CAS as first line of treatment in the future
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1 Azienda Ospedaliera Universitaria Senese CHIRURGIA VASCOLARE Chief:Prof. Carlo Setacci CAS as first line of treatment in the future Prof. Carlo Setacci Chief of Vascular Surgery University of Siena - Italy
2 Disclosure Speaker name: Carlo Setacci, MD I have the following potential conflicts of interest to report: Consulting Boston Scientific EndoLogix evascular Terumo 2/24
3 Carotid artery stenting renaissance
4 CEA vs CAS Current Evidence based on trials vs Trial Status End point CAS CEA P value SAPPHIRE CEA high risk Symptomatic > 50% Asymptomatic > 80% 30 days: MI; 1 year: ipsilateral stroke or death 12,2% 20,1% 0.05 SPACE Symptomatic > 50% 30 days: ipsilateral stroke or death 6,8% 6,3% NS EVA-3S Symptomatic > 70% 30 days: death; 4 years: ipsilateral stroke 9,6% 3,9% NS CREST Symptomatic > 50% Asymptomatic > 80% 4 years: ipsilateral stroke or surgical death 7,2% 6,8% NS ICSS Symptomatic > 50% 120 days: stroke, death, or periprocedural ; MI 8,5% 5,2% 0,006
5 META-ANALYSIS OF RCTS UPDATED 2011 CONCLUSIONS: For every 1000 patients opting for stenting rather than endarterectomy: 19 more patients would have strokes, 3 more patients would be dead 10 fewer would have MIs J Vasc Surg Mar;53(3):792-7.
6 CAROTID ARTERY STENTING AS AN ENDOVASCULAR ORIENTED VASCULAR SURGEON I BELIEVE IN THE RENAISSANCE OF CAS
7 LONG TERM CREST RESULTS : RESULTS AT 4 YEAR THE ONLY DIFFERENCE IS HERE!!
8 WE NEED BETTER PROTECTION AGAINST SMALL EMBOLUS Brott TG et al. N Engl J Med 2010;363:11-23.
9 WHICH STENT? closed cell Wallstent (BSCI) Adapt (BSCI) open cell Precise (Cordis) Acculink (Guidant)
10 IDEAL STENT - Low profile - High trackability & flexibility - Complete plaque coverage - Perfect vessel apposition Answer by OCT
11 OCT FOR STENT SELECTION Optical Coherence Tomography is an intravascular high-resolution (10 micron) imaging technology that employs near-infrared light 0.2 mm
12 OCT FOR STENT SELECTION J Endovasc Ther 2012 Jun;19(3):303-11
13 OCT & CAROTID STENT DESIGN Design Prospective single center study Objectives To evaluate the rate of: - stent malapposition - plaque prolapse - fibrous cap rupture G. de Donato, F. Setacci, P. Sirignano, G. Galzerano, A.Cappelli, C. Setacci. OPTICAL COHERENCE TOMOGRAPHY AFTER CAROTID STENTING: RATE OF STENT MALAPPOSITION, PLAQUE PROLAPSE AND FIBROUS CAP RUPTURE ACCORDING TO STENT DESIGN. Eur J Vasc Endovasc Surg 2013;45: Embedded
14 Design Prospective single center study Objectives To evaluate the rate of: OCT & CAROTID STENT - stent malapposition - plaque prolapse - fibrous cap rupture DESIGN G. de Donato, F. Setacci, P. Sirignano, G. Galzerano, A.Cappelli, C. Setacci. OPTICAL COHERENCE TOMOGRAPHY AFTER CAROTID STENTING: RATE OF STENT MALAPPOSITION, PLAQUE PROLAPSE AND FIBROUS CAP RUPTURE ACCORDING TO STENT DESIGN. Eur J Vasc Endovasc Surg 2013;45:579-87
