Dr. Kris Kerestan Garbig
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1 Dr. Kris Kerestan Garbig It's very important for people to be aware of what conditions they have, what medications they're taking and how these meds may increase the risk of certain vision problems. Every med. has an effect on Multiple Organs
2 70 % of Americans are on at least ONE rx. 50 % take at least TWO rxes 20 % take at least FIVE rxes The most commonly prescribed drugs are: Antibiotics -- taken by 17 % of Americans Antidepressants % of Americans Opiods (Pain) % of Americans. Followed by: HBP -- 11% Vaccines -- 11% Chronic Condition Heart Disease/ Diabetes/Arthritis Depression Nearly 20 % of women ages 50 to % of the overall population were found to be on antidepressants Pain Opiods High addiction rate
3 Below age 19 Vaccines Antibiotic Anti-Asthma Middle Age Antidepressant Opiods Older Cardiovascular What are the most common Systemic meds. that cause Visual side effects? What are the specific Visual side effects? How to minimize visual loss while taking these meds? Must be familiar with common systemic meds and their associated visual side effects Transient Mild Moderate Severe Vision Loss
4 It ALL begins with the CASE HISTORY!!! A careful and detailed case hx. is critical to revealing the patients medication hx Can often identify the problem prior to testing MU 2 Rx requirements-complete list from physician Chief Complaint/RFV Visual and Ocular history General Health history ALL Medications Allergies to medications Family Eye and Medical histories Brand names Acutane Amnesteem Claravis Sotret
5 Uses: Treatment of severe acne that hasn t responded to other treatments Initial SCIENTIFIC Treatments Benzoyl Peroxide - Kills Acne bacteria Salicylic Acid - Unclogs Pores Glycolic Acid -Renews Skin Sulfur - Dries Sebum Azelaic Acid - Normalizes Skin NATURAL ALTERNATIVES Green Tea - Kills Acne Bacteria Passion Flower - Reduces inflammation Aloe Vera - Soothes Irritated Skin Sage Extract - Fights Free Radicals Gotu Kola - Improves Skin Healing
6 Dry Eyes- mild to severe Blepharoconjunctivitis Keratitis Corneal opacities Transient blurred vision Sudden decrease in night vision Photosensitivity Papilledema Swelling of Optic Nerve caused by increase in intracranial pressure Usually Bilateral
7 Symptoms None early Headache Enlargement of the blind spot Blurred vision Total loss of vision may occur Signs Venous engorgement Loss of venous pulsation Hemorrhages over and adjacent to the optic disc Blurring of optic margins Elevation of optic disc Paton's lines = radial retinal lines cascading from the optic disc Chapped lips (90%) Dry and itchy skin (80%) Dryness of nose/nosebleeds (80%) Irritation of eyes and eyelids (40%) Joint and muscle pain (15%) Comprehensive Case History Discussion and review of ALL meds 6 month Office Visit while taking meds Annual Comprehensive Vision Exams
8 Claritin Zyrtec Allegra Benadryl Sudafed Uses: Relieves hay fever and allergy symptoms Reduces inflammation due to allergic reactions Mechanism of Action: Blocks the histamines that are produced by the body that cause runny nose, watery eyes, sneezing, itching and inflammation due to allergic rxn or the common cold Dry eyes Mydriasis Blurred vision due to the loss of accommodation Lacrimation
9 Angle Closure Glaucoma (Ocular Emergency) Rapid increase in ocular pressure Ocular and Systemic symptoms Headache Severe eye pain Nausea and vomiting Blurred vision Seeing halos around lights Anatomy and Physiology Dry mouth Drowsiness Dizziness Nausea/Vomiting Restlessness or moodiness (in some children) Blurred vision Confusion Trouble urinating or not being able to urinate
10 Avoid mydriatics (pupil dilating agents) Avoid Anticholinergics and Antispasmodics Asthma and COPD meds Scopalomine patches used for dizziness and sea sickness Drugs that calm diarrhea and muscle spasms in people with GI problems Annual comprehensive vision exams Plaquenil (Hydroxychloroquine) Quineprox Aralen (Chloroquine) Uses: Rheumatoid arthritis Lupus Erythemtosus Prevention of and treatment for Malaria (Parasitic disease kills 2.7 million people annually)
11 Keratopathy Retinal toxicity leading to permanent vision loss (Dose related toxicity) Bilateral Pigmentary Retinopathy Asymptomatic early on Later - Bull s eye maculopathy accompanied by paracentral and central scotomas End stage - Widespread RPE and retinal atrophy with a loss of central vision, peripheral vision, and night vision GI problems Skin changes CNS involvement Neuromuscular toxicity Cardiac toxicity
12 Baseline vision exam prior to treatment SLE 10-2 Humphrey visual field (HVF) Macular OCT Fundus autofluorescence (Optomap Daytona) Annual comprehensive vision exams repeating the above tests Prednisone Cortisone Dexamethasone Hydrocortisone Primary Uses: Systemic inflammatory conditions including arthritis, lupus, psoriasis Severe allergies, asthma, breathing disorders, bronchitis, ulcerative colitis
13 Posterior Subcapsular Cataracts Elevated IOP Glaucoma Decreased vision Mydriasis Photophobia Adrenal Insufficiency- decreased ability to respond to physical stress Immunosuppression- leading to infectious complications Steroid Withdrawal Syndrome could result in fatigue, joint pain, muscle stiffness, muscle tenderness, fever and Flu-like symptoms Gastrointestinal Ulcers or Bleeding Osteoporosis Weight gain Insomnia Mood Changes Fluid Retention Elevated BP Elevated Blood Sugar:
14 Comprehensive Eye exam immediately after start steroids for SLE and IOP check Monitor IOP Q 3months Call if develop eye pain, halos around lights or blurred vision Annual Comprehensive Vision Exams Viagra Cialis Levitra Uses:
15 Blurred Vision Sensitivity to light Seeing a temporary blue tinge to objects Sudden vision loss (advertised on commercial) Non Arteritic Ischemic Optic Neuropathy NAION is an ischemic insult to the optic nerve Acute Monocular Painless Visual Loss Optic disc swelling Pallor of the Optic Nerve Headache Stuffy nose Facial Flushing Dizziness Lightheadedness.
