MEMBRANE-BOUND ELECTRON TRANSFER AND ATP SYNTHESIS (taken from Chapter 18 of Stryer)
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1 MEMBRANE-BOUND ELECTRON TRANSFER AND ATP SYNTHESIS (taken from Chapter 18 of Stryer)
2 FREE ENERGY MOST USEFUL THERMODYNAMIC CONCEPT IN BIOCHEMISTRY Living things require an input of free energy for 3 major purposes 1. Mechanical Muscle contraction and other cellular movement 2. Active transport of molecules and ions 3. Synthesis of macromolecules and other biomolecules from simple precursors
3 First law of thermodynamics Energy can be neither created nor destroyed But, it can be converted from one form into another
4 Free energy for these processes comes from the environment Phototrophs - obtained by trapping light energy Chemotrophs energy by oxidation of foodstuffs Free energy donor for most energy requiring processes is Adenosine triphosphate (ATP)
5 ATP Large amounts of free energy is liberated when ATP is hydrolysed to ADP + Pi or AMP + PPi ATP is continuously formed and consumed Phototrophs harness the free energy in light to generate ATP - Photosynthesis Chemotrophs form ATP by oxidation of fuel molecules Oxidative phosphorylation
6 OXIDATIVE PHOSPHORYLATION Glucose is converted to pyruvate And under aerobic conditions undergoes oxidative decarboxylation to form AcCoA which is then oxidised to CO 2 by the citric acid cycle
7 Stages of Catabolism
8 Activated Carriers Citric Acid Cycle Glycolysis
9 Activated Carriers These pathways along with fatty acid oxidation produce energy rich molecules NADH and FADH 2 as well as small amounts of ATP Chemotrophs derive energy from oxidation of fuel molecules and in aerobic organisms the ultimate electron acceptor is O 2 Electron is not transferred directly Electron is transferred through special carriers, Pyridine nucleotides Electron acceptor NAD + Electron donor NADH FAD FADH 2
10 Electron transfer and oxidative phosphorylation Respiratory electron transfer is the transfer of electrons from the NADH and FADH 2 (formed in glycolysis, fatty acid oxidation and the citric acid cycle) to molecular oxygen, releasing energy. Oxidative phosphorylation is the synthesis of ATP from ADP and P i using this energy. Both processes are located on the IMM
11 Mitochondrion
12 Mitochondrion Outer membrane Permeable (12000da) Porin 30-35kd pore forming protein Inner membrane Impermeable all ions and polar molecules Possess family of transporter molecules (for ATP/ADP, P i, pyruvate, citrate, etc.). Matrix side (N-negative), cytosolic side (Ppostive)
13 Mitochondria are the result of an Endosymbiotic event Organelles contain their own DNA which encode 13 respiratory chain proteins Many proteins encoded by cell nuclear DNA Cells depend on organelle for oxidative phosphorylation, mitochondrion depend on cell for their very existence Suggested that all extant mitochondria are derived from bacterial Rickettsia prowazekii
14 Oxidative phosphorylation Oxidative phosphorylation is conceptually simple and mechanistically complex. Flow of electrons from NADH and FADH 2 to O 2 occurs via protein complexes located in the IMM Leads to the pumping of protons from the matrix to the cytosol across the IMM. ATP is synthesised when protons flow back into the matrix via a protein complex in the IMM.
15 An example of energy coupling via an electrochemical gradient across a membrane.
16 REDOX POTENTIAL AND FREE ENERGY CHANGES The energy stored in ATP is expressed as the phosphoryl transfer potential which is given by G o for hydrolysis of ATP (-7.3kcal/mol) The electron transfer potential of NADH is represented as E o the redox potential ( or reduction potential or oxidationreduction potential) which is an electrochemical concept. Redox potential is measured relative to the H + : H 2 couple which has a defined redox potential of 0V (Volts).
17 Redox couples X - + H + X H 2 X - X + e - H + + e H 2
18 Redox potential A negative redox potential means that a substance has a lower affinity for electrons than H 2. A positive redox potential means a substance has a higher affinity for electrons than H 2. NAD + / NADH at -0.32V is a strong reducing agent and poised to donate electrons 1/2 O 2 / H 2 O at +0.82V is a strong oxidising reagent and poised to accept electrons. 1/2 O 2 + NADH + H + H 2 O + NAD + The difference ( E o = 1.14V) is equivalent to kcal/mole.
