Establishment of an individualized three-dimensional finite element model of type A coronary artery lesions (36):

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1 Chinese Journal of Tissue Engineering Research December 28, 2017 Vol.21, No.36 A 3D ( ). A 3D [J] (36): DOI: /j.issn ORCID: ( ) A 3D MRI Geomagic Studio Mimics Ansys D MRI 3D A A :R318 :B : (2017) MRI A 3D 3 A MRI Dicom Mimics 17.0 Geomagic Studio 11.0 ANSYS14.0 3D 3D 3 A D 3D A 3D (2017MS(LH)0833) Establishment of an individualized three-dimensional finite element model of type A coronary artery lesions Han Di, Wang Yue-xi, A Rong, Zhang Ying-jun, Wang Chun-yan (Department of Cardiology, the First Affiliated Hospital of Inner Mongolia Medical University, Hohhot , Inner Mongolia Autonomous Region, China) Abstract BACKGROUND: A cardiac model can be established by finite element analysis based on patient s MRI Han Di, Master, Attending physician, Department of Cardiology, the First Affiliated Hospital of Inner Mongolia Medical University, Hohhot , Inner Mongolia Autonomous Region, China Corresponding author: A Rong, Master, Department of Cardiology, the First Affiliated Hospital of Inner Mongolia Medical University, Hohhot , Inner Mongolia Autonomous Region, China ISSN CN /R CODEN: ZLKHAH 5841

2 . A 3D imaging data. The established model can be used to evaluate the rheological changes of the coronary artery by liquid-solid coupling. OBJECTIVE: To establish finite element models of the heart and coronary artery in patients with type A coronary artery disease using finite element analysis software, followed by three-dimensional (3D) printing, thereby providing a scientific basis for further simulation of interventional surgery. METHODS: Three patients with type A coronary artery lesions underwent MRI scanning from the aortic arch to the apex. The MRI images were then imported into the Mimics 17.0 software in Dicom format, and a complete cardiac model involving the coronary arteries was established by modeling and geometry cleanup. The 3D model was imported into Geomagic Studio 11.0 software, and was further processed. Finally, the 3D model was imported into ANSYS14.0 finite element analysis software. The finite element model with biofunction was established by attaching the material properties, followed by 3D printing on a 3D printer. RESULTS AND CONCLUSION: The 3D finite element model of type A coronary artery lesion was established successfully in three cases. The established heart model in each case presented with grid-based hexahedral solid elements. The number of solid elements was , , and , respectively. In the meanwhile, the model of each coronary branch was established: the number of element at the right coronary artery was 3 320, 3 518, and 3 310; the number of elements at the circumflex branch was 1 148, 1 176, and 1 164; and the number of elements at the anterior descending coronary artery was 1 025, 1 049, and 1 068, respectively. Afterwards, the 3D printing was performed successfully. These results suggest that the established 3D finite element model of the heart with coronary arteries, after 3D printing, displays the right coronary artery, anterior descending artery, circumflex artery and coronary sinus clearly, which paves ways for interventional simulation. Most importantly, it lays a solid foundation for the study on the blood-vessel dual-directional coupling, which is expected to be a new scientific method for rheological research. Subject headings: Coronary Stenosis; Finite Element Analysis; Tissue Engineering Funding: the Natural Science Foundation of Inner Mongolia Autonomous Region, No. 2017MS(LH)0833 Cite this article: Han D, Wang YX, A R, Zhang YJ, Wang CY. Establishment of an individualized three-dimensional finite element model of type A coronary artery lesions. Zhongguo Zuzhi Gongcheng Yanjiu. 2017;21(36): Introduction A 10 mm 45 > 85% A 20% [1] A % 5022A 34.9% [2] A [3] CT A A [2] A A 1Subjects and methods P.O. Box 10002, Shenyang

3 . A 3D A MRI CTA SKYRA MRI () Mimics 17.0Geomagic studio 11.0 ANSYS SKYRA MRI 120 kv 125 mv0.625 mm MRI Dicom Mimics MRI Dicom MRIMimics mimics iges solidworks 2 5 solidworks 6 7 solidworks stl 3D 3D 3D A 2Results A solid mm 3.80 mm 2.83 mm 9.32 mm 3Discussion [4-5] A A [6] [7-12] ISSN CN /R CODEN: ZLKHAH 5843

4 . A 3D 1 Figure 1 MRI images of the heart window 4 Figure 4 Local outline 2 Solidworks Figure 2 Front view of the heart outline in Solidworks 5 Figure 5 Local outline after lofting 3 Solidworks (45 ) Figure 3 The three-dimensional heart outline (45 ) in Solidworks 6 Figure 6 The cardiac model before geometry cleanup 7 Figure 7 The finite element model after geometry cleanup A A [13-14] [15] 3 A MRI mm MRIDicom Mimics 17.0 solid D 3.43 mm 3.80 mm 5844 P.O. Box 10002, Shenyang

5 . A 3D 1 Table1 Number of the elements in the heart and coronary arteries (mm) Table2 The maxinmum value of the outer circumference of each coronary branch 8 3D Figure 8 The three-dimensional model of the heart with coronary branches 2.83 mm 9.32 mm X 1987 Sigwart [16-17] [18] A ST A [19] [ ( ) 1] [20] 1.42 MPa [21] (1.19±0.26) MPa [22] A A ISSN CN /R CODEN: ZLKHAH 5845

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