The Relationship between Lichen Planus and Carotid Intima Media Thickness
|
|
- Frank Manning
- 5 years ago
- Views:
Transcription
1 Brief Report Acta Cardiol Sin 2016;32: doi: /ACS A The Relationship between Lichen Planus and Carotid Intima Media Thickness Koseoglu C, 1 Erdogan M, 2 Koseoglu G, 3 Kurmus O, 4 Ertem AG, 2 Efe TH, 5 Kurmus GI, 6 Durmaz T, 2 Keles T 2 and Bozkurt E 2 Background: Lichen planus (LP) is a chronic inflammatory disease. Although the association between chronic inflammation and subclinical atherosclerosis has been reported in the literature, the relationship between LP and carotid intima media thickness (CIMT) has not been previously investigated. The aim of this study was to investigate the relationship between LP and CIMT. Methods: One hundred eleven LP patients and 105 controls were enrolled in the study. Then, CIMT examination was performed with an ultrasonography device. Cross-sectional associations of LP with CIMT were analyzed using linear regression models adjusted for related confounders. Results: No statistical difference was found between LP and the controls except for the female gender, white blood cell, LDL cholesterol and triglycerides (p = 0.046, p = 0.019, p = and p = 0.013, respectively). Significant difference was found between the groups in terms of CIMT ( mm vs mm, p = 0.001). CIMT was correlated with longevity of the LP, but we did not find LP to be an independent predictor of increased CIMT in logistic regression analysis (r = 0.449, p < 0.001, = , p = 0.092; respectively). Conclusions: The results of our study suggested that LP was associated with increased mean CIMT, and furthermore that CIMT was correlated with longevity of LP. However, LP was not an independent predictor of increased CIMT. Key Words: Carotid intima media thickness Lichen planus Subclinical atherosclerosis INTRODUCTION Received: May 20, 2015 Accepted: February 24, Deparment of Cardiology, Ankara Training and Research Hospital; 2 Department of Cardiology, Ataturk Training and Research Hospital; 3 Department of Dermatology, Ankara University Faculty of Medicine, Ankara; 4 Department of Cardiology, Tarsus State Hospital, Mersin; 5 Department of Cardiology; 6 Department of Dermatology, D skap Y ld r mbeyaz t Training and Research Hospital, Ankara, Turkey. Address correspondence and reprint requests to: Dr. Cemal Koseoglu, Ankara Training and Research Hospital, Alt ndag, Ankara, Turkey. Tel: ; drcemalkoseoglu@hotmail.com Lichen planus (LP) is a chronic, idiopatic, immunemediated inflammatory disease that affects the skin and mucous membranes. 1 The disease occurs in % of the population and mostly influences middle-aged women. 2 It has been described in the literature that chronic inflammation in LP may predispose to dyslipidemia, diabetes mellitus, and increased oxidative stress, and also that these factors and inflammation are associated with endothelial dysfunction and atherosclerosis. 2,3-5 Clinical and subclinical cardiovascular involvement have been reported in patients with psoriasis, which is recognised as a chronic inflammatory skin disease that displays a similar physiopathology as LP. 6 However, there is considerable lack of evidence of a relationship between LP and the subclinical atherosclerotic process. Carotid intima media thickness (CIMT) is an indicator of subclinical atherosclerosis, and studies have shown that it points out cardiovascular events and mortality. 7,8 CIMT has also been found to be associated with coronary artery disease and coronary atherosclerotic load. 9,10 In this study, we aimed to evaluate the subclinical atherosclerotic process with measurement of CIMT in patients with LP. Acta Cardiol Sin 2016;32:
2 Carotis Intima Media Thickness and Lichen Planus MATERIAL AND METODS Patient selection A total of 153 patients with lichen planus, who were admitted to the outpatient clinic of the department of dermatology according to exclusion and inclusion criterias described below, were consecutively enrolled in this study. Additionally, 105 age-matched controls were admitted to the outpatient clinic of department of cardiology and consecutively enrolled in the study. Inclusion criteria for the study group were as follows: 1) men or women > 18 years of age, and 2) LP that was confirmed according to clinical and histopathologic criteria established by World Health Organisation criteria. LP was assessed clinically in a standardized dermatological examination by experienced, trained physicians, including dermatological consultants. The patient examinations involved the entire body, including the scalp and nails. Longevity of LP is defined as length of the time from first diagnosis of LP to the study enrollment. Patients with renal failure, hepatic insufficiency, a history of cardiovascular, cerebrovascular disease or connective tissue disease, hypertension and presence of epithelial dysplasia were excluded from the study. Thirty-five patients with systemic treatment, such as steroid, immune-suppresive treatment, retinoids, lipidlowering therapy, antihypertensive or antiaggregant drugs, were excluded from the study. Seven patients from the LP group (two men and five women) were excluded as they had lichenoid drug eruptions. Ultimately, the final number of patients included in our study was 111. Cutaneous involvement was presented in 62 (55.8%) patients, mucosal lesions were presented in 39 (35.1%) patients and 10 (9.0%) patients had mucocutaneous involvement. The study was approved by the local ethics committee,andinformedconsentwasobtainedfromall of the participants. Clinical and biochemical parameters For this study, we first measured body height and weight, blood pressure and body mass index. Thereafter, serum triglycerides, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, glucose levels were determined in samples collected after a 12-hour fasting period. Total plasma cholesterol, triglyceride, and HDL cholesterol were measured by an enzymatic colorimetric method using an autoanalyzer and reagents from (Olympus AU 600, Olympus Diagnostics GmbH, Hamburg, Germany). The LDL cholesterol levels were calculated using the Friedewald formula, and blood glucose was measured by the glucose oxidase method. The blood was collected in tripotassium