Odds of ivf transfer success with fet and 5bb blast

Transcription

1 Search Odds of ivf transfer success with fet and 5bb blast The number explains the degree of embryo expansion of the blastocyst cavity and its progress in hatching out of the zona pellucida on a scale from 1-6; as the embryo expands, the degree of expansion increases. The first letter indicates on a scale from A to C (A being the highest) the quality of the inner cell mass, which potentially becomes the cells that form the body of the embryo after implantation. I'm a big believer in single embryo transfers. Especially if this is your first cycle. Twins are a blessing but also create a high-risk pregnancy. My doctor highly discouraged transferring two but I was on the fence. Then I listened to an episode of the Beat Infertility podcast that totally convinced me to go single. It's exciting to hear the positive stories, like yours! Congratulations!!!. I did a retrieval cycle in 2015 at the age of 33 and transferred one fresh day 5 blast that resulted in my 16 month old daughter. We had two embryos to freeze. I just underwent an FET with one of those embryos. I was encouraged to do one and I felt strongly about only doing one. I'm currently 5w1d pregnant. I work in a high risk OB clinic and with what I see from those cases, I didn't want to risk a twin pregnancy. The risk of preterm birth (and babies being in the NICU), hypertension, pre-eclampsia, gestational diabetes, etc are all increased. As is the chance for a c-section. I would look at your clinic's success rates for single transfers vs. two and determine if the greater success is worth the risk of a high-risk pregnancy. Find advice, support, and good company (and some stuff just for fun). FET transferred our one remaining blast he was not high enough quality for either transfer or freeze on day 5. They decided to give it til day 6. Somehow he turned himself around and became a 6BB on day 6 and was frozen. He is now our 2 year old. Oh yeah, I was 218 years old at time of transfer with zero previous pregnancies. 12/12: 50mg clomid= bfn 1/13: 100mg clomid= bfn. We transferred a AA hatching blast on 12/22 and I am 10 weeks now. Much luck! Yup! We did a 3dt of 2 embies during our fresh cycle, and it ended in a chemical pregnancy. My RE recommended a SET based on the quality of our frozen blasts and the fact that my high NK cells were discovered after the fresh cycle. I just had my 9w ultrasound today and baby is perfect! Ivf 1 fresh cycle bfn 4AA embryo. FET 1 bfp 4AA embryo and beta stopped doubling d&c at 6.5 weeks. Here's to FET 2. Like you it was tough for us but now we are going with 2 if both thaw they are also 4AA embryos. My level was 592 at my first beta test. I think you are good. Watch for them to rise. That's what matters. Congratulations. I had no symptoms with my FET, good luck. All Databases Assembly Biocollections BioProject BioSample BioSystems Books ClinVar Clone Conserved Domains dbgap dbvar EST Gene Genome GEO DataSets GEO Profiles GSS GTR HomoloGene Identical Protein Groups MedGen MeSH NCBI Web Site NLM Catalog Nucleotide OMIM PMC PopSet Probe Protein Protein Clusters PubChem BioAssay PubChem Compound PubChem Substance PubMed SNP Sparcle SRA Structure Taxonomy ToolKit ToolKitAll ToolKitBookgh UniGene. Chin Med J (Engl) Jun 5; 131(11): So I went for my blood test today. I am 11dp6dt. My beta count was 700 and progesterone 84. Apparently that's good, but I have no idea. I'm not good with numbers and their meaning. I don't need to go for another beta test as it's high enough, so will only need to go for my scan in 2 weeks time. Last December my wife and I transferred 2 PGS tested embryos, as my doctor strongly recommended 1. We went with our

2 hearts and glad we did, only 1 took and I'm now 10 days away from my due date. I'm very happy we stuck to our decision to transfer 2, because this baby girl we're having soon, may not have been coming along if we went with the doctor's advice. We were going to transfer the boy first had we done only 1 and he didn't make it:-(! Like a pp said, not all PGS tested!embryos make it to a take home baby. I definitely say follow your heart. We were undecided for a month. So one day I decided to draw 1 & 2 from a hat every night. Two embryos won and that's what we did, lol. Best of luck to you:-)! I did my first fresh transfer at 26 and my frozen at 27. I did 2 5AA blasts for each, and had 1 baby each time. they never till me not to until this last one ( Monday) they said they're being instructed to push elective single embryo transfers, I still chose to put 2 in. they aren't pgs tested, that wasn't even that big of a thing during my original cycle. OHSS 8/13: FET #1 (x1 4AA)=First EVER BFP 4dp5dt!!. Letrozole for Ovulation Induction: How It Works, Why We Use Thanks so much! This is exactly what I needed to hear:-) My