Eva Polverino has achieved her medical degree in Naples and her specialty and PhD in Respiratory Medicine at the University of Pisa (Italy).

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1 Eva Polverino has achieved her medical degree in Naples and her specialty and PhD in Respiratory Medicine at the University of Pisa (Italy). After training in research on pathophysiology of respiratory disease she started working in the field of clinical and translational research in respiratory infections. She developed her major experience in this field as post doctoral investigator at Fundació Clinic of Barcelona. She was associated Professor of the Faculty of medicine (University of Barcelona) between 2014 and 2016 and director of 5 doctoral theses and of an end-of-course project of a medical student. Her main lines of investigation currently are: non cystic fibrosis bronchiectasis (NCFBE), cystic fibrosis (CF); immunodeficiencies and respiratory diseases; Community-acquired pneumonia (CAP) and Health-care associated pneumonia (HCAP). She is particularly active at European level as: 1. Secretary of the European Assembly of respiratory infections (Assembly 10) and member of the long range planning committee of Assembly 10 of European Respiratory Society ERS). 2. Spanish delegate for the HERMES project (Harmonising education in respiratory medicine for European specialists) in respiratory infections for ERS; 3. Co-chair of the European Registry of Bronchiectasis (EMBARC, and clinical research collaboration) of ERS. 4. Chair of the European Task force for the guidelines of Bronchiectasis (funded by ERS) 5. Co-investigator of different EU funded projects aimed at investigating new treatments, reduce antibiotic overuse and resistance occurrence control (a. iabc - Inhaled Antibiotics in Bronchiectasis and Cystic fibrosis, Innovative Medicine Initiative EU 2014 Consortium EFPIA, coleader of WP4b; b. Genomics to combact Resistance against Antibiotics in Community- Acquired LRTI in Europe ; c. Combating Bacterial Resistance in Europe ; d. An integrated platform enabling Theranostic applications at the point of primary care ); 6. Principal investigator and collaborator of numerous clinical trials in respiratory infections (new drugs for CAP, CF and NCFBE) and in respiratory physiotherapy. Responsible of the Outpatient Clinics and surveillance service of NCFBE and CAP at Hospital Clinic (Barcelona), she is now working at Hospital Vall D Hebron in the CF and NCFBE Unit and is senior investigator in respiratory infection at Vall D Hebron Instuitut de Recerca (VHIR). Member of the Panel for the development of Spanish guidelines of Bronchiectasis and of the Group of respiratory infections of the Spanish Society of Pneumology (Area TIR, SEPAR). 1

2 Editor for Springer and ERJ monograph, author of > 50 scientific publications, reviewer of >10 scientific journals, and for the Spanish Agencia Nacional de Evaluación y Prospectiva (ANEP), the candidate is expert in medical writing. Dr Polverino is a frequent speaker and moderator at scientific congresses (ERS, SEPAR, etc.) and seminars/classes regarding infections in respiratory diseases. The candidate has gained particular experience in 1) promoting and leading collaborative research across different countries and centers, 2) in scientific communication and 3) educational activities. Main publications in the field of bronchiectasis. 1: Lonni S, Chalmers JD, Goeminne PC, McDonnell MJ, Dimakou K, De Soyza A, Polverino E, Van de Kerkhove C, Rutherford R, Davison J, Rosales E, Pesci A, Restrepo MI, Torres A, Aliberti S. Etiology of Non-Cystic Fibrosis Bronchiectasis in Adults and Its Correlation to Disease Severity. Ann Am Thorac Soc Dec;12(12): doi: /AnnalsATS OC. PubMed PMID: ; 2: Wilson R, Welte T, Polverino E, De Soyza A, Greville H, O'Donnell A, Alder J, Reimnitz P, Hampel B. Ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis: a phase II randomised study. Eur Respir J May;41(5): doi: / Epub 2012 Sep 27. PubMed PMID: 3: Polverino E, Cilloniz C, Menendez R, Gabarrus A, Rosales-Mayor E, Alcaraz V, Terraneo S, Puig de la Bella Casa J, Mensa J, Ferrer M, Torres A. Microbiology and outcomes of community acquired pneumonia in non cystic-fibrosis 2

