La Dieta Mediterrània en la DM2. L estudi Predimed
|
|
- Aubrey Lane
- 5 years ago
- Views:
Transcription
1 Dr. María-Isabel Covas Cardiovascular Risk and Nutrition Research Group The REGICOR Study Group IMIM Hospital del Mar Research Institut Barcelona Spain CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN) V JORNADES D ACTUALITZACIÓ EN DIABETIS GEDAPS DE LA CAMFIC Barcelona, 28 de Maig del 2013 La Dieta Mediterrània en la DM2. L estudi Predimed (Primary Prevention of Cardiovascular Disease by the Mediterranean Diet)
2 Cardiovascular disease is the main cause of death at the onset of the I Century AMI Stroke AOLLEE Aortic aneurysm
3 BEST WEAPONS AGAINST CARDIOVASCULAR DISEASE: DIET AND EERCISE
4 high intake Traditional Mediterranean Diet
5 moderate and low intake Traditional Mediterranean Diet
6 Mediterranean Food Pattern Rapidly increasing evidence Increased Longevity Prevention of CV mortality Cancer mortality CVD incidence Metabolic syndrome Diabetes Dementia Depression Scarcity of large randomized trials
7 Mediterranean Diet, Risk Factors and Cardiovascular Events after a Heart Attack: Report of the Lyon Diet Heart Study Design Randomized clinical trial on the effects of a Mediterranean-style Diet in a sample of 605 patients who had had a myocardial infarction. Intervention Groups Mediterranean Diet supplemented with margarine enriched with a-linolenic acid (n= 303) Step I Diet of the American Association of Cardiology (n= 302) Follow-up 46 months (Circulation, 1999; 99: )
8 The Effect of the Mediterranean Diet on the Primary Prevention of Cardiovascular Disease.The PREDIMED Study Hospital de Álava de Vitoria Univ Pais Vasco Facultad de Medicina de Navarra Facultad de Medicina de Reus I.C.S.-División Primaria IMIM IDIBAPS-Hospital Clínic Univ.de Barcelona Hospital de Bellvitge Facultad de Medicina de Valencia Hospital Son Espases Univ. Illes Balears Centro de Salud San Pablo Instituto de la Grasa Sevilla Facultad de Medicina de Málaga 19 Research Groups of 7 Spanish Regions 10 Recruitment Centers Universidad de las Palmas de Gran Canaria
9 PREDIMED TRIAL: DESIGN Men: yr Women: yr High CV risk without CVD type 2 diabetics 3+ risk factors Random 1. Smoking 2. Hypertension 3. LDL 4. HDL 5. Overweight/obese 6. Family history CHD
10 PREDIMED Participants Mediet + VOO (n= 2543) MeDiet + Nuts (n=2454) Control (n=2450) Age (SD) 67 (6) 67 (6) 67 (6) Women (%) Diabetes (%) Hypertension (%) Current smokers (%) Dyslipidemia (%) BMI, kg/m 2 (SD) 30 (4) 30 (4) 30 (4) Waist circumf. (SD) 100 (10) 100 (10) 101 (11) Med Diet 0-14 pts. (SD) 8.7 (2) 8.7 (2) 8.3 (2)
11
12
13 PREDIMED INTERVENTION Strategies for behavior change Repeated personal contacts: every 3-mo. Group sessions: every 3-mo. Holistic approach Written information Self-monitoring Individualized goal-setting Quick feedback Individual motivational interviews (every 3-mo.) adapted to the patient s features clinical condition preferences beliefs expressed in servings/d to improve understanding
14 PREDIMED INTERVENTION Strategies for behavior change Additional strategies Seasonal buying lists Menus and recipes Only in the 2 MeDiet groups Provision of key food items for free Control Group: Small gifts non-related with food