issue is PCOS, as well, and I'm still young so that's not an issue for us either, and this is also our first try with IVF/FET. GL with the rest of your pregnancy! First let's define a blastocyst. In the IVF process, after eggs are retrieved by the physician, they go to the embryology lab. There, the eggs are fertilized by the sperm and the fertilized eggs (embryos) are further cultured. The embryos divide over the next few days and have a typical appearance as they progress. Approximately 5 days after retrieval, the embryos reach what is called as the blastocyst stage. I'm trying not to read too much into my "symptoms." The dizziness was certainly unusual tho! Q from U: Is thawing and refreezing embryos harmful to the embryo?. With the advent of genetic screening of biopsied embryos, which based on the last ASRM meeting, is becoming more and more widespread in US clinics, the freezing of blastocysts is becoming routine after biopsy and results are good with thawing of these once-frozen blastocysts. Because other patients who have untested frozen blastocysts in storage will likewise wonder if they might benefit from genetic testing which in their case would require thawing for biopsy, then refreezing to save embryos pending genetic test results. So having twice-frozen twice-thawed embryos for embryo transfer will likely become more common. I haven't been able to find any studies with large numbers because we just haven't collected (or reported) the data yet beyond anecdotal reports of a small number of patients in clinics. And of course, it will take even longer to have any long-term outcome data on the health of these TEENs born from twice-frozen, twice-thawed, biopsied embryos. Thank You SO much for the prompt response! Yes, this clarifies a lot. Thanks for buying the e-book to keep this blog Ad-free!. The efficacy of the transfer of twice frozen-thawed embryos with the vitrification method. I'm dying for an update!!! Hope it took!! I've had a long fertility road myself. It took 2 years and 8 IUIs to have our sweet daughter. She's 2 now and decided it was time for another, I'm also 35. We did 4 IUIs and none of them took. It was very frustrating because it worked before. We decided so switch to IVF. I had 15 retrieved, 14 mature and fertilized. Only six made it to blast, we froze them all. Then we took a month off to give time for my body to heal. We just transfer 2 embryos 4/30. The wait is sooooo hard! I'm overanalyzing every symptom. We did a FET in late July and I was pregnant. I really had no symptoms other than tender breasts, which could also be from the progesterone. I miscarried in August at 5 weeks, 1 day. What a shitty day (it didn't help that I started bleeding on a plane). This retrospective study in a private fertility clinic looked at outcomes from 49 women who had excess embryos refrozen. These women had embryos thawed for a frozen embryo transfer cycle, some of which remained as excess embryos. The embryos remaining after the transfer were refrozen and re-thawed in a future frozen embryo transfer cycle. The pregnancy rates and implantation rates between those embryo that had undergone one freeze-thaw versus two freeze-thaw cycles were compared. Implantation rates and pregnancy rates were similar (no statistical difference) in the two groups. Vitrification was the freezing method used. This is a report on the birth of a normal, healthy baby after embryo transfer

3 using blastocysts that have been twice frozen and twice thawed. Eight frozen blastocysts were thawed for a frozen embryo transfer. One blastocyst was transferred to the uterus and four of the thawed blastocysts were refrozen. The patient became pregnant but suffered a miscarriage at 7 weeks. The four remaining blastocysts were re-thawed and all four transferred. The second transfer resulted in a healthy singleton birth at 38 weeks. Anecdotal reports such as this one can also be found in the literature:. The short answer is yes, particularly with the newer method of vitrification is used (as opposed to older slow freezing methods), embryo quality seems to be preserved after at least one round of refreezing. In my own lab in Indy, we found ourselves in the position of having to refreeze when we thawed more than we needed because we assumed fewer embryos would survive. This happened quite a bit as we transitioned from using slow freeze to vitrification because slow freeze had taught us to have very low expectations regarding embryo quality after thaw. A good thaw in the old days of slow freeze was if more than half the cells in the embryo were intact. That was pretty sad. With vitrificatiom, we saw embryos that looked the same post-thaw as they did when they were fresh. This was very exciting but we had to adjust the numbers of embryos we thawed to get just enough for transfer. We found that we also had pregnancies from twice frozen-twice thawed embryos at any stage, when we used vitrification. Google pineapple and you'll read it's good for implantation. Nonsense. The same goes for green tea, raspberry leaves, bananas, tofu and 101 other so-called implantation foods. If your uterus needed specific foods to boost implantation, your clinic would have prescribed them. How many Mongolian yams does your pharmacy keep in stock? Implantation can't happen if your endometrial lining is too thin. It's vital to check how your lining is thickening during an IVF cycle. 