19
20 Electrons can be transferrred between groups that are not in contact Distance between electron carrying groups
21 THE RESPIRATORY ELECTRON TRANSFER CHAIN CONSISTS OF THREE PROTON PUMPS LINKED BY TWO MOBILE ELECTRON CARRIERS I Electrons are transferred from NADH to O 2 by a chain of three large transmembrane respiratory chain protein complexes III IV II
22 These are a) Complex I also known as NADH-Ubiquinone (UQ) oxidoreductase NADH-Q reductase b) Complex III also known as Ubiquinol (UQH 2 )-Cytochrome c oxidoreductase Cytochrome reductase c) Complex IV also known as Cytochrome c- Oxygen oxidoreductase Cytochrome oxidase
23 Q- coenzyme Q or ubiquinone
24 NADH-Q Oxidoreductase x 2e -
25 NADH-Q reductase NADH transfer of e - to flavin mononucleotide to produce FMNH 2 e - from FMNH 2 transferred to iron sulfur clusters e - from iron sulfur (Fe-S) clusters shuttle to coenzyme Q (ubiquinone) Results in pumping of 4 H + out of matrix NADH + Q + 5H + matrix NAD + +QH2 + 4H + cytosol
26 Succinate Q reductase FADH 2 already part of complex, transfers electrons to Fe-S centres and then to Q This transfer does not result in transport of protons
27 Q-cytochrome c Oxidoreductase
28 Q-cytochrome c Oxidoreductase Transfers e - from QH 2 (2 e - ) cytochrome c (1 e - ) via heme Mechanism known as Q cycle QH 2 + 2Cyt c ox + 2H + matrix Q +2Cyt c red + 4H + cytosol
29
30 Cytochrome c Oxidase
31 Cytochrome c Oxidase
32 Proton transport by cytochrome c oxidase
33
34 Electrons are carried from Complex I to Complex III by UQH 2, the hydrophobic quinol (reduced quinone) diffuses rapidly within the IMM. Electrons are carried from Complex III to Complex IV by cytochrome c, a small hydrophilic peripheral membrane protein located on the cytosolic or P side of the IMM. Complex II (Succinate-UQ oxidoreductase) is membrane bound and contains the FADH 2 as a prosthetic group. So electrons from FADH 2 feed in to UQH 2. These respiratory chain complexes contain redox groups to carry the electrons being transferred through them. These are flavins, iron-sulfur clusters, haems and copper ions.
35 PROTON PUMPS AND THE ATP SYNTHASE The free energy change of the reactions catalysed by Complexes I, III and IV is large enough for them to pump protons from the matrix or N side of the IMM to the cytosolic or P side of the IMM. There is not enough energy released in Complex II, so no proton pumping occurs in this complex.
36 OXIDATION AND PHOSPHORYLATION ARE COUPLED BY A PROTON- MOTIVE FORCE This is the chemiosmotic hypothesis put forward by Peter Mitchell in Transfer of electrons from NADH (or FADH 2 ) to oxygen leads to the pumping of protons to the cytosolic side of the IMM. The H + concentration (ph) becomes higher (lower ph) on the cytosolic side, and an electrical potential (membrane potential) with the cytosolic side of the IMM positive is generated
37
38 So a proton-motive force ( p) is generated which consists of both a ph and a. Mitchell proposed that this proton-motive force drives the synthesis of ATP by another transmembrane protein complex, as the protons return back across the IMM through this protein complex. This protein complex is called the ATPase (because like any enzyme it is reversible and was first discovered by it s ability to hydrolyse ATP) It s preferred name is the ATP synthase.
39 ATPase
40
41
42 It is now thought that the proton-motive force induces a conformational change in the ATP synthase, which allows the release of tightly bound ATP (the product) from the enzyme, and thus catalyses ATP synthesis. So this is an example of energy coupling via an activated protein conformation.
43 C-ring
44
45 10 subunits Rotates 360º Requires 3 protons per molecule of ATP formed
46
47 THE COMPLETE OXIDATION OF GLUCOSE YIELDS ABOUT 30 ATP
48 Net Yield per glucose Glycolysis 2 ATP Citric Acid cycle 2 ATP (GTP) Oxidative phosphorylation ~26 ATP Most of the ATP is generated by oxidative phosphorylation
49 POWER TRANSMISSION BY PROTON GRADIENTS: A CENTRAL MOTIF OF BIOENERGETICS Proton gradients power a variety of energyrequiring processes i.e.
50 IT IS EVIDENT THAT PROTON GRADIENTS ARE A CENTRAL INTERCONVERTIBLE CURRENCY OF FREE ENERGY IN BIOLOGICAL SYSTEMS. THE RATE OF OXIDATIVE PHOSPHORYLATION IS DETERMINED BY THE NEED FOR ATP Under most physiologic conditions, electron transfer is tightly coupled to phosphorylation. Electrons do not usually flow through the electron transfer chain unless ADP is simultaneously phosphorylated to ATP. Oxidative phosphorylation and thus electron transfer require a supply of NADH O 2 ADP and P i
51 Regulation The most important factor controlling the rate of oxidative phosphorylation is the level of ADP Regulated by the energy charge. This regulation of the rate of oxidative phosphorylation by the ADP level is called respiratory control.
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