CAN MY MEDICATIONS CAUSE VISION PROBLEMS?
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- Ira Perry
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1 CAN MY MEDICATIONS CAUSE VISION PROBLEMS? YES ABSOLUTELY!! v It's very important for people to be aware of what conditions they have, what medications they're taking and how these meds may increase the risk of certain vision problems. Dr. Kris Kerestan Garbig krisgarbig@fuse.net WHAT S THE DANGER? Every med. has an effect on Multiple Organs WHAT S THE DANGER? WHAT S THE DANGER? 70 % of Americans are on at least ONE prescription drug 50 % take at least TWO prescriptions 20 % take at least FIVE prescriptions The most commonly prescribed drugs are: Antibiotics -- taken by 17 % of Americans Antidepressants % of Americans Opiods (Pain) % of Americans. Followed by: HBP -- 11% Vaccines -- 11% 1
2 CHRONIC CONDITION OR OTHER? MEDS BY AGE Chronic Condition Heart Disease/ Diabetes/Arthritis Depression Nearly 20 % of women ages 50 to % of the overall population were found to be on antidepressants Pain Opiods High addiction rate (WVA and KY two of highest) Younger than 19 Vaccines Antibiotic Anti-Asthma Middle Age Antidepressant Opiods Older Cardiovascular COURSE OBJECTIVES ROLE OF OPTOMETRIC ASSISTANT What are the most common Systemic meds. that cause Visual side effects? What are the specific Visual side effects? How to minimize visual loss while taking these meds? Must be familiar with common systemic meds and their associated visual side effects Transient Mild Moderate Severe Vision Loss ROLE OF OPTOMETRIC ASSISTANT CASE HISTORY It ALL begins with the CASE HISTORY!!! A careful and detailed Case Hx. is critical to revealing the patients Medication Hx. Can often identify the problem even before any testing is completed q Chief Complaint/RFV q Visual and Ocular history q General Health history q ALL Medications q Allergies to medications q Family Eye and Medical histories MU 2 Rx requirements-complete list from physician 2
3 # 1 ACNE MEDICATIONS (ISORETINOIN) Brand names Acutane Amnesteem Claravis Sotret ACNE MEDICATIONS Treatment of severe acne that hasn t responded to other treatments Initial SCIENTIFIC Treatments Benzoyl Peroxide - Kills Acne bacteria Salicylic Acid - Unclogs Pores Glycolic Acid -Renews Skin Sulfur - Dries Sebum Azelaic Acid - Normalizes Skin OTC OPTIONS NATURAL ALTERNATIVES Green Tea - Kills Acne Bacteria Passion Flower - Reduces inflammation Aloe Vera - Soothes Irritated Skin Sage Extract - Fights Free Radicals Gotu Kola - Improves Skin Healing 3
4 Dry Eyes- mild to severe Decreased CL tolerance Blepharoconjunctivitis Keratitis Photophobia Increase in hordeolumand chalazion frequency Corneal opacities Headache Transient blurred vision Sudden decrease in night vision Subjective visual obscurations Photosensitivity Tinnitis Papilledema PAPILLEDEMA PAPILLEDEMA Swelling of Optic Nerve caused by increase in intracranial pressure Usually Bilateral Symptoms None early on Headache Enlargement of the blind spot Blurred vision Total loss of vision may ultimately occur Signs Venous engorgement Loss of venous pulsation Hemorrhages over and adjacent to the optic disc Blurring of optic margins Elevation of optic disc Paton's lines = radial retinal lines cascading from the optic disc Chapped lips (90%) Dry and itchy skin (80%) Dryness of nose/nosebleeds (80%) Irritation of eyes and eyelids (40%) q Comprehensive Case History q Discussion and review of ALL meds q 6 month Office Visit while taking meds q Annual Comprehensive Vision Exams Joint and muscle pain (15%) 4
