TIME FOR CHANGE. It's up to you to make a difference

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1 TIME FOR CHANGE It's up to you to make a difference

2 TIME TO CHANGE TO CHANGE TIME Urinary tract infections (UTIs) make up a large proportion of healthcare-associated infections (HCAIs) in the UK and four out of every five can be traced to indwelling catheters. (Health Protection Agency, 2009) This means there is massive scope for both improving the quality of patients lives and saving precious healthcare resources by reducing the occurrence of UTIs. Catheter-associated urinary tract infections (CAUTIs) cause immense problems for the UK National Health Service (NHS) Catheters are associated with 80% of all nosocomial UTIs 1 CAUTIs are the largest source of antibiotic-resistant pathogens 2 1 4% of patients with CAUTI develop secondary bacteraemia % of these patients die 3 Urinary tract infections (UTIs) are a major source of healthcare associated infections (HCAIs) As a result, Department of Health guidelines now make the reduction of CAUTIs a priority 6 The bacterial spectrum of nosocomial UTIs is broad and antibiotic resistance is common 4 CAUTIs cause between 21 to 45% of HAIs 1 Hospital-acquired UTIs cost the NHS 124 million every year 5 Every UTI costs an extra 1,327 per patient and blocks a bed for an extra six days 5 UTIs CAN BE REDUCED WITH CORRECT CARE

3 Bardex I.C. anti-infective Foley Catheters work H OW CA UTIs CA USE DA M A G E Urethra is damaged by friction, the passage of fluids and the inflammatory response to bacteria7 DAMAGED URETHRA Catheter surfaces attract bacteria which develop into a biofilm7 which means infection is harder to treat BIOFILM This may cause increased pain and discomfort for your patients Inflammatory impact on cells of urethral mucosa over 72 hours as 8 measured on a 4-point scale CATHETER 0 Bardex I.C. * Bacti-Guard Silver Alloy Hydrogel Uncoated Latex Bardex I.C. Foley Catheters are proven more effective than conventional catheters in reducing CAUTIs A wide range of clinical studies clearly show the advantages of Bardex I.C. Foley Catheters over conventional catheters. Researcher Study Size Results Liedberg, Lundeberg & Ekman, patients 80% reduction in CAUTIs Rupp et al., 2004 >500,000 patient days 57% reduction in CAUTIs 180 patients Bacteriuria reduced by 47% Newton, Still & Law, ,757 patients CAUTI/1000 patient days fell from 7.2 to 4.4 Karchmer et al., ,828 patients Risk of CAUTI reduced by 32% Bologna et al., ITUs, 108 beds CAUTI/1000 patient days fell from 8.1 to 4.9 Gentry & Cope patients 33.5% reduction in CAUTIs Seymour patients Risk of CAUTI reduced by 71.2% 9 10 Verleyen et al., point scale: 1. No oedema or other inflammatory sign 2. Mild oedema and loss of surface epithelium 3. Inflammatory infiltrate and epithelial loss 4. Inflammatory infiltrate, epithelial loss, exudate and haemorrhage. & EVIDENCE BASED TECHNOLOGY

4 Isn t it time to change? RE D U C T IO N O F CA UTIs IS NO W A P R I OR I TY FOR THE NHS T he occurrence of UTI is 3.7 times greater in patients catheterised with a standard catheter than in patients catheterised with the Bardex I.C. Foley Catheter with Bacti-Guard * Silver Alloy coating and Bard Hydrogel 6 The Cochrane Review found a 40% reduction in symptomatic infection with silver alloy-coated catheters versus standard catheters T he Bardex I.C. Foley Catheter was the first device to receive a level one recommendation from the Rapid Review Panel to tackle HAIs 19 The results suggest that the use of silver alloy indwelling catheters for catheterising hospitalised adults short-term reduces the risk of catheter acquired urinary tract infection. 20 HYDROGEL Bardex I.C. Foley Catheters fighting infection and restoring patient comfort GOLD & PALLADIUM Unique combination of noble metals and hydrogel coating allows extended slow release of silver ions 21 SILVER + Ag Ag These silver ions inhibit biofilm formation and reduce the risk of infection by 32% 13 + Ag Silver alloy catheters Preserve the integrity of the urethral mucosa, preventing inflammation, loss of epithelium and formation of biofilm 8,22 Are proven effective in reducing infection compared with conventional catheters 10,11 Biocompatible surface may reduce patient discomfort and aid speedy recovery +

