Know Your Number Aggregate Report Single Analysis Compared to National Averages

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1 Know Your Number Aggregate Report Single Analysis Compared to National s Client: Study Population: 2242 Population: 3,000 Date Range: 04/20/07-08/08/07 Version of Report: V6.2

2 Page 2 Study Population Demographics Gender Distribution Gender Number % Male % Female % % Male Female Age Distribution Age Number % % % % % % % >80 0 % % >80 Ethnicity Distribution Race Number % White % Black % Asian % Hispanic % Others % % White Black Asian Hispanic Others

3 Page 3 Health Status and Risk Factor Profile: Comparisons with National s Clinical Measures with Yes/No Values Number of Percentage National individuals %* ** Diagnosed (self reported) diseases Coronary Heart Disease % 3.6% Stroke % 1.5% Other Cardiovascular Diseases % 5.6% Heart Failure % 1.3% Diabetes % 4.8% On antihypertensive medication % 13.8% On lipid lowering medication % 6.3% Physical exercise level % 21.6% Moderate % 46.4% % 32.1% Current smoking % 27.3% Overweight (BMI kg/m2) 672 3% 29.0% Obesity (BMI>=30 kg/m2) % 32.4% waist (male>40 inch, female>35 inch) % 50.5% Prehypertension (>=120/80 and <140/90 mmhg) % 33.4% Hypertension (>=140/90 mmhg) % 14.6% Metabolic syndrome *** % 25.9% cholesterol>=200 mg/dl % 48.2% HDL (<40 mg/dl) % 18.6% LDL>=130 mg/dl % 38.6% LDL>=ATP III suggested goal % 24.8% Triglyceride>=150 mg/dl % 27.1% Undiagnosed diabetes (glucose>=126 mg/dl) % 1.4% Prediabetes (100<=glucose<126 mg/dl) % 14.2% Clinical Measures with Numerical Values Population Population National Mean SD**** Weight (lbs) BMI (kg/m2) Waist (inch) Systolic blood pressure (mmhg) Diastolic blood pressure (mmhg) cholesterol (mg/dl) HDL cholesterol (mg/dl) LDL cholesterol (mg/dl) Triglyceride (mg/dl) Fasting glucose (mg/dl) * Numbers in red indicate that the population may be less healthy than the National. ** The National is derived from the NHANES population and it is weighted by the age and gender distribution of the study population. In other words, the National is the average value among a national sample that have the same age and gender distribution as the study population. *** Metabolic syndrome is diagnosed based on the ATP III guideline criteria. **** SD stands for standard deviation.

4 Page 4 Health Status and Risk Factor Profile: Comparisons with National s (continued) Females Clinical Measures with Yes/No Values Number of Percentage National individuals % Diagnosed (self reported) diseases Coronary Heart Disease % 3.0% Stroke % 1.4% Other Cardiovascular Diseases % 5.3% Heart Failure % 1.1% Diabetes % 4.6% On antihypertensive medication % 13.9% On lipid lowering medication % 5.9% Physical exercise level % 22.8% Moderate % 47.1% % 3% Current smoking % 25.9% Overweight (BMI kg/m2) % 26.7% Obesity (BMI>=30 kg/m2) % 33.6% waist (male>40 inch, female>35 inch) % 53.5% Prehypertension (>=120/80 and <140/90 mmhg) % 30.5% Hypertension (>=140/90 mmhg) % 14.0% Metabolic syndrome % 26.0% cholesterol>=200 mg/dl % 47.3% HDL (<40 mg/dl) % 15.0% LDL>=130 mg/dl % 36.9% LDL>=ATP III suggested goal % 22.5% Triglyceride>=150 mg/dl % 25.3% Undiagnosed diabetes (glucose>=126 mg/dl) % 1.3% Prediabetes (100<=glucose<126 mg/dl) % 12.7% Clinical Measures with Numerical Values Population Population National Mean SD Weight (lbs) BMI (kg/m2) Waist (inch) Systolic blood pressure (mmhg) Diastolic blood pressure (mmhg) cholesterol (mg/dl) HDL cholesterol (mg/dl) LDL cholesterol (mg/dl) Triglyceride (mg/dl) Fasting glucose (mg/dl)

