PrOspective multicenter study of carotid artery stenting Usinng mer Stent OCEANUS study!!!
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1 PrOspective multicenter study of carotid artery stenting Usinng mer Stent OCEANUS study!!! Prof Piotr Pieniazek MD PhD Jagiellonian University Institute of Cardiology, John Paul II Hospital Krakow, Poland
2 Disclosure Speaker name:.piotr PIENIAZEK. I have the following potential conflicts of interest to report: X Consulting Employment in industry Stockholder of a healthcare company Owner of a healthcare company Other(s) I do not have any potential conflict of interest
3 Open vs closed cell design carotid stent always upto-date question Open cell Closed cell
4 M E R S T E N T
5
6 PrOspective multicenter study of carotid artery stenting Usinng mer Stent OCEANUS study!!! MER
7 Carotid self-expanding stent MER with delivery system (RX) Self- expanding stent dedicated to carotid artery made of Nitinol Open cells design Strut thickness: 0.19 mm Cell area: 6.2 mm 2 Atraumatic, flexible distal tip of the delivery system
8 Carotid self-expanding stent MER with delivery system (RX) Stent material Nitinol Guidewire max.014 Delivery system Use with introducer 5F 5F Guiding catheter ID min.071 Nominal stent diameter Nominal stent length Delivery system working length 2 types of the delivery system Rapid Exchange 4 10 mm (straight and tapered stent) mm 135 cm 1. delivery system with handle 2. delivery system pull-back
9 2 types of the delivery system 1. Delivery system with handle 2. Delivery system pull-back
10 !!
11 Enrollment and timelines First patient in the study: 10-Oct-2016 Last patient enrollmend to the study: 23-May month FU to be completed for all subjects: Jun months FU to be completed for all subjects: Nov months FU to be completed for all subjects:june Enrollment by Sites Department of Vascular Surgery, John Paul II Hospital Kraków, Poland The Department of Vascular Surgery, American Heart of Poland, Chrzanów, Poland Department General and Vascular Surgery, University Katowice, Poland Institute of Psychiatry and Neurology 2 nd Department of Neurology, Warszawa, Poland
12 Demographics and baseline data Hypertension 90% Hypercholesterolemia 69% Male 64% Current or previous smoking 57% Symptomatic subject 45% Previous stroke 41% Diabetes mellitus 38% Previous PCI 33% Previous MI 26% Previous TIA 20% Previous CABG 14% Family history of stroke 12% 0% 20% 40% 60% 80% 100% Variable Measure Total Age at enrollment, years n 100 Mean (±SD) (±8.24) Mean 95% CI (66.87; 70.23) Me (Q1; Q3) (62.00; 75.00) Min/Max / Systolic blood pressure, mmhg n 100 Mean (±SD) (±23.68) Mean 95% CI (147.51; ) Me (Q1; Q3) (135.00; ) Min/Max / Diastolic blood pressure, mmhg n 100 Mean (±SD) (±11.48) Mean 95% CI (76.04; 80.77) Me (Q1; Q3) (70.00; 85.00) Min/Max / Diameter stenosis NASCET, % n 100 Mean (±SD) (±9.79) Mean 95% CI (74.40; 78.43) Me (Q1; Q3) (72.00; 83.00) Min/Max / 95.00
13 Baseline lesions characteristics Variable Measure Total Diameter stenosis QCA n 100 Lesion characteristics Mean(±SD) (±9.23) Mean 95% CI (80.17; 84.03) CCA 6% ICA 94% Calcification 51% Mild calcification 23% Moderate calcification 21% Moderate-severe calcification 7% 0% 20% 40% 60% 80% 100% Reference vessel diameter, mm Me(Q1;Q3) (77.00; 90.00) Min/Max / n 100 Mean(±SD) 5.69 (±0.94) Mean 95% CI (5.49; 5.89) Me(Q1;Q3) 5.80 (5.00; 6.00) Min/Max 2.60 / 8.00 Lesion length, mm n 100 Mean(±SD) (±8.34) Mean 95% CI (15.28; 18.79) Me(Q1;Q3) (10.00; 21.65) Min/Max 2.80 / 46.50