EDTA tubes, and blood counts were measured on a Sysmex XT-1800i Hematology Analyzer (Sysmex Corporation, Kobe, Japan). CIMT The carotid artery B-mode ultrasonography examinations were carried out with a Vivid 7 Pro ultrasonography device (Vingmed System Seven GE ultrasound, Horten, Norway) using a 5-12 MHz linear array transducer. All ultrasonography examinations were performed by the same operator who was unaware of the patients diagnosis. Those images obtained during ultrasonographic imaging were recorded electronically and then evaluated. The carotid artery imaging was performed while the patient was lying in a supine position lifting his neck at an angle of approximately 20 to the front. The far walls of the right and left common carotid arteries were evaluated. The intima media thickness was defined as the distance between the leading edge of the lumen-intima echo and the leading edge of the media-adventitia echo. CIMT measurements were carried out from the longitudinal plane during the B-mode examination. The averages of the CIMT values obtained from the far walls of the right and left common carotid arteries were then calculated. Statistical analysis We used the Kolmogorov-Smirnov test to evaluate normal distrubition. Continuous variables were expressed as mean standard deviation (SD), and categorical variables were defined as numbers and percentages. Student s t-test was used to compare continuous variables and the Mann-Whitney U test was used for non-normally distributed data. Differences in the distrubition of categorical variables were assessed by chi-square analysis. Pearson s and Spearman s analyses were used for correlation analysis, and multiple logistic regression analysis was performed for parameters affecting the CIMT. The SPSS (SPSS, 16.0, Chicago, IL, USA) package 739 Acta Cardiol Sin 2016;32:
3 Koseoglu C et al. program was used for all statistical analyses. p values less than 0.05 were tabulated as statistically significant. RESULTS Demographical, clinical and biochemical parameters of patients are shown in Table 1. Patients in the two groups were well balanced with regard to age, body mass index, smoking history, diabetes mellitus, systolic blood pressure, and diastolic blood pressure. Hematological variables of both groups and the comparisons are also summarized in Table 1. No statistical differences were found between LP and the controls except for the gender (73.8% vs. 40%, p = 0.046), white blood cell (WBC) ( / L, / L, p = 0.019), LDL cholesterol ( mg/dl vs mg/dl, p = 0.011) and triglycerides ( mg/dl vs mg/dl, p = 0.013). There was a significant difference between the groups in terms of CIMT ( mm vs mm, p = 0.001). There was a positive correlation between the CIMT and WBC, male sex and longevity of the LP (r = 0.421, p = vs. r = 0.278, p = 0.021; r = 0.449, p < 0.001; respectively) (Table 2). After adjustments for relevant confounders (age, sex, smoking, diabetes mellitus, systolic blood pressure, diastolic blood pressure, LDL cholesterol, triglycerides), LP was not an independent predictor of increased CIMT ( = , p = 0.092). Only age and diastolic blood pressure were found to be independent predictors of increased CIMT ( = 0.248, p = vs. = , p = 0.040) (Table 3). In subgroup analysis regarding involment of LP, CIMT was higher in both mucosal LP, cutaneouslpandmucocutaneouslppatientscomparedtothe controls (p = 0.002, p < 0.001, p = 0.001, respectively). DISCUSSION This prospective case-control study showed that CIMT was increased in patients with LP who had no clinical evidence of heart disease. There was a positive correlation between the CIMT and longevity of the LP. Additionally, LP was not an independent predictor of increased CIMT after adjustments for relevant confounders (age, sex, smoking, diabetes mellitus, systolic blood Table 1. Baseline characteristics of the study population Variables Patients with lichen planus (n = 111) Control patients (n = 105) p value Age (years) Female, n (%) 82 (73.8) 42 (40) Body mass index (kg/m 2 ) Systolic blood pressure, (mmhg) Dystolic blood pressure, (mmhg) Diabetes mellitus, n (%) 19 (17.1) 20 (19.0) Smoking, n (%) 31 (27.9) 30 (28.5) Hypercholesterolemia, n (%) 47 (42.3) 28 (26.6) Low density lipoprotein, (mg/dl) High density lipoprotein, (mg/dl) Triglycerides, (mg/dl) Total cholesterol, (mg/dl) Creatinine, (mg/dl) Glucose, (mg/dl) Heamoglobine, (g/l) White blood cell, (10 3 / L SD) Left ventricule ejection fraction, n (%) Mean time with lichen planus, (month) Carotid intima media thickness, (mm) Mucosal lichen planus, n = 39 (35.1%) Cutaneous lichen planus, n = 62 (55.8%) < < Mucocutaneous lichen planus, n = 10 (9.0%) Acta Cardiol Sin 2016;32:
4 Carotis Intima Media Thickness and Lichen Planus Table 2. Correlation of carotid intima media thickness in patients with lichen planus Variables *r p value Age, (years) Male sex Body mass index (kg/m 2 ) Diabetes mellitus Smoking SBP, (mmhg) DBP, (mmhg) LDL cholesterol, (mg/dl) Trigyceride, (mg/dl) White blood cell, (10 3 / L SD) Longevity of LP < < * Coefficient of correlation. DBP, diastoilc blood pressure; LDL, low density lipoprotein; LP, lichen planus; SBP, systolic blood pressure. pressure, diastolic blood pressure, LDL cholesterol, triglycerides). CIMT is recognized as a marker of subclinical atherosclerosis. A population-based study of 15,792 subjects established the association of CIMT with incident coronary heart disease. 11 InastudybyO Learyetal.,itwas found that increased CIMT was associated with increased risk of new myocardial infarction in subjects without clinical cardiovascular disease. 12 Nambi et al. stated that measurement of intima media thickness of common carotid arteries in concert with plaque information improved coronary heart disease risk prediction. 7 Increased CIMT has been reported in several chronic inflammatory diseases such as androgenetic alopecia and psoriasis. 13,14 A similar mechanism probably explains the increased CIMT in LP. It has been hypothesizedthattheassociationbetweenlpandcardiovascular (CV) risk is due to chronic systemic inflammation. 