Variants of Brugada Syndrome: the evolving picture
|
|
|
- Darcy Wood
- 6 years ago
- Views:
Transcription
1 2015 Venice Arrhythmia Core Curriculum: Arrhythmogenic genetic syndrome: what s new? Brugada Syndrome: What s new? October 16 th, 2015 Venice, Italy Variants of Brugada Syndrome: the evolving picture Wataru Shimizu M.D., Ph.D. Nippon Medical School, Tokyo, Japan Nippon Medical School
2 Conflicts of Interest: Wataru Shimizu Consulta)on*fees:none stock*ownership/profit:none patent*fees:none remunera)on*for*lecture:daiichi Sankyo., Ltd. Tanabe Mitsubishi Pharma Corporation Nippon Boehringer Ingelheim Co., Ltd. Bayer Yakuhin, Ltd. Bristol-Myers K.K. Pfizer Japan Inc. Ono Pharma Corporation manuscript*fees:none trust*research/joint*research*funds:none scholarship*fund:daiichi Sankyo., Ltd. Tanabe Mitsubishi Pharma Corporation Nippon Boehringer Ingelheim Co., Ltd. Bristol-Myers K.K. Affilia)on*with*Endowed*Department:none
3 Idiopathic VF with J wave and ST elevation in the inferior leads: Brugada Syndrome Variants? TakagiM,ShimizuW.etalJCE2000 KallaH.etalJCE2000 Variants: Inferior type of Brugada Syndrome National Cerebral and Cardiovascular Center Nippon Medical School
4 Early repolarization pattern in infero/lateral leads Sudden cardiac arrest associated with early repolarization (Haissaguerre M. et al NEJM 2008) Early Repolarization Syndrome
5 Idiopathic VF with J wave and ST elevation in the inferior leads: Brugada Syndrome Variants? TakagiM,ShimizuW.etalJCE2000 KallaH.etalJCE2000 This is Early Repolarization Syndrome National Cerebral and Cardiovascular Center Nippon Medical School
6 Japanese Brugada Registry Kamakura S, Shimizu W, et al. Circ Arrhythm Electrophysiol 2009; 2: Early Repolarization in infero-lateral leads Early Repolarization Early Repolarization + P= " Brugada patients associated with early repolarization in infero-lateral leads showed poorer prognosis than those without N. of pts. with early repolarization Early Rep Early Rep National Cerebral and Cardiovascular Center Nippon Medical School
7 Type 1 Brugada patient with infero-lateral ER Kawata H, Shimizu W et al. Heart Rhythm 2013:10: I II HR 64 V1 Type 1 V2 V3 coved III V4 avr avl V5 avf National Cerebral and Cardiovascular Center V6 1 sec 1 mv Nippon Medical School
8 Survival Curve of Brugada patients with VF document depending on presence and frequency of infero-lateral ER Kawata H, Shimizu W et al. Heart Rhythm 2013:10: Free of SCD or VF Log Rank Non ER (N=18) p=0.0001betweenpandn p=0.0595betweeniandn p=0.1124betweenpandi Intermittent ER (N=16) Number of patients Persistent Intermittent Non Follow up duration (months) National Cerebral and Cardiovascular Center Persistent ER (N=15) Nippon Medical School
9 Similarities between Brugada syndrome and ERS Shimizu W et al. Unpublished data Male predominance Late adulthood onset Genotype More frequent ventricular arrhythmias during sleep and rest than during physically active periods Dynamicity of the J-point elevation in an ER pattern and ST-segment elevation in a Brugada ECG Pause- and bradycardia-dependent augmentation of the J-point elevation in the ER pattern and ST-segment elevation in the Brugada ECG Response to pharmacological therapy (Isoproterenol, Quinidine, Bepridil, Denopamine, Cilostazol) National Cerebral and Cardiovascular Center Nippon Medical School
10 J wave syndrome Antzelevitch C. Heart Rhythm. 2010; 7: I KGATP I Na I Ca I to Brugada*syndrome I Na I Ca I KGATP I KGAch Inferolateral*ERS " Brugadasyndrome(BrS)andERSareconsideredtoshareasimilarcharacterisRcsandto representaconrnuousspectrumofphenotypicexpressiontermedjgwavesyndrome.