15 Objectives To evaluate the rate of: OCT & CAROTID STENT Design Prospective single center study - stent malapposition - plaque prolapse - fibrous cap rupture DESIGN G. de Donato, F. Setacci, P. Sirignano, G. Galzerano, A.Cappelli, C. Setacci. OPTICAL COHERENCE TOMOGRAPHY AFTER CAROTID STENTING: RATE OF STENT MALAPPOSITION, PLAQUE PROLAPSE AND FIBROUS CAP RUPTURE ACCORDING TO STENT DESIGN. Eur J Vasc Endovasc Surg 2013;45:579-87
16 OCT & CAROTID STENT DESIGN Design Prospective single center study Objectives To evaluate the rate of: - stent malapposition - plaque prolapse - fibrous cap rupture according to carotid stent design Closed cell (CC) Open cell (OC) Hyb G. de Donato, F. Setacci, P. Sirignano, G. Galzerano, A.Cappelli, C. Setacci. OPTICAL COHERENCE TOMOGRAPHY AFTER CAROTID STENTING: RATE OF STENT MALAPPOSITION, PLAQUE PROLAPSE AND FIBROUS CAP RUPTURE ACCORDING TO STENT DESIGN.. Eur J Vasc Endovasc Surg 2013;45: open closed open
17 IDEAL STENT - OCT ANSWER - Stent malapposition is more frequent with closed cell stent - Plaque prolapse is more common with open cell stents We need new stent design We need MESH-STENT
18 IDEAL STENT - OCT ANSWER
19 NEW CAROTID STENT DESIGN Terumo - Roadsaver Gore Mesh carotid stent Inspire C-Guard
20 IMPACT OF NEW STENT DESIGN Expert Rev Cardiovasc Ther Aug 16:1-10. doi: / Device selection for carotid stenting: reviewing the evidence. Setacci C 1, Mele M 1, de Donato G 1, Mazzitelli G 1, Benevento D 1, Palasciano G 1, Setacci F 1.
21 IMPACT OF NEW STENT DESIGN Sustained embolic protection Double layer micromesh nitinol design Smallest cell stent size preventing embolic release Double layer micromesh design -- Chronic embolic protection Lesion specific scaffolding: Extremely high plaque coverage Superior in vessel flexibility Excellent wall apposition: the two mash layers enable a flexible scaffold
22 IMPACT OF NEW STENT DESIGN
23 IMPACT OF NEW STENT DESIGN
24
25 IMPACT OF NEW STENT DESIGN EuroIntervention May 9. pii: EIJ-D doi: /EIJ-D [Epub ahead of print] 30-day results from prospective multi-specialty evaluation of carotid artery stenting using the CGuard micronet-covered embolic prevention stent system in real world multicenter clinical practice: the IRON-GUARD study. Speziale F 1, Capoccia L, Sirignano P, Mansour W, Pranteda C, Casana R, Setacci C, Accrocca F, Alberti D, de Donato G, Ferri M, Gaggiano A, Galzerano G, Ippoliti A, Mangialardi N, Pratesi G, Ronchey S, Ruffino MA, Siani A, Spinazzola A, Sponza M.