7 mm is the target on transfer day, but 8 mm or more is optimal. If you're having donor eggs, donor embryos or a frozen embryo cycle, you'll be on estrogen. Check your lining thickness at least 4 days before you're due to start your progesterone. This gives you time to increase your estrogen intake if needed. And avoid estrogen patches: pills work better. ASRM 2013 Update: Safety: Effect of the ART lab environment. Implantation bleeding after an IVF cycle is common. Look out for a little light spotting a pink or brown discharge in the days just after your transfer. If it's accompanied by mild cramping, things may really be going your way. Whatever happens, don't stop your meds. Do a pregnancy test on the day you should (not before) to find out. I also know that Friday's blood test is only the first hurdle. I'm going to be more nervous this time around after last time but I think our luck is about to change! Hi! I think this would make a great discussion topic. It certainly interests me. My husband and I have 7 frozen early blasts 2AA, 2AB, 2BB). In a perfect world we'd like to do a complete chromosomal screening on them to find which ones are euploid. My RE says this is possible and the embryologist would thaw, biopsy and re-vitrify them. She states the lab has had a lot if success doing this.my concern is for the damage to the embryos. How good are labs at doing this? What is the general rate of failure? For the latest fertility news, tips and updates, like us on Facebook and follow us on Twitter. After further investigation, I had a polyp and had it surgically removed in September. The reader who asked this question shared that her RE told them they have a lot of success with this. Great! Then they shouldn't mind sharing numbers. What's does a "lot of success" look like in actual data? Your uterus loves progesterone. Take the right one. Posted on October 27, 2013 at 10:23 am. The reason it's dangerous to fixate on specific foods around implantation is that they may cause more harm than good. They detract you from what you should be doing: eating a balanced diet from at least three months before your fertility treatment starts. Avoid processed foods, limit your sugar, eat good carbohydrates, add in oily fish twice a week, don't neglect proteins and pulses, take a daily multivitamin with folic acid you get the idea. 9. Have a scratch your uterus will love you. Fertil Steril Feb;91(2): doi: /j.fertnstert Epub 2008 Mar 4. Right now, the best thing to do is to relax and not worry. We're on the same

4 page right now. Just trust the professionals and be as positive as you could be. Everything happens for a reason, and I believe that when it's time to happen it will happen. Personhood bills may end clinical In Vitro Fertilization in the US. I'm 43 and had tubes tied 13 years ago but my husband and I want another baby. After 9 IVF cycles (and two recent, consecutive mid-trimester pregnancy losses), I am carefully assessing each and every step for the next cycle. So far, we have always tested (acgh) day 3 embryos, but now considering to test the blastocysts (acgh results probably more reliable with higher amount of DNA also, there's that fear of potential harm from the day 3 biopsy then the issues of mosaicism and "chaotic" cleavage stage embryos though I believe, perhaps incorrectly, that the majority of mosaic embryos would be diagnosed as abnormal on day 3 and on day 5). In any case, because we'd like to try a day 5 biopsy, I am trying to understand the potential "risks" and scenarios.. How many times have you performed this intervention (biospy and refreezing followed by an FET)?. I'm dying for an update!!! Hope it took!! I've had a long fertility road myself. It took 2 years and 8 IUIs to have our sweet daughter. She's 2 now and decided it was time for another, I'm also 35. We did 4 IUIs and none of them took. It was very frustrating because it worked before. We decided so switch to IVF. I had 15 retrieved, 14 mature and fertilized. Only six made it to blast, we froze them all. Then we took a month off to give time for my body to heal. We just transfer 2 embryos 4/30. The wait is sooooo hard! I'm overanalyzing every symptom. Thank you all for sharing your thoughts and insights. I found this post to be quite detailed and very informative, very