3 bronchiectasis patients. J Infect Jul;71(1): doi: /j.jinf Epub 2015 Apr 14. PubMed PMID: : Prina E, Ranzani OT, Polverino E, Cillóniz C, Ferrer M, Fernandez L, Puig de la Bellacasa J, Menéndez R, Mensa J, Torres A. Risk factors associated with potentially antibiotic-resistant pathogens in community-acquired pneumonia. Ann Am Thorac Soc Feb;12(2): doi: /AnnalsATS OC. 5: Herrero-Cortina B, Vilaró J, Martí D, Torres A, San Miguel-Pagola M, Alcaraz V, Polverino E. Short-term effects of three slow expiratory airway clearance techniques in patients with bronchiectasis: a randomised crossover trial. Physiotherapy Dec;102(4): doi: /j.physio Epub 2015 Dec 1. PubMed PMID: : Battaglia S, Torres A, Polverino E. The Importance of Phenotyping Bronchiectasis. Respiration. 2016;92(3): doi: / Epub 2016 Sep 3. PubMed PMID: : Muñoz G, Buxó M, de Gracia J, Olveira C, Martinez-Garcia MA, Giron R, Polverino E, Alvarez A, Birring SS, Vendrell M. Validation of a Spanish version of the Leicester Cough Questionnaire in non-cystic fibrosis bronchiectasis. Chron Respir Dis May;13(2): doi: / Epub 2016 Feb 8: Aliberti S, Masefield S, Polverino E, De Soyza A, Loebinger MR, Menendez R, Ringshausen FC, Vendrell M, Powell P, Chalmers JD; EMBARC Study Group. Research priorities in bronchiectasis: a consensus statement from the EMBARC Clinical 3

4 Research Collaboration. Eur Respir J Sep;48(3): doi: / Epub 2016 Jun 10. PubMed PMID: : Chalmers JD, Aliberti S, Polverino E, Vendrell M, Crichton M, Loebinger M, Dimakou K, Clifton I, van der Eerden M, Rohde G, Murris-Espin M, Masefield S, Gerada E, Shteinberg M, Ringshausen F, Haworth C, Boersma W, Rademacher J, Hill AT, Aksamit T, O'Donnell A, Morgan L, Milenkovic B, Tramma L, Neves J, Menendez R, Paggiaro P, Botnaru V, Skrgat S, Wilson R, Goeminne P, De Soyza A, Welte T, Torres A, Elborn JS, Blasi F. The EMBARC European Bronchiectasis Registry: protocol for an international observational study. ERJ Open Res Jan 20;2(1). pii: ecollection 2016 Jan. PubMed PMID: ; PubMed 10: Wilson R, Aksamit T, Aliberti S, De Soyza A, Elborn JS, Goeminne P, Hill AT, Menendez R, Polverino E. Challenges in managing Pseudomonas aeruginosa in non-cystic fibrosis bronchiectasis. Respir Med Aug;117: doi: /j.rmed Epub 2016 Jun 7. Review. PubMed PMID: : Polverino E, Rosales-Mayor E, Dale GE, Dembowsky K, Torres A. The Role of Neutrophil Elastase Inhibitors in Lung Diseases. Chest Aug;152(2): doi: /j.chest Epub 2017 Apr 23. Review. PubMed PMID: : Rosales-Mayor E, Polverino E, Raguer L, Alcaraz V, Gabarrus A, Ranzani O, Menendez R, Torres A. Comparison of two prognostic scores (BSI and FACED) in a Spanish cohort of adult patients with bronchiectasis and improvement of the FACED predictive capacity for exacerbations. PLoS One Apr 6;12(4):e doi: 4

5 /journal.pone ecollection PubMed PMID: ; 13: Polverino E, Goeminne PC, McDonnell MJ, Aliberti S, Marshall SE, Loebinger MR, Murris M, Cantón R, Torres A, Dimakou K, De Soyza A, Hill AT, Haworth CS, Vendrell M, Ringshausen FC, Subotic D, Wilson R, Vilaró J, Stallberg B, Welte T, Rohde G, Blasi F, Elborn S, Almagro M, Timothy A, Ruddy T, Tonia T, Rigau D, Chalmers JD. European Respiratory Society guidelines for the management of adult bronchiectasis. Eur Respir J Sep 9;50(3). pii: doi: / Print 2017 Sep. PubMed PMID: : Polverino E, Bothamley GH, Goletti D, Heyckendorf J, Sotgiu G, Aliberti S. The best of respiratory infections from the 2015 European Respiratory Society International Congress. ERJ Open Res Jul 11;2(3). pii: ecollection 2016 Jul. PubMed PMID: ; 15: Olveira C, Padilla A, Martínez-García MÁ, de la Rosa D, Girón RM, Vendrell M, Máiz L, Borderías L, Polverino E, Martínez-Moragón E, Rajas O, Casas F, Cordovilla R, de Gracia J. Etiology of Bronchiectasis in a Cohort of 2047 Patients. An Analysis of the Spanish Historical Bronchiectasis Registry. Arch Bronconeumol Jul;53(7): doi: /j.arbres Epub 2017 Jan 21. English, Spanish. PubMed PMID: : Chalmers JD, Crichton M, Goeminne PC, Loebinger MR, Haworth C, Almagro M, Vendrell M, De Soyza A, Dhar R, Morgan L, Blasi F, Aliberti S, Boyd J, Polverino E. The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC): experiences from a successful ERS Clinical Research Collaboration. 5