11 Japanese Brugada Registry Kamakura S, Shimizu W, et al. Circ Arrhythm Electrophysiol 2009; 2: J wave amplitude = 1.6mm (< 2.0mm) Non type 1 ECG V1 Coved type Saddleback type " WealsoreportedinJapaneseBrugadaRegistrythatpaRentswithnonGtype1STG segmentelevaron(erpavern)instandardv1gv2leadsevenaxerdrugprovocaron testshowpoorprognosis,justasparentswithtype1brugadasyndrome. National Cerebral and Cardiovascular Center Nippon Medical School
12 Diagnosis of Brugada Syndrome Priori SG, Wilde AA, Krahn A, Shimizu W, et al. Europace 15(10): , BrSisdiagnosedwhenatypeG1STGsegmentelevaRonisobserved DiagnosRccriteria2005 " Atleast2rightprecordialleads (V 1 tov 3 ) Consensusstatementin2013 " Atleast1rightprecordiallead (V 1 andv 2 ) " Standard12GleadECG " SpontaneouslyoraXerdrug challengetestbyasodium channelblockingagent " Standardora*higher*posi)on* (uptothe2 nd intercostalspace) " SpontaneouslyoraXerdrug challengetestbyasodium channelblockingagent National Cerebral and Cardiovascular Center Nippon Medical School
13 Hypothesis Kamakura S, Shimizu W, et al. Circ Arrhythm Electrophysiol 2009; 2: J wave amplitude = 1.6mm (< 2.0mm) Non type 1 ER pattern V1 Coved type Saddleback type " PaRentswithnonGtype1ER(NT1GER)inhighcostal(2 nd and3 rd )ECGrecordingsmay beanothervariantofbrugadasyndrome. " Therefore,wecomparedtheclinicalprofileandlongGtermprognosisbetween parentswithandwithoutnt1gerinhighcostal(2 nd and3 rd )ECGamonginferoG lateralersparents. National Cerebral and Cardiovascular Center Nippon Medical School
14 Methods Kamakura T, Shimizu W et al. J Am Coll Cardiol 2013; 62: " 31paRents(27men,meanage:42.0±14.1years)withinferoGlateralERSand apriorepisodeofvfweredividedinto2groups. # baselineandhighcostal(2 nd and3 rd )ECGrecordings # drugprovocarontestswithasodiumchannelblocker(pilsicainide1mg/kg) $ ERS[A]Jgroup*(n=12)pa)ents*with*an*inferolateral*ER*combined*with*NT1JER** V 1 GV 3 standard+highcostal $ ERS[B]Jgroup*(n=19)*:*pa)ents*with*pure*inferolateral*ER*without*NT1JER* " ClinicalprofilesandVFrecurrencesduringfollowGupwerecomparedamong ERS(A)group,ERS(B)group,40paRentswithBrugadasyndromeandahistory ofvf(bsgroup),and13parentswithidiopathicvfwithoutjwaves(ivf group). National Cerebral and Cardiovascular Center Nippon Medical School
15 51y.o.Male Baseline 4th 3rd National Cerebral and Cardiovascular Center 2nd STGsegmentaugmentaRon bysodiumchannelblocker ERS (A) group Kamakura T, Shimizu W et al. J Am Coll Cardiol 2013; 62: AXer50mgpilsicainideinjecRon 4th InferolateralER+nonGtype1ERinhighcostalECG VF*recurrence*(+) 3rd 2nd Nippon Medical School
16 39y.o.Male ERS (B) group Kamakura T, Shimizu W et al. J Am Coll Cardiol 2013; 62: Baseline 4th 3rd 2nd PureInferolateralER DisappearanceofER bysodiumchannelblocker VF*recurrence*(J) AXer50mgpilsicainideinjecRon 4th 3rd 2nd National Cerebral and Cardiovascular Center Nippon Medical School
17 Clinical Characteristics Kamakura T, Shimizu W et al. J Am Coll Cardiol 2013; 62: Group ERS(n=31) ERS(A)(n=12)ERS(B)(n=19) BS(n=40) IVF(n=13) Pvalue (A)vs.(B) Age(years) 41.2± ± ± ± Menn,(%) 9(75%) 18(95%) 40(100%) 8(62%) 0.27 FHofSCDn,(%) 1(8%) 0(0%) 8(20%) 2(15%) 0.39 VF/CAduringsleep(%) 10(8,2)(83%) 2(2,0)(11%) 22(17,5)(55%) 1(1,0)(8%) < National Cerebral and Cardiovascular Center Nippon Medical School
18 Clinical Course Kamakura T, Shimizu W et al. J Am Coll Cardiol 2013; 62: Group ERS(n=31) ERS(A)(n=12)ERS(B)(n=19) BS(n=40) IVF(n=13) Pvalue (A)vs.(B) FollowGup(months) 90±57 76±46 104±63 82± VFrecurrencen,(%) 7(58%) 2(11%) 22(55%) 2(15%) VFstormn,(%) 5(42%) 0(0%) 10(25%) 0(0%) ICDimplantaRonn(%) 12(100%) 18(95%) 38(95%) 10(77%) 1.0 National Cerebral and Cardiovascular Center Nippon Medical School
19 Kaplan-Meier analysis of free of VF Kamakura T, Shimizu W et al. J Am Coll Cardiol 2013; 62: ERS(A)Ggroup ERS(B)Ggroup 0,8 IVFGgroup(n=13) ERS(B)Ggroup(n=19) BSGgroup IVFGgroup Free*of*VF 0,6 0,4 ERS(A)Ggroup(n=12) BSGgroup(n=40) 0,2 0 LogGrankP= ERS(A)vs.ERS(B) FollowJup*(Month) National Cerebral and Cardiovascular Center Nippon Medical School
20 Summary Kamakura T, Shimizu W et al. J Am Coll Cardiol 2013; 62: " Infero-lateral ERS patients can be divided into 2 heterogeneous groups: Patients with pure infero-lateral ER Patients with infero-lateral ER + non-type 1 ER pattern in high costal ECG. " Non-type 1 ER pattern in high costal ECG seems to be a key predictor of poor outcome in patients with inferolateral ERS. Patients with non-type 1 ER pattern in high costal ECG may be another variant of Brugada syndrome National Cerebral and Cardiovascular Center Nippon Medical School
21 J wave syndrome Antzelevitch C. Heart Rhythm. 2010; 7: ERS* ERS1(lateralGI,V4GV6):goodprognosis ERS2(inferiorGII,III,aVF) ERS3(global):poorprognosis I KGATP I Na I Ca I to I Na I Ca I KGATP I KGAch Brugada*syndrome Inferolateral*ERS
22 Early repolarization syndrome (ERS) Kamakura T, Shimizu W et al. J Am Coll Cardiol 2013; 62: I KGATP I Na I Ca I to PosiRveresponseto sodiumchannelblocker JGSTaugmentaRoninleadsV 1 GV 3 (includinghighcostal),avlavf NonGtype1BS NegaRveresponseto sodiumchannelblocker JGSTaugmentaRon(G)) Type1BS ERS InferoJlateral*ERS** Pure*inferoJlateral*ERS *NonJtype1*ER*in* high*costal*ecg** Heterogeneous IVF high*vf*recurrence* VF*during*sleep low*vf*recurrence*** VF*during*ac)vity