15 Results-Adherence to Mediterranean Diet MeDiet (both groups)* Control
16 Adherence to MedDiet plus Virgin Olive Oil intervention
17 Adherence to the MedDiet plus nuts Intervention
18 Odds ratios (ORs) and 95% confidence intervals (CIs) of 1-year reversion among MetS participants and incidence among participants who did not have MetS at baseline (bottom) in the PREDIMED Study (n = 1224) Metabolic syndrome regression Metabolic syndrome development Odds ratio (95% confidence interval) Control group MedDiet + VOO MedDiet + Nuts Salas-Salvadó et al. Arch Int Med, 2008
19 Evidence pro the Mediterranean type Diet Effect of a Mediterranean-Style Diet, on Endothelial Dysfunction, Vascular Inflammation in the metabolic Syndrome. Esposito K, Marfella R, Ciotola M, et al. JAMA 2004;292: Italians with Metabolic Syndrome. 2 years-intervention study. Components Intervention (MedDiet) 2 years Change Control 2 years Change P between of Met S% groups After 2 years,in the intervention group (n=82),only 40 could be 3 31 (34) (66) -17 <0.001 classified as Met S. In control group (n=82), 78 patients 4 10 (11) (13) -4 remained as Met S 5 1(1) -7 7 (8) -1
20 Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet Salas-Salvadó J et al. Dia Care 2011;34:14-19 Cumulative diabetes free-survival by group of intervention (n =418 non-diabetic participants) MedDiet+ VOO MedDiet+Nuts MedDiet + VOO =0.49 ( ) MedDiet + Nuts = 0.48 ( ) Low fat diet Adjusted by sex, age, baseline energy intake, BMI, waist circumference, physical activity, smoking status, fasting serum glucose, use of lipid-lowering drugs, MedDiet Score, and weight change during the study Copyright 2011 American Diabetes Association, Inc.
21 Evidence pro the Mediterranean type Diet Effects of a Mediterranean-style diet on the need for antihyperglycemic drug therapy in patients with newly diagnosed type 2 diabetes: a randomized trial. Esposito K, et al. Ann Int Med overweight people with newly diagnosed type 2 diabetes who were never treated with antihyperglycemic drugs.4years-intervention study. After 4 years, 44% of patients in the Mediterranean-style diet group and 70% in the low-fat diet group required treatment
22 PREDIMED Steering Committee R. Estruch (chair); D. Corella; M.I. Covas; M.A. Martínez-Gonzalez; E. Ros;J. Salas-Salvadó Projected follow-up = 6 years (median) PREDIMED Independent Data and Safety Monitoring Board avier Pi-Sunyer (chair). Columbia University. USA Carlos A. González. Institut Catalá d Oncologia (ICO), Spain Frank B. Hu. Harvard University, USA Joan Sabaté. Loma Recruitm. Linda University, CA, USA Year % 1 of yr Cum. % recruitment yr yr yr yr yr Interim Analyses with Data until Dec 2010 Total 100
23 Median Follow-up: 4.8 (2.8 to 5.8) Participants: 7447 Intention-to-treat-analyses
24 PRIMARY END-POINT Composite of: Cardiovascular death Non-fatal myocardial infarction Non-fatal stroke SECONDARY END-POINTS Cardiovascular death Non-fatal myocardial infarction Non-fatal stroke Death from any cause Angina leading to revascularization procedure Heart failure