3,15 It is generally accepted that cell-mediated immune dysfunction is implicated in LP etiology and pathophysiology. Antigens are processed by Langerhans cells and then presented to T lymphocytes. This stimulated T lymphocytic infiltrate attacks keratinocytes. Then, a larger number of cytokines is released by wounded keratinocytes. This induces further release of cytokines and chemokines belonging to either T helper-1 or T helper-2 groups. 16 It was found by Mattsson et al. that serum levels of interleukin IL-2, IL-6 and IL-10 [besides tumor Table 3. Independent predictors of carotid intima media thickness in all study patients Variable * pvalue Age, (years) Male sex Body mass index (kg/m 2 ) Diabetes mellitus Smoking SBP, (mmhg) DBP, (mmhg) LDL cholesterol, (mg/dl) Trigyceride, (mg/dl) White blood cell, (10 3 / L SD) LP * Coefficient of logistic regression analysis. DBP, diastoilc blood pressure; LDL, low density lipoprotein; LP, lichen planus; SBP, systolic blood pressure. necrosis factor- (TNF- ) and transforming growth factor- (TGF- )] were elevated within the subepithelial infiltrate in patients with LP. 17 In LP patients, increased levels of TNF-, interleukin IL-2, and IL-6 have been reported. In our study, indicators of inflammation such as white blood cell were significantly higher in patients with LP. We also found positive correlation between CIMTandWBCinpatientswithLP,andwesurmisedthat thereasonforthismaybeattributabletochronicinflammation in that similar results were demonstrated in patients with psoriasis by Yurtdas et al. 18 Yiu et al. demostrated that severity and area of psoriasis were associated with CIMT. 19 We found that CIMT was higher in all involvement types of LP than in the controls. But there were only ten patients with mucocutaneous involvement in our study, and this small sample size limited our investigation to evaluating the correlation between CIMT and severity of disease. Dyslipidemia constitutes a risk factor for atherosclerosis. Cabellero et al. showed a correlation between familial dyslipidemia and CIMT. 20 Recently, a case-control study demonstrated that lichen planus was associated with dyslipidemia in a large series of patients. 3 Furthermore, we also found significantly higher LDL cholesterol and trigylceride levels in patients with LP. To identify whether LP can be associated with increased CIMT through dyslipidemia, we performed correlation and regression analysis. However, LDL and triglyceride values were not correlated with CIMT and they were not pre- 741 Acta Cardiol Sin 2016;32:
5 Koseoglu C et al. dictors of increased CIMT in LP patients. Although a higher prevalence of dyslipidemia was detected in patients with LP, data revealing the association between dyslipidemia and LP were limited. Lipid profile screening in patients with LP may be useful in detecting individuals at risk but further large scale studies are required to identify aggressive and early risk modification in men andwomenwithlp. CONCLUSIONS Carotid intima media thickness was increased in patients with LP who had no clinical evidence of heart disease. Although LP was not found to be an independent predictor of increased CIMT, these results may be important in the early detection of subclinical atherosclerotic process and subsequent cardiovascular events in patients with LP. This is the first study which investigated the relationship with LP and CIMT, and further large studies are necessary for this relation to be better illuminated. Study limitation The small number of study patients and lack of long-term clinical follow-up are the major limitations of this investigation. In our study, age is an independent predictor of CIMT, and longevity of LP is correlated with CIMT. The other limitation is that older patients may have a longer duration of LP and the association between longevity of LP and CIMT may be confounded by age. Further studies with large sample size are neccessary to evaluate the relation between LP, severity of disease and subclinical atherosclerotic risk. CONFLICT OF INTEREST None. REFERENCES 1. Arias-Santiago S, Buendia-Eisman A, Aneiros-Fernandez J, et al. Lipid levels in patients with lichen planus: a case-control study. J Eur Acad Dermatol Venereol 2011;25: Seyhan M, Ozcan H, Sahin I, et al. High prevalence of glucose metabolism disturbance in patients with lichen planus. Diabetes Res Clin Prac 2007;77: Dreiher J, Shapiro J, Cohen AD. Lichen planus and dyslipidaemia: a case control study. Br J Dermatol 2009;161: Aly DG, Shahin RS. Oxidative stress in lichen planus. Acta Dermatovenerol Alp Pannonica Adriat 2010;19: Balta S, Cakar M, Demirkol S, et al. Arterial stiffness itself without other inflammatory markers may not provide information to clinicians. J Clin Hypertens 2013;15: Rocha-Pereira P, Santos-Silva A, Rebelo I, et al. Dislipidemia and oxidative stress in mild and in severe psoriasis as a risk for cardiovascular disease. Clin Chim Acta 2001;303: Nambi V, Chambless L, He M, et al. Common carotid artery intima-media thickness is a good as carotid intima-media thickness of all carotid artery segments in improving prediction of coronary heart disease risk in the Atherosclerosis Risk in Communities (ARIC) study. Eur Heart J 2012;33: Lorenz MW, Schaefer C, Steinmetz H, et al. Is carotid intima media thickness useful for individual prediction of cardiovascular risk? Ten-year results from the Carotid Atherosclerosis Progression Study (CAPS). Eur Heart J 2010;31: Amato M, Montorsi P, Ravani A, et al. Carotid intima-media thickness by B-mode ultrasound as surrogate of coronary atherosclerosis: correlation with quantitative coronary angiography and coronary intravascular ultrasound findings. Eur Heart J 2007; 28: Guaricci AI, Arcadi T, Brunetti ND, et al. Carotid intima media thickness and coronary atherosclerosis linkage in symptomatic intermediate risk patients evaluated by coronary computed tomography angiography. Int J Cardiol 2014;176: Chambless LE, Heiss G, Folsom AR, et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, Am J Epidemiol 1997;146: O Leary DH, Polak JF, Kronmal RA, et al. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. NEngJMed1999;340: Arias-Santiago S, Gutiérrez-Salmerón MT, Castellote-Caballero L, et al. Elevated aldosterone levels in patients with androgenetic alopecia. Br J Dermatol 2009;161: Arias-Santiago S, Gutierrez-Salmerón MT, Buendía-Eisman A, et al. Hypertension and aldosterone levels in women with earlyonset androgenetic alopecia. Br J Dermatol. 2009;162: Fedele S, Sabbah W, Donos N, et al. Common oral mucosal diseases, systemic inflammation and cardiovascular diseases in a large cross-sectional US survey. Am Heart J 2011;161: Pezelj-Ribaric S, Prso IB, Abram M, et al. Salivary levels of tumor necrosis factor-alpha in oral lichen planus. Mediators Inflamm 2004;13: Simark-Mattsson C, Bergenholtz G, Jontell M, et al. Distribution of interleukin-2, -4, -10, tumor necrosis factor-alpha and transforming growth factor beta mrnas in oral lichen planus. Arch Acta Cardiol Sin 2016;32:
