess the A, B, C, Ds Obtain seizure history from a dependable witness: How long was the seizure? What did it look like (movements, eye deviation)? History of previous seizures (child and family)? Does the child have a current illness/fever? Any indications of trauma or abuse? Length of postictal state List current medications Include any antipyretics given (time and dose) 46

47 FIRST UNPROVOKED SEIZURE: PREHOSPITAL MANAGEMENT Monitor the A, B, C, Ds Position with C-Spine protection (if trauma) Follow seizure and aspiration precautions (per protocol) Physical assessment Check blood glucose If blood glucose < 60 mg/dl, treat as appropriate Refer to EMSC Seizure protocols (Appendix A) 47

48 FIRST UNPROVOKED SEIZURE: ED ASSESSMENT Baseline assessment Vital signs (including temperature) Assess the A, B, C, Ds Continue providing and documenting seizure and aspiration precautions 48

49 FIRST UNPROVOKED SEIZURE: ED ASSESSMENT (CONT.) If still seizing, follow the Status Epilepticus protocol Full History Obtain seizure history from a dependable witness: Recent exposures (chemical, industrial)? When did the seizure occur? How long was the seizure and what did it look like? How was the child acting immediately before the seizure? History of previous seizures (child and family)? History of developmental delay/recent loss of milestones? Does the child have a current illness? Any indications of trauma or abuse? Immunization history? Length of postictal state? 49

50 FIRST UNPROVOKED SEIZURE: ED ASSESSMENT (CONT.) List current medications Include any antipyretics given (time and dose) Include anticonvulsants given by prehospital team (time and dose) Physical exam Head-to-toe assessment 50

51 FIRST UNPROVOKED SEIZURE: DIAGNOSTIC TESTING 14 Laboratory tests are based on individual clinical circumstances and may include: CBC with differential Blood glucose Electrolytes Calcium, magnesium, phosphorous Urine drug/toxicology screen Urine HCG (age/sex dependent) Lumbar puncture is only indicated if there are other symptoms that suggest a diagnosis of meningitis. 51

52 FIRST UNPROVOKED SEIZURE: DIAGNOSTIC TESTING MRI 14,15 MRI should be considered for: Children under 1 year of age All children with significant acute cognitive or motor impairment Unexplained abnormalities on neurologic exam Seizure of focal onset without generalization Abnormal EEG Abnormalities on MRI are seen in up to 1/3 of children However, most abnormalities do not influence immediate treatment or management (such as need for hospitalization) 52

53 FIRST UNPROVOKED SEIZURE: DIAGNOSTIC TESTING CT SCAN 14,15 Emergent CT Scan (without contrast) should be considered for any child who exhibits any of the following: Significant, acute cognitive or motor impairment New focal deficit not quickly resolving Not returned to baseline MRI is the modality of choice, if available. 53

54 FIRST UNPROVOKED SEIZURE: DIAGNOSTIC TESTING EEG 14,15 Obtain on ALL children in whom a nonfebrile seizure has been diagnosed Can be arranged as an outpatient Should be interpreted by a neurologist (preferably pediatric neurologist) EEG results will: Help predict the risk of recurrence Classify the seizure type or epilepsy syndrome Influence the decision to perform additional neuroimaging studies 54

55 FIRST UNPROVOKED SEIZURE: ED MANAGEMENT If child is still actively having seizures Refer to the Status Epilepticus protocol When child is stable Consult with Neurologist (or Intensivist) For possible medication recommendations To determine disposition: Admit to observe Transfer (if neurologist is unavailable) Discharge home with Primary Care Provider and Neurology follow-up 55

56 FIRST UNPROVOKED SEIZURE: RECURRENCE RISK The majority of children who experience an unprovoked seizure will have few or no recurrences Approximately 10% will go on to have additional seizures regardless of therapy Predictors of recurrence include: abnormal EEG, underlying etiology, and abnormal neurologic exams Remote symptomatic recurrence risk over 2 years is above 50% Cryptogenic or idiopathic recurrence risk over 2 years is 30-50% If first seizure is prolonged, recurrent seizures are more likely to be prolonged. 56