25 Incidence of the Composite Kaplan-Meier Estimates of the Incidence of the Primary End-point Events
26 The PREDIMED Study. Subgroup analyses
27 The PREDIMED Study. Subgroup analyses
28 Mechanisms by which the Mediterranean Diet could exert protective effects
29 Changes in fasting glucose, insulin, and HOMA index after 3- months (n =305 non dibetic participants). The PREDIMED Study * * * * * * Glucose, mg/dl Insulin, pmol/l Homa index (x10) * P < 0.05 versus control -35 TMD+VOO TMD+Nuts Control TMD, traditional Mediterranean Diet; VOO, virgin olive oil Estruch R et al. Ann Int Med 2006
30 Changes in Glucose and Lipid Profile after 3-months (n =772).The PREDIMED Study TMD+VOO TMD+ Nuts Low-fat Glucose Cholesterol 127±44 220±39 121±42 215±37 126±38 213±39 122±38 209±37 133±49 219±40 137±48 221±42 Triglycerides 137±62 133±66 139±63 132±63 147±70 151±80 HDL - cholesterol 44±9 47±10 45±10 46±11 47±10 47±11 LDL - cholesterol 147±35 141±36 140±35 136±33 144±34 145±34 LDL / HDL TMD, traditional Mediterranean Diet; VOO, virgin olive oil p<0.05 Estruch R et al. Ann Int Med, 2006
31 Change % de (%) Cambio Changes in Blood Pressure at 3-month Interventions, (mmhg, N =772). The PREDIMED Study * * * * SBP DBP -5-6 MD+ VOO MD + Nuts Low Fat Estruch R et al. Ann Int Med, 2006 * P < 0.01, 3 mo vs baseline P < 0.001, versus low-fat changes
32 Fitó for the PREDIMED group. Arch Inter Med 2007;167: n = 372 Mediet+VOO=123 Mediet+nuts=128 control=121
33 Changes from baseline in plasma inflammatory biomarkers. The PREDIMED Study (n =772) Changes in ICAM-1 (ng/ml) Changes in CRP (mg/l) Changes in IL-6 (pg/ml) Changes in VCAM-1 (ng/ml) ** MedDiet + VOO MedD + nuts Low fat diet ** * ** ** * ** ** * Estruch et al. Ann Int Med, 2006.
34 Limitations The protocol for the control group was changed halfway through the trial (October 2006). A lower intensity of dietary intervention for the control group during the first few years might have caused a bias toward a benefit in the Mediet groups, since the participants in these groups received a more intensive intervention during that time. However, we found no significant interaction between the period of trial enrollment (before vs. after the protocol change) and the benefit in the Mediet groups.
35 Limitations The generalizability of our findings is limited because all the study participants lived in a Mediterranean country and were at high cardiovascular risk. Whether the results can be generalized to persons at lower risk or to other settings requires further research.
36 Conclusions 1. Among individuals at cardiovascular risk, a traditional Mediterranean diet supplemented with Extra Virgin Olive Oil or with Nuts promoted: 1.1 A 52% reduction of diabetes incidence at a median follow-up of 4 years 1.2 A 30% reduction in the incidence of major cardiovascular events at a median follow-up of 4.8 years
37 Conclusions 2. Results of the PREDIMED Study provide first level evidence on the benefits of the traditional Mediterranean diet on the primary prevention of diabetes and cardiovascular disease.