5 #2 ANTIHISTAMINES Claritin Zyrtec Allegra Benadryl Sudafed #2 ANTIHISTAMINES Relieves hay fever and allergy symptoms Reduces inflammation due to allergic reactions Mechanism of Action: Blocks the histamines that are produced by the body that cause runny nose, watery eyes, sneezing, itching and inflammation due to allergic rxn. or the common cold Dry eyes Mydriasis Blurred vision due to the loss of accommodation Lacrimation Angle Closure Glaucoma (Ocular Emergency) Rapid increase in ocular pressure Ocular and Systemic symptoms Headache Severe eye pain Nausea and vomiting Blurred vision Seeing halos around lights Anatomy and Physiology of Acute Angle Closure Glaucoma Dry mouth Drowsiness Dizziness Nausea/Vomiting Restlessness or moodiness (in some children) Blurred vision Confusion Trouble urinating 5
6 q Avoid mydriatics (pupil dilating agents) #3 ANTIMALARIALS q Avoid Anticholinergics and Antispasmodics Asthma and COPD meds Scopalomine patches used for dizziness and sea sickness Drugs that calm diarrhea and muscle spasms in people with GI problems Plaquenil (Hydroxychloroquine) Quineprox Aralen (Chloroquine) q Annual comprehensive vision exams Rheumatoid arthritis Lupus Erythemtosus Sjogren s Syndrome Prevention of and treatment for Malaria (Parasitic disease kills 2.7 million people annually) Keratopathy Retinal toxicity leading to permanent and irreversible vision loss (Dose related toxicity) Bilateral Pigmentary Retinopathy Asymptomatic early on BULL S EYE MACULOPATHY GI problems Skin changes Later - Bull s eye maculopathy accompanied by paracentral and central scotomas End stage - Widespread RPE and retinal atrophy with a loss of central vision, peripheral vision, and night vision CNS involvement Neuromuscular toxicity Cardiac toxicity 6
7 q Baseline vision exam prior to treatment SLE Q 6 months 10-2 Humphrey Visual Field Macular OCT Fundus autofluorescence (Optomap Daytona) # 4 CORTICOSTEROIDS Prednisone Cortisone Dexamethasone Hydrocortisone q Annual comprehensive vision exams repeating the above tests Primary Systemic inflammatory conditions arthritis, lupus, psoriasis Severe allergies, asthma, breathing disorders, bronchitis, ulcerative colitis Ocular conditions Contact dermatitis, Acute Allergic rxn, Anterior uveitis Posterior Subcapsular Cataracts Elevated IOP Glaucoma Decreased vision Mydriasis Photophobia Adrenal Insufficiency- decreased ability to respond to physical stress (Fight or Flight) Immunosuppression- Can t fight off infections Steroid Withdrawal Syndrome could result in fatigue, joint pain, muscle stiffness, muscle tenderness, fever and Flu-like symptoms 7
8 Gastrointestinal Ulcers or Bleeding Osteoporosis Weight gain Insomnia Mood Changes Fluid Retention Elevated BP Elevated Blood Sugar: q q Comprehensive Eye exam immediately after start steroids for SLE and IOP check Monitor IOP Q 3 months q Call if develop eye pain, halos around lights or blurred vision q Annual Comprehensive Vision Exam # 5 ERECTILE DYSFUNCTION MEDS Viagra Cialis Levitra Seeing a temporary blue tinge to objects Blurred Vision Sensitivity to light Conjunctival Hyperemia Sudden vision loss (advertised on commercial) NON ARTERITIC ISCHEMIC OPTIC NEUROPATHY -NAION NAION is an ischemic insult to the optic nerve Acute Monocular Painless Visual Loss Optic disc swelling Pallor of the Optic Nerve Non Arteritic Ischemic Optic Neuropathy 8
9 Headache Stuffy nose Facial Flushing Dizziness Lightheadedness. q Comprehensive Case History q Discussion and review of ALL meds q Call if notice any vision changes q Annual Comprehensive Vision Exams # 6 ETHAMBUTOL Decrease in visual acuity/clarity Difficulty seeing certain colors Toxic Optic Neuropathy Myambutol Antibiotic used to treat tuberculosis (TB) TOXIC OPTIC NEUROPATHY TOXIC OPTIC NEUROPATHY Visual symptoms generally appear between 4 months to a year after taking meds: (Dose Dependant) Mild Unilateral Dimness of vision initially PainlessVisual Loss Bilateral vision loss no worse than 20/200 Pupils are bilaterally sluggish to light Always R/G or B/Y defect Normal-appearing optic nerves initially making early diagnosis a challenge Visible Optic Atrophy develops later 9
