Health & Exercise Sciences Research Group. Kevin Tipton Feb NIHR Age and Ageing Specialty Group in Scotland

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1 Using research networks to develop and build capacity for research into musculoskeletal ageing Research focus on exercise, protein nutri8on, metabolism and muscle Muscle mass is cri8cal for health and performance Strength and power Insulin sensi8vity Energy expenditure Muscle is lost with age and illness Dietary protein is important for maintenance and growth of muscle Other nutrients? Kevin Tipton, PhD Professor of Sport, Health and Exercise Sciences University of Stirling Post-doctoral Training in Texas Metabolism Unit Shriner s Burns Hospital and University of Texas Medical Branch Research on Muscle Protein Metabolism in Humans Metabolism Unit - Shriner s Burns Hospital University of Texas Medical Branch 1

2 Research on Muscle Protein Metabolism in Humans Ageing related research at UTMB Univ of Birmingham ( ) University of S8rling (2010- ) 2

3 Health and Exercise Sciences Research in the Health and Exercise Sciences Spanning the health spectrum and across the lifespan ATHLETE PERFORMANCE HEALTHY LIFESTLYES TREATMENT / PREVENTION OF DISEASE Research in the Health and Exercise Sciences World Class Research Facili8es Basic Science Sports Science Muscle Molecular Biology and Metabolism Athle8c performance and strength 3

4 HESRG Staff Research Interests HESRG Staff Research Interests Dr. Stuart Galloway Nutri8on, physical ac8vity and maintenance of func8on Dr. Angus Hunter Exercise, neuromuscular control in exercise, disuse and disease states Dr. Colin Moran Gene8cs, epigene8cs in predisposi8on to disease and response to exercise Dr. Oliver Witard Nutri8on, muscle metabolism, maintenance of muscle mass, sarcopenic obesity Dr. Naomi Brooks Satellite cells (muscle stem cells) and molecular pathways in preven8ng/allevia8ng skeletal muscle disuse atrophy and sarcopenia. Applica8on of exercise and nutri8onal interven8ons, par8cularly in the community. Dr. Lee Hamilton Molecular mechanisms of disease and adapta8ons to training Dr. Iain Gallagher High- throughput genomics, proteomics and bioinforma8cs to study both pathology and normal physiology Dr. Ian Walshe Exercise, stress and inflammatory processes in health and disease, Omega- 3 Fa_y Acids reported health benefits Cardioprotec8ve Decrease blood triglycerides Increase HDL cholesterol levels Reduce hypertension Immunoprotec8ve An8inflammatory Reduce insulin resistance Mental disorders Others? Muscle? Nutri8on Research in the Health and Exercise Sciences Protein Metabolic basis for changes in muscle mass High protein intake during weight loss spares muscle mass Omega- 3 fa_y acids Muscle Immune func8on Insulin resistance Carbohydrate Exercise performance Neuromuscular func8on Molecular and metabolic mechanisms of diet- induced insulin resistance Gene8c and epigene8c influence of nutrients on health and performance 4

5 Dietary omega- 3 FA augment the anabolic response to feeding Increased n- 3 FA content of muscle w fish oil supplementa8on is associated w increased anabolic signalling proteins FSR! (%/h) Young Older Muscle Protein Synthesis FSR! (%/h) 0.12 ability of muscle to respond to nutrients? Muscle Protein Synthesis How does omega-3 FA supplementation enhance the n-3 PUFA c b a,b a Week T-FAK:! tubulin (AU) a Week 0 0 Before n-3 FA After n-3 FA Before n-3 FA After n-3 FA Smith et al. 2010, 2011 Mcglory et al. in prep Will omega-3 FAs augment the anabolic response to exercise? Basal Biopsy* Resistance Exercise 30g protein Post Biopsy (both legs) 2 groups of trained weightlifters 8 weeks of fish oil supplementation Infusion of metabolic tracers Blood samples h Biopsy (both legs) Special Thanks to All Collaborators and Coauthors McMaster Univ Professor Stuart Phillips Dr. Dan Moore Dr. Marty Gibala Australian Institute of Sport Professor Louise Burke Dr. Gary Slater Univ Arkansas Med School Professor Arny Ferrando Professor Robert Wolfe Univ California - Davis Dr. Keith Baar Dr. Andy Philp KU Leuven Professor Peter Hespel Maastricht Univ Professor Luc van Loon Dr. Rene Koopman Univ of Connecticut Dr. Nancy Rodriguez Dr. Matt Pikosky Univ Nottingham Professor Mike Rennie Dr. Phil Atherton Univ Auckland Dr. Johan Edge Univ Copenhagen Professor Bente Kiens ETH Zurich Dr. Sam Mettler Dr. Paolo Colombani k.d.tipton@stir.ac.uk Royal Melbourne Inst Techn Univ Professor John Hawley Dr. Vernon Coffey Univ of Warwick Mr. Matt Costa Dr. Juul Achten EIS/British Cycling Nigel Mitchell Univ Birmingham Prof Asker Jeukendrup Prof Anton Wagenmakers Dr. Olly Witard Dr. Chris Shaw Ms. Sarah Jackman Dr. Leigh Breen 5