57 FIRST UNPROVOKED SEIZURE: DRUG THERAPY 14,15 Type of medication (if offered) depends on: Type, frequency and severity of seizures Side effects, titration, drug interactions, dosing forms, cost of drug Neurologist preference 57

58 FIRST UNPROVOKED SEIZURE: DISCHARGE & FAMILY EDUCATION Prior to discharge home Identify Primary Care Provider and Neurologist for follow-up appointments Provide plan for outpatient EEG Provide parental support Access to prescription resources Social services resources Consider rescue medication for home, based on neurologist recommendation (e.g., rectal diazepam) 58

59 FIRST UNPROVOKED SEIZURE: FAMILY EDUCATION 11 Instruct parent/caregivers to prevent injury during a seizure: Position child while seizing in a side-lying position Protect head from injury Loosen tight clothing about the neck Prevent injury from falls Reassure child during event Do not place anything in the child s mouth 59

60 FIRST UNPROVOKED SEIZURE: FAMILY EDUCATION (CONT.) Instruct in use of or ambulance services Provide developmentally appropriate explanation to child about the seizure event and treatment Discourage swimming alone No driving a car until cleared by a physician 60

61 FIRST UNPROVOKED SEIZURE: FAMILY EDUCATION (CONT.) Here are some frequently asked questions parents/caregivers may have prior to discharge: How likely is it that my child will have seizures again? The risk of recurrence relates to the underlying etiology and EEG results (normal or abnormal). The majority of children who experience an unprovoked seizure will have few or no recurrences. Approximately 10% will go on to have additional seizures regardless of therapy. 14 Is there a risk of dying from the seizure if we don t start medication today? Sudden unexpected death is very uncommon (usually related to an underlying neurologic handicap rather than seizure activity). There are no studies showing treatment after a first seizure alters the small risk of sudden death

62 FIRST UNPROVOKED SEIZURE: TEST YOURSELF 1. Which of the following is a true statement regarding a First Unprovoked Seizure: A. Occurs without a precipitating event B. Is never associated with an underlying neurological condition C. Always leads to epilepsy D. Requires immediate initiation of antiepileptic medication 2. Children who have a First Unprovoked Seizure A. Should have their blood glucose checked by ambulance staff B. Could proceed to have Status Epilepticus C. Will require anti-pyretics to prevent seizures D. A and B 3. All children who have had a First Unprovoked Seizure should have an outpatient EEG. A. True B. False 4. The majority of children who have a First Unprovoked Seizure will have few or no recurrences. A. True B. False Proceed to next slide for answers 62

63 FIRST UNPROVOKED SEIZURE: TEST YOURSELF: ANSWER KEY 1. Which of the following is a true statement regarding a First Unprovoked Seizure: A. Occurs without a precipitating event 3. All children who have had a First Unprovoked Seizure should have an outpatient EEG. A. True 2. Children who have a First Unprovoked Seizure D. A and B 4. The majority of children who have a First Unprovoked Seizure will have few or no recurrences. A. True 63

64 Return to Table of Contents 64

65 STATUS EPILEPTICUS: DEFINITIONS 19 Seizures that persist without interruption for more than 5 minutes Two or more sequential seizures without full recovery of consciousness between seizures This is a life threatening emergency that requires immediate treatment. 65

66 STATUS EPILEPTICUS 19 Commonly occurs in children with epilepsy (9-27% over time) Complications from Status Epilepticus result from both the impact of the convulsive state on the body systems (such as the cardiac and respiratory systems) and the neuronal cellular injury which leads to cell death Rapid termination of the seizure activity protects against neuronal injury 66

67 STATUS EPILEPTICUS: CLASSIFICATION 20 Type Incidence Description Remote Symptomatic SE 33% Acute Symptomatic SE 26% Febrile SE 22% Status Epilepticus (SE) with no immediate event but the child had a previous history of CNS malformation, traumatic brain injury or chromosomal disorder SE with concurrent acute illness (e.g., meningitis, encephalitis, hypoxia, trauma, intoxication) SE with a febrile illness but not a Central Nervous System infection (e.g., sinusitis, sepsis, upper respiratory infection) Cryptogenic SE 15% SE with no identifiable cause 67