6 Carotis Intima Media Thickness and Lichen Planus Oral Biol 1999;44: Yurtda M, Yaylali YT, Kaya Y, et al. Neutrophil-to-lymphocyte ratio may predict subclinical atherosclerosis in patients with psoriasis. Echocardiography 2014; Yiu KH, Yeung CK, Zhao CT, et al. Prevalence and extent of subclinical atherosclerosis in patients with psoriasis. JInternMed 2013; Caballero P, Alonso R, Rosado P, et al. Detection of subclinical atherosclerosis in familial hypercholesterolemia using non-invasive imaging modalities. Atherosclerosis 2012; Acta Cardiol Sin 2016;32:
Pyrex Journals
Pyrex Journals 235-212 Pyrex Journal of Medicine and Medical Sciences Vol 2 (2) pp 31-36 May, 215 http:///pjmms Copyright 215 Pyrex Journals Full Length Research Paper Lichen Planus Not Associated With
More informationAutonomic nervous system, inflammation and preclinical carotid atherosclerosis in depressed subjects with coronary risk factors
Autonomic nervous system, inflammation and preclinical carotid atherosclerosis in depressed subjects with coronary risk factors Carmine Pizzi 1 ; Lamberto Manzoli 2, Stefano Mancini 3 ; Gigliola Bedetti
More informationCoronary artery disease (CAD) risk factors
Background Coronary artery disease (CAD) risk factors CAD Risk factors Hypertension Insulin resistance /diabetes Dyslipidemia Smoking /Obesity Male gender/ Old age Atherosclerosis Arterial stiffness precedes
More informationAssociation between arterial stiffness and cardiovascular risk factors in a pediatric population
+ Association between arterial stiffness and cardiovascular risk factors in a pediatric population Maria Perticone Department of Experimental and Clinical Medicine University Magna Graecia of Catanzaro
More informationAsian J. Exp. Sci., Vol. 27, No. 1, 2013; 67-72
Carotid Intima-media Thickness as a Surrogate Marker of Atherosclerosis and its Correlation with Coronary Risk Factors and Angiographic Severity of Coronary Artery Disease. 1 2 Rajeev Gupta and Rajendra
More informationEchocardiography analysis in renal transplant recipients
Original Research Article Echocardiography analysis in renal transplant recipients S.A.K. Noor Mohamed 1*, Edwin Fernando 2, 1 Assistant Professor, 2 Professor Department of Nephrology, Govt. Stanley Medical
More informationCorporate Medical Policy
Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: carotid_intimal_medial_thickness 12/2006 10/2016 10/2018 10/2017 Description of Procedure or Service Ultrasonographic
More informationOriginal Research Article
A STUDY TO ESTIMATE SUBCLINICAL ATHEROSCLEROSIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS BY MEASURING THE CAROTID INTIMAL MEDIAL THICKNESS Natarajan Kandasamy 1, Rajan Ganesan 2, Thilakavathi Rajendiran
More informationObjective Calcium score carotid IMT hs-crp
P3952 Role of coronary calcium score, carotid intima-media thickness and C-reactive protein in predicting extent of coronary artery disease in young patients. Bedside Poster P3952 Role of coronary calcium
More informationCVD Risk Assessment. Michal Vrablík Charles University, Prague Czech Republic
CVD Risk Assessment Michal Vrablík Charles University, Prague Czech Republic What is Risk? A cumulative probability of an event, usually expressed as percentage e.g.: 5 CV events in 00 pts = 5% risk This
More informationSociety for Behavioral Medicine 33 rd Annual Meeting New Orleans, LA
Society for Behavioral Medicine 33 rd Annual Meeting New Orleans, LA John M. Violanti, PhD* a ; LuendaE. Charles, PhD, MPH b ; JaK. Gu, MSPH b ; Cecil M. Burchfiel, PhD, MPH b ; Michael E. Andrew, PhD
More informationSerum levels of galectin-1, galectin-3, and galectin-9 are associated with large artery atherosclerotic
Supplementary Information The title of the manuscript Serum levels of galectin-1, galectin-3, and galectin-9 are associated with large artery atherosclerotic stroke Xin-Wei He 1, Wei-Ling Li 1, Cai Li
More informationIntima-Media Thickness
European Society of Cardiology Stockholm, 30th August 2010 Intima-Media Thickness Integration of arterial assessment into clinical practice Prof Arno Schmidt-Trucksäss, MD Institute of Exercise and Health
More informationOriginal article: Evaluation of association between serum gamma glutamyltransferase activity and carotid intima media thickness
Original article: Evaluation of association between serum gamma glutamyltransferase activity and carotid intima media thickness *Dr. Madhulika Mahashabde, **Dr. Suryaprakash Rajesh Kothe *Associate Professor,
More informationJMSCR Vol 4 Issue 06 Page June 2016
www.jmscr.igmpublication.org Impact Factor 5.244 Index Copernicus Value: 5.88 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: http://dx.doi.org/10.18535/jmscr/v4i6.69 Role of Aging, Hypertension and Dyslipidaemia
More informationHDL and Arterial Wall
JIFA January 31th 2014 HDL and Arterial Wall P-J TOUBOUL INSERM698 Bichat University Conflict of Interest M Ath intellectual property owner Involvement in R & D for atherosclerosis software developments
More informationClinical Trial Synopsis TL-OPI-518, NCT#
Clinical Trial Synopsis, NCT# 00225264 Title of Study: A Double-Blind, Randomized, Comparator-Controlled Study in Subjects With Type 2 Diabetes Mellitus Comparing the Effects of Pioglitazone HCl vs Glimepiride
More informationNomogram of the Relation of Brachial-Ankle Pulse Wave Velocity with Blood Pressure
801 Original Article Nomogram of the Relation of Brachial-Ankle Pulse Wave Velocity with Blood Pressure Akira YAMASHINA, Hirofumi TOMIYAMA, Tomio ARAI, Yutaka KOJI, Minoru YAMBE, Hiroaki MOTOBE, Zydem
More informationResearch Article Is There Really Relationship between Androgenetic Alopecia and Metabolic Syndrome?
