Secondary interventions following endovascular repair of infrarenal AAA: implications of a normal initial post repair CT angiogram
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1 Secondary interventions following endovascular repair of infrarenal AAA: implications of a normal initial post repair CT angiogram Poster No.: C-2484 Congress: ECR 2015 Type: Authors: Keywords: DOI: Scientific Exhibit A. H. Shah, A. Snoddon, C. J. Hammond; Leeds/UK Vascular, Arteries / Aorta, Interventional vascular, CT- Angiography, CT, Stents /ecr2015/C-2484 Any information contained in this pdf file is automatically generated from digital material submitted to EPOS by third parties in the form of scientific presentations. References to any names, marks, products, or services of third parties or hypertext links to thirdparty sites or information are provided solely as a convenience to you and do not in any way constitute or imply ECR's endorsement, sponsorship or recommendation of the third party, information, product or service. ECR is not responsible for the content of these pages and does not make any representations regarding the content or accuracy of material in this file. As per copyright regulations, any unauthorised use of the material or parts thereof as well as commercial reproduction or multiple distribution by any traditional or electronically based reproduction/publication method ist strictly prohibited. You agree to defend, indemnify, and hold ECR harmless from and against any and all claims, damages, costs, and expenses, including attorneys' fees, arising from or related to your use of these pages. Please note: Links to movies, ppt slideshows and any other multimedia files are not available in the pdf version of presentations. Page 1 of 10
2 Aims and objectives Endovascular aneurysm repair (EVAR) is a minimally invasive alternative to open repair for patients with large abdominal aortic aneurysms (AAA). It is associated with lower 30- day mortality and morbidity, shorter hospital inpatient stay and improved time to recovery of activity when compared with open repair but is associated with novel complications and higher rates of secondary intervention[1,2] % of patients require a secondary intervention after EVAR[2-6]and while rates have fallen over time they remain significant. This necessitates prolonged surveillance which is associated with increased cost[7],patient inconvenience and the risks of repeated exposure to ionizing radiation and iodinated contrast[8,9]. In order to reduce the burden of follow up post EVAR, attempts have been made to identify patients at low risk of secondary intervention based on pre-operative aneurysm morphology. Aneurysm size, neck features (diameter, angulation, length, shape and degree of thrombus), size and number of branch vessels and iliac artery anatomy have been shown to correlate with rates of future complication[10-12],but it has been impossible to identify any particular single- or group of-preoperative aneurysm morphological characteristics that reduce the rate of secondary intervention sufficiently to obviate the need for ongoing surveillance post EVAR. We hypothesised that a normal first post-evar CTA would be predictive of reduced rates of secondaryintervention, and whether this would obviate the need for on going surveillance. Methods and materials We retrospectively reviewed the electronic records of all patients undergoing EVAR for infrarenal AAA in our institution (a large tertiary referral centre) between to inclusive. No patients were excluded. Page 2 of 10
3 Databases interrogated were the radiology Picture Archive and Communication System(Agfa PACS), the radiology information system (CRIS -Healthcare Software Solutions Ltd), an in-house bespoke electronic pathology results server and an inhouse bespoke electronic patient record system (Patient Pathway Manager [PPM]). PPM contains outpatient clinic letters, operative notes, attendance details and inpatient episode discharge summaries. Original paper notes were not accessed. Data collected were basic demographics (age at EVAR, gender),date of EVAR, indication for EVAR (elective or emergency), device type, results of follow up imaging, date and nature of any secondary intervention (surgical or endovascular) and if the patient died, the date of death. Cause of death was not recorded. Data was captured for events occurring from the date of EVAR up until (and including) End of follow up was defined as the date of the last recorded interaction of the patient with the hospital or the date of death, whichever was the earliest. This allowed for a theoretical minimum follow-up (for surviving patients) of 12 months and maximum of 82 months. Scan reports describing "normal" or "unremarkable" post EVAR appearances were classified as normal. A scan report describing endoleak (all types), graft migration, component disintegrity, strut fracture, inadvertent vessel occlusion or limb- or runoff-iliacvessel kink or stenosis was classified as abnormal. Survival and freedom from secondary intervention analyses were performed using Kaplan Meierlifetable analysis, censored for date of last interaction with the hospital or a compound of date of death or date of last interaction with the hospital respectively. Analysis was by pre-determined subgroups of the full dataset (elective or emergency indication, device type and normal or abnormal first scan). Results Demographics 256 patients (222 males) were included. Page 3 of 10