23 Acknowledgement Shiga Univ. School of Medical Science Minoru Horie, Seiko Ohno Hiroshi Matsuura, Futoshi Toyoda Keio University Keiichi Fukuda, Shinsuke Yuasa Yoshiyasu Aizawa Nagasaki University Naomasa Makita Tokyo Medical and Dental University Tetsushi Furukawa Toshihiro Tanaka Niigata University Hiroshi Watanabe Tokyo Womens Medical University Nobuhisa Hagiwara Nihon University Naokata Sumitomo Kanazawa University Masakazu Yamagishi, Kenshi Hayashi Kyoto University Takeru Makiyama Okayama University Hiroshi Morita, Kazufumi Nakamura Kagoshima Medical Center Masao Yoshinaga Tsukuba University Hitoshi Horigome, Kazutaka Aonuma Nippon Medical School Yasushi Miyauchi, Meiso Hayashi National Cerebral and Cardiovascular Center Tsukasa Kamakura, Shiro Kamakura, Aiba Takeshi Yoshihiro Miyamoto Akihiro Sekine Isao Shiraishi Hisaki Makimoto Hiro Kawata Tsukasa Kamakura Kenichiro Yamagata Kohei Ishibashi Ikutaro Nakajima Koji Miyamoto Hideo Okamura Takashi Noda Kengo F. Kusano Academic Medical Center, Amsterdam Connie Bezzina Arthur AM Wilde Tel-Aviv University, Israel Sami Viskin Lankenau Institute for Medical Research, USA Charlies Antzelevitch Thank you for your attention
Risk Stratification in Patients With Brugada Syndrome Without Previous Cardiac Arrest
310 OKAMURA H et al. Circulation Journal ORIGINAL ARTICLE Official Journal of the Japanese Circulation Society http://www.j-circ.or.jp Arrhythmia/Electrophysiology Risk Stratification in Patients With
/$ -see front matter 2012 Heart Rhythm Society. All rights reserved. doi: /j.hrthm
Effect of sodium-channel blockade on early repolarization in inferior/lateral leads in patients with idiopathic ventricular fibrillation and Brugada syndrome Hiro Kawata, MD,* Takashi Noda, MD, PhD,* Yuko
J-wave syndromes: update on ventricular fibrillation mechanisms
J-wave syndromes: update on ventricular fibrillation mechanisms Michael Nabauer University of Munich, Germany 28.8.2011 I have no conflicts of interest ECG labelling by Einthoven Circ 1998 Osborn wave
Appearance of J wave in the inferolateral leads and ventricular fibrillation provoked by mild hypothermia in a patient with Brugada syndrome
Appearance of J wave in the inferolateral leads and ventricular fibrillation provoked by mild hypothermia in a patient with Brugada syndrome Yasuaki Hada, MD, * Mitsuhiro Nishizaki, MD, * Noriyoshi Yamawake,
J Wave Syndromes. Osama Diab Lecturer of Cardiology Ain Shams University
J Wave Syndromes Osama Diab Lecturer of Cardiology Ain Shams University J Wave Syndromes Group of electric disorders characterized by > 1 mm elevation of the J point or prominent J wave with or without
Pronounced Shortening of QT Interval With Mexiletine Infusion Test in Patients With Type 3 Congenital Long QT Syndrome
340 FUNASAKO M et al. Circulation Journal ORIGINAL ARTICLE Official Journal of the Japanese Circulation Society http://www.j-circ.or.jp Arrhythmia/Electrophysiology Pronounced Shortening of Interval With
Augmented ST-Segment Elevation During Recovery From Exercise Predicts Cardiac Events in Patients With Brugada Syndrome
Journal of the American College of Cardiology Vol. 56, No. 19, 2010 2010 by the American College of Cardiology Foundation ISSN 0735-1097/$36.00 Published by Elsevier Inc. doi:10.1016/j.jacc.201.033 Heart
Clinical and Electrocardiographic Characteristics of Patients with Brugada Syndrome: Report of Five Cases of Documented Ventricular Fibrillation
J Arrhythmia Vol 25 No 1 2009 Original Article Clinical and Electrocardiographic Characteristics of Patients with Brugada Syndrome: Report of Five Cases of Documented Ventricular Fibrillation Seiji Takashio
Accepted Manuscript. Eiichiro Nakagawa, M.D., Ph.D., Takahiko Naruko, M.D., Ph.D., Tosinori Makita, M.D., Ph.D
Accepted Manuscript Reproducibility and diagnostic usefulness of repeated sodium channel blocker test at higher precordial ECG recording in a patient with Brugada syndrome Eiichiro Nakagawa, M.D., Ph.D.,
Ripolarizzazione precoce. Torino, 24th October Non così innocente come si pensava
Asymptomatic inherited arrhythmia syndromes: Drug induced Brugada Syndrome: when a prophylactic ICD is indicated? how high (or low) is QT the risk? Asymptomatic short Ripolarizzazione precoce. Torino,
Tailored treatment in Brugada syndrome
Tailored treatment in Brugada syndrome Lars Eckardt Department of Cardiology and Angiology Division of Experimental and Clinical Electrophysiology University of Münster, Germany 45 yr old male preoperative
State of the Art: Brugada Syndrome Novel diagnostic approaches and risk stratification
State of the Art: Brugada Syndrome Novel diagnostic approaches and risk stratification Lars Eckardt Division Electrophysiology Department of Cardiovascular Medicine University of Münster, Germany I have
Prevalence and QT Interval of Early Repolarization. in a Hospital-based Population
Original Article in a Hospital-based Population Hideki Hayashi MD PhD, Akashi Miyamoto MD, Katsuya Ishida MD, Tomohide Yoshino MD, Yoshihisa Sugimoto MD PhD, Makoto Ito MD PhD, Minoru Horie MD PhD Department
Invasive Risk Stratification: When is it needed?