Dermatology Research and Practice Volume 2015, Article ID 980310, 4 pages http://dx.doi.org/10.1155/2015/980310 Research Article Is There Really Relationship between Androgenetic Alopecia and Metabolic
More informationThe presenter does not have any potential conflicts of interest to disclose
Carotid intima-media thickness as a predictor of multi territory atherosclerotic occlusive disease in patients with symptomatic subclavian artery obstruction Leszek Wrotniak 1, Anna Kabłak Ziembicka 1,
More informationCarotid artery intima-media thickness is a marker for coronary artery disease
Scientific Journal of Medical Science (2013) 2(8) 145-150 ISSN 2322-5025 doi: 10.14196/sjms.v2.i8.894 Contents lists available at Sjournals Journal homepage: www.sjournals.com Original article Carotid
More informationCorrespondence should be addressed to Huijuan Zhang;
Hindawi Diabetes Research Volume 2017, Article ID 3510275, 6 pages https://doi.org/10.1155/2017/3510275 Research Article Serum 25-Hydroxyvitamin D3 Levels Are Associated with Carotid Intima-Media Thickness
More informationCLINICAL STUDY. Yasser Khalil, MD; Bertrand Mukete, MD; Michael J. Durkin, MD; June Coccia, MS, RVT; Martin E. Matsumura, MD
117 CLINICAL STUDY A Comparison of Assessment of Coronary Calcium vs Carotid Intima Media Thickness for Determination of Vascular Age and Adjustment of the Framingham Risk Score Yasser Khalil, MD; Bertrand
More informationAndrejs Kalvelis 1, MD, PhD, Inga Stukena 2, MD, Guntis Bahs 3 MD, PhD & Aivars Lejnieks 4, MD, PhD ABSTRACT INTRODUCTION. Riga Stradins University
CARDIOVASCULAR RISK FACTORS ORIGINAL ARTICLE Do We Correctly Assess the Risk of Cardiovascular Disease? Characteristics of Risk Factors for Cardiovascular Disease Depending on the Sex and Age of Patients
More informationLow fractional diastolic pressure in the ascending aorta increased the risk of coronary heart disease
(2002) 16, 837 841 & 2002 Nature Publishing Group All rights reserved 0950-9240/02 $25.00 www.nature.com/jhh ORIGINAL ARTICLE Low fractional diastolic pressure in the ascending aorta increased the risk
More informationEffects of Statins on Endothelial Function in Patients with Coronary Artery Disease
Effects of Statins on Endothelial Function in Patients with Coronary Artery Disease Iana I. Simova, MD; Stefan V. Denchev, PhD; Simeon I. Dimitrov, PhD Clinic of Cardiology, University Hospital Alexandrovska,
More informationCarotid intima-media thickness (CIMT) and carotid plaques in young Nepalese patients with angiographically documented coronary artery disease
Original Article Carotid intima-media thickness (CIMT) and carotid plaques in young Nepalese patients with angiographically documented coronary artery disease Yuba Raj Limbu, Rajib Rajbhandari, Ranjit
More informationBackground. Metabolic syndrome T2DM CARDIOVASCULAR DISEASE. Major Unmet Clinical Need. Novel Risk Factors. Classical Risk Factors LDL-C.
The effect of metabolic syndrome for left ventricular geometry, arterial stiffness and carotid intima-media thickness in Korean general population Result from Atherosclerosis RIsk of Rural Area in Korea
More informationPATIENTS AND METHODS:
BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by erosive synovitis that involves peripheral joints and implicates an important influence in the quality
More informationCho et al., 2009 Journal of Cardiology (2009), 54:
Endothelial Dysfunction, Increased Carotid Artery Intima-media Thickness and Pulse Wave Velocity, and Increased Level of Inflammatory Markers are Associated with Variant Angina Cho et al., 2009 Journal
More informationPrevalence and Significance of Carotid Plaques in Patients With Coronary Atherosclerosis
ORIGINAL ARTICLE DOI 10.4070 / kcj.2009.39.8.317 Print ISSN 1738-5520 / On-line ISSN 1738-5555 Copyright c 2009 The Korean Society of Cardiology Prevalence and Significance of Carotid Plaques in Patients
More informationSubclinical atherosclerosis in CVD: Risk stratification & management Raul Santos, MD
Subclinical atherosclerosis in CVD: Risk stratification & management Raul Santos, MD Sao Paulo Medical School Sao Paolo, Brazil Subclinical atherosclerosis in CVD risk: Stratification & management Prof.
More informationCRP and fibrinogen imply clinical outcome of patients with type-2 diabetes. and coronary artery disease
CRP and fibrinogen imply clinical outcome of patients with type-2 diabetes and coronary artery disease Marijan Bosevski 1, *, Golubinka Bosevska 1, Lily Stojanovska 2, Vasso Apostolopoulos 2, * 1 University
More informationPlasma fibrinogen level, BMI and lipid profile in type 2 diabetes mellitus with hypertension
World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers All Rights Reserved Available online at: http://www.wjpsonline.org/ Original
More informationIntermediate Methods in Epidemiology Exercise No. 4 - Passive smoking and atherosclerosis
Intermediate Methods in Epidemiology 2008 Exercise No. 4 - Passive smoking and atherosclerosis The purpose of this exercise is to allow students to recapitulate issues discussed throughout the course which
More informationSCIENTIFIC STUDY REPORT
PAGE 1 18-NOV-2016 SCIENTIFIC STUDY REPORT Study Title: Real-Life Effectiveness and Care Patterns of Diabetes Management The RECAP-DM Study 1 EXECUTIVE SUMMARY Introduction: Despite the well-established
More informationRates and Determinants of Site-Specific Progression of Carotid Artery Intima-Media Thickness. The Carotid Atherosclerosis Progression Study
Rates and Determinants of Site-Specific Progression of Carotid Artery Intima-Media Thickness The Carotid Atherosclerosis Progression Study Andrew D. Mackinnon, MRCP; Paula Jerrard-Dunne, MRCPI; Matthias
More informationJMSCR Vol 06 Issue 12 Page December 2018
www.jmscr.igmpublication.org Impact Factor (SJIF): 6.379 Index Copernicus Value: 79.54 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v6i12.115 Evaluation of Carotid Intima
More informationSupplementary Online Content
Supplementary Online Content Kavousi M, Leening MJG, Nanchen D, et al. Comparison of application of the ACC/AHA guidelines, Adult Treatment Panel III guidelines, and European Society of Cardiology guidelines
More informationA: Epidemiology update. Evidence that LDL-C and CRP identify different high-risk groups
A: Epidemiology update Evidence that LDL-C and CRP identify different high-risk groups Women (n = 27,939; mean age 54.7 years) who were free of symptomatic cardiovascular (CV) disease at baseline were
More informationPFIZER INC. THERAPEUTIC AREA AND FDA APPROVED INDICATIONS: See USPI.
PFIZER INC. These results are supplied for informational purposes only. Prescribing decisions should be made based on the approved package insert. For publications based on this study, see associated bibliography.