38 Primary Prevention by the Mediterranean Diet The PREDIMED Study Hospital de Álava de Vitoria Univ Pais Vasco Facultad de Medicina de Navarra Facultad de Medicina de Reus Facultad de Medicina de Valencia I.C.S.-División Primaria IDIBAPS-Hospital Clínic IMIM Univ.de Barcelona Hospital de Bellvitge We thank the participants in the trial for their enthusiastic and sustained collaboration and Joan Vila from Institut Municipal d Investigació Mèdica, Barcelona, for expert Hospital Son Espases Univ. Illes Balears assessment in the statistical analyses. Centro de Salud San Pablo Instituto de la Grasa Sevilla Facultad de Medicina de Málaga Universidad de las Palmas de Gran Canaria
39 ACKNOWLEDGEMENTS Centro de Investigación Biomédica En Red Fisiopatología de la Obesidad y Nutrición Centro de Investigaciones Biomédicas en Red Physiopathology of Obesity and Nutrition. CIBERobn CB06/03 is an initiative of the Instituto de Salud Carlos III. Ministry of Science and Innovation Spanish Network G03/140 AGL ; AGL C03-02/01 AGL C02-01; RETICS RD06/0045/0003 Programa INGENIO CONSOLIDER 2010, FUN-C- FOOD (CSD )
40 THANK YOU FOR YOUR ATTENTION
41 Encuesta de 14 puntos
42
43 Forest plot of the association between a 2-point increase of adherence score to the Mediterranean diet and the risk of all-cause mortality by American Society for Nutrition Sofi F et al. Am J Clin Nutr 2010;92:
44 Forest plot of the association between a 2-point increase of adherence score to the Mediterranean diet and the risk of all-cause mortality by American Society for Nutrition Sofi F et al. Am J Clin Nutr 2010;92:
45 Encuesta de 14 puntos
46 Stratified by recruiting Center and adjusted by age, sex, family history of CHD, smoking, BMI, Waist-to height, and hypertension, dyslipidemia and diabetes at baseline Stratified by recruiting Center and adjusted by age, sex, family history of CHD, and smoking Additionally adjusted by BMI, Waist-to height, and hypertension, dyslipidemia and diabetes at baseline
47 Kaplan-Meier Estimates of the Incidence of Total Mortality MeDiet+EVOO MedDiet+Nuts Low-Fat No. of events: Crude rate/1000 person-yr (95% CI): 10.0 ( ) 11.2 ( ) 11.7 ( )
48 DBP, mmhg SBP, mmhg Systolic and diastolic blood pressure (mean ± s.e.) according to tertiles of in vivo circulating oxidized low density lipoproteins (oxldl) in the PREDIMED population (N=1130) P = for linear trend * Low Medium High P = for linear trend Low Medium High Tertiles of oxldl *P value < 0.01, P value < 0.01 and P value < 0.01 vs. low tertile. Guxens M, et al. Am J Hypertens 2009
49 Metabolic syndrome and Diabetes are associated with elevated circulating oxidized LDL - Metabolic Syndrome + Oxidized LDL Abdominal Obesity Impaired glucose homeostasis Inflammation - Mediterranean Diet Hypertriglyceridemia + Low HDL cholesterol High Blood Pressure - Holvoet P et al. Futur Lipidol, 2008
50 Measurements Eligilibilty questionnaire General questionnaire Follow-up questionnaire Food Freq. questionnaire 14 item score of Med diet Physical activity ques. EKG, BP, and Anthropometric Blood samples Fresh urine sample Toenail sample * Specific measurements Intervention compliance assessment * * Years Urinary tyrosol and hydroxytyrosol Plasma fatty acid composition (oleic and -linolenic acids)
New evidences of the effects of the Mediterranean diet in the prevention of cardiovascular disease
THE PREDIMED STUDY New evidences of the effects of the Mediterranean diet in the prevention of cardiovascular disease Dr. María Isabel Covas Cardiovascular Risk and Nutrition Research Group The REGICOR
More informationThe Mediterranean Diet: The Optimal Diet for Cardiovascular Health
The Mediterranean Diet: The Optimal Diet for Cardiovascular Health Vasanti Malik, ScD Research Scientist Department of Nutrition Harvard School of Public Health Cardiovascular Disease Prevention International
More informationOverview. The Mediterranean Diet: The Optimal Diet for Cardiovascular Health. No conflicts of interest or disclosures
The Mediterranean Diet: The Optimal Diet for Cardiovascular Health No conflicts of interest or disclosures Vasanti Malik, ScD Research Scientist Department of Nutrition Harvard School of Public Health
More informationMA Martínez-González.