26 ITALIAN REGISTRY - ROADSAVER Torino: Dr. C.Rabbia Radiologist Cotignola: Dr. A.Cremonesi Cardiologist Carotid artery stenting with a new-generation double-mesh stent in three high-volume Italian centres: clinical results of a multidisciplinary approach. Nerla R, Castriota F, Micari A, Sbarzaglia P, Secco GG, Ruffino MA, de Donato G, Setacci C, Cremonesi A. EuroIntervention Aug 5;12(5):e Siena: Prof. C. Setacci Vascular Surgeon
27 3 ITALIAN CENTRES ITALIAN REGISTRY - ROADSAVER Cotignola n= 82 Siena n= 52 Torino n= (OCTOBER OCTOBER 2015) Carotid artery stenting with a new-generation double-mesh stent in three high-volume Italian centres: clinical results of a multidisciplinary approach. Nerla R, Castriota F, Micari A, Sbarzaglia P, Secco GG, Ruffino MA, de Donato G, Setacci C, Cremonesi A. EuroIntervention Aug 5;12(5):e677-83
28 ITALIAN REGISTRY - ROADSAVER Subgroup analysis_oct 36 patients Plaque prolapse 2/36 cases studied with OCT (5.5%)
29 ITALIAN REGISTRY ROADSAVER 30-DAYS RESULTS 0% STROKE AND DEATH 0% TIA 0% MI PROCEDURAL SUCCESS: 100%
30 CLEAR ROAD - PROSPECTIVE INTERNATIONAL TRIAL -97.9% freedom from MAE (94,4% symptomatic patients vs 100% asymptomatic patients) -MAE rate: 2.1%: no notable difference between symptomatic and asymptomatic patients or between EPD use
31 CLEAR ROAD - PROSPECTIVE INTERNATIONAL TRIAL Siena - Italy Europe Belgium and Germany 0 % of MAE 2.5% of MAE (all in symptomatic patients)
32 CLEAR ROAD - PROSPECTIVE INTERNATIONAL TRIAL Critical Issue Coming Out from the Data Little Cohort of patients (bias in statistics?) Selective use of EPD
33 Scaffold Clinical Study
34 10 top rules for CAS 1.Correct patient selection and adequate learnig curve
35 10 top rules for CAS 1.Correct patient selection and adequate learnig curve 2. Overview of Anatomy (Arch and intracranial vessels)
36 10 top rules for CAS 1. Correct patient selection and adequate learnig curve 2. Overview of Anatomy 3. Plaque evaluation
37 10 top rules for CAS 1. Correct patient selection and adequate learning curve 2. Overview of Anatomy 3. Plaque evaluation 4. Pre-, Intra- & post-procedural medical therapy
38 10 top rules for CAS 1. Correct patient selection and adequate learnig curve 2. Overview of Anatomy 3. Plaque evaluation 4. Pre-, Intra- & post-procedural medical therapy 5. Vascular access (brachial/radial/cervical)
39 10 top rules for CAS 1. Correct patient selection and adequate learnig curve 2. Overview of Anatomy 3. Plaque evaluation 4. Pre-, Intra- & post-procedural medical therapy 5. Vascular access (brachial/radial/cervical) 6. Correct Embolic Protection Device
40 10 top rules for CAS 1. Correct patient selection and adequate learnig curve 2. Overview of Anatomy 3. Plaque evaluation 4. Pre-, Intra- & post-procedural medical therapy 5. Vascular access (brachial/radial/cervical) 6. Correct Embolic Protection Device 7. Correct Stent
41 10 top rules for CAS 1. Correct patient selection and adequate learnig curve 2. Overview of Anatomy 3. Plaque evaluation 4. Pre-, Intra- & post-procedural medical therapy 5. Vascular access (brachial/radial/cervical) 6. Correct Embolic protection Device 7. Correct Stent 8. Intravascular imaging during CAS
42 10 top rules for CAS 1. Correct patient selection and adequate learnig curve 2. Overview of Anatomy 3. Plaque evaluation 4. Pre-, Intra- & post-procedural medical therapy 5. Vascular access (brachial/radial/cervical) 6. Correct Embolic protection Device 7. Correct Stent 8. Intravascular imaging during CAS 9. Intracranial evaluation post-cas
43 10 top rules for CAS 1. Correct patient selection and adequate learnig curve 2. Overview of Anatomy 3. Plaque evaluation 4. Pre-, Intra- & post-procedural medical therapy 5. Vascular access (brachial/radial/cervical) 6. Correct Embolic protection Device 7. Correct Stent 8. Intravascular imaging during CAS 9. Intracranial evaluation post-cas 10. Vascular access evaluation after CAS
44 PERSONAL CONSIDERATIONS The ideal stent still does not exists at the moment! Patient s tailored approach remains by now the logical answer for treating standard as well as complex carotid lesions and anatomies (different stents for different anatomies and plaque morphology) New generation of stents offering high scaffolding and conformability properties will give new rush to CAS...Long term results of CAS are perfect, however there is still room for peri-procedural improvement!!
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