6 Breathe (Sheff) Sep;13(3): doi: / Review. 17: Girón RM, de Gracia Roldán J, Olveira C, Vendrell M, Martínez-García MÁ, de la Rosa D, Máiz L, Ancochea J, Vázquez L, Borderías L, Polverino E, Martínez-Moragón E, Rajas O, Soriano JB. Sex bias in diagnostic delay in bronchiectasis: An analysis of the Spanish Historical Registry of Bronchiectasis. Chron Respir Dis Nov;14(4): doi: / Epub 2017 Apr 10. PubMed PMID: : Hill AT, Haworth CS, Aliberti S, Barker A, Blasi F, Boersma W, Chalmers JD, De Soyza A, Dimakou K, Elborn JS, Feldman C, Flume P, Goeminne PC, Loebinger MR, Menendez R, Morgan L, Murris M, Polverino E, Quittner A, Ringshausen FC, Tino G, Torres A, Vendrell M, Welte T, Wilson R, Wong C, O'Donnell A, Aksamit T; EMBARC/BRR definitions working group. Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research. Eur Respir J Jun 8;49(6). pii: doi: / Print 2017 Jun. 19: Polverino E, Torres A. Diagnostic strategies for healthcare-associated pneumonia. Semin Respir Crit Care Med Feb;30(1): doi: /s Epub 2009 Feb 6. Review. PubMed PMID: : Martínez-García MÁ, Máiz L, Olveira C, Girón RM, de la Rosa D, Blanco M, Cantón R, Vendrell M, Polverino E, de Gracia J, Prados C. Spanish Guidelines on the Evaluation and Diagnosis of Bronchiectasis in Adults. Arch Bronconeumol Nov 8. pii: S (17) doi: /j.arbres [Epub ahead of print] English, Spanish. PubMed PMID:

7 21: Martínez-García MÁ, Máiz L, Olveira C, Girón RM, de la Rosa D, Blanco M, Cantón R, Vendrell M, Polverino E, de Gracia J, Prados C. Spanish Guidelines on Treatment of Bronchiectasis in Adults. Arch Bronconeumol Nov 8. pii: S (17) doi: /j.arbres [Epub ahead of print] English, Spanish. PubMed PMID: : Menéndez R, Méndez R, Polverino E, Rosales-Mayor E, Amara-Elori I, Reyes S, Sahuquillo-Arce JM, Fernández-Barat L, Alcaraz V, Torres A. Risk factors for multidrug-resistant pathogens in bronchiectasis exacerbations. BMC Infect Dis Sep 30;17(1):659. doi: /s PubMed PMID: ; 23: Chalmers JD, Timothy A, Polverino E, Almagro M, Ruddy T, Powell P, Boyd J. Patient participation in ERS guidelines and research projects: the EMBARC experience. Breathe (Sheff) Sep;13(3): doi: / Review. PubMed PMID: ; 24: Menéndez R, Méndez R, Polverino E, Rosales-Mayor E, Amara-Elori I, Reyes S, Posadas T, Fernández-Barat L, Torres A. Factors associated with hospitalization in bronchiectasis exacerbations: a one-year follow-up study. Respir Res Sep 30;18(1):176. doi: /s x. PubMed PMID: ; PubMed 25: Aksamit T, Bandel TJ, Criollo M, De Soyza A, Elborn JS, Operschall E, Polverino E, Roth K, Winthrop KL, Wilson R. The RESPIRE trials: Two phase III, randomized, multicentre, placebo-controlled trials of Ciprofloxacin Dry Powder for Inhalation (Ciprofloxacin DPI) in non-cystic fibrosis bronchiectasis. Contemp Clin Trials Jul;58: doi: /j.cct Epub 2017 May 8. 7

8 26: Larsson LO, Polverino E, Hoefsloot W, Codecasa LR, Diel R, Jenkins SG, Loebinger MR. Pulmonary disease by non-tuberculous mycobacteria - clinical management, unmet needs and future perspectives. Expert Rev Respir Med Dec;11(12): doi: / Epub 2017 Oct 10. 8