5 Page 5 Health Status and Risk Factor Profile: Comparisons with National s (continued) Males Clinical Measures with Yes/No Values Number of Percentage National individuals % Diagnosed (self reported) diseases Coronary Heart Disease % 6.4% Stroke 4 1.0% 1.7% Other Cardiovascular Diseases 8 2.0% 7.2% Heart Failure 2 0.5% 2.0% Diabetes % 5.7% On antihypertensive medication % 13.5% On lipid lowering medication % 8.3% Physical exercise level % 15.6% Moderate % 42.7% % 41.7% Current smoking % 34.2% Overweight (BMI kg/m2) % 40.1% Obesity (BMI>=30 kg/m2) % 27.1% waist (male>40 inch, female>35 inch) % 36.4% Prehypertension (>=120/80 and <140/90 mmhg) % 47.5% Hypertension (>=140/90 mmhg) % 17.2% Metabolic syndrome % 25.4% cholesterol>=200 mg/dl % 52.5% HDL (<40 mg/dl) % 35.9% LDL>=130 mg/dl % 46.8% LDL>=ATP III suggested goal % 36.1% Triglyceride>=150 mg/dl % 36.0% Undiagnosed diabetes (glucose>=126 mg/dl) 9 2.3% 1.7% Prediabetes (100<=glucose<126 mg/dl) % 21.3% Clinical Measures with Numerical Values Population Population National Mean SD Weight (lbs) BMI (kg/m2) Waist (inch) Systolic blood pressure (mmhg) Diastolic blood pressure (mmhg) cholesterol (mg/dl) HDL cholesterol (mg/dl) LDL cholesterol (mg/dl) Triglyceride (mg/dl) Fasting glucose (mg/dl)

6 Page 6 Distribution of Disease Risks in Population By Percentiles Type 2 Diabetes N*= 2031 Coronary Heart Disease N= 2242 Below Below 21% 20% 20% 19% 21% 20% 24% 24% 20% 14% 25% 25% 20% 20% 15% 15% 10% 10% 5% 5% 0% Below 0% Below Stroke N= 2226 Heart Failure N= 1242 Below Below 34% 21% 19% 15% 10% 29% 26% 18% 14% 13% 35% 30% 25% 20% 15% 10% 5% 0% Below 30% 25% 20% 15% 10% 5% 0% Below Notes: Disease risk is classifed by risk percentile of the following groups: <20th percentile Moderate >=20th & <40th percentile >=40th & <60th percentile Moderate >=60th &< 80th percentile >=80th percentile Percentile is age and gender specific. H *N refers to the number of people who had a prediction for the specific disease. No data for COPD and lung cancer because those models were only run for smokers.

7 Page 7 Study Population Projected & Cases of Disease Onset within Next Five Years and Comparisons* with National s Type 2 Diabetes Coronary Heart Disease ** *** Study Population Study Population National **** National ** *** Study Population National **** Study Population National Stroke Heart Failure Study Population Study Population National National Study Population National Study Population National * The study population may be less healthy than the National when numbers are shown in red. ** cases are the projected number of new cases in the next 5 years in the study population. *** cases are the cases that can be avoided in the next 5 years, if all modifiable risk factors are brought within the normal range. **** The National is derived from the NHANES population and it is weighted by the age and gender distribution of the study population. In other words, the National is the average value among a national sample that have the same age and gender distribution as the study population.

8 Page 8 Study Population Projected & Cases of Disease Onset within Next Five Years and Comparisons with National s (continued) COPD Study Population National Study Population National Lung Cancer Study Population National Study Population National

9 Date of Single Report: 8/16/2007 Page 9 Cases* of Disease Onset by Risk Factor Rist Factors Diabetes CHD Stroke CHF COPD Lung Cancer** Weight Blood Pressure Exercise Smoking Cholesterol Glucose Aspirin Cases The spaces in the table refer to a risk factor that does not contribute to the risk of that disease Diabetes CHD Stroke CHF COPD Lung Cancer** Weight Blood Pressure Exercise Smoking Cholesterol Glucose Aspirin * cases are the cases that can be avoided in the next 5 years, if each modifiable risk factor is brought within the normal range. ** Even though almost all of lung cancer cases are attributed to smoking, quitting smoking can only reduce a small portion of lung cancer risk within the next 5 years. The impact of quitting smoking would be much higher in 10 to 20 years.

