Memberships and Profesional Associations. Education and Training

Transcription

1 Maria José de los Santos, Msc, Ph.D. Dr. Maria J. de los Santos started her career in 1991 in the IVF laboratory of IVI Valencia. She received her PhD in Biology from University of Valencia in 1996, and from she carried out her postdoctoral fellowship in Reproductive Immunology at Fearing Research Laboratory at Harvard Medical School, under the supervision of Dr. Deborah Anderson and Dr. Joseph Hill. She also worked as clinical embryologist at the Brigham and Women s Hospital under the direction of Dr. Catherine Racowsky. As a clinical ESHRE and ASEBIR Senior Clinical Embryologist and researcher her main focus is study embryo quality, embryo development and in vitro embryo culture conditions. Currently, she is the Director of the Clinical Embryology Laboratory at IVI Valencia and designated participant from Spanish Government for the 3 rd and 4 th edition of Guide to the Quality and Safety of Tissues and Cells for Human Application of the European Council. She has published over 40 original peer review articles in leading reproductive journals (Hum Reprod, Fertil & Steril, PLos One, etc.) and wrote than 20 book chapters. She has also participated as researcher in competitive projects funded by Generalitat Valenciana (IMPIVA) and Spanish Government (CDTI). Dr. De los Santos has been involved in teaching since his early career, imparting courses since Presently she is the Coordinator of two modules (The Clinical Embryology Laboratory and Improving Embryo Quality) from the Master's Degree in Biotechnology of Assisted Human Reproduction (former doctorate degree of the Pediatrics, Obstetrics and Gynaecology Department of University of Valencia School of Medicine) given by ADEIT since Memberships and Profesional Associations 1992-present Member of Sociedad Española de Infertilidad (SEF) 1993-present Member of ASEBIR Member of ESHRE Board Member of ASEBIR President of the Interest Group in Embryo Quality of ASEBIR Deputy of the Interest Group in Embryo Quality of ASEBIR Deputy Member of Special Interest Group in Embryology ESHRE Coordinator of Special Interest Group in Embryology ESHRE 2015-present Past -Coordinator of Special Interest Group in Embryology ESHRE 2015-preset Designated participant from Spanish Government for the 3 rd and 4 th edition of Guide to the Quality and Safety of Tissues and Cells for Human Application of the European Council Education and Training B.Sc. Biology. University of Valencia, Spain (1990), Spain Master Degree Biology of Reproduction. University of Valencia, Spain (1991), Spain Ph.D (Biology) Valencia School of Medicine. University of Valencia, Spain (1996)

2 Fellowship Postdoctoral fellowship on Immunology of Reproduction at Fearing Research Laboratory. Harvard Medical School, MA, USA ( ) Grants WILLIAM F. MILTON FUNDATION 1997 Real Colegio Complutense (RCC), Harvard 1998 Honors and Recognition 1991 Sociedad Española de Infertilidad Award. Alicante. Spain American Fertility for Reproductive Medicine Award. Seattle. USA Sociedad Española de Infertilidad Oral Communication Award. Tenerife. Spain Sociedad Española de Infertilidad Oral Communication Award. Sevilla. Spain ASEBIR Best Clinical Oral Communication Award. Valencia. Spain 2013 Associate Editor of Medres Publications 1. De Los Santos MJ, Diez Juan A 2, Mifsud A, Mercader A, Meseguer M, Rubio C Pellicer A. Variables associated with mitochondrial copy number in human blastocysts: what can we learn from trophectoderm biopsies? Fertil Steril In press 2. Bellver J, De Los Santos MJ, Alama P, Castello D, Privitera L, Galliano D, Labarta E, Vidal C, Pellicer A and Dominguez F. Day-3 embryo metabolomics in the spent culture media is altered in obese women undergoing in vitro fertilization. Fertility and sterility 2015; 103: e Cobo A, Bellver J, De Los Santos MJ and Remohi J. Viral screening of spent culture media and liquid nitrogen samples of oocytes and embryos from hepatitis B, hepatitis C, and human immunodeficiency virus chronically infected women undergoing in vitro fertilization cycles. Fertility and sterility 2012; 97: Cobo A, Bosch E, Alvarez C, De Los Santos MJ, Pellicer A and Remohi J. Effect of a sharp serum oestradiol fall before HCG administration during ovarian stimulation in donors. Reproductive biomedicine online 2007; 15: Cobo A, De Los Santos MJ, Castello D, Gamiz P, Campos P and Remohi J. Outcomes of vitrified early cleavage-stage and blastocyst-stage embryos in a cryopreservation program: evaluation of 3,150 warming cycles. Fertility and sterility 2012; 98: e Cobo A, Perez S, De Los Santos MJ, Zulategui J, Domingo J and Remohi J. Effect of different cryopreservation protocols on the metaphase II spindle in human oocytes. Reproductive biomedicine online 2008; 17: Cobo A, Romero JL, Perez S, De Los Santos MJ, Meseguer M and Remohi J. Storage of human oocytes in the vapor phase of nitrogen. Fertility and sterility 2010; 94: De Los Santos MJ. Reply of the authors. Fertility and sterility 2014; 101:e De Los Santos MJ, Anderson DJ, Racowsky C, Simon C and Hill JA. Expression of interleukin-1 system genes in human gametes. Biology of reproduction 1998; 59:

3 10. De Los Santos MJ, Apter S, Coticchio G, Debrock S, Lundin K, Plancha CE, Prados F, Rienzi L, Verheyen G, Woodward B et al. Revised guidelines for good practice in IVF laboratories (2015). Hum Reprod 2016; 31: De Los Santos MJ, Gamiz P, Albert C, Galan A, Viloria T, Perez S, Romero JL and Remohi J. Reduced oxygen tension improves embryo quality but not clinical pregnancy rates: a randomized clinical study into ovum donation cycles. Fertility and sterility 2013; 100: De Los Santos MJ, Gamiz P, de Los Santos JM, Romero JL, Prados N, Alonso C, Remohi J and Dominguez F. The Metabolomic Profile of Spent Culture Media from Day-3 Human Embryos Cultured under Low Oxygen Tension. PloS one 2015; 10:e De Los Santos MJ, Garcia-Laez V, Beltran D, Labarta E, Zuzuarregui JL, Alama P, Gamiz P, Crespo J, Bosch E and Pellicer A. The follicular hormonal profile in lowresponder patients undergoing unstimulated cycles: Is it hypoandrogenic? Hum Reprod 2013; 28: De Los Santos MJ, Garcia-Laez V, Beltran-Torregrosa D, Horcajadas JA, Martinez- Conejero JA, Esteban FJ, Pellicer A and Labarta E. Hormonal and molecular characterization of follicular fluid, cumulus cells and oocytes from pre-ovulatory follicles in stimulated and unstimulated cycles. Hum Reprod 2012; 27: De Los Santos MJ, Mercader A, Frances A, Portoles E, Remohi J, Pellicer A and Simon C. Role of endometrial factors in regulating secretion of components of the immunoreactive human embryonic interleukin-1 system during embryonic development. Biology of reproduction 1996; 54: De Los Santos MJ and Ruiz A. Protocols for tracking and witnessing samples and patients in assisted reproductive technology. Fertility and sterility 2013; 100: Escriba MJ, Escobedo-Lucea C, Mercader A, De Los Santos MJ, Pellicer A and Remohi J. Ultrastructure of preimplantation genetic diagnosis-derived human blastocysts grown in a coculture system after vitrification. Fertility and sterility 2006; 86: Escriba MJ, Zulategui JF, Galan A, Mercader A, Remohi J and De Los Santos MJ Vitrification of preimplantation genetically diagnosed human blastocysts and its contribution to the cumulative ongoing pregnancy rate per cycle by using a closed device. Fertility and sterility 2008; 89: Escrich L, Grau N, De Los Santos MJ, Romero JL, Pellicer A and Escriba MJ. The dynamics of in vitro maturation of germinal vesicle oocytes. Fertility and sterility 2012; 98: Gamiz P, Rubio C, De Los Santos MJ, Mercader A, Simon C, Remohi J and Pellicer A. The effect of pronuclear morphology on early development and chromosomal abnormalities in cleavage-stage embryos. Hum Reprod 2003; 18: García Léaez V, De los Santos JM, Serra V, Pellir A, De Los Santos MJ. Expresión del complejo principal de histocompatibilidad (MHC) clase I y clase II en gametos humanos Revista Iberoamericana de Fertilidad 2008; Gil-Salom M, Minguez Y, Rubio C, De Los Santos MJ, Remohi J and Pellicer A. Efficacy of intracytoplasmic sperm injection using testicular spermatozoa. Hum Reprod 1995; 10:

4 23. Gil-Salom M, Romero J, Minguez Y, Rubio C, De Los Santos MJ, Remohi J and Pellicer A. Pregnancies after intracytoplasmic sperm injection with cryopreserved testicular spermatozoa. Hum Reprod 1996; 11: Gimeno MA MM, De los Santos JM, Pellicer A, Remohi J, De Los Santos MJ. Estudio comparativo de dos medios de cultivo HTF e ISM-1: implicaciones en el fenotipo embrionario y resultados clínicos Revista Iberoamericana de Fertilidad 2006; Gomez E, De Los Santos MJ, Ruiz A, Tarin JJ, Remohi J and Pellicer A. Effects of epidermal growth factor in the final stages of nuclear and cytoplasmic oocyte maturation in humans. Hum Reprod 1993; 8: De Los Santos MJ, Anderson DJ, Racowsky C and Hill JA. Presence of Fas-Fas ligand system and bcl-2 gene products in cells and fluids from gonadotropin-stimulated human ovaries. Biology of reproduction 2000; 63: Kovacic B, Plas C, Woodward BJ, Verheyen G, Prados FJ, Hreinsson J, De Los Santos MJ, Magli MC, Lundin K and Plancha CE. The educational and professional status of clinical embryology and clinical embryologists in Europe. Hum Reprod 2015; 30: Mendoza R, Perez S, De Los Santos MJ,Larreategui Z, Ayerdi F, Exposito A, Burgos J, Martinez Indart L, Pijoan JI and Matorras R. Congenital malformations, chromosomal abnormalities and perinatal results in IVF/ICSI newborns resulting from very poor quality embryos: a case-control study. Gynecologic and obstetric investigation 2015; 79: Meseguer M, De Los Santos MJ, Simon C, Pellicer A, Remohi J and Garrido N. Effect of sperm glutathione peroxidases 1 and 4 on embryo asymmetry and blastocyst quality in oocyte donation cycles. Fertility and sterility 2006; 86: Motato Y, De Los Santos MJ, Escriba MJ, Ruiz BA, Remohi J and Meseguer M. Morphokinetic analysis and embryonic prediction for blastocyst formation through an integrated time-lapse system. Fertility and sterility 2016; 105: e Muriel L, Garrido N, Fernandez JL, Remohi J, Pellicer A, De Los Santos MJ and Meseguer M. Value of the sperm deoxyribonucleic acid fragmentation level, as measured by the sperm chromatin dispersion test, in the outcome of in vitro fertilization and intracytoplasmic sperm injection. Fertility and sterility 2006; 85: Pellicer A, De Los Santos MJ and Remohi J. Simultaneous induction of multiple follicular development with gonadotrophins and steroid replacement for in-vitro fertilization. Hum Reprod 1992; 7: Pellicer A, Mari M, De Los Santos MJ, Simon C, Remohi J and Tarin JJ. Effects of aging on the human ovary: the secretion of immunoreactive alpha-inhibin and progesterone. Fertility and sterility 1994; 61: Pellicer A, Tarin JJ, Miro F, Sampaio M, De Los Santos MJ and Remohi J. The use of gonadotrophin releasing-hormone analogues (GnRHa), in in-vitro fertilization: some clinical and experimental investigations of a direct effect on the human ovary. Hum Reprod 1992; 7 Suppl 1: Pinero-Sagredo E, Nunes S, De Los Santos MJ, Celda B and Esteve V. NMR metabolic profile of human follicular fluid. NMR in biomedicine 2010; 23: Remohi J, Gallardo E, Levy M, Valbuena D, De Los Santos MJ, Simon C and Pellicer A. Oocyte donation in women with recurrent pregnancy loss. Hum Reprod 1996; 11:

5 37. Rubio C, Bellver J, Rodrigo L, Bosch E, Mercader A, Vidal C, De Los Santos MJ, Giles J, Labarta E, Domingo J et al. Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials. Fertility and sterility 2013; 99: Rubio C, Minguez Y, De Los Santos MJ, Ruiz A and Romero J. Intracytoplasmic sperm injection (ICSI). Frontiers in bioscience : a journal and virtual library 1997; 2:f Simon C, Gomez E, Mir A, De Los Santos MJ and Pellicer A. Glucocorticoid treatment decreases sera embryotoxicity in endometriosis patients. Fertility and sterility 1992; 58: Simon C, Gutierrez A, Vidal A, De Los Santos MJ, Tarin JJ, Remohi J and Pellicer A. Outcome of patients with endometriosis in assisted reproduction: results from invitro fertilization and oocyte donation. Hum Reprod 1994; 9: Tarin JJ, De Los Santos MJ, de Oliveira MN, Pellicer A and Bonilla-Musoles F. Ascorbate-supplemented media in short-term cultures of human embryos. Hum Reprod 1994; 9: Tejera A, Herrero J, De Los Santos MJ, Garrido N, Ramsing N and Meseguer M. Oxygen consumption is a quality marker for human oocyte competence conditioned by ovarian stimulation regimens. Fertility and sterility 2011; 96: e Wang ZC, Yunis EJ De Los Santos MJ, Xiao L, Anderson DJ and Hill JA. T helper 1-type immunity to trophoblast antigens in women with a history of recurrent pregnancy loss is associated with polymorphism of the IL1B promoter region. Genes and immunity 2002; 3:38-42.