Stroke/Carotid Artery Disease Outcome Detail (Form 121/132, CaD ppts)
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1 This file contains outcomes collected through the end of Ext1. ID WHI Participant Common ID Col#1 N Missing 0 ASCSOURCE Ascertainment Source Col#2 1 Local Form Central Form Central Form 132 1, CAROTID Carotid Artery Disease Col#3 1 Yes Missing 1, Carotid Artery Disease was adjudicated for CT and OS participants through Ext1. Carotid Areter Disease occurring on or after a Stroke is not counted. STRKHEMO Hemorrhagic Stroke Col#4 1 Yes Missing 1, Defined as a Stroke where the diagnosis question indicates a hemorrhagic stroke. Hemorrhagic Stroke is adjudicated for CT and OS participants. Form 121 and early versions of 132 were not able to record Hemorrhagic/Ischemic classification for procedure related Strokes. See the Stroke Diagnosis variable for more detail. STRKISCH Ischemic Stroke Col#5 1 Yes 1, Missing Defined as a Stroke where the diagnosis question indicates an iscemic stroke. Ischemic Stroke is adjudicated for CT and OS participants. Form 121 and early versions of 132 were not able to record Hemorrhagic/Ischemic classification for procedure related Strokes. See the Stroke Diagnosis variable for more detail. STROKE Stroke Col#6 1 Yes 1, Missing Defined as the first occurrence of Stroke or a Death due to Cerebrovascular. Stroke is adjudicated for CT and OS participants. In order to be able to classify strokes, WHI uses central adjudications if possible, even though Strokes were only fully centrally adjudicated in HT participants. This file does not include Strokes determined solely by the cause of death. Page 1 of 5
2 STROKEDX Stroke diagnosis Col#7 1 Subarachnoid hemorrhage Intraparenchymal hemorrhage Other or unspec intracranial hemorrhage Occlusion of cerebral arteries w/infarction 1, Acute but ill-defined cerebrovascular disease 6 Central nervous system complications during/from procedure Missing Value 6 was only on form 121 and early versions of form 132. Strokes with a diagnosis code of 6 were unable to be classified as Hemorrhagic or Ischemic. STROKEPROC Stroke occurred during or resulted from a procedure Col#8 0 No 1, Yes Unknown Missing Not collected on early versions of F132. A stroke is defined as procedure-related if it occurs within 24 hours after any procedure or within 30 days after a cardioversion or invasive cardiovascular procedure. STROKEOUTPAT F132 Stroke diagnosed or managed as outpatient Col#9 Was the stroke diagnosed or managed as an outpatient?* *The outpatient setting includes any emergency department or observation unit, short hospital stays of less than 24 hours duration or a direct admission to a rehab facility without an associated admission to an acute care hospital. 0 No Yes Missing Only collected after WHI closeout. STROKEOXFORD Oxfordshire Classification Col#10 1 Total Anterior Circulation Infarction (TACI ) Partial Anterior Circulation Infarction (PACI) Lacunar Infarction (LACI) Posterior Circulation Infarction (POCI) Missing Page 2 of 5
3 STROKETOAST TOAST Classification Col#11 Trial of Org in Acute Stroke Treatment (TOAST) Classification 1 Probable large artery atherosclerosis Probable cardioembolism Probable small vessel occlusion (lacune) Probable stroke of other determined etiology 5 Possible large artery atherosclerosis Possible cardioembolism Possible small vessel occlusion (lacune) Possible Stroke of other determined etiology 11 Stroke undetermined two or more causes identified 12 Stroke undetermind negative evaluation Stroke undetermined incomplete evaluation Missing A "probable" diagnosis is made if the clinical findings, neuroimaging data, and results of diagnostic studies are consistent with one subtype and other etiologies have been excluded. A "possible" diagnosis is made when the clinical findings and neuroimaging data suggest a specific subtype but other studies are not done. STROKEBASE Stroke diagnosis based on Col#12 1 Rapid neuro deficit & CT/MRI lesion & w/o evid. of blood 2 Rapid neuro deficit duration >= 24 hrs & rad n/a 3 Rapid neuro deficit duration >= 24hrs & rad early no acute 4 Surgical evidence of ischemic infarction CT or MRI blood hemor. in subarachnoid or intra-parenchymal 6 Positive lumbar puncture Surgical evidence of hemorrhage None of the above Missing STROKE28DEATH Hospitalized stroke within 28 days of death Col#13 If stroke fatal: Hospitalized stroke within 28 days of death 0 No Yes STROKEPREV Previous stroke and no other lethal disease Col#14 If stroke fatal: Previous stroke and no known potentially lethal non-cerebrovascular disease process 0 No Yes Page 3 of 5
4 STROKEPOSTMORT Stroke diagnosed at post-mortem Col#15 If stroke fatal: Stroke diagnosed as cause of death at post-mortem examination 0 No Yes STROKEDEATHCERT Stroke listed on death certificate Col#16 If stroke fatal: Stroke listed as underlying cause of death on death certificate 0 No Yes STROKEGLASGOW Glascow stroke outcome scale Col#17 Participant s functional status at the time of discharge (Glasgow Outcome Scale) 1 Good recovery Moderately disabled Severely disabled Vegetative survival Deceased Unable to assign category Missing CARDX Carotid artery disease diagnosis Col#18 1 Occlusion/stenosis w/o documentation of cerebral infarction 2 Occlusion/stenosis w documentation of cerebral infarcation Missing 1, CARBHOSP Carotid artery disease based on hosp discharge Col#19 Carotid artery disease based on: Symptomatic disease with carotid artery disease listed on the hospital discharge summary 0 No Yes Page 4 of 5
5 CARBABNORMAL Carotid artery disease based on abnormal findings Col#20 Carotid artery disease based on: Symptomatic disease with abnormal findings (>= 50% stenosis) on carotid angiogram, MRA, or Doppler flow study 0 No Yes CARBPROC Carotid artery disease based on vasc/surg proc. Col#21 Carotid artery disease based on: Vascular or surgical procedure to improve flow to the ipsilateral brain. 0 No Yes Page 5 of 5
Stroke/Carotid Artery Disease Outcome Detail (Form 121/132)
In Ext2 these outcomes are only adjudicated for Medical Record Cohort (MRC) ppts. ID WHI Participant Common ID Col#1 ASCSOURCE Ascertainment Source Col#2 1 Local Form 121 1,112 14.4 2 Central Form 121
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