much appreciated. Thank you. The short answer is yes, particularly with the newer method of vitrification is used (as opposed to older slow freezing methods), embryo quality seems to be preserved after at least one round of refreezing. In my own lab in Indy, we found ourselves in the position of having to refreeze when we thawed more than we needed because we assumed fewer embryos would survive. This happened quite a bit as we transitioned from using slow freeze to vitrification because slow freeze had taught us to have very low expectations regarding embryo quality after thaw. A good thaw in the old days of slow freeze was if more than half the cells in the embryo were intact. That was pretty sad. With vitrificatiom, we saw embryos that looked the same post-thaw as they did when they were fresh. This was very exciting but we had to adjust the numbers of embryos we thawed to get just enough for transfer. We found that we also had pregnancies from twice frozentwice thawed embryos at any stage, when we used vitrification. The reader who asked this question shared that her RE told them they have a lot of success with this. Great! Then they shouldn't mind sharing numbers. What's does a "lot of success" look like in actual data? Here's a much larger study that looked at the same question in 49 IVF cases. Hi! I think this would make a great discussion topic. It certainly interests me. My husband and I have 7 frozen early blasts 2AA, 2AB, 2BB). In a perfect world we'd like to do a complete chromosomal screening on them to find which ones are euploid. My RE says this is possible and the embryologist would thaw, biopsy and re-vitrify them. She states the lab has had a lot if success doing this.my concern is for the damage to the embryos. How good are labs at doing this? What is the general rate of failure? All you ladies out there, keep your chin up! Wishing us all the best!. Thanks for your comments. How did things turn out for you? Hi, So at 40 I started IVF after 2 years of trying naturally. The clinic suggested I purchase 3 rounds which sounded crazy to me. I was 40 and a half at this point but we reluctantly agreed. Well..5 cycles later we have 2 genetically viable embryos and probably 9 that made it to maturity but tested abnormally. Today I did my first transfer so fingers crossed. I guess what I have realized through this is that it might (at least it was for me) not as easy as I expected and obviously ended up costing us a lot more money but you are only 40 so if it is at all possible to do another round, better now than later. I went through 5 straight months of IVF cycles which was probably the hardest thing I have done but hopefully we will now have at least one healthy baby. Every cycle yielded such different results, you could do

5 one more and it could be your success so please don't give up hope!! I am 2 days away from being done with my 2WW it's been hard. I have all these symptoms that mimic pregnancy. But I'm taking progesterone suppositories and orally and the side effects are similar to pregnancy symptoms. It's my second round of IVF 3 day transfer. Hoping for the best! And Ironically my menstrual supposed to start today. Here's a mouse study that looks at that question:. Research says blastocysts have higher implantation rates than younger embryos. You need great embryos (and a receptive uterus) to maximise implantation after IVF. Sure, your doctor will tell you day-3 embryos can make it. But if your embryos develop into good-quality blastocysts, things may turn out better. Transfer a hatching or expanding blastocyst and implantation is even more likely. By the way, what are the typical survival rates for (normal) blastocysts frozen on day 5 and 6, respectively?. Heard the one about embryo glue? Or time-lapse cameras? Or uterine testing to predict your most fertile window for embryo transfer? They sound good, but the truth is, their effectiveness hasn't been conclusively proved in large, randomized medical trials. They claim to improve implantation rates. Until we see more research, take those claims with a pinch of salt. Trust the traditional light microscope and embryologist skill. You're better off checking the experience and credentials of your clinic's embryology team that paying through the nose for technology that hasn't been rubber-stamped yet. Hi Biliana, It's Carole. In answer to yoru questions: Even if possible; is it actually advisable to do a fresh day 6 transfer (as compared to freezing the blasts immediately after biopsy)? What I mean is if a blastocyst is "ready" to be transferred on day 5, would an additional day in the culture compromise it/its ability to implant? Is there any data/experience with this? From the "cell metabolism" point of view is it perhaps better to biopsy and freeze the blastocysts, and then transfer the normal ones in a subsequent FET?