ECMO 1. 背景 2. 国内で臨床使用されている心肺補助デバイスの呼吸 ECMOへの応用 ECMO. Nobumasa KATAGIRI. rest. madiator ventilator-induced biotrauma 2)
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1 ECMO ECMO Nobumasa KATAGIRI 1. 背景 ventilatorinduced lung injury 1) madiator ventilator-induced biotrauma 2) extracorporeal membrane oxygenation ECMO lung rest 3) extracorporeal CO2 removal ECCO2R: ECMO 4) 2009 H1N1 ECMO 5),6) Extracorporeal Life Support Organization ELSO 7) H1N1 Registry ECMO ECMO ECMO 300 著者連絡先 katagiri@ri.ncvc.go.jp ECMO lung rest ECMO 8) ECMO 8.5 ECMO 4.0 ECMO ECMO 2. 国内で臨床使用されている心肺補助デバイスの呼吸 ECMOへの応用 ) 2008 ECMO 2014 ECMO 図 ECMO 30 PMP ECMO
2 / 年 図 1 ECMO PMP LX 2 SL Xcoating EBS SP kg NHP NSH-R HPO-23WH-C NSH-R NSH SOLAS 8.1 kg PMP BIOCUBE BIOCUBE T-NCVC 1 ROTAFLOW 2 Gyro Endumo 6 ECMO 1 ECMO 3. 呼吸 ECMO 用デバイスとして使用可能な海外製品 Novalung GmbH CO2 removal arterio-venous AV ECMO ila Interventional lung assist ila PMP Novalung
3 図 2 CARDIOHELP W255 D427 H315 mm 1,089 cm 2 10 kg O2 10),11) ECMO Getinge Group CARDIOHELP 図 2 12) CARDIOHELP W255 D427 H315 mm 1,089 cm 2 10 kg ECMO ECMO PMP ECMO 30 CE veno-venous VV veno-arterial VA ECMO 13),14) CARDIOHELP ECMO 6 Getinge Group AVALON Elite VV-ECMO 15),16) ambulatory ECMO lung rest QOL 17) 4. 研究開発中のECMOデバイス 18),19) PMP BIOCUBE T-NCVC VA-ECMO ECMO 50 図 3 ACT ECMO
4 図 3 ECMO ECMO 図 4 W290 D205 H260 mm O2 H405 cm 595 cm kg O2 8.9 kg ECMO ECMO W290 D205 H260 mm 595 cm kg 図 4 BIOCUBE BIOFLOAT NCVC T-NCVC 図 3 ECMO 28 ECMO 図 5 14 ECMO 2 9 mm 4 ACT
5 図 5 ECMO ECMO 28 ECMO BIOCUBE ECMO ECMO ECMO lung rest ambulatory ECMO enmodes RAS-Q PMP 10 ECMO ECMO ambulatory ECMO Pittsburgh Pittsburgh Ambulatory Assist Lung PAAL 20) Pittsburgh Pediatric Ambulatory Lung P-PAL PMP ambulatory ECMO 30 the Impeller Percutaneous Respiratory Assist Catheter IPRAC CO2 Vienna CO2 ambulatory ECMO Liquid ventilation perfluorocarbon 5. まとめ ECMO ECMO QOL ECMO
6 利益相反の開示 文献 1) Slutsky AS, Ranieri VM: Ventilator-induced lung injury. N Engl J Med 369: , ),, Ventilator-Induced Biotrauma 39: 12-5, ) Peek GJ, Mugford M, Tiruvoipati R, et al; CESAR trial collaboration: Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): a multicentre randomised controlled trial. Lancet 374: , ) Bein T, Weber-Carstens S, Goldmann A, et al: Lower tidal volume strategy ( 3 ml/kg) combined with extracorporeal CO 2 removal versus 'conventional' protective ventilation (6 ml/kg) in severe ARDS: the prospective randomized Xtravent-study. Intensive Care Med 39: , ) Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators, Davies A, Jones D, Bailey M, et al: Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome. JAMA 302: , ) Freed DH, Henzler D, White CW, et al; Canadian Critical Care Trials Group: Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada. Can J Anaesth 57: 240-7, ) H1N1 Registry. Extracorporeal Life Support Organization. Accessed 2 Nov ) Takeda S, Kotani T, Nakagawa S, et al; Committee of Crisis Control, the Japanese Society of Respiratory Care Medicine and Committee of Pandemic H1N1 Surveillance, the Japanese Society of Intensive Care Medicine: Extracorporeal membrane oxygenation for 2009 influenza A(H1N1) severe respiratory failure in Japan. J Anesth 26: 650-7, ) Accessed 2 Nov ) Walles T: Clinical experience with the ila Membrane Ventilator pumpless extracorporeal lung-assist device. Expert Rev Med Devices 4: , ) Sanchez-Lorente D, Iglesias M, Rodríguez A, et al: The pumpless extracorporeal lung membrane provides complete respiratory support during complex airway reconstructions without inducing cellular trauma or a coagulatory and inflammatory response. J Thorac Cardiovasc Surg 144: , ) CARDIOHELP System. Getinge Group maquet.com/int/products/cardiohelp-system/ Accessed 2 Nov ) Philipp A, Arlt M, Amann M, et al: First experience with the ultra compact mobile extracorporeal membrane oxygenation system Cardiohelp in interhospital transport. Interact Cardiovasc Thorac Surg 12: , ) Haneya A, Philipp A, Foltan M, et al: First experience with the new portable extracorporeal membrane oxygenation system Cardiohelp for severe respiratory failure in adults. Perfusion 27: 150-5, ) Bermudez CA, Rocha RV, Sappington PL, et al: Initial experience with single cannulation for venovenous extracorporeal oxygenation in adults. Ann Thorac Surg 90: 991-5, ) Chimot L, Marqué S, Gros A, et al: Avalon bicaval duallumen cannula for venovenous extracorporeal membrane oxygenation: survey of cannula use in France. ASAIO J 59: , ) Turner DA, Cheifetz IM, Rehder KJ, et al: Active rehabilitation and physical therapy during extracorporeal membrane oxygenation while awaiting lung transplantation: a practical approach. Crit Care Med 39: , ) Nishinaka T, Tatsumi E, Taenaka Y, et al: At least thirty-four days of animal continuous perfusion by a newly developed extracorporeal membrane oxygenation system without systemic anticoagulants. Artif Organs 26: , ) Tsukiya T, Mizuno T, Takewa Y, et al: Preclinical study of a novel hydrodynamically levitated centrifugal pump for long-term cardiopulmonary support: In vivo performance during percutaneous cardiopulmonary support. J Artif Organs 18: 300-6, ) Madhani SP, Frankowski BJ, Burgreen GW, et al: In vitro and in vivo evaluation of a novel integrated wearable artificial lung. J Heart Lung Transplant 36: ,
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