68 STATUS EPILEPTICUS: PREHOSPITAL ASSESSMENT Assess the A, B, C, Ds Obtain seizure history from a dependable witness: When did the seizure begin? What did it look like (movements, eye deviation)? History of previous seizures (child and family)? Does the child have a current illness/fever? Any indications of trauma or abuse? Emergency Information Form for Children with Special Needs? 68

69 STATUS EPILEPTICUS: PREHOSPITAL ASSESSMENT List current medications Include any antipyretics given (time and dose) Do the parents have any anticonvulsant medications (e.g., rectal diazepam)? Have parents given any anticonvulsant medications (time, route, and dose)? 69

70 STATUS EPILEPTICUS: PREHOSPITAL ASSESSMENT Assess the A, B, C, Ds Positioning (with C-Spine protection if trauma) Jaw thrust Recovery position (side-lying) Provide nasal airway, if needed Seizure safety precautions (per protocol) Aspiration precautions (per protocol) Oxygen Suction Blood glucose testing If blood glucose < 60 mg/dl, treat as appropriate 70

71 STATUS EPILEPTICUS: PREHOSPITAL ASSESSMENT If parent/caregiver has rectal diazepam and has not given it, the parent/caregiver should be requested to administer it Document time and dose Follow Pediatric Seizures ALS guideline (if appropriate) Contact Medical Control REFER TO APPENDIX A for EMSC Seizure Protocols 71

72 STATUS EPILEPTICUS: ED GOALS OF THERAPY 19,21 Minimize seizure time as much as possible and provide drug therapy promptly. Drug therapy to halt seizure With IV/IO access, administer *LORazepam IV/IO If no IV/IO access, administer: Diazepam PR, or Midazolam IN *The Institute for Safe Medication Practices recommends using Tall Man (mixed case) letters in order to distinguish drugs with similar sounding names decreasing the chances of safety errors. 72

73 STATUS EPILEPTICUS: ED ASSESSMENT Assess the A, B, C, Ds Full vital signs; check bedside glucose and treat (per protocol) Continue to provide and document seizure and aspiration precautions (per protocol) Review Prehospital History and Treatment 73

74 STATUS EPILEPTICUS: ED MANAGEMENT Full History Obtain seizure history from a dependable witness: How long has the seizure been going on and what did it look like when it started? How was the child acting immediately before the seizure? History of previous seizures (child and family)? History of developmental delay/recent loss of milestones? Does the child have a current illness? Any indications of trauma or abuse? Immunization history? 74

75 STATUS EPILEPTICUS: ED ASSESSMENT Assess E (exposure) List current medications When were they last given? Recent exposures - chemical, industrial, infectious? Was patient recently out of the country? 75

76 STATUS EPILEPTICUS: ED MANAGEMENT FIRST 5 MINUTES 21 Evaluate airway Suction, position and provide nasal airway as needed Provide 100% oxygen (non-rebreather) Establish vascular access Draw labs as determined by history, e.g. : CBC, Electrolytes, Blood glucose, Calcium, Magnesium, Phosphorus Toxicology screen, if indicated by history Antiepileptic drug level, as indicated Administer benzodiazepines LORazepam IV/IO 0.1 mg/kg No IV access, give either: Diazepam PR 0.5 mg/kg (max PR dose = 20 mg) or Midazolam IM 0.1 mg/kg or IN 0.2 mg/kg Benzodiazepines may cause respiratory and cardiac depression. REFER TO APPENDIX B for sample guidelines 76