14 Procedural data Neuroprtection systems used SpiderFX 31% FilterWire 27% Neuroprotection system used 100% Mo.MA 18% Proximal neuroprotection 18% Emboshield 9% Distal neuroprotection 82% WIRION 8% Robin 7% Predilatation 43% 0% 10% 20% 30% 40% Stent implantation 100% Postdilatation 99% 0% 20% 40% 60% 80%100% Variable Occlusion time for proximal protection, min:sec Measure Total n 18 Mean(±S D) Mean 95% CI Me(Q1;Q 3) 6:19 (±2:55) (4:46; 7:52) 5:55 (4:45; 7:08) Min/Max 3:30 / 16:00
15 Do we still need open-cell carotid stents???? Unique vessel flexibility and adaptability with carotid MER stent
16 MER stents used during procedure Data reported for 100 subjects Two subjects required 2 nd stent implantation (102 stents used) MER stents used during procedure 30% 30% 24% 20% 13% 10% 0% 9% 5% 5% 5% 3% 2% 2% 1% 1% 1% n Diameter 6x8 6x8 6x8 7 7x9 7x9 7x10 7x10 8 8x10 8x Length
17 Symptomatic pt. angiography of RICA Critical stenosis of RICA 85%!!!
18 Back pressure 25/15 mmhg During predilatation symptomatic neurological symptoms due to Proximal EPD intolerance Required active aspiration and restoration of the flow to release neurological symptoms!!! System Mo.Ma Ultra 8F Predilatation with balloon 3.0x20mm 12 atm.
19 After 5 min deflation of proximal balloon of Mo.Ma back pressure 35/20 mmhg. After predilatation stent implantation Postdilatation with balloon Mer 6-8x40mm Sterling 4.5x20mm max. 15atm Aspiration, deflation of Mo.Ma balloons many particles and thrombogenic material.
20 Angiography after stent MER implantation Large plaque protrusion of lesion through the MER stent. Red arrows Third inflation of balloons under Mo.Ma protection Postdilatation with bigger balloon Sterling 5.0x20mm max. 15atm
21 Finall angiography after RICA CAS!! Aspiration in external filter many particles of atherosclerotic debris.
22 Control intracranial angiogrphy after RICA-CAS
23 Severe angulation more than 180 degree!!! in pt. with contraindication to endarterectomy!!! Standard coronary wire no successful passing with MER and Roadsaver ( most flexible ) stent implantation!!!
24 Use of GRANDSLAM wire to straighten the ICA!! Than very easy implantation of 20mm MER stent with optimal angiographic result
25 Complication during hospitalization & 30d follow-up TIA 0% Stroke ( ischemic ) at day 4 1pts 1%!!!!! Death 0% MI 0% Edge dyssection required additional MER stent implantation 1pts 1% Haematoma or bleeding complication 0% Renal impairement 0% Hypotonia required inotropic agents 1pts 1%
26 Excellent 6 months follow-up with MER stents
27 MER stent 6 months follow-up Doppler-US investigation. Luminal blood flow in MER Stent PSV 0,9 m/s EDV 0,3 m/s.
28 Conclusions CAS is a fast developing interventional treatment of carotid artery stenosis. Great technological progress is observed in the field of devices used for Carotid Artery Stenting. Example a new MER carotid stent!!! The 30-day and 6 months clinical outcome of 100 patients treated with a nitinol open-cell carotid self-expandable MER stent shows very good results. Our study suggests that the MER stent is safe and effective device for endovascular treatment in both symptomatic and asymptomatic patients.
29 Thank you John Paul II Hospital Krakow PL.
30 PrOspective multicenter study of carotid artery stenting Usinng mer Stent OCEANUS study!!! Prof Piotr Pieniazek MD PhD Jagiellonian University Institute of Cardiology, John Paul II Hospital Krakow, Poland
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