Inherited Cardiomyopathies and Channelopathies: Who is at risk for Sudden Cardiac Death? Invasive Risk Stratification: When is it needed? Hung-Fat Tse, MD, PhD Department of Medicine The University of
Early repolarization syndrome (ERS) is defined as inferolateral
Significance of Coronary Artery Spasm Diagnosis in Patients With Early Repolarization Syndrome Tsukasa Kamakura, MD, PhD; Mitsuru Wada, MD; Kohei Ishibashi, MD, PhD; Yuko Y. Inoue, MD, PhD; Koji Miyamoto,
Are there low risk patients in Brugada syndrome?
Are there low risk patients in Brugada syndrome? Pedro Brugada MD, PhD Andrea Sarkozy MD Risk stratification in Brugada syndrome In the last years risk stratification in Brugada syndrome has become the
Risk Stratification for Asymptomatic Patients With Brugada Syndrome
Circ J 2003; 67: 312 316 Risk Stratification for Asymptomatic Patients With Brugada Syndrome Prediction of Induction of Ventricular Fibrillation by Noninvasive Methods Hiroshi Morita, MD; Shiho Takenaka-Morita,
When VF is the endpoint, wait and see is not always the best option.
Being free of symptoms does not necessarily mean free of arrhythmias. This Holter is from a asymptomatic 48 years old female with LQT2 When VF is the endpoint, wait and see is not always the best option.
Vagally mediated ventricular arrhythmia in Brugada syndrome
Vagally mediated ventricular arrhythmia in Brugada syndrome Nicholay Teodorovich, MD, FHRS, * Yonatan Kogan, MD, * Offir Paz, MD, * Moshe Swissa, MD, FHRS * From the * Department of Cardiology, Kaplan
Brugada Syndrome: An Update
Brugada Syndrome: An Update Osama Diab Associate professor of Cardiology Ain Shams university, Cairo, Egypt Updates Mechanism and Genetics Risk stratification Treatment 1 Brugada syndrome causes 4 12%
Ripolarizzazione precoce. Non così innocente come si pensava
Brugada syndrome: tests and diagnosis. Torino, 27 ottobre 2017 Ripolarizzazione precoce. Non così innocente come si pensava Carla Giustetto Carla Giustetto Divisione di Cardiologia Divisione Università
A case of Brugada syndrome coexisting with vasospastic angina: Caution should be taken when using calcium channel blockers
Journal of Cardiology Cases (2011) 4, e143 e147 Available online at www.sciencedirect.com jou rn al h om epa g e: www.elsevier.com/locate/jccase Case Report A case of Brugada syndrome coexisting with vasospastic
CME Article Brugada pattern masking anterior myocardial infarction
Electrocardiography Series Singapore Med J 2011; 52(9) : 647 CME Article Brugada pattern masking anterior myocardial infarction Seow S C, Omar A R, Hong E C T Cardiology Department, National University
Low Risk for Arrhythmic Events in Asymptomatic Patients With Drug-Induced Type 1 ECG
Circulation Journal Official Journal of the Japanese Circulation Society http://www.j-circ.or.jp CONTROVERSIES IN CARDIOVASCULAR MEDICINE Low Risk for Arrhythmic Events in Asymptomatic Patients With Drug-Induced
The Early Repolarization ECG Pattern An Update
Acta Medica Marisiensis 2017;63(4):165-169 DOI: 10.1515/amma-2017-0032 REVIEW The Early Repolarization ECG Pattern An Update István Adorján Szabó 1, Annamária Fárr 2, Ildikó Kocsis 1, Lehel Máthé 3, László
J Wave Syndrome: Clinical Diagnosis, Risk Stratification And Treatment Kamal K Sethi,Kabir Sethi,Surendra K Chutani
J Wave Syndrome: Clinical Diagnosis, Risk Stratification And Treatment Kamal K Sethi,Kabir Sethi,Surendra K Chutani Division of Cardiology and Cardiac Electrophysiology,Delhi Heart & Lung Institute,New
Introduction. CLINICAL RESEARCH Electrophysiology and ablation
Europace (2013) 15, 109 115 doi:10.1093/europace/eus259 CLINICAL RESEARCH Electrophysiology and ablation J-waves in patients with an acute ST-elevation myocardial infarction who underwent successful percutaneous
726 MIYAZAKI A et al. Circ J 2017; 81: ORIGINAL ARTICLE doi: /circj.CJ
726 MIYAZAKI A et al. Circ J 2017; 81: 726 732 ORIGINAL ARTICLE doi: 10.1253/circj.CJ-16-0991 Pediatric Cardiology and Adult Congenital Heart Disease Mid-Term Follow-up of School-Aged Children With Borderline
Distinguishing benign from malignant early repolarization : The value of the ST-segment morphology
Distinguishing benign from malignant early repolarization : The value of the ST-segment morphology Raphael Rosso, MD,* Eran Glikson,* Bernard Belhassen, MD,* Amos Katz, MD, Amir Halkin, MD,* Arie Steinvil,
How to manage a patient with short QT syndrome?