10 Page 10 Extrapolation to Population * Projected & Cases of Disease Onset within Next Five Years and Comparisons** with National s Population: N= 3000 Type 2 Diabetes Coronary Heart Disease **** ***** Population Population National *** National **** ***** Population National *** Population National Stroke Heart Failure Population Population National National Population National Population National * population is the population that the study population represents. ** The total population may be less healthy than the National when numbers are shown in red. *** The National is derived from the NHANES population and it is weighted by the age and gender distribution of the total population. In other words, the National is the average value among a national sample that have the same age and gender distribution as the total population. **** cases are the projected number of new cases in the next 5 years in the total population. ***** cases are the cases that can be avoided in the next 5 years in the total population, if all modifiable risk factors are brought within the normal range.

11 Page 11 Extrapolation to Population * Cases** of Disease Onset by Risk Factor Population: N= 3000 Risk Factors Diabetes CHD Stroke CHF COPD Lung Cancer*** Weight Blood Pressure Exercise Smoking Cholesterol Glucose Aspirin Cases The spaces in the table refer to a risk factor that does not contribute to the risk of that disease. 9 Diabetes 8 CHD 7 6 Stroke 5 4 CHF 3 COPD 2 1 Lung Cancer*** Weight Blood Pressure Exercise Smoking Cholesterol Glucose Aspirin * population is the population that the study population represents. ** cases are the cases that can be avoided in the next 5 years, if each modifiable risk factor is brought within the normal range. *** Even though almost all of lung cancer cases are attributed to smoking, quitting smoking can only reduce a small portion of lung cancer risk within the next 5 years. The impact of quitting smoking would be much higher in 10 to 20 years.

12 Page 12 Predicted Five-year Cost * of Future Chronic Disease Onset Comparisons** with National s Study Population*** Study Population N= 2242 Diseases Study Population National Predicted Predicted Predicted Predicted Cost Cost Cost Cost Type 2 Diabetes $2,147,752 $1,788,338 $1,983,937 $1,670,801 Coronary Heart Disease $989,580 $633,155 $1,030,986 $715,525 Stroke $751,198 $577,651 $302,177 $222,642 Heart Failure $265,105 $97,970 $129,098 $44,505 COPD $104,351 $43,588 $141,072 $55,495 Lung Cancer $51,157 $31,428 $181,924 $98,578 All Diseases $4,309,142 $3,172,128 $3,769,194 $2,807,546 Extrapolation to Population**** Population N= 3000 Diseases Population National Predicted Predicted Predicted Predicted Cost Cost Cost Cost Type 2 Diabetes $2,873,888 $2,392,959 $2,654,689 $2,235,684 Coronary Heart Disease $1,324,148 $847,219 $1,379,553 $957,438 Stroke $1,005,171 $772,950 $404,340 $297,915 Heart Failure $354,734 $131,092 $172,745 $59,551 COPD $139,631 $58,324 $188,767 $74,258 Lung Cancer $68,452 $42,053 $243,431 $131,906 All Diseases $5,766,024 $4,244,596 $5,043,525 $3,756,752 * The formula used to calculate probable cost is: probability of disease onset (KYN) x 2.5 years x annual cost of disease. ** The population may have more expenses for the specific disease compared with the National when it is shown in red. *** Study population is the population who participated in Know Your Number. **** population is the population that the study population represents. The annual cost for type 2 diabetes was $10,909; CHD was $9,595; stroke was $11,196; CHF was $6,385; COPD was $3,263; lung cancer was $27,324 per patient year. The costs included direct and indirect medical costs associated with occurrence of each disease. They were calculated using the most current annual costs based on national averages documented by the American Heart Association, the American Diabetes Association, the American Lung Association and National Cancer Institute.

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