Vascular grafts made of expanded polytetrafluoroethylene for repair of peripheral arterial injuries 19(34):

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1 Chinese Journal of Tissue Engineering Research August 20, 2015 Vol.19, No.34 ( ) % 12 92%(35/38) :R318 :B : (2015) [J] (34): doi: /j.issn Vascular grafts made of expanded polytetrafluoroethylene for repair of peripheral arterial injuries Zhang Han-jiang, Wang Zhi-wei (Department of Cardiovascular Surgery, People s Hospital of Wuhan University, Wuhan , Hubei Province, China) Abstract BACKGROUND: Vascular grafts made of expanded polytetrafluoroethylene have been shown to have highly hydrophobic surface characterized by resistance to water penetration and biological durability. OBJECTIVE: To investigate the effects of vascular grafts made of expanded polytetrafluoroethylene for repair of peripheral arterial injuries. METHODS: Thirty-eight patients with peripheral arterial injuries, consisting of 30 males and 8 females, aged years, were included in this study. After conventional fluid infusion, anti-shock treatment, anti-inflammation, and debridement, they received implantation of vascular grafts made of expanded polytetrafluoroethylene. A 12-month follow-up observation was performed to investigate the recovery of affected limbs and vascular patency in patients. RESULTS AND CONCLUSION: After implantation of vascular grafts made of expanded polytetrafluoroethylene, all vessels were unblocked and no cases died or had limbs amputated. Blood supply of all affected limbs recovered to normal and there was no vascular anastomotic infection. Imaging results showed that vascular patency rate was 100%. Ultrasound examination results showed that at the end of the follow-up period, the inner wall of the vascular grafts was smooth, obvious mural thrombus or anastomotic stenosis did not occur in any case, vascular patency rate was 92% (35/38), and no adverse reactions related to artificial vessels were observed. These findings suggest that vascular grafts made of expanded polytetrafluoroethylene for repair of peripheral arterial injuries exhibit striking surface anticoagulant property and long-term patency. Subject headings: Biocompatible Materials; Polytetrafluoroethylene; Blood Vessel Prosthesis Zhang Han-jiang, Studying for master s degree, Attending physician, Department of Cardiovascular Surgery, People s Hospital of Wuhan University, Wuhan , Hubei Province, China Corresponding author: Wang Zhi-wei, Department of Cardiovascular Surgery, People s Hospital of Wuhan University, Wuhan , Hubei Province, China Accepted: P.O. Box 10002, Shenyang

2 . Zhang HJ, Wang ZW. Vascular grafts made of expanded polytetrafluoroethylene for repair of peripheral arterial injuries. Zhongguo Zuzhi Gongcheng Yanjiu. 2015;19(34): Introduction [1] C F 100% [2] [3] Subjects and methods (37.25±10.15) h ( ) YZB/ ISSN CN /R CODEN: ZLKHAH 5497

3 cm 70/50 mm Hg (1 mm Hg=0.133 kpa) 11 cm 10 cm ( 2) 12 1 Figure 1 Implantation of vascular grafts made of expanded polytetrafluoroethylene 12 2 Results % % %(35/38) Figure 2 Vascular grafts made of expanded polytetrafluoroethylene for repair of femoral artery and vein injuries 3 Discussion [4-7] [8-10] [11-16] (PET)(ePTFE)(PU) (Dacron) Soyer P.O. Box 10002, Shenyang

4 . [17-21] [22-33] [34-36] [37] % [37-38] [39] 12 92%(35/38) [40] 100% References [1],,,. [J].,2012,10(9): , 699, 720. [2],,,. [J].,2011,15(47): [3],,,. / [J].,2008, 12(14): [4],,,. [J].,2011,25(12): [5],,,. [J].,2014,36(3): [6],,,. [J].,2014,18(34): [7],,,. [J]., 2010,30(9): [8],,,. [J].,2014,18(30): [9],,,. [J].,2014,31(4): [10].CD133 / [D].,2013. ISSN CN /R CODEN: ZLKHAH 5499