How to manage a patient with short QT syndrome? Torino, 27 ottobre2012 Carla Giustetto Division of Cardiology University of Torino QT 280 ms QTc 260 ms Narrow, tall and peaked T waves High incidence of
Διαχείρηση Ασυμπτωματικού ασθενούς με ΗΚΓ τύπου Brugada
Διαχείρηση Ασυμπτωματικού ασθενούς με ΗΚΓ τύπου Brugada Άννα Κωστοπούλου Επιμελήτρια Α Ωνάσειο Καρδιοχειρουργικό Κέντρο Τμήμα Ηλεκτροφυσιολογίας και Βηματοδότησης BrS: Diagnosis 5:10000 First described
Silvia G Priori MD PhD
The approach to the cardiac arrest survivor Silvia G Priori MD PhD Molecular Cardiology, IRCCS Fondazione Salvatore Maugeri Pavia, Italy AND Leon Charney Division of Cardiology, Cardiovascular Genetics
Pediatric Cohort With Long QT Syndrome
696 OZAWA J et al. Circulation Journal ORIGINAL ARTICLE Official Journal of the Japanese Circulation Society http://www.j-circ.or.jp Pediatric Cardiology and Adult Congenital Heart Disease Pediatric Cohort
Early Repolarization: Culprit or Innocent Bystander
EP Morning Conference Early Repolarization: Culprit or Innocent Bystander December 2, 2010 Vic Froelicher, MD Early Repolarization: Culprit or Innocent Bystander Nikhil A. Jain Abhimanyu Uberoi Marco Perez
Ajmaline attenuates electrocardiogram characteristics of inferolateral early repolarization
Ajmaline attenuates electrocardiogram characteristics of inferolateral early repolarization Laurent Roten, MD, Nicolas Derval, MD, Frédéric Sacher, MD, Patrizio Pascale, MD, Stephen B. Wilton, MD, MSc,
Three cases of corticosteroid therapy triggering ventricular fibrillation in J-wave syndromes
Heart Vessels (2014) 29:867 872 DOI 10.1007/s00380-013-0443-x CASE REPORT Three cases of corticosteroid therapy triggering ventricular fibrillation in J-wave syndromes Naka Sakamoto Nobuyuki Sato Masahide
Interpretation and Consequences of Repolarisation Changes in Athletes
Interpretation and Consequences of Repolarisation Changes in Athletes Professor Sanjay Sharma E-mail sasharma@sgul.ac.uk @SSharmacardio Disclosures: None Athlete s ECG Vagotonia Sinus bradycardia Sinus
ECG INTERPRETATION MANUAL
Lancashire & South Cumbria Cardiac Network ECG INTERPRETATION MANUAL THE NORMAL ECG Lancashire And South Cumbria Cardiac Physiologist Training Manual THE NORMAL ECG E.C.G CHECKLIST 1) Name, Paper Speed,
Sudden cardiac death (SCD) in infants, children, and
Circ J doi: 10.1253/circj.CJ-17-0735 Advance Publication by-j-stage ORIGINAL ARTICLE Pediatric Cardiology and Adult Congenital Heart Disease Standard Values and Characteristics of Electrocardiographic
Ripolarizzazione precoce.
Controversia: impianto di defibrillatore in prevenzione primaria Caso clinico: Ripolarizzazione precoce. Sindrome di Brugada Non così innocente come si pensava Torino, 31 marzo 2017 Carla Giustetto Carla
The Role of Defibrillator Therapy in Genetic Arrhythmia Syndromes
The Role of Defibrillator Therapy in Genetic Arrhythmia Syndromes RHEA C. PIMENTEL, MD, FACC, FHRS UNIVERSITY OF KANSAS HOSPITAL MID AMERICA CARDIOLOGY AUGUST 19, 2012 Monogenic Arrhythmia Syndromes Mendelian
Arrhythmia Mechanisms
Arrhythmia Mechanisms Brugada Syndrome and Early Repolarisation: Distinct Clinical Entities or Different Phenotypes of the Same Genetic Disease? Giulio Conte, 1 Maria Luce Caputo, 1 François Regoli, 1
Exercise guidelines in athletes with isolated repolarisation abnormalities and structurally normal heart.
Exercise guidelines in athletes with isolated repolarisation abnormalities and structurally normal heart. Hanne Rasmusen Consultant cardiologist, PhD Dept. of Cardiology Bispebjerg University Hospital
Family Medicine for English language students of Medical University of Lodz ECG. Jakub Dorożyński
Family Medicine for English language students of Medical University of Lodz ECG Jakub Dorożyński Parts of an ECG The standard ECG has 12 leads: six of them are considered limb leads because they are placed
Implantable loop recorders Michele Brignole Arrhythmologic Center, Lavagna, Italy
Implantable loop recorders Michele Brignole Arrhythmologic Center, Lavagna, Italy DECLARATION OF CONFLICT OF INTEREST Medtronic, minimal ILR: available devices Reveal DX/XT, Medtronic Confirm, St Jude
Brugada syndrome, which was introduced as a clinical
Prolonged QRS Duration in Lead V and Risk of LifeThreatening Ventricular Arrhythmia in Patients With Brugada Syndrome Kimie Ohkubo, MD, Ichiro Watanabe, MD, Yasuo Okumura, MD, Sonoko Ashino, MD, Masayoshi
Εμφύτευση απινιδωτών για πρωτογενή πρόληψη σε ασθενείς που δεν περιλαμβάνονται στις κλινικές μελέτες
Εμφύτευση απινιδωτών για πρωτογενή πρόληψη σε ασθενείς που δεν περιλαμβάνονται στις κλινικές μελέτες Δημήτριος M. Κωνσταντίνου Ειδικός Καρδιολόγος, MD, MSc, PhD, CCDS Πανεπιστημιακός Υπότροφος Dr. Konstantinou
Accepted Manuscript. Early repolarization syndrome caused by de novo duplication of KCND3 detected by next generation sequencing
Accepted Manuscript Early repolarization syndrome caused by de novo duplication of KCND3 detected by next generation sequencing Samuel Chauveau, MD, Alexandre Janin, PharmD, Marianne Till, MD, PhD, Elodie
Ventricular Arrhythmia Induced by Sodium Channel Blocker in Patients With Brugada Syndrome
Journal of the American College of Cardiology Vol. 42, No. 9, 2003 2003 by the American College of Cardiology Foundation ISSN 0735-1097/03/$30.00 Published by Elsevier Inc. doi:10.1016/s0735-1097(03)01124-0
7:00 8:00 9:00 10:00 11:00 11:20 12:00 12:50 13:00 14:00 14:40 15:00 16:00 16:10 16:30 17:00 18:00. Luncheon Seminar 1 Bayer Yakuhin, Ltd.