77 STATUS EPILEPTICUS: ED MANAGEMENT NEXT 10 MINUTES 21 Reassess the A, B, Cs Continue supportive airway management Suction, position and provide nasal airway as needed Provide 100% oxygen (non-rebreather) Assess need for intubation Evaluate results of rapid blood glucose testing If the seizure activity continues Administer medications (per guidelines) Repeat IV LORazepam 0.1 mg/kg Administer IV/IM Fosphenytoin 20 mg/kg PE (Phenytoin equivalents) PHENobarbital is preferred in neonates. REFER TO APPENDIX B for sample guidelines 77

78 STATUS EPILEPTICUS: ED MANAGEMENT NEXT 15 MINUTES Having administered 2-3 doses of benzodiazepines, and a dose of Fosphenytoin without halting the seizure, consider the patient in refractory Status Epilepticus 21 Consult with Neurology and/or Intensivist for further management recommendations If available, evaluate lab results REFER TO APPENDIX B for sample guidelines 78

79 STATUS EPILEPTICUS: ED MANAGEMENT REFRACTORY SE If seizure activity persists (after appropriate doses of benzodiazepines and Fosphenytoin), load with a second long-acting AED that was not used initially (e.g., valproic acid, levetiracetam) Manage with continuous EEG monitoring Contact PICU/NICU to begin transfer to higher level of care It is imperative to stop the seizure activity. If rapid sequence induction is necessary, use short-acting paralytics to ensure that ongoing seizure activity is not masked. REFER TO APPENDIX B for sample guidelines 79

80 Status Epilepticus: ED Management Transfer 22 For a child in Status Epilepticus after 30 minutes of refractory SE, enact plans to transfer to your PICU/NICU or transport to a higher level of care Continued testing can be arranged in that setting Consider EEG with new onset SE Neuroimaging (CT/MRI) if etiology is unknown REFER TO APPENDIX B for sample guidelines 80

81 STATUS EPILEPTICUS: DISPOSITION Discuss child s progress and advice regarding admission or transfer based on patient status and neurology consultation with parents/caregiver Utilize a specialty/critical care transport team As applicable, explain these events to the child in a developmentally appropriate manner 81

82 STATUS EPILEPTICUS: PARENT EDUCATION Provide parents/caregivers information regarding child s condition and treatment plan Provide emotional/psychosocial support Encourage use of the Emergency Information Form [developed by the American Academy of Pediatrics (AAP) & American College of Emergency Physicians (ACEP)] for possible future events 82

83 STATUS EPILEPTICUS: EMERGENCY INFORMATION FORM The Emergency Information Form (EIF) for Children With Special Needs resource was developed by the AAP and the ACEP. A standardized medical summary with Information for prehospital and hospital emergency care personnel Updates entered by caregivers English and Spanish versions 24-hour accessibility Free, Downloadable, interactive forms are available at the ACEP website. To be completed by both the child s medical team and parents/caregivers. Copies should be kept by parents, as well as on file at the PCP s office, subspecialist s office, local ED, and school nurse s office. 83

84 STATUS EPILEPTICUS: TEST YOURSELF 1. You respond to a call for a 4-year-old child. You find the child on the floor of the playroom, unresponsive to voice with rhythmic movements of both the upper and lower extremities. The parents report that the child has had seizures, starting at age 2. The seizure activity has always lasted only about 1 minute. The parents called when the initial seizure stopped, but the seizure started again with about one minute in between. They estimate the child has been seizing for about 15 minutes. Your FIRST response is to: A. Move the child to the bed B. Establish vascular access C. Protect/position the airway D. Give rectal diazepam Proceed to next slide for answer 84

85 STATUS EPILEPTICUS: TEST YOURSELF: ANSWER KEY 1. You respond to a call for a 4-year-old child. You find the child on the floor of the playroom, unresponsive to voice with rhythmic movements of both the upper and lower extremities. The parents report that the child has had seizures, starting at age 2. The seizure activity has always lasted only about 1 minute. The parents called when the initial seizure stopped, but the seizure started again with about one minute in between. They estimate the child has been seizing for about 15 minutes. Your FIRST response is to: C. Protect/position the airway 85