5 Bard Bardex I.C. Catheter Comprehensive Care Foley Trays RELEASING TIME TO CARE FOR PATIENTS The best just got better 19 Image shows Hospital Foley Tray with 2 litre Bed Bag All in One anti-infective Foley catheterisation kit All in One place, Only One price Encourages best practice Cost effective 15 Provides a sterile environment Reduces risk of infection - clinically proven anti-infection technology, a true closed system 23 Instant protection - for the clinician and the patient Everything you need - more time with the patient Available in Hospital and on the Drug Tariff Less waste Isn't it time you changed?

6 It s up to you to make a difference - 80% of all nosocomial UTIs are CAUTIs 1 You can make a difference Switching from standard catheters to silver alloy-coated catheters significantly reduces the risk of CAUTIs 8,18 Using the Bard Comprehensive Care Foley Tray ensures all the items you need are together in one convenient pack Adopting silver alloy catheters is a proven solution Bardex I.C. Foley Catheters with Bacti-Guard * silver alloy coating and Bard Hydrogel have a level one recommendation from the UK Department of Health 19 and are recognised by the epic guidelines 24 The efficacy of Bardex I.C. Foley Catheters is supported by a wealth of clinical evidence More than 30 studies have shown a reduction in incidence of CAUTIs with Bardex I.C. Foley Catheters 25 Ordering Information Bardex I.C. Foley Catheters Bardex I.C. Aquafil with Bacti-Guard * Silver Alloy Coating and Bard Hydrogel Foley Catheters with 10mL prefilled syringe of sterile water NHS SC Code ** NHS SC Code ** UKS FSS UKS FSS457 D236512S D236912S UKS FSS UKS FSS458 D236514S D236914S UKS FSS UKS FSS459 D236516S D236916S UKS FSS375 D236518S UKS FSS377 D236520S UKS FSS378 D236522S UKS FSS381 Bardex I.C. Foley Tray - Hospital Bardex I.C. Foley Catheter with Bacti-Guard * Silver Alloy Coating and Bard Hydrogel Collection System Preconnected to Urinemeter Preconnected to 2 Litre Bed Bag Preconnected to 500mL Leg Bag TR2365UM12 TR2365UM14 TR2365UM16 TR23652L12 TR23652L14 TR23652L16 TR23655M12 TR23655M14 TR23655M16 NHS SC Code ** FSS798 FSS799 FSS800 FSS801 FSS802 FSS803 FSS804 FSS805 FSS806 TR2369UM12 TR2369UM14 TR2369UM16 TR23692L12 TR23692L14 TR23692L16 TR23695M12 TR23695M14 TR23695M16 NHS SC Code ** FSS807 FSS808 FSS809 FSS810 FSS811 FSS813 FSS814 FSS815 FSS816 Bardex I.C. Foley Tray - Community Collection System D23655S12 D23655S14 D23655S16 D23655M12 D23655M14 D23655M16 D23655L12 D23655L14 D23655L16 D23695S12 D23695S14 D23695S16 D23695M12 D23695M14 D23695M16 D23695L12 D23695L14 D23695L16 Bardex I.C. Foley Catheter with Bacti-Guard * Silver Alloy Coating and Bard Hydrogel Preconnected to Uriplan Leg Bag D5S direct inlet Preconnected to Uriplan Leg Bag D5M 10cm inlet Preconnected to Uriplan Leg Bag D5L 30cm inlet ** Available through NHS Supply Chain and licensed for use up to 28 days For further information on the product range please call References: 1.Plowman R, et al. An economic model to assess the cost and benefits of the routine use of silver alloy coated urinary catheters to reduce the risk of urinary tract infections in catheterized patients. Journal of Hospital Infection (2001) 48: Maki DG, Tambyah PA. Engineering out the risk for infection with urinary catheters. Emerg Infect Dis 2001;7(2): Pratt RJ, Pellowe C, Loveday HP et al. The epic project: developing national evidence-based guidelines for preventing healthcare associated infections. Phase I: Guidelines for preventing hospital-acquired infections. Department of Health (England). J Hosp Infect 2001;47 Suppl:S Wagenlehner FM, Weidner W, Naber KG. Emergence of antibiotic resistance amongst hospital-acquired urinary tract infections and pharmacokinetic/pharmacodynamic considerations. J Hosp Infect 2005;60(3): Plowman R, et al. The Socioeconomic