More informationKnow Your Number Aggregate Report Single Analysis Compared to National Averages
Know Your Number Aggregate Report Single Analysis Compared to National s Client: Study Population: 2242 Population: 3,000 Date Range: 04/20/07-08/08/07 Version of Report: V6.2 Page 2 Study Population Demographics
More informationThe Impact of Smoking on Acute Ischemic Stroke
Smoking The Impact of Smoking on Acute Ischemic Stroke Wei-Chieh Weng, M.D. Department of Neurology, Chang-Gung Memorial Hospital, Kee-Lung, Taiwan Smoking related mortality Atherosclerotic vascular disease
More informationD Terentes-Printzios, C Vlachopoulos, G Vyssoulis, N Ioakeimidis, P Xaplanteris, K Aznaouridis, E Christoforatou, A Samentzas, A Siama, C Stefanadis
Peripheral Vessels Unit, 1st Department of Cardiology Athens Medical School Hippokration Hospital, Athens, Greece D Terentes-Printzios, C Vlachopoulos, G Vyssoulis, N Ioakeimidis, P Xaplanteris, K Aznaouridis,
More informationSTUDIES ON ARTERIAL ENDOTHELIAL FUNCTION AND INTIMA- MEDIA THICKNESS USING ULTRASOUND TECHNIQUE. Morteza Rohani
STUDIES ON ARTERIAL ENDOTHELIAL FUNCTION AND INTIMA- MEDIA THICKNESS USING ULTRASOUND TECHNIQUE Morteza Rohani Stockholm 2008 DEPARTMENT OF MEDICINE, HUDDINGE KAROLINSKA INSTITUTET, STOCKHOLM, SWEDEN STUDIES
More informationThe EFFERVESCENT Study
Effect of Angiotensin II Type I Receptor Blockade on Carotid Artery Atherosclerosis: A Double Blind Randomized Clinical Trial Comparing Valsartan and Placebo The EFFERVESCENT Study Ronnie Ramadan, Ayman
More informationWhich CVS risk reduction strategy fits better to carotid US findings?
Which CVS risk reduction strategy fits better to carotid US findings? Dougalis A, Soulaidopoulos S, Cholongitas E, Chalevas P, Vettas Ch, Doumtsis P, Vaitsi K, Diavasti M, Mandala E, Garyfallos A 4th Department
More informationIs the Ankle-Brachial Index a Useful Screening Test for Subclinical Atherosclerosis in Asymptomatic, Middle-Aged Adults?
Is the Ankle-Brachial Index a Useful Screening Test for Subclinical Atherosclerosis in Asymptomatic, Middle-Aged Adults? Rachael A. Wyman, MD; Jon G. Keevil, MD; Kjersten L. Busse, RN, MSN; Susan E. Aeschlimann,
More informationResearch Article Comparison of Different Anthropometric Measurements and Inflammatory Biomarkers
International Inflammation Volume 2012, Article ID 124693, 5 pages doi:10.1155/2012/124693 Research Article Comparison of Different Anthropometric Measurements and Inflammatory Biomarkers Yaron Arbel,
More information2003 World Health Organization (WHO) / International Society of Hypertension (ISH) Statement on Management of Hypertension.
2003 World Health Organization (WHO) / International Society of Hypertension (ISH) Statement on Management of Hypertension Writing Group: Background Hypertension worldwide causes 7.1 million premature
More informationPreclinical Detection of CAD: Is it worth the effort? Michael H. Crawford, MD
Preclinical Detection of CAD: Is it worth the effort? Michael H. Crawford, MD 1 Preclinical? No symptoms No physical findings No diagnostic ECG findings No chest X-ray X findings No diagnostic events 2
More informationReceived: March 2008; in final form May 2008.
RELATIONSHIP BETWEEN BRACHIAL ARTERY FLOW- MEDIATED DILATION AND CAROTID ARTERY INTIMA MEDIA THICKNESS IN THE MIDDLE-AGED SUBJECTS WITH LOW CARDIOVASCULAR RISK GERMAINE SĂVOIU*, LAVINIA NOVEANU**, O. FIRA-MLADINESCU*,
More informationClinical material and methods. Departments of 1 Cardiology and 2 Anatomy, Gaziantep University, School of Medicine, Gaziantep, Turkey
Interatrial Block and P-Terminal Force: A Reflection of Mitral Stenosis Severity on Electrocardiography Murat Yuce 1, Vedat Davutoglu 1, Cayan Akkoyun 1, Nese Kizilkan 2, Suleyman Ercan 1, Murat Akcay
More informationEzetimibe and SimvastatiN in Hypercholesterolemia EnhANces AtherosClerosis REgression (ENHANCE)
Ezetimibe and SimvastatiN in Hypercholesterolemia EnhANces AtherosClerosis REgression (ENHANCE) Thomas Dayspring, MD, FACP Clinical Assistant Professor of Medicine University of Medicine and Dentistry
More informationCOMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP)
European Medicines Agency Pre-Authorisation Evaluation of Medicines for Human Use London, 30 May 2008 Doc. Ref. EMEA/CHMP/EWP/255210/2008 COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP) CONCEPT PAPER
More informationShort stature is an inflammatory disadvantage among middle-aged Japanese men
Environ Health Prev Med (2016) 21:361 367 DOI 10.1007/s12199-016-0538-y REGULAR ARTICLE Short stature is an inflammatory disadvantage among middle-aged Japanese men Yuji Shimizu 1,2 Hiroyuki Yoshimine
More informationsurtout qui n est PAS à risque?