Thursday, September 14 7:00 8:00 9:00 10:00 11:00 11:20 12:00 12:50 13:00 14:00 14:40 15:00 16:00 16:10 16:30 17:00 18:00 Invited Symposium 1AF1 Driver Mapping and Ablation for Atrial Fibrillation Luncheon
Thromboembolism During Sinus Rhythm in Patients with a History of Atrial Fibrillation
48 th Annual New York Cardiovascular Symposium Thromboembolism During Sinus Rhythm in Patients with a History of Atrial Fibrillation Is Left Atrial Appendage Dysfunction Sufficient to Generate Clots? December
Study methodology for screening candidates to athletes risk
1. Periodical Evaluations: each 2 years. Study methodology for screening candidates to athletes risk 2. Personal history: Personal history of murmur in childhood; dizziness, syncope, palpitations, intolerance
Syncope in patients with inherited arrhythmogenic syndromes. Is it enough to justify ICD implantation?
Innovations in Interventional Cardiology and Electrophysiology Thessaloniki 2014 Syncope in patients with inherited arrhythmogenic syndromes. Is it enough to justify ICD implantation? K. Letsas, MD, FESC
Conflict of Interest and Funding
Conflict of Interest and Funding Funding: French National grant («Programme Hospitalier de Recherche Clinique») The authors have no conflicts to declare Outcome of patients with syncope and Early Repolarization
Exercise stress test reveals ineligibility for subcutaneous implantable cardioverter
1 Original Article Exercise stress test reveals ineligibility for subcutaneous implantable cardioverter defibrillator in patients with Brugada syndrome First author s surname: Tachibana Name of grant:
Update of Diagnosis and Management of Inherited Cardiac Arrhythmias
Circulation Journal Official Journal of the Japanese Circulation Society http://www.j-circ.or.jp REVIEW Update of Diagnosis and Management of Inherited Cardiac Arrhythmias Wataru Shimizu, MD, PhD Over
La strategia diagnostica: il monitoraggio ecg prolungato. Michele Brignole
La strategia diagnostica: il monitoraggio ecg prolungato Michele Brignole ECG monitoring and syncope In-hospital monitoring Holter Monitoring External loop recorder Remote (at home) telemetry Implantable
Incidence of Ischemic Stroke in Japanese Patients With Atrial Fibrillation Not Receiving Anticoagulation Therapy
432 SUZUKI S et al. Circulation Journal ORIGINAL ARTICLE Official Journal of the Japanese Circulation Society http://www.j-circ.or.jp Stroke Incidence of Ischemic Stroke in Japanese Patients With Atrial
Destructive Device Removal - Sparks and Deletion of Therapy History From an Implantable Cardioverter Defibrillator. Case Reports
Case Reports Destructive Device Removal - Sparks and Deletion of Therapy History From an Implantable Cardioverter Defibrillator Takashi Kurita, 1 MD, Shigeyuki Ueda, 2 MD, Hideo Okamura, 2 MD, Takashi
Genotype-Phenotype Correlation of SCN5A
1.1161/CIRCULATIONAHA.117.27983 Genotype-Phenotype Correlation of SCN5A Mutation for the Clinical and Electrocardiographic Characteristics of Probands with Brugada Syndrome: A Japanese Multicenter Registry
Prevalence and Characteristics of Early Repolarization in the CASPER Registry
Journal of the American College of Cardiology Vol. 58, No. 7, 2011 2011 by the American College of Cardiology Foundation ISSN 0735-1097/$36.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2011.04.022
Epinephrine Unmasks Latent Mutation Carriers With LQT1 Form of Congenital Long-QT Syndrome
Journal of the American College of Cardiology Vol. 41, No. 4, 2003 2003 by the American College of Cardiology Foundation ISSN 0735-1097/03/$30.00 Published by Elsevier Science Inc. doi:10.1016/s0735-1097(02)02850-4
How agressively should we treat asymptomatic patients with Brugada syndrome. Josep Brugada Medical Director Hospital Clínic, University of Barcelona
How agressively should we treat asymptomatic patients with Brugada syndrome Josep Brugada Medical Director Hospital Clínic, University of Barcelona The ECG in Brugada syndrome - Prolonged PR - RBBB - ST
IN THE NAME OF GOD. Dr.Sima Sayah
IN THE NAME OF GOD Dr.Sima Sayah Epidemiology: Prevalence: ranging from 0.14% in the japanese to 0.61% in europeans & may reach to 3% in southeast Asia. In up to 60% of patients,the disease can be sporadic.