MA Martínez-González Coordinador RD 06/0045 PREDIMED (Alimentación saludable en la prevención primaria de enfermedades crónicas) www.unav.es/preventiva Estrategia Estructura organizativa Trabajo en red
More informationEffects of polyphenol intake on cardiovascular risk markers
Effects of polyphenol intake on cardiovascular risk markers OMICS: Advances, Applications and Translation in Nutrition and Epidemiology Boston, May 30, 2017 Rosa M. Lamuela-Raventós Departament of Nutrition,
More informationINC International Nut & Dried Fruit Council Symposium Nuts in Health and Disease. Granada, 19 th September 2013 Press Kit
INC International Nut & Dried Fruit Council Symposium Nuts in Health and Disease Granada, 19 th September 2013 Press Kit Index Introduction Keynote Speakers Conference Abstract Useful Information The International
More informationDietary fat intake and risk of cardiovascular disease and all-cause mortality in a population at high risk of cardiovascular disease 1
Dietary fat intake and risk of cardiovascular disease and all-cause mortality in a population at high risk of cardiovascular disease 1 Marta Guasch-Ferré, 2,3 Nancy Babio, 2,3 Miguel A Martínez-González,
More informationInterestinhowmicroRNAscanbeusedinthepreventionand treatment of cardiovascular disease (CVD) 4 has increased over
MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial 1 3 Dolores Corella, Jose V Sorlí, Ramon
More informationAssociation between arterial stiffness and cardiovascular risk factors in a pediatric population
+ Association between arterial stiffness and cardiovascular risk factors in a pediatric population Maria Perticone Department of Experimental and Clinical Medicine University Magna Graecia of Catanzaro
More informationAuthor, year Study Location Outcome(s) Exposure n Follow-up Results/observations. MedDiet rich in alpha-linolenic diet vs usual post-infarct prudent
SUPPLEMENTAL MATERIAL Table 3. Main prospective observational studies and randomized controlled trials published until May 2017, assessing the effects of the Mediterranean diet on from or incidence of
More informationPredictors of short- and long-term adherence with a Mediterranean-type diet intervention: the PREDIMED randomized trial
Downer et al. International Journal of Behavioral Nutrition and Physical Activity (2016) 13:67 DOI 10.1186/s12966-016-0394-6 RESEARCH Open Access Predictors of short- and long-term adherence with a Mediterranean-type
More informationPrimary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts
Original Article Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts R. Estruch, E. Ros, J. Salas Salvadó, M.-I. Covas, D. Corella, F.
More informationImplications of The LookAHEAD Trial: Is Weight Loss Beneficial for Patients with Diabetes?
Implications of The LookAHEAD Trial: Is Weight Loss Beneficial for Patients with Diabetes? Boston, MA November 7, 213 Edward S. Horton, MD Professor of Medicine Harvard Medical School Senior Investigator
More informationPROOF. (not for distribution)
THELANCETDE-D-16-00306R1 S2213-8587(16)30085-7 Embargo: June 6, 2016 [23:30] BST Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: a prespecified secondary outcomes analysis
More informationMediterranean Diet: Miracle or Mirage. Edwin Cox, M.D.
Mediterranean Diet: Miracle or Mirage Edwin Cox, M.D. The Mediterranean Diet Unique Distinction The only major diet whose effectiveness has been demonstrated in controlled trials In subjects with a first
More informationDiabetes Mellitus: A Cardiovascular Disease
Diabetes Mellitus: A Cardiovascular Disease Nestoras Mathioudakis, M.D. Assistant Professor of Medicine Division of Endocrinology, Diabetes, & Metabolism September 30, 2013 1 The ABCs of cardiovascular
More informationcomparegroups updated: version 2.0
comparegroups updated: version 2.0 Isaac Subirana & Joan Vila & Héctor Sanz & Judith Peñafiel & Gavin Lucas & David Giménez isubirana@imim.es, hsanz@imim.es & jvila@imim.es & jpenafiel@imim.es & gavin.lucas@cleargenetics.com
More information(n=6279). Continuous variables are reported as mean with 95% confidence interval and T1 T2 T3. Number of subjects
Table 1. Distribution of baseline characteristics across tertiles of OPG adjusted for age and sex (n=