3*25 min et surtout qui n est PAS à risque? 2018 ESC/ESH Hypertension Guidelines 2018 ESC-ESH Guidelines for the Management of Arterial Hypertension 28 th ESH Meeting on Hypertension and Cardiovascular
More informationVascular disease. Structural evaluation of vascular disease. Goo-Yeong Cho, MD, PhD Seoul National University Bundang Hospital
Vascular disease. Structural evaluation of vascular disease Goo-Yeong Cho, MD, PhD Seoul National University Bundang Hospital resistance vessels : arteries
More informationRelationship between body mass index, coronary disease extension and clinical outcomes in patients with acute coronary syndrome
Relationship between body mass index, coronary disease extension and clinical outcomes in patients with acute coronary syndrome Helder Dores, Luís Bronze Carvalho, Ingrid Rosário, Sílvio Leal, Maria João
More informationGlycemic and blood pressure control in older patients with hypertension and diabetes: association with carotid atherosclerosis
Journal of Geriatric Cardiology (2011) 8: 24 30 2011 IGC All rights reserved; www.jgc301.com Research Articles Open Access Glycemic and blood pressure control in older patients with hypertension and diabetes:
More informationhypertension Head of prevention and control of CVD disease office Ministry of heath
hypertension t. Samavat MD,Cadiologist,MPH Head of prevention and control of CVD disease office Ministry of heath RECOMMENDATIONS FOR HYPERTENSION DIAGNOSIS, ASSESSMENT, AND TREATMENT Definition of hypertension
More informationSpotty Calcification as a Marker of Accelerated Progression of Coronary Atherosclerosis : Insights from Serial Intravascular Ultrasound
Spotty Calcification as a Marker of Accelerated Progression of Coronary Atherosclerosis : Insights from Serial Intravascular Ultrasound Department of Cardiovascular Medicine Heart and Vascular Institute
More informationSUPPLEMENTAL MATERIAL. Materials and Methods. Study design
SUPPLEMENTAL MATERIAL Materials and Methods Study design The ELSA-Brasil design and concepts have been detailed elsewhere 1. The ELSA-Brasil is a cohort study of active or retired 15,105 civil servants,
More informationPHENOTYPING FAMILIES OF A HYPERTENSIVE PATIENT
PHENOTYPING FAMILIES OF A HYPERTENSIVE PATIENT Christian Delles BHF Glasgow Cardiovascular Research Centre Advantages Cardiovascular of a Family-based ContinuumDesign Related subjects are more likely to
More informationAntihypertensive Trial Design ALLHAT
1 U.S. Department of Health and Human Services Major Outcomes in High Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic National Institutes
More informationPsoriasi e rischio CV
Psoriasi e rischio CV Claudio Borghi Dipartimento di Scienze Mediche e Chirurgiche Università di Bologna David Plunkert 5 Biggest Heart Risks for Men Plos Med, 2006 Sequenza di eventi che causano malattie
More informationASSOCIATION BETWEEN COMMON CAROTID INTIMA-MEDIA THICKNESS (CAROTID IMT) AND CORONARY ARTERY DISEASE Srinivasa Rao Malladi 1
ASSOCIATION BETWEEN COMMON CAROTID INTIMA-MEDIA THICKNESS (CAROTID IMT) AND CORONARY ARTERY DISEASE Srinivasa Rao Malladi 1 HOWTOCITETHISARTICLE: Srinivasa Rao Malladi. Association between Common Carotid
More informationAssociation between Plasma Homocysteine Concentrations and Carotid Intima-Media Thickness in Patients with Coronary Artery Disease
Association between Plasma Homocysteine Concentrations and Carotid Intima-Media Thickness in Patients with Coronary Artery Disease ROXANA BUZAŞ, CORINA ŞERBAN, IOANA SUCEAVA, DANIEL LIGHEZAN University
More informationSTABILITY Stabilization of Atherosclerotic plaque By Initiation of darapladib TherapY. Harvey D White on behalf of The STABILITY Investigators
STABILITY Stabilization of Atherosclerotic plaque By Initiation of darapladib TherapY Harvey D White on behalf of The STABILITY Investigators Lipoprotein- associated Phospholipase A 2 (Lp-PLA 2 ) activity:
More informationORIGINAL INVESTIGATION. C-Reactive Protein Concentration and Incident Hypertension in Young Adults
ORIGINAL INVESTIGATION C-Reactive Protein Concentration and Incident Hypertension in Young Adults The CARDIA Study Susan G. Lakoski, MD, MS; David M. Herrington, MD, MHS; David M. Siscovick, MD, MPH; Stephen
More informationCARDIOVASCULAR RISK FACTORS & TARGET ORGAN DAMAGE IN GREEK HYPERTENSIVES
CARDIOVASCULAR RISK FACTORS & TARGET ORGAN DAMAGE IN GREEK HYPERTENSIVES C. Liakos, 1 G. Vyssoulis, 1 E. Karpanou, 2 S-M. Kyvelou, 1 V. Tzamou, 1 A. Michaelides, 1 A. Triantafyllou, 1 P. Spanos, 1 C. Stefanadis
More informationSupplementary table 1 Demographic and clinical characteristics of participants by paraoxonase-1 (PON-1) gene polymorphisms
Supplementary table 1 Demographic and clinical characteristics of participants by paraoxonase-1 (PON-1) gene polymorphisms QQ QR/RR n = 36 n = 80 Men (%) 20 (55) 54 (67) 0.216 Age (years) 57 ± 10 56 ±
More informationIndividual Study Table Referring to Item of the Submission: Volume: Page:
2.0 Synopsis Name of Company: Abbott Laboratories Name of Study Drug: Meridia Name of Active Ingredient: Sibutramine hydrochloride monohydrate Individual Study Table Referring to Item of the Submission:
More informationEndothelial dysfunction and subclinical atherosclerosis in HIV/HCV- coinfected patients in the Lower Silesia Region, Poland
Endothelial dysfunction and subclinical atherosclerosis in HIV/HCV- coinfected patients in the Lower Silesia Region, Poland Katarzyna Barska 1,2, Wiesława Kwiatkowska 1,2, Brygida Knysz 1,3, Justyna Drelichowska
More informationCorrelation of LV Longitudinal Strain by 2D Speckle Tracking with Cardiovascular risk in Elderly. (A pilot study of EGAT-Echo study.
