Table of Included Studies for Early versus Late Referral Systematic Review

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1 University of New England From the SelectedWorks of Neil Smart 2011 Table of Included Studies for Early versus Late Referral Systematic Review Neil A Smart, Assoc. Prof. Available at:

2 Characteristics of Included Studies Study Setting Location No. of Patients Definition of late referral Data Collection Dates Data Collection Method Arora 1 Hospital Tertiary Care USA months Oct 1992-Dec1997 Retrospective cohort study Ballerini 2 Multi-centre study Italy months Jan 1998-Dec 1999 Database analysis Caskey 3 Multi-national study Europe month Jul 1998-Oct 1999 Retrospective cohort study Cass 4 Nationwide/multicentre Australia months Apr 1995-Dec 1998 Retrospective cohort study Curtis 5 Multicenter/nationwide Canada months Oct1998-Dec 1999 Prospective cohort study Dogan 6 University hospital Turkey weeks Jan 1998-Dec 2002 Retrospective cohort study Ellis 7 University hospital UK weeks Jan 1996-Dec 1997 Retrospective cohort study Fan 8 University hospital UK 98 1 month Jun 1998-Aug 1999 Retrospective cohort study Gallego 9 University hospital Spain months Jan 1994-Dec 1998 Prospective cohort study Goransson 10 Single centre study Norway months Jan 1994-Dec 1998 Retrospective cohort study Hoffman 11 Single centre study France months Retrospective cohort study Jungers 12 University hospital France months Jan 1989-Dec 2000 Retrospective cohort study *Kazmi 13 Multicentre study (DMMS) USA months Retrospective cohort study Ledoux 14 University hospital France 62 3 month* 1993 Retrospective cohort study Lin 15 Single centre Taiwan months Feb 2000-Jun 2003 Retrospective cohort study Lorenzo 16 Single centre Spain months Jul 1996-Dec 2001 Prospective cohort study Nakamura 17 Single centre Japan months Retrospective cohort study Pena 18 University hospital Spain months Jan 1991-Dec2001 Retrospective cohort study

3 Ravani 19 Multi-centre study Italy months Jan 1999-Jun 2002 Retrospective cohort study Roubicek 20 University hospital France months Jan1989-Dec1996 Retrospective cohort study Sabath 21 University Hospital Spain months Jan 1999-Jun 2001 Retrospective cohort study Schmidt 22 Multicentre study USA month Jan1990-Apr1997 Retrospective cohort study Shin 23 University hospital Korea months Jan 1999-Dec 2004 Retrospective cohort study *Stack 24 Multicentre study (DMMS) TX, USA months May1996-July1997 Retrospective cohort study Stoves 25 University hospital UK months 1980-July1999 Retrospective cohort study Van Biesen 26 Multicentre study Europe month Jan 1996-Dec 1997 Retrospective cohort study Winklemayer 27 Multicentre study USA months 1991-mid1996 Statewide database study * Ledoux data was presented in the original manuscript as 1, 3 and 6 month data for the same 62 patients, to avoid duplication only median 3 month data were utilised. REFERENCES 1. Arora P, Obrador GT, Ruthazer R, et al. Prevalence, predictors, and consequences of late nephrology referral at a tertiary care center. J Am Soc Nephrol. Jun 1999;10(6): Ballerini L, Conte F, Paris V. [Early or late referral patterns of 1137 patients starting dialysis in 15 Italian dialysis centres]. G Ital Nefrol. Jul-Aug 2002;19(4): Caskey FJ, Wordsworth S, Ben T, et al. Early referral and planned initiation of dialysis: what impact on quality of life? Nephrol Dial Transplant. Jul 2003;18(7): Cass A, Cunningham J, Arnold PC, Snelling P, Wang Z, Hoy W. Delayed referral to a nephrologist: outcomes among patients who survive at least one year on dialysis. Med J Aust. Aug ;177(3): Curtis BM BB, Jindal K, Djurdjev O, Levin A, Barre P, et al. Canadian survey of clinical status at dialysis initiation : A multicenter prospective survey. Clinical Nephrology. 2002;58(4):