Name of Presenter: Marwan Refaat, MD
NAAMA s 24 th International Medical Convention Medicine in the Next Decade: Challenges and Opportunities Beirut, Lebanon June 26 July 2, 2010 I have no actual or potential conflict of interest in relation
How to Read an Athlete s ECG. Sanjay Sharma BSc (Hons), MD, FRCP, FESC
How to Read an Athlete s ECG Sanjay Sharma BSc (Hons), MD, FRCP, FESC Athlete s EKG Vagotonia Sinus bradycardia Sinus arrhythmia First degree AVB ST-elevation Tall T waves Increased chamber size Left ventricular
ΤΙ ΠΡΕΠΕΙ ΝΑ ΓΝΩΡΙΖΕΙ ΟΓΕΝΙΚΟΣ ΚΑΡΔΙΟΛΟΓΟΣ ΓΙΑ ΤΙΣ ΔΙΑΥΛΟΠΑΘΕΙΕΣ
ΤΙ ΠΡΕΠΕΙ ΝΑ ΓΝΩΡΙΖΕΙ ΟΓΕΝΙΚΟΣ ΚΑΡΔΙΟΛΟΓΟΣ ΓΙΑ ΤΙΣ ΔΙΑΥΛΟΠΑΘΕΙΕΣ ΣΤΕΛΙΟΣ ΠΑΡΑΣΚΕΥΑÏΔΗΣ ΔΙΕΥΘΥΝΤΗΣ ΕΣΥ Α Καρδιολογική Κλινική ΑΠΘ, Νοσοκομείο ΑΧΕΠΑ, Θεσσαλονίκη NO CONFLICT OF INTEREST Sudden Cardiac Death
Spontaneous type 1 pattern, ventricular arrhythmias and sudden cardiac death in Brugada Syndrome: an updated systematic review and meta-analysis
Journal of Geriatric Cardiology (2017) 14: 639 643 2017 JGC All rights reserved; www.jgc301.com Letter to the Editor Open Access Spontaneous type 1 pattern, ventricular arrhythmias and sudden cardiac death
The Electrophysiologic Mechanism of ST-Segment Elevation in Brugada Syndrome
Journal of the American College of Cardiology Vol. 40, No. 2, 2002 2002 by the American College of Cardiology Foundation ISSN 0735-1097/02/$22.00 Published by Elsevier Science Inc. PII S0735-1097(02)01964-2
The New Definition of Early Repolarisation. Peter W. Macfarlane. Institute of Cardiovascular and Medical Sciences University of Glasgow
1 The New Definition of Early Repolarisation Peter W. Macfarlane Institute of Cardiovascular and Medical Sciences University of Glasgow Address for Correspondence: Electrocardiology Group Level 1, New
Asymptomatic Long QT. Prof. Dr. Martin Borggrefe Mannheim
Asymptomatic Long QT Prof. Dr. Martin Borggrefe Mannheim QT interval Distribution of QTc intervals in large population-based studies Viskin S, Heart Rhythm 2009; 6: 711-715 QT interval Distribution of
MICS OF MYOCARDIAL ISCHEMIA AND INFARCTION REVISED FOR LAS VEGAS
ECG MIMICS OF MYOCARDIAL ISCHEMIA AND INFARCTION 102.06.05 Tzong-Luen Wang MD, PhD, JM, FESC, FACC Professor. Medical School, Fu-Jen Catholic University Chief, Emergency Department, Shin-Kong Wu Ho-Su
Introduction. CLINICAL RESEARCH Sudden death and ICDs
Europace (2017) 19, 259 266 doi:10.1093/europace/euv447 CLINICAL RESEARCH Sudden death and ICDs True idiopathic ventricular fibrillation in out-of-hospital cardiac arrest survivors in the Swiss Canton
There are future perspectives in the pharmacological treatment of arrhythmias
There are future perspectives in the pharmacological treatment of arrhythmias George Andrikopoulos, MD, PhD, FESC, Cardiologist, Director, 1st Department of Cardiology/ Department of Electrophysiology
P. Brugada 1, R. Brugada 2 and J. Brugada 3. Introduction. U.S.A.; 3 Unitat d Arritmias, Hospital Clinic, Barcelona, Spain
European Heart Journal (2000) 21, 321 326 Article No. euhj.1999.1751, available online at http://www.idealibrary.com on Sudden death in patients and relatives with the syndrome of right bundle branch block,
ECG Underwriting Puzzler Dr. Regina Rosace AVP & Medical Director
December 2018 ECG Underwriting Puzzler Dr. Regina Rosace AVP & Medical Director To obtain best results Select Slide Show from the ribbon at the top of your PowerPoint screen Select From Beginning on the
Atrial Fibrillation and Atrial Vulnerability in Patients With Brugada Syndrome
Journal of the American College of Cardiology Vol. 40, No. 8, 2002 2002 by the American College of Cardiology Foundation ISSN 0735-1097/02/$22.00 Published by Elsevier Science Inc. PII S0735-1097(02)02167-8
Atrial Fibrillation and Brugada Syndrome
Journal of the American College of Cardiology Vol. 51, No. 12, 2008 2008 by the American College of Cardiology Foundation ISSN 0735-1097/08/$34.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2007.10.062
The Brugada Syndrome*
Journal of the American College of Cardiology Vol. 51, No. 12, 2008 2008 by the American College of Cardiology Foundation ISSN 0735-1097/08/$34.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2007.12.006
Atrial fibrillation in Cardiac Channelopathies
Atrial fibrillation in Cardiac Channelopathies Thejus, Jayachandran Francis, Johnson Introduction Atrial fibrillation is the commonest arrhythmia encountered in day-to-day clinical practice. Its prevalence
Inherited Arrhythmia Syndromes
Inherited Arrhythmia Syndromes When to perform Genetic testing? Arthur AM Wilde February 4, 2017 Which pts should undergo genetic testing? SCD victims with a likely diagnosis Pts diagnosed with an inherited
Original Article. Tachycardia-Induced J-Wave Changes in Patients With and Without Idiopathic Ventricular Fibrillation
Original Article Tachycardia-Induced J-Wave Changes in Patients With and Without Idiopathic Ventricular Fibrillation Yoshiyasu Aizawa, MD, PhD; Seiji Takatsuki, MD, PhD; Takahiko Nishiyama, MD, PhD; Takehiro