Burden of Hospital Acquired Infection. Central Public Health Laboratory and London School of Hygiene and Tropical Medicine. London, QIPPworkstreams/DH_ Trautner BW, Darouiche RO. Role of biofilm in catheter-associated urinary tract infection. Am J Infect Control 2004 May;32(3): Liedberg H. Catheter induced urethral inflammatory reaction and urinary tract infection. An experimental and clinical study. Scand J Urol Nephrol Suppl 1989;124: Liedberg H, Lundeberg T, Ekman P. Refinements in the coating of urethral catheters reduces the incidence of catheter-associated bacteriuria. An experimental and clinical study. Eur Urol 1990;17(3): Rupp ME, Fitzgerald T, Marion N et al. Effect of silver-coated urinary catheters: efficacy, cost-effectiveness, and antimicrobial resistance. Am J Infect Control 2004;32(8): Verleyen P, De Ridder D, Van Poppel H et al. Clinical application of the Bardex IC Foley catheter. Eur Urol 1999;36(3): Newton T, Still JM, Law E. A comparison of the effect of early insertion of standard latex and silver-impregnated latex foley catheters on urinary tract infections in burn patients. Infect Control Hosp Epidemiol 2002;23(4): Karchmer TB, Giannetta ET, Muto CA et al. A randomized crossover study of silver-coated urinary catheters in hospitalized patients. Arch Intern Med 2000;160(21): Bologna RA, Tu LM, Polansky M et al. Hydrogel/silver ion-coated urinary catheter reduces nosocomial urinary tract infection rates in intensive care unit patients: a multicenter study. Urology 1999;54(6): Gentry H, Cope S (2005) Using silver to reduce catheter-associated urinary tract infections. Nursing Standard. 19, 50, Date of acceptance: June Coral Seymour (2006). Audit of catheter-associated UTI using silver alloy-coated Foley Catheters. British Journal of Nursing, 2006, Vol 15, No 11. Date of acceptance: April Bard data on file. 18. Brosnahan J, Jull A, Tracy C. Types of urethral catheters for management of short-term voidi ng problems in hospitalised adults. Cochrane Database Syst Rev 2004(1):CD Health Protection Agency. Rapid Review Panel Reports: Bardex IC - silver alloy coated hydrogel catheters. Available at Schumm K, Lam TBL (2008). Types of urethral catheters for management of short-term voiding problems in hospitalised adults (Review) This is a reprint of a Cochrane review, prepared and maintained by The Cochrane Collaboration and published in The Cochrane Library 2008, Issue BARD. Data on file. 22. Ahearn DG, Grace DT, Jennings MJ et al. Effects of hydrogel/silver coatings on in vitro adhesion to catheters of bacteria associated with urinary tract infections. Curr Microbiol 2000;41(2): Madeo M, Roodhouse AJ, (2009) Reducing the risks associated with urinary catheters. Nursing Standard. 23, Pellowe C, Pratt R, Loveday H et al. The epic project: updating the evidence base for national evidence-based guidelines for preventing healthcare-associated infections in NHS hospitals in England. A report with recommendations. Br J Infect Control 2004;59(4):5,6, Clinical Data Compendium, Bard Limited. References: 25. Bard data on file. Bard Limited, Forest House, Tilgate Forest Business Park, Brighton Road, Crawley, West Sussex RH11 9BP, UK Telephone: Fax: Bard Customer Care: NURSE ADVICE LINE FREEPHONE Freephone: Fax: ukcustomercare@crbard.com Web: Please consult product labels and inserts for any indication, contraindications, hazards, warnings, cautions and directions for use. Aquafil, Bard, Bardex, Script-easy and Uriplan are trademarks and/or registered trademarks of C.R. Bard, Inc. *Bacti-Guard is a registered trademark of Bactiguard AB. The Foley Catheters included in the Bardex I.C. System contain Bacti-Guard silver alloy coating, which is licensed from Bactiguard AB C. R. BARD, Inc. All Rights Reserved 0115/2732

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