4 6. Dogan E, Erkoc R, Sayarlioglu H, Durmus A, Topal C. Effects of late referral to a nephrologist in patients with chronic renal failure. Nephrology (Carlton). Oct 2005;10(5): Ellis PA, Reddy V, Bari N, Cairns HS. Late referral of end-stage renal failure. QJM. Nov 1998;91(11): Fan SL MF, Raftery MJ, Yaqoob MM. Do patients referred late for peritoneal dialysis do badly? Peritoneal Dialysis International. 2002;22(5): Gallego E, Lopez A, Lorenzo I, et al. [Influence of early or late referral to nephrologist over morbidity and mortality in hemodialysis]. Nefrologia. 2003;23(3): Goransson LG, Bergrem H. Consequences of late referral of patients with end-stage renal disease. J Intern Med. Aug 2001;250(2): Hoffmann M, Binaut R, Maisonneuve N, et al. [Patterns of nephrology referral and predialysis management of patients with chronic kidney disease]. Nephrol Ther. Feb 2006;2(1): Jungers P, Joly D, Nguyen-Khoa T, Mothu N, Bassilios N, Grunfeld JP. [Continued late referral of patients with chronic kidney disease. Causes, consequences, and approaches to improvement]. Presse Med. Jan 2006;35(1 Pt 1): Kazmi WH, Obrador GT, Khan SS, Pereira BJ, Kausz AT. Late nephrology referral and mortality among patients with end-stage renal disease: a propensity score analysis. Nephrol Dial Transplant. Jul 2004;19(7): Ledoux F, Rasamimanantsoa D, Moulin B, Hannedouche T. [From the first symptoms to terminal renal failure: need for a nephrologic follow-up]. Rev Med Interne. Mar 2001;22(3): Lin CL, Chuang FR, Wu CF, Yang CT. Early referral as an independent predictor of clinical outcome in end-stage renal disease on hemodialysis and continuous ambulatory peritoneal dialysis. Ren Fail. Sep 2004;26(5): Lorenzo V, Martn M, Rufino M, Hernandez D, Torres A, Ayus JC. Predialysis nephrologic care and a functioning arteriovenous fistula at entry are associated with better survival in incident hemodialysis patients: an observational cohort study. Am J Kidney Dis. Jun 2004;43(6): Nakamura S, Nakata H, Yoshihara F, et al. Effect of early nephrology referral on the initiation of hemodialysis and survival in patients with chronic kidney disease and cardiovascular diseases. Circ J. Apr 2007;71(4): Pena JM, Logrono JM, Pernaute R, Laviades C, Virto R, Vicente de Vera C. [Late nephrology referral influences on morbidity and mortality of hemodialysis patients. A provincial study]. Nefrologia. 2006;26(1): Ravani P, Marinangeli G, Stacchiotti L, Malberti F. Structured pre-dialysis programs: more than just timely referral? J Nephrol. Nov-Dec 2003;16(6): Roubicek C, Brunet P, Huiart L, et al. Timing of nephrology referral: influence on mortality and morbidity. Am J Kidney Dis. Jul 2000;36(1): Sabath E, Vega O, Correa-Rotter R. [Early referral to the nephrologist: impact on initial hospitalization and the first 6 months of continuous ambulatory peritoneal dialysis]. Rev Invest Clin. Sep-Oct 2003;55(5): Schmidt RJ, Domico JR, Sorkin MI, Hobbs G. Early referral and its impact on emergent first dialyses, health care costs, and outcome. Am J Kidney Dis. Aug 1998;32(2): Shin SJ, Kim HW, Chung S, et al. Late referral to a nephrologist increases the risk of uremia-related cardiac hypertrophy in patients on hemodialysis. Nephron Clin Pract. 2007;107(4):c Stack AG. Impact of timing of nephrology referral and pre-esrd care on mortality risk among new ESRD patients in the United States. Am J Kidney Dis. Feb 2003;41(2): Stoves J, Bartlett CN, Newstead CG. Specialist follow up of patients before end stage renal failure and its relationship to survival on dialysis. Postgrad Med J. Sep 2001;77(911): Van Biesen W, Wiedemann M, Lameire N. End-stage renal disease treatment: a European perspective. J Am Soc Nephrol. Dec 1998;9(12 Suppl):S Winkelmayer WC, Owen WF, Jr., Levin R, Avorn J. A propensity analysis of late versus early nephrologist referral and mortality on dialysis. J Am Soc Nephrol. Feb 2003;14(2):

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