5 . [11] Weale AR,Bevis P,Neary WD,et al.a comparison between transposed brachiobasilic arteriovenous fistulas and prosthetic brachioaxillary access grafts for vascular access for hemodialysis.j Vasc Surg.2007;46(5): [12] Tseng DY,Edelman ER.Effects of amide and amine plasma-treated eptfe vascular grafts on endothelial cell lining in an artificial circulatory system.j Biomed Mater Res. 1998;42(2): [13] van Vugt R,Kruse RR,Fritschy WM,et al.treatment of dilated venous bypass grafts with an expanded polytetrafluoroethylene-covered nitinol endoprosthesis.vasc Endovascular Surg. 2009;43(2): [14] Misra S,Fu AA,Puggioni A,et al.increased expression of hypoxia-inducible factor-1 alpha in venous stenosis of arteriovenous polytetrafluoroethylene grafts in a chronic renal insufficiency porcine model.j Vasc Interv Radiol.2008;19 (2 Pt.1): [15] Hynecek RL,Sadek M,Derubertis BG,et al.evaluation of pressure transmission and intra-aneurysmal contents after endovascular repair using the Trivascular Enovus expanded polytetrafluoroethylene stent graft in a canine model of abdominal aortic aneurysm.j Vasc Surg.2007;46(5): [16] Lenti M,Cieri E,De-Rango P,et al.endovascular treatment of long lesions of the superficial femoral artery: results from a multicenter registry of a spiral, covered polytetrafluoroethylene stent.j Vasc Surg.2007;45(1): [17] Yu H,Dai W,Yang Z.et al.neointimal hyperplasia on a cell-seeded polytetrafluoroethylene graft is promoted by transfer of tissue plasminogen activator gene and inhibited by transfer of nitric oxide synthase gene.j Vasc Surg. 2005; 41(1): [18],,,.CD133 / [J].:,2013,39(3): ,274. [19] Laurila K,Lepantalo M,Teittinen K,et al.does an adjuvant AV-fistula improve the patency of a femorocrural PTFE bypass with distal vein cuff in critical leg ischaemia?--a prospective randomised multicentre trial.eur J Vasc Endovasc Surg. 2004;27(2): [20] Savader SJ,Lund GB,Scheel PJ,et al.forearm loop, upper arm straight, and brachial-internal jugular vein dialysis grafts: a comparison study of graft survival utilizing a combined percutaneous endovascular and surgical maintenance approach.j Vasc Interv Radiol.1999;10(5): [21] Rubin BG,Sicard GA.The Hemobahn endoprosthesis: a self-expanding polytetrafluoroethylene-covered endoprosthesis for the treatment of peripheral arterial occlusive disease after balloon angioplasty.j Vasc Surg. 2001;33(2 Suppl.):S [22] Abu Rahma AF,Robinson PA,Saiedy S,et al.prospective randomized trial of carotid endarterectomy with primary closure and patch angioplasty with saphenous vein, jugular vein, and polytetrafluoroethylene: long-term follow-up.j Vasc Surg.1998;27(2): [23] Acin F,De Benito L,Guilleuma J,et al.peroneal arteriovenous fistula as a complication of above-knee femoropopliteal polytetrafluorethylene graft thrombectomy with the Fogarty catheter.j Cardiovasc Surg (Torino).1996;37(2): [24],,,. [J].,2014,52(8): [25],,, [J].,2013, 14(9): [26],,,. / [J].,2012,29(4): [27],,,. [J].,2010,26(1): [28]. [D].,2010. [29],,,. [J].,2013,29(7): [30],,,. [J].,2008,12(1): [31],,,. [J].,2012,16(29): [32],,,. [J].,2008,31(5): [33],,,. [J].,2006,26(12): [34].ePTFE[D].,2010. [35],,,. [J].,2002,25(1): [36],,,. [J]., 2010,14(8): [37],,,.ePTFE [J]. :,2014,40(4): [38],,,. VEGF [J].,2006,27(12): [39],,,. [J].,2006,23(11): [40],,,. [J].,2006,16(11): P.O. Box 10002, Shenyang