Supera for the Juxta-anastomotic AVF Stenosis
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1 Supera for the Juxta-anastomotic AVF Stenosis Dr Shannon D. Thomas Vascular Access Surgeon Conjoint Senior Lecturer University of New South Wales Sydney, Australia
2 Disclosure Speaker name: Dr S. D. Thomas... I have the following potential conflicts of interest to report: x Consulting: Abbott Vascular Employment in industry Stockholder of a healthcare company Owner of a healthcare company Other(s) I do not have any potential conflict of interest
3 Venous Stenosis is the leading cause of Access Failure The Juxta-anastomotic stenosis is the most common site? Injury to vein during mobilisation? Stripping of adventitia?torsion of Swing Vein?Wall Sheer Stress, Flow Turbulence? Geometry of the anastomosis 1. Beathard et al. Aggressive treatment of early fistula failure. Kidney Int.2003;64: Falk et al. Treatment of swing point stenoses in hemodialysis arteriovenous fistulae. Clinical Nephrology. 2003;60:35-41
4 Juxta-Anastomotic Stenosis (JXAS) stenosis can lead to loss of the AVF JXAS stenosis frequency ranging from 43% 2 to 100% 5 of all AVFs JXAS stenosis was identified as the cause of a failure to mature 25-64% of Radiocephalic AVFs 2,18 that had failed to mature JXAS stenosis can cause recurrent thrombosis/ AVF dysfunction in the mature AVF 2. Falk et al. Treatment of swing point stenoses in hemodialysis arteriovenous fistulae. Clinical Nephrology. 2003;60: Sivanesan S, How TV, Bakran A. Sites of stenosis in AV fistulae for haemodialysis access. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1999;14: Clark TW, Cohen RA, Kwak A, et al. Salvage of nonmaturing native fistulas by using angioplasty. Radiology 2007;242:
5 Venous Stenosis is the leading cause of Access Failure The Juxta-anastomotic stenosis is the most common site? Injury to vein during mobilisation? Stripping of adventitia?torsion of Swing Vein?Wall Sheer Stress, Flow Turbulence? Geometry of the anastomosis 1. Beathard et al. Aggressive treatment of early fistula failure. Kidney Int.2003;64: Falk et al. Treatment of swing point stenoses in hemodialysis arteriovenous fistulae. Clinical Nephrology. 2003;60:35-41
6 Juxta-Anastomotic Geometry Computational Fluid Dynamic Modelling suggests an obtuse shape leads to improved haemodynamics Standard End to Side AVF Configuration Obtuse Shape AVF Configuration Carroll J, Varcoe RL, Barber T, Simmons A. Reduction in anastomotic flow disturbance within a modified end-to-side arteriovenous fistula configuration: Results of a computational flow dynamic model. Nephrology (Carlton) 2018.
7 Juxta-Anastomotic Geometry Computational Fluid Dynamic Modelling suggests an obtuse shape leads to improved haemodynamics: Particle Tracking Standard End to Side AVF Configuration Obtuse Shape AVF Configuration Carroll J, Varcoe RL, Barber T, Simmons A. Reduction in anastomotic flow disturbance within a modified end-to-side arteriovenous fistula configuration: Results of a computational flow dynamic model. Nephrology (Carlton) 2018.
8 Juxta-Anastomotic Geometry Computational Fluid Dynamic Modelling suggests an obtuse shape leads to improved haemodynamics: Velocity Dynamics Standard End to Side AVF Configuration Obtuse Shape AVF Configuration Carroll J, Varcoe RL, Barber T, Simmons A. Reduction in anastomotic flow disturbance within a modified end-to-side arteriovenous fistula configuration: Results of a computational flow dynamic model. Nephrology (Carlton) 2018.
9 Lee, J. Et al. Assessing radiocephalic wrist arteriovenous fistulas of obtuse anastomosis using computational fluid dynamics and clinical application JVA 2016; 17(6): Juxta-Anastomotic Geometry Computational Fluid Dynamic Modelling suggests an obtuse shape leads to improved haemodynamics: Wall Shear Stress Standard End to Side AVF Configuration Obtuse Shape AVF Configuration
10 Lee, J. Et al. Assessing radiocephalic wrist arteriovenous fistulas of obtuse anastomosis using computational fluid dynamics and clinical application JVA 2016; 17(6): Juxta-Anastomotic Geometry An Obtuse shaped anastomosis is associated with improved AVF patency and maturation
11 CAN A VASCULOMIMETIC STENT BE USED TO FAVORABLY CHANGE THE ANASTOMOTIC GEOMETRY?
12 Standard Bare Metal Nitinol Stent in Juxtaanastomotic shape demonstrating Kink Abbott Vascular Supera Nitinol Stent in Juxta-anastomotic shape demonstrating kink resistance
13 Supera can be used to change the anastomotic Shape Pre-Stent JXAS Stenosis Post-Stent Supera JXAS
14 A Stent can be used to taper the diameter transition from artery to vein
15 A Stent can be used to taper the diameter transition from artery to vein
16 CFD Simulation Particle Acceleration and Tracking Syst+ Diast Cycle Pre-Stent JXAS Syst+ Diast Cycle Post-Stent Supera JXAS Particles Coloured to Velocity- Magnitude in m/s
17 DOES IMPROVED GEOMETRY AND HAEMODYNAMICS LEAD TO IMPROVED CLINICAL OUTCOMES?
18 Retrospective Study First 42 consecutive patients at our institution Failing/ Failed AVF Mean Follow up 1 year 5mm Supera Stent of Various Length
19 JXAS Primary Patency: 92.5% at 6 months, 59.8% at 12 months
20 JXAS Assisted Primary Patency 97.5% at 6 months, 92.9% at 12 months
21 JXAS Assisted Primary Patency 97.5% at 6 months, 92.9% at 12 months JXAS Endovascular Re-Intervention rate.31/year
22 Dialysis Performance Mean Arterial Pressure on Dialysis Mean Venous Pressure on Dialysis Ultrasound Brachial Flow Rates Pressure -mmhg Pressure mmhg ml/min Preintervention 1 month 3 month 6 month 12 month p= Preintervention 1 month 3 month 6 month 12 month p=.47 0 Preintervention 1 month 3 month 6 month 12 month p=.047 Dialysis performance parameters improved post intervention and were maintained
23 Discussion How does it compare to other therapies Primary patency compares favorably published JXAS interventions and surgery
24 Discussion How does it compare to other therapies Very Low Re-intervention rate with no AVFs lost/ abandoned
25 Conclusion Early results suggest a Vasculomimetic stent provides favourable patency of the JXAS stenosis Longer term results still pending This is a promising technique to maintain long term vascular access through an arteriovenous fistula
26 Thank you
27 Supera for the Juxta-anastomotic AVF Stenosis Dr Shannon D. Thomas Vascular Access Surgeon Conjoint Senior Lecturer University of New South Wales Sydney, Australia
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