86 STATUS EPILEPTICUS: TEST YOURSELF 2. How quickly should the first benzodiazepine be given after Status Epilepticus begins? A. At 30 minutes B. At 20 minutes C. Within 5 minutes D. After 60 minutes 3. What drugs are used first in status epilepticus? A. Lorazepam B. Fosphenytoin C. Diazepam D. A and C 4. Who is likely to have status epilepticus? A. Child with a history of epilepsy B. Child with encephalitis C. Child with a traumatic brain injury D. All of the above Proceed to next slide for answers 86

87 STATUS EPILEPTICUS: TEST YOURSELF: ANSWER KEY 2. How quickly should the first benzodiazepine be given after Status Epilepticus begins? C. Within 5 minutes 3. What drugs are used first in status epilepticus? D. A and C 4. Who is likely to have status epilepticus? D. All of the above 87

88 Resources and Appendices Return to Table of Contents 88

89 Online Resources American Epilepsy Society American Academy of Neurology Patient Education Materials CDC: Epilepsy Citizens United for Research in Epilepsy (CURE) Epilepsy Foundation: Epilepsy and Seizure Response for Law Enforcement and EMS (free online training) Epilepsy Therapy Project Return to Table of Contents 89

90 Video Resources Understanding Epilepsy Types of Seizures Understanding Partial Seizures Understanding Generalized Seizures What Causes Epilepsy? Diagnosing Epilepsy Seizure Imitators Overview Return to Table of Contents 90

91 APPENDIX A EMSC PREHOSPITAL PROTOCOLS Return to Table of Contents 91

92 EMSC PREHOSPITAL All Pediatric Seizure care guidelines follow this sequence: Initial Medical Care/Assessment PROTOCOLS Protect the child from Injury Vomiting and aspiration precautions THE NEXT STEPS DEPEND ON THE LEVEL OF CARE OF THE RESPONDER 92

93 EMSC PREHOSPITAL PROTOCOLS The below prehospital guidelines can be accessed as attachments to this educational module: BLS/EMERGENCY MEDICAL RESPONDER (EMR) CARE GUIDELINE ALS/ILS CARE GUIDELINE Source: Illinois EMSC Pediatric Prehospital Protocols 93

94 APPENDIX B SAMPLE EMERGENCY DEPARTMENT GUIDELINES Return to Table of Contents 94

95 SAMPLE ED SEIZURE GUIDELINES The below organizations are providing access to their ED pediatric seizures guidelines. Please acknowledge/cite these organizations if using their work in developing your guidelines and/or educational resources. Advocate Children s Hospital Emergency Department Guidelines Status Epilepticus Guidelines OSF St. Francis Medical Center/Children s Hospital of Illinois Pediatric Status Epilepticus Guidelines (click on attachment icon at bottom right of this slide) Seattle Children s Hospital Pediatric Seizures Febrile Seizures University of Chicago Comer Children s Hospital Pediatric Emergency Clinical Guidelines 95

96 APPENDIX C NEONATAL SEIZURES Return to Table of Contents 96

97 NEONATAL SEIZURES Neonatal seizures can be difficult to diagnose May consist of very subtle and unusual physical signs Eye deviation, staring episodes, winking In neonates, onset of seizure activity is important in determining etiology First hours of life Ischemic hypoxia 72 hours to 1 week of age Familial neonatal seizures Metabolic disorders 97

98 NEONATAL SEIZURES Beyond the standard history, ask about the pregnancy, labor and delivery and maternal risk factors Physical exam should include head circumference and careful inspection for dysmorphic features and cutaneous lesions 14 Consult with a pediatric neurologist to identify infantile seizure disorders 98

99 NEONATAL SEIZURES: STATUS EPILEPTICUS Assess the A, B, Cs Evaluate and maintain airway Provide 100% oxygen Establish vascular access Obtain rapid glucose Administer Medications PHENobarbital 20 mg/kg IV Repeat up to 40 mg/kg total dose Contact Neurology 99