ARVC when TO IMPLANT THE ASYMPTOMATIC PERSON
EUROPACE 2011 INHERITED ELECTRICAL CARDIAC DISORDERS ARVC when TO IMPLANT THE ASYMPTOMATIC PERSON June 26 th 2011 Robert Lemery MD CONFLICTS of INTEREST None ASYMPTOMATIC ARVC 1. ECG 2. ASYMPTOMATIC PVC
Introduction Implantation of an automatic cardioverterdefibrillator
Excellent Long-Term Reproducibility of the Electrophysiologic Efficacy of Quinidine in Patients with Idiopathic Ventricular Fibrillation and Brugada Syndrome BERNARD BELHASSEN, M.D., AHARON GLICK, M.D.,
The patient with electric storm
The complex patient in the cardiac care unit: The patient with electric storm Helmut U. Klein University of Rochester Medical Center Heart Research Follow-up Program and Isar Heart Center Muenchen Presenter
Prognostic Value of Cardiopulmonary Exercise Testing in Patients with Atrial Fibrillation
Prognostic Value of Cardiopulmonary Exercise Testing in Patients with Atrial Fibrillation Hidekazu Tsuneoka 1)2), Akira Koike 2), Osamu Nagayama 2), Koji Sakurada 2), Hitoshi Sawada 2), Kazutaka Aonuma
Optimal management of Brugada syndrome
Optimal management of Brugada syndrome Cristian Stătescu 1,2, Teodor Vasilcu 1,2, Ioana Mădălina Chiorescu*,1,2, Grigore Tinică 1,2, Cătălina Arsenescu-Georgescu 1,2, Radu Sascău 1,2 1 "Grigore T. Popa"
Japanese Stem Cell Efforts
Japanese Stem Cell Efforts Yuko Sekino, Ph. D. Organizer of JiCSA Head, Division of Pharmacology, National Institute of Health Sciences (NIHS) Pharmaceutical and Medical Safety Bureau NI HS Since 1874
In vivo studies of Scn5a+/ mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalities
Available online at www.sciencedirect.com Journal of Electrocardiology 43 (2010) 433 439 www.jecgonline.com In vivo studies of Scn5a+/ mice modeling Brugada syndrome demonstrate both conduction and repolarization
All About STEMIs. Presented By: Brittney Urvand, RN, BSN, CCCC. Essentia Health Fargo Cardiovascular Program Manager.
All About STEMIs Presented By: Brittney Urvand, RN, BSN, CCCC Essentia Health Fargo Cardiovascular Program Manager Updated 10/2/2018 None Disclosures Objectives Identify signs and symptoms of a heart attack
Supplementary information for: A functional variation in BRAP confers risk of myocardial infarction in Asian populations
Supplementary information for: A functional variation in BRAP confers risk of myocardial infarction in Asian populations Kouichi Ozaki 1, Hiroshi Sato 2, Katsumi Inoue 3, Tatsuhiko Tsunoda 4, Yasuhiko
Death after Syncope: Can we predict it? Daniel Zamarripa, MD Senior Medical Director December 2013
Death after Syncope: Can we predict it? Daniel Zamarripa, MD Senior Medical Director December 2013 Death after Syncope: Can we predict it? Those who suffer from frequent and severe fainting often die suddenly
Clinical observations have shown that conduction abnormalities
Arrhythmia/Electrophysiology Fragmented QRS as a Marker of Conduction Abnormality and a Predictor of Prognosis of Brugada Syndrome Hiroshi Morita, MD; Kengo F. Kusano, MD; Daiji Miura, PhD; Satoshi Nagase,
Comparison of Three-year Outcome after PCI and CABG in Triple Vessel Coronary Artery Disease. CREDO-Kyoto PCI/CABG Registry Cohort-2
Comparison of Three-year Outcome after PCI and CABG in Triple Vessel Coronary Artery Disease Stratified analysis by the SYNTAX Score CREDO-Kyoto PCI/CABG Registry Cohort-2 Hiroki Shiomi, Junichi Tazaki,
CLINICAL INVESTIGATIONS. Methods
CLINICAL INVESTIGATIONS Jpn Circ J 2001; 65: 702 706 Correlation Between the Effective Refractory Period and Activation-Recovery Interval Calculated From the Intracardiac Unipolar Electrogram of Humans
Approximately 5% of patients who experience sudden death
Sodium Channel Blockers Identify Risk for Sudden Death in Patients With ST-Segment Elevation and Right Bundle Branch Block but Structurally Normal Hearts Ramon Brugada, MD; Josep Brugada, MD; Charles Antzelevitch,
Current ECG interpretation guidelines in the screening of athletes
REVIEW ARTICLE 7 How to differentiate physiological adaptation to intensive physical exercise from pathologies Current ECG interpretation guidelines in the screening of athletes Gemma Parry-Williams, Sanjay
Supraventricular arrhythmias in Brugada syndrome. Prof. Dr. Martin Borggrefe Mannheim
Supraventricular arrhythmias in Brugada syndrome Prof. Dr. Martin Borggrefe Mannheim Brugada syndrome 1992-2012 Time interval between description of the disease and discovery of first causal gene Brugada
ICD in a young patient with syncope
ICD in a young patient with syncope Konstantinos P. Letsas, MD, FESC Second Department of Cardiology Evangelismos General Hospital of Athens Athens, Greece Case presentation A 17-year-old apparently healthy
The impact of clinical and genetic findings on the management of young Brugada Syndrome patients
12 ème Congrès Médico-Chirugical de la FCPC 21 au 24 novembre 2015 Schoelcher, Martinique The impact of clinical and genetic findings on the management of young Brugada Syndrome patients Institut du Thorax,