16 Comprehensive Case History Discussion and review of ALL meds Call if notice any vision changes Annual Comprehensive Vision Exams Myambutol Uses: Antibiotic used to treat tuberculosis (TB) Decrease in visual acuity/clarity Difficulty seeing certain colors Toxic Optic Neuropathy
17 Visual symptoms generally appear between 4 months to 1 year after taking meds: (Dose Dependant) Mild Unilateral Dimness of vision initially Painless Visual Loss Bilateral vision loss no worse than 20/200 Pupils are bilaterally sluggish to light Always R/G or B/Y defect Normal-appearing optic nerves initially making early diagnosis a challenge Visible Optic Atrophy develops later
18 Enlarged Blind Spot with Cecocentral Scotoma Headache Loss of appetite Upset stomach Nausea Vomiting Baseline Vision Exam Call if notice any visual changes or change to color vision Annual Comprehensive Vision Exams
19 Tamsulosin Uses: Treatment of Benign Prostatic Hyperplasia Minimizes pain during urination in men with enlarged prostates Alpha Blockers that work by relaxing bladder and prostate muscles Medication builds up in the iris preventing pupil from being able to dilate Intra-Operative Floppy Iris Syndrome during cataract surgery (IFIS) Incidence of IFIS with the use of tamsulosin ranges from 43% to 63% (Although prevalence of IOFS is only 1-2%) Miotic Pupils Iris clips
20 Headache - 4% to 20% Dizziness - 5% to 15% Back or chest pains - 4% to 8% Diarrhea - 5% Nausea and vomiting - 3% Flu-like syndrome or infection 2% Men considering cataract surgery MUST make sure cataract surgeon knows they are taking Annual vision exams Thorazine Mellaril Uses:.Antipsychotic used to treat schizophrenia and other severe mental/emotional illness Used to treat nausea and vomiting Severe hiccups
21 Sensitivity to light Color vision changes Difficulty with night vision Pigment changes on the lens Inability to move eyes Constipation Mild Drowsiness Dry mouth Dizziness Lightheadedness Decreased sweating Nasal congestion
22 Take LOWEST dose possible Avoid long term use If any symptoms persist or worsen, notify your doctor Annual comprehensive eye exams Soltamox Nolvadex Uses: Anti-estrogen drug used to treat breast cancer Blurred Vision Increased risk of Cataracts Sub-epithelial corneal opacities
23 Crystalline Retinopathy Irregular periods Hot flashes Nausea/Vomiting Noisy or rattling breathing Redness of the face, neck, arms or occasionally, upper chest Skin changes Swelling of the fingers, hands, feet, or lower legs Troubled breathing at rest Weight gain or loss
24 Baseline Comprehensive Vision Exam Report any visual or systemic side effects to your doc Annual Comprehensive Vision Exams Topamax Uses: Anti-convulsant used to treat seizure disorders Prevention of migraine headaches Angle-Closure Glaucoma (Medical Emergency) Rapid increase in IOP due to: Swelling of the Ciliary Body Closing of the Angle between the Iris and Cornea
25 Severe peri-ocular pain Photophobia Circum-limbal hyperemia Corneal edema Non-responsive pupil Extreme Headache Blurred/Double vision Nausea and vomiting Seeing halos or rainbows around lights Visual Field Defects Paresthesia- numbness and tingling Fatigue Taste change Weight loss Difficulty with concentration/attention/memory
26 Baseline Comprehensive Vision Exam Report any visual or systemic side effects to your doc Annual Comprehensive Vision Exams
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