100 References Return to Table of Contents 100

101 REFERENCES 1. E p i l e p sy a n d S e i z u re S t a t i s t i c s. E p i l e p syfo u n d at i o n. o rg. Re t r i e ve d A u g u s t 3 0, f ro m h t t p : / / w w w. e p i l e p syfo u n d at i o n. o rg /aboute p i l e p sy / w h at i s e p i l e p sy/statistics.cfm. 2. C e n t e rs f o r D i s e a s e C o n t ro l a n d P r e v e n t i o n. E p i l e p sy Fa s t Fa c t s. Re t r i e ve d A u g u s t 3 0, f ro m h t t p : / / w w w. c d c. go v /e p i l e p sy/basics/fa s t - fa c t s. h t m. 3. B e g l e y, C. E. & D u rg i n, T. L. ( ). T h e d i re c t c o s t o f e p i l e p sy i n t h e U n i t e d S t a t e s : a systematic r e v i e w o f e s t i m ate s. E p i l e p s i a, 5 6 ( 9 ), d o i : /e p i A H R Q H C U P n e t o n l i n e q u e r y system, w i t h I l l i n o i s d a t a p ro v i d e d b y I D P H t o A H R Q. Re t r i e ve d A u g u s t 3 0, f ro m h t t p : / / h c u p n et. a h rq. go v / 5. I l l i n o i s E m e r g e n c y M e d i c a l S e r v i c e s f o r C h i l d re n. ( ). Pe d i a t r i c s e i z u re s i n t h e e m e r g e n c y d e p a r t m e n t : s u m m a r y r e p o r t. Re t r i e ve d S e p t e m b e r 1 7, f ro m : \ \ c h i l d re n s m e m o r i a l. o rg \ D e p a r t \ I l l i n o i s E M S C P ro g ra m \ [ R ESTO R E ] \ E M S C F i l e s \ G ra n t _ T I _ \ S e i z u re _ Q I To o l \ S e i z u re D a t a Re p o r t s \ S e i z u re s _ s u m m a r y _ report.pdf 6. P i l l o w s, M.T., K i m m e l, K., D o c t o r, S. U., & H o w e s, D. S. ( ) S e i z u re A s s e s s m e n t i n t h e E m e r g e n c y D e p a r t m e n t. e M e d i c i n e. M e d s c a p e. c o m. U p d ated J a n u a r y 2 3, F i s h e r, P. G. ( ). F i rst a n d s e c o n d s e i z u re : w h a t t o d o a n d k n o w. C o n t e m p o r a r y Pe d i a t r i c s, 24( 4 ),

102 REFERENCES (CONT.) 8. Steering Committee o n Quality Improvement and Management, Subcommittee on Febrile S eizures. (2008). Febrile seizures: clinical practice guidelines for the long-term management o f the child w ith simple febrile seizures. Pediatrics, 121(6), doi: /peds Millichap, J. J. (2018). Clinical features and evaluation o f febrile seizures. UpToDate. Retrieved July 18, 2018 f ro m: galter.northwestern.edu 10. Freedman, S.B. & Powell, E.C. (2003). Pediatric seizures and their management in the emergency department. Clinical Pediatric Em ergency Medicine, 4 (3), doi: /S (03) American Association o f N euroscience N urses. (2009). Care of the patient with seizures. 2 nd ed: Glenview, IL. 12. Steering Committee o n Quality Improvement and Management, Subcommittee on Febrile S eizures: (2011). Febrile seizures: guidelines fo r the neurodiagnostic evaluation o f the child w ith a simple febrile seizure. Pediatric s, 127 (2), doi: /peds Millichap, J. J. (2018). Treatment and pro gnosis o f febrile seizures. UpToDate. Retrieved July 18, 2018 from galter.northwestern.edu 102