4 TheMedian age at intervention was 76years. Median follow up (of surviving patients) was 39months (range11-74 months). 203 patients were treated electively. Types of stent graft used were Medtronic Talent (106), Medtronic Endurant (112), Gore Excluder (12), Cook Zenith Flex (13), VascuTek Anaconda (8), VascuTek Anaconda fenestrated (2) and Lombard MedicalAorfix (1). Additionally 2 patients received a device designed for the thoracic aorta (Medtronic Valiant) as a tube graft in an AAA. Mortality 30-day mortality in the elective patient group was 2.4% (5 deaths) and in the emergency patient group was 21.2% (11 deaths). All cause mortality was 12.8%, 19.7% and 32.0% at 1, 2 and 5 years (elective group) and 32.7%, 34.6% and 44.2% (emergency group) respectively (figure1). Seven patients died before any post procedural imaging could be undertaken. These were all from the emergency group Rates of secondary intervention The overall rate of secondary intervention was 18.8 % (48 of 256 patients). Median interval from from EVAR to firstsecondary intervention was 233 days (range 2 to 2144 days). Secondary intervention rate was higher in the emergency patient cohort than the elective one, 31.0% (13/42) compared to 17.6% (35/198) Normal vs abnormal first follow-up CTA in elective patients The 203 elective patients were subdivided into two groups: normal first postoperative CTA and abnormal first postoperative CTA. Rates of secondary interventions were analysed (table1, figure2). Page 4 of 10
5 Secondary intervention rate in all elective patients was 17.6% at median followup of 43 months. In the cohort of patient with a normal first CTA this was substantially less at 7.6%. Elective patient with a normal first CTA: Talent vs Endurant stentgrafts 55 Endurant and 55 Talent stenetgraft patients in this cohort. In the subset of patients with a normal first CTA who received a Talent stenet graft seven patients required a secondary intervention- a rate of 12.7 % at 43 months median followup. Interestingly the subset of patients with a normal first CTA who received an Endurant stentgraft had no secondary interventions at 43 months median followup (tabe 2, figure 3). Images for this section: Page 5 of 10
6 Fig. 1: All cause mortality Kaplan Meier curve Table 1: Normal vs Abnormal first followup CTA in elective patients Fig. 2: Kaplan-Meier chart representing rates of secondary intervention in elective patients with a normal or abnormal first CTA. Page 6 of 10
7 Table 2: Elective patients with a normal first CTA: Talent vs Endurant stent grafts Fig. 3: Kaplan Meier chart of elective patients with a normal first CTA: Talent vs Endurant stentgrafts Page 7 of 10
8 Conclusion In elective EVAR patients with a normal first follow-up scan the overall rate of secondary intervention was7.6% at 43months median follow-up, compared to 17.6% in all elective patients and 16-33% in published literature [2-6]. The finding that no secondary interventions were undertaken in 55 patients undergoing elective EVAR with Endurant stentgrafts and a normal first CTA is interesting but requires further confirmation. We intend to analyse the effect of further baseline parameters such as neck anatomy and compliance with IFU, devicetpye and elective vs acute EVAR. Personal information References 1.Parodi JC P, JC, Barone HD: Transfemoral intraluminal graft implantation for abdominal aortic aneurysms. Ann Vasc Surg 5:5:. Transfemoral intraluminal graft implantation for abdominal aortic aneurysms.. Ann Vasc Surg ;5. 2. Prinssen M, Verhoeven EL, Buth J, Cuypers PW, van Sambeek MR, Balm R, et al. A randomized trial comparing conventional and endovascular repair of abdominal aortic aneurysms. The New England journal of medicine. 2004;351(16): participants Et. Endovascular aneurysm repair versus open repair in patients with abdominal aortic aneurysm (EVAR trial 1): randomised controlled trial. Lancet. 2005;365(9478): Becquemin JP, Pillet JC, Lescalie F, Sapoval M, Goueffic Y, Lermusiaux P, et al. A randomized controlled trial of endovascular aneurysm repair versus open surgery Page 8 of 10
9 for abdominal aortic aneurysms in low- to moderate-risk patients. Journal of vascular surgery. 2011;53(5): e1. 5. Lederle FA, Freischlag JA, Kyriakides TC, Padberg FT, Jr., Matsumura JS, Kohler TR, et al. Outcomes following endovascular vs open repair of abdominal aortic aneurysm: a randomized trial. JAMA : the journal of the American Medical Association. 2009;302(14): Stather PW, Sidloff D, Dattani N, Choke E, Bown MJ, Sayers RD. Systematic review and meta-analysis of the early and late outcomes of open and endovascular repair of abdominal aortic aneurysm. The British journal of surgery. 2013;100(7): EpsteinDM et al. Modelling the long-term cost-effectiveness of endovascular or open repair for abdominal aortic aneurysm. Br J Surg 2008; 95: Alsac JM, Zarins CK, Heikkinen MA, Karwowski J, Arko FR, Desgranges P, et al. The impact of aortic endografts on renal function. Journal of vascular surgery. 2005;41(6): Brenner DJ, Doll R, Goodhead DT, Hall EJ, Land CE, Little JB, et al. Cancer risks attributable to low doses of ionizing radiation: assessing what we really know. Proceedings of the National Academy of Sciences of the United States of America. 2003;100(24): Du Toit DF, Saaiman JA, Labuschagne BC, Vorster W, Van Beek FJ, Boden BH, et al. EVAR: critical applied aortic morphology relevant to type-ii endoleaks following device enhancement in patients with abdominal aortic aneurysms. Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners. 2004;15(4): Wisniowski B, Barnes M, Jenkins J, Boyne N, Kruger A, Walker PJ. Predictors of outcome after elective endovascular abdominal aortic aneurysm repair and external validation of a risk prediction model. Journal of vascular surgery. 2011;54(3): Karthikesalingam A, Holt PJ, Vidal-Diez A, Choke EC, Patterson BO, Thompson LJ, et al. Predicting aortic complications after endovascular aneurysm repair. The British journal of surgery. 2013;100(10): Page 9 of 10
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