Bifurcations Bad Krozingen I
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1 Bifurcations Bad Krozingen I Clinical outcome 5 years after routine T-Stenting versus provisional T-stenting in the treatment of de novo coronary bifurcation lesions using sirolimus-eluting stents M. Ferenc
2 Background Previous studies demonstrated no benefit of systematic double stenting compared with single stenting in de-novo coronary bifurcation lesions (NORDIC; BBK I; BBC;) during short follow-up There is a lack of complete long term follow-up comparing single and double stenting
3 Objective We analysed the long term follow-up after percutaneus treatment of coronary bifurcation lesions with sirolimus-eluting stents (CYPHER) routine T-stenting of both main and the side branch reduces the restenosis in the side branch compared with provisional T-stenting.
4 Patient selection Inclusion criteria Stable angina pectoris and/or posi2ve stress test De novo bifurcated lesion of a na2ve coronary artery Reference vessel diameter of 2.5 to 4.0 mm in the main branch and of 2.25 mm in the side branch > 50% diameter stenosis of main branch and/or side branch Exclusion criteria Acute myocardial infarc2on within 72 hours Contraindica2on to aspirin, heparin, clopidogrel, stainless steel, sirolimus History of bleeding diathesis or coagulopathy Intraluminal thrombus, heavy calcifica2on and/or severe tortuosity
5 Prospective randomized study April 2005 August patients with de novo bifurcation lesion Provisional T-stenting n = 101 Systematic T-stenting n = 101 Angiographic follow-up with QCA at 9 months ( Medis bifurcation program) Primary endpoint In-segment percent diameter stenosis of the side branch at angiographic follow-up Clinical follow-up at 1,2 and 5 years
6 Provisional T- sten2ng Technical approach Rou2ne modified T- sten2ng Stent placement in the main branch
7 Provisional T- sten2ng Technical approach Rou2ne modified T- sten2ng Final kissing balloon dilata2on
8 Provisional T- sten2ng Technical approach Rou2ne modified T- sten2ng Final kissing balloon dilata2on
9 Provisional T- sten2ng Technical approach Rou2ne modified T- sten2ng
10 Baseline demographics Provisional T-Stenting n = 101 Routine T-Stenting n = 101 p- Value Age (yrs) 66.7 ± ± Male sex (%) Previous MI (%) History of PCI (%) or 3-vessel disease (%) History of CABG (%) Ejection fraction (%) Diabetes (%)
11 Distribution of Medina classification 35% 111 5% 6% p= % % % % % % % 2% 3% 8% 6% True bifurcation = 68 % True bifurcation = 68 % Provisional T-Stenting Systematic T-Stenting
12 Procedural data Provisional T-Stenting n = 101 Systematic T-Stenting n = 101 p- Value Cross-over (%) <0.001 Final kissing balloon (%) n.s.
13 Cumula2ve distribu2on (%) % Ferenc et al., Eur Heart J 2008 The BBK I - Study: 202 pa2ents - SES - Angiographic Primary Endpoint % P = 0.15 Provisional T- Sten2ng Rou2ne T- Sten2ng Percent diameter stenosis of the side branch
14 BBK I - TLR 5 years post index-pci 20 Cumulative incidence (%) P = 0.97 Provisional T-stenting Routine T-stenting 16.3 % 16.2 % Years after PCI
15 BBK I - MACE 5 years post index-pci Cumulative incidence (%) P = 0.91 Provisional T-stenting Routine T-stenting 22.9 % 22.8 % Years after PCI
16 BBK I - Death / MI 5 years post index-pci 20 Cumulative incidence (%) P = 0.40 Provisional T-stenting Routine T-stenting 13.9 % 9.9 % Years after PCI
17 BBK I - Death 5 years post index-pci % Cumulative incidence (%) P = 0.65 Provisional T-stenting Routine T-stenting 7.9 % Years after PCI
18 BBK I - probable/definite stent thrombosis 5 years post index-pci Cumulative incidence (%) Inten2on- to- treat cohort: Rou2ne T- sten2ng Provisional T- sten2ng P= Years a_er PCI
19 BBK I - probable/definite stent thrombosis 5 years post index-pci Cumulative incidence (%) Inten2on- to- treat cohort: Rou2ne T- sten2ng Provisional T- sten2ng As- treated cohort: Double sten2ng Single sten2ng 6.1 % P=0.25 P= % Years a_er PCI
20 BBK I study - Clinical outcome 5 years post PCI - Analysis as treated - Single T-Stenting Double T-Stenting n=85 n=117 TLR (%) Any MACE (%) Death (%) Death and/or MI (%) Stent thrombosis (def/prob) (%) p
21 Conclusions During 5-year follow-up, routine T-stenting offered no advantage over provisional T-stenting with respect to TLR or MACE. Double stenting compared with single stenting was associated with an increased 5-year risk of stent thrombosis.
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