103 REFERENCES (CONT.) 14. Hirtz, D., B erg, A., B ettis, D., Camf ield, C., Camf ield, P., Crumrine, P., et al. (2003). Practice parameter: treatment o f the child w ith a f irst unpro voked seizure: report of the quality standards subco mmittee o f the American Academy of N eurology and the practice co mmittee o f the Child N euro logy S o ciety. Neurology, 60, doi: /01.WNL B6 15. Hirtz, D., Ashwal, S., B erg, A., B ettis, D., Camf ield, C., Camf ield, P., et al. (2000). Practice parameter: evaluating a f irst nonfebrile seizure in children: report of the quality standards subco mmittee o f the American Academy o f N eurology, the Child N eurology S o ciety, and the American Epilepsy S o ciety. Neurology, 55 (5), doi: /WNL Wilfong, A. (2017). S eizures and epilepsy in children: classification, etiology, and clinical features. UpToDate. Retrieved July 18, 2018 f ro m - uptodate.com.ezproxy. galter.northestern.edu 17. Wilfong, A. (2016). Clinical and laboratory diagnosis o f seizures in infants and children. UpToDate. Retrieved July 18, 2018 from - uptodate.com.ezproxy. galter.northestern.edu 18. Wilfong, A. (2017). S eizures and epilepsy in children: initial treatment and monitoring. UpToDate. Retrieved July 18, 2018 f ro m - uptodate.com.ezproxy. galter.northestern.edu 103

104 REFERENCES (CONT.) 19. M i l l i ka n, D., R i c e, B., & S i l b e rg l e i t, R. ( ). E m e r g e n c y t r e at m e n t o f stat u s e p i l e p t i c u s : c u r re n t t h i n k i n g. E m e r g e n c y M e d i c i n e C l i n i c s o f North A m e r i c a, 2 7 ( 1 ), d o i : j. e m c R i v i e l l o, J. J., A s h w a l., S., H i r t z, D., B a l l a b a n - G i l., K., M o r t o n, L. D., P h i l l i p s, S., et a l. ( ). P ra c t i c e p a ra m e t e r : d i a g n o s t i c a s s e s s m e n t o f t h e c h i l d w i t h s t a t u s e p i l e p t i c u s ( a n e v i d e n c e b a s e d r e v i e w ) : r e p o r t o f t h e q u a l i t y s t a n d a rd s s u b c o m m i t t e e o f t h e A m e r i c a n A c a d e my o f N e u ro l o g y a n d t h e p ra c t i c e c o m m i t t e e o f t h e C h i l d N e u ro l o g y S o c i e t y. N e u r o l o g y, 6 7 ( 9 ), d o i : / 0 1.w n l d 21. Ku r z, J. E., & G o l d s t e i n, J. ( ). S t a t u s e p i l e p t i c u s i n t h e p e d i at r i c e m e r g e n c y d e p a r t m e n t. C l i n i c a l Pe d i a t r i c E m e r g e n c y M e d i c i n e, 1 6 ( 1 ), d o i : j. c p e m A b e n d, N. S., & D l u g o s, D. J. ( ). Tr e at m e n t o f ref ra c t o r y s t a t u s e p i l e p ti c u s : l i t e rat u re r e v i e w a n d a p ro p o s e d p ro t o c o l. Pe d i a t r i c N e u r o l o g y, 3 8 ( 6 ), d o i : / j. p e d i at r n e u ro l Tay l o r, C., P i a n t i n o, J., H a g e m a n, J., Ly o n s, E., J a n i e s, K., L e o n a rd, D., e t a l. ( ). E m e r g e n c y d e p a r t m e n t m a n a ge m e n t o f p e d i at r i c u n p ro v o ke d s e i z u re s a n d s t a t u s e p i l e p t i c u s i n t h e s t a t e o f I l l i n o i s. J o u r n a l o f C h i l d N e u r o l o g y, 3 0 ( 1 1 ), d o i : / C a ra p e t i a n, S., H a g e m e n t, J., Ly o n s, E., L e o n a rd, D., J a n i e s, K., Ke l l e y, K., et a l. ( ). E m e r g e n c y d e p a r t m e n t e v a l u at i o n a n d m a n a g e m e n t o f c h i l d re n w i t h s i m p l e f e b r i l e s e i z u res. C l i n i c a l Pe d i a t r i c s, 5 4 ( 1 0 ), d o i : /

105 THE END 105