Correlation of LV Longitudinal Strain by 2D Speckle Tracking with Cardiovascular risk in Elderly. (A pilot study of EGAT-Echo study.) Researcher: Dr. Atthakorn Wutthimanop, MD. Research adviser: Dr.PrinVathesathokit,
More informationImaging Biomarkers: utilisation for the purposes of registration. EMEA-EFPIA Workshop on Biomarkers 15 December 2006
Imaging Biomarkers: utilisation for the purposes of registration EMEA-EFPIA Workshop on Biomarkers 15 December 2006 Vascular Imaging Technologies Carotid Ultrasound-IMT IVUS-PAV QCA-% stenosis 2 ICH E
More informationCarotid intima media thickness as an usefull tool in predicting cerebrovaskular events
Carotid intima media thickness as an usefull tool in predicting cerebrovaskular events Poster No.: C-0005 Congress: ECR 2015 Type: Authors: Keywords: DOI: Scientific Exhibit A. Rahimic - Catic; Sarajevo/BA
More informationCardioHealth Station. powered by. Healthcare CardioHealth
CardioHealth Station FDA cleared, in-office ultrasound imaging that helps you directly identify atherosclerotic cardiovascular disease (ASCVD) allowing you to make a more informed decision about your patients
More informationThe relationship between mechanical properties of carotid artery and coronary artery disease
European Heart Journal Cardiovascular Imaging (2012) 13, 568 573 doi:10.1093/ejechocard/jer259 The relationship between mechanical properties of carotid artery and coronary artery disease Su-A Kim, Seong-Mi
More informationArterial function and longevity Focus on the aorta
Arterial function and longevity Focus on the aorta Panagiota Pietri, MD, PhD, FESC Director of Hypertension Unit Athens Medical Center Athens, Greece Secrets of longevity Secrets of longevity Unveiling
More informationPrognostic Value of Brachial Artery Endothelial Function and Wall Thickness
Journal of the American College of Cardiology Vol. 46, No. 6, 2005 2005 by the American College of Cardiology Foundation ISSN 0735-1097/05/$30.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2005.05.070
More informationCorrelation of novel cardiac marker
Correlation of novel cardiac marker and mortality in EGAT population. Soluble ST2 hscrp Poh Chanyavanich, MD SukitYamwong, MD Piyamitr Sritara, MD Ramathibodi hospital Background hscrp - the most widely
More informationReeju Manandhar, Chaofeng Sun. Original article
Original article Association of different blood parameters with the early patency of Infarct related artery in ST elevation Myocardial Infarction, a comparative analysis. Reeju Manandhar, Chaofeng Sun
More informationJournal of American Science 2014;10(8)
Role of Doppler Ultrasound and Peripheral Angiography (as a Diagnostic Modality of Atherosclerosis) in Combination with Conventional Atherosclerosis Risk Factors in Coronary Artery Disease Prediction Hussein
More informationArteriosclerosis & Atherosclerosis
Arteriosclerosis & Atherosclerosis Arteriosclerosis = hardening of arteries = arterial wall thickening + loss of elasticity 3 types: -Arteriolosclerosis -Monckeberg medial sclerosis -Atherosclerosis Arteriosclerosis,
More informationTotal risk management of Cardiovascular diseases Nobuhiro Yamada
Nobuhiro Yamada The worldwide burden of cardiovascular diseases (WHO) To prevent cardiovascular diseases Beyond LDL Multiple risk factors With common molecular basis The Current Burden of CVD CVD is responsible
More informationWelcome and Introduction
Welcome and Introduction This presentation will: Define obesity, prediabetes, and diabetes Discuss the diagnoses and management of obesity, prediabetes, and diabetes Explain the early risk factors for
More informationRelationship between Arterial Stiffness and the Risk of Coronary Artery Disease in Subjects with and without Metabolic Syndrome
243 Original Article Hypertens Res Vol.30 (2007) No.3 p.243-247 Relationship between Arterial Stiffness and the Risk of Coronary Artery Disease in Subjects with and without Metabolic Syndrome Yutaka KOJI
More informationEndothelial function is impaired in women who had pre-eclampsia
Endothelial function is impaired in women who had pre-eclampsia Christian Delles, Catriona E Brown, Joanne Flynn, David M Carty Institute of Cardiovascular and Medical Sciences University of Glasgow United
More informationUnraveling the concealed and calculated cardiovascular risks in diabetes
15 P B Fernando Memorial Oration 2015 Unraveling the concealed and calculated cardiovascular risks in diabetes Weerarathna T P 1 Journal of the Ceylon College of Physicians, 2016, 47, 15-19 Abstract Cardiovascular
More informationEpidemiologic and clinical comparison of renal artery stenosis in black patients and white patients
ORIGINAL ARTICLES Epidemiologic and clinical comparison of renal artery stenosis in black patients and white patients Andrew C. Novick, MD, Safwat Zald, MD, David Goldfarb, MD, and Ernest E. Hodge, MD,
More informationAssociation between carotid intima-media thickness and presence of coronary artery disease in chronic obstructive pulmonary disease patients
Original Investigation 601 Association between carotid intima-media thickness and presence of coronary artery disease in chronic obstructive pulmonary disease patients Cemal Köseoğlu, Özge Kurmuş 1, Ahmet
More informationLipoprotein Particle Profile
Lipoprotein Particle Profile 50% of people at risk for HEART DISEASE are not identified by routine testing. Why is LPP Testing The Most Comprehensive Risk Assessment? u Provides much more accurate cardiovascular
More informationCan Hematologic Parameters be an Indicator of Metabolic Disorders Accompanying Rosacea?
2017;25(2):145-150 CASE REPORT Can Hematologic Parameters be an Indicator of Metabolic Disorders Accompanying Rosacea? Asli Akin Belli 1, Asude Kara 1, Seyran Ozbas Gok 2 1 Mugla Sitki Kocman University
More informationThe Effects of Moderate Intensity Exercise on Lipoprotein-Lipid Profiles of Haramaya University Community
International Journal of Scientific and Research Publications, Volume 4, Issue 4, April 214 1 The Effects of Moderate Intensity Exercise on Lipoprotein-Lipid Profiles of Haramaya University Community Mulugeta
More informationSMARTool clinical and biohumoral results. Chiara Caselli IFC-CNR
SMARTool clinical and biohumoral results Chiara Caselli IFC-CNR SMARTool Flow chart EVINCI and ARTreat Populations SMARTool: WP1 and WP2 WP1 Objective: To collect retrospective EVINCI clinical and imaging
More informationA study of brachial artery flow mediated dilatation and carotid intima media thickness in subjects having risk factors for coronary artery disease
International Journal of Advances in Medicine http://www.ijmedicine.com pissn 2349-3925 eissn 2349-3933 Original Research Article DOI: http://dx.doi.org/10.18203/2349-3933.ijam20171037 A study of brachial
More informationSerum Creatinine and Blood Urea Nitrogen Levels in Patients with Coronary Artery Disease
Serum Creatinine and Blood Urea Nitrogen Levels in Patients with Coronary Artery Disease MAK Akanda 1, KN Choudhury 2, MZ Ali 1, MK Kabir 3, LN Begum 4, LA Sayami 1 1 National Institute of Cardiovascular
More informationARIC Manuscript Proposal #1233. PC Reviewed: 4_/_10/07 Status: _A Priority: 2_ SC Reviewed: Status: Priority:
ARIC Manuscript Proposal #1233 PC Reviewed: 4_/_10/07 Status: _A Priority: 2_ SC Reviewed: Status: Priority: 1.a. Full Title: Subclinical atherosclerosis precedes type 2 diabetes in the ARIC study cohort
More informationJMSCR Vol 04 Issue 10 Page October 2016
www.jmscr.igmpublication.org Impact Factor 5.244 Index Copernicus Value: 83.27 ISSN (e)-2347-176x ISSN (p) 2455-0450 DOI: https://dx.doi.org/10.18535/jmscr/v4i10.82 Carotid Intima Media Thickness and Can
More information