10 TOXIC OPTIC NEUROPATHY TOXIC OPTIC NEUROPATHY Papillomacular bundle damage with Central or Ceco-central Scotoma Headache Loss of appetite Upset stomach Nausea Vomiting q Baseline Vision Exam q Color Vision testing q Amsler Grid q Visual field testing q OCT q Call if vision or color vision changes q Annual Comprehensive Vision Exams # 7 FLOMAX Treatment of Benign Prostatic Hyperplasia Minimizes pain during urination in men with enlarged prostates Work by relaxing bladder and prostate muscles Medication builds up in the iris preventing pupil from being able to dilate Intra-Operative Floppy Iris Syndrome - cataract surgery Incidence of IFIS with the use of flomax is 43% to 63% while revalence in general population is only 1-2% 10
11 IFIS Miotic Pupils Headache - 4% to 20% Dizziness - 5% to 15% Back or chest pains - 4% to 8% Diarrhea - 5% Iris clips Nausea and vomiting - 3% Flu-like syndrome or infection 2% q Men considering cataract surgery MUST make cataract surgeon aware q Annual vision exams Thorazine Mellaril #8 PHENOTHIAZINES Antipsychotic used to treat schizophrenia and other severe mental/emotional illness Used to treat nausea and vomiting Severe hiccups Sensitivity to light Color vision changes Inability to move eyes Constipation Mild Difficulty with night Pigment changes on the lens vision Drowsiness Dry mouth 11
12 Dizziness Lightheadedness Decreased sweating Nasal congestion q Take LOWEST dose possible q Avoid long term use q If any symptoms persist or worsen, notify your doctor q Annual comprehensive eye exams #9 TAMOXIFEN Soltamox Nolvadex Anti-estrogen drug used to treat breast cancer Blurred Vision Sub-epithelial corneal opacities Increased risk of Cataracts Crystalline Retinopathy Crystalline Retinopathy Initially asymptomatic Decrease in vision Dyschromatopsia Dose dependent - >120mg BID Irregular periods Hot flashes Nausea/Vomiting Noisy or rattling breathing Redness of the face, neck, arms or occasionally, upper chest 12
13 Skin changes Swelling of the fingers, hands, feet, or lower legs Troubled breathing at rest q Baseline Comprehensive Vision Exam q Report any visual or systemic side effects to your doc q Annual Comprehensive Vision Exams Weight gain or loss Topamax #10 TOPIRAMATE Anti-convulsant used to treat seizure disorders Prevention of migraine headaches Treament of Bipolar Disorder, OCD and PTSD Weight loss in Obesity Treatment for Pseudo-tumor Cerebri Angle-Closure Glaucoma (Medical Emergency) Rapid increase in IOP due to: Swelling of the Ciliary Body Closing of the Angle between the Iris and Cornea ANGLE-CLOSURE GLAUCOMA ANGLE-CLOSURE GLAUCOMA Severe peri-ocular pain Photophobia Circum-limbal hyperemia Corneal edema Non-responsive pupil Extreme Headache Blurred or double vision Nausea and vomiting Seeing halos or rainbows around lights 13
14 OTHER Blurred Vision Visual Disturbances Peri-orbital pain Visual Field Defects (April 2014) Paresthesia- numbness and tingling Fatigue Taste change Weight loss Difficulty with concentration/attention/memory q Baseline Comprehensive Vision Exam q Report any visual or systemic side effects to your doc q Annual Comprehensive Vision Exams THANK YOU!!! Any???? Dr. Kris Kerestan Garbig krisgarbig@fuse.net 14
Dr. Kris Kerestan Garbig
Dr. Kris Kerestan Garbig krisgarbig@fuse.net It's very important for people to be aware of what conditions they have, what medications they're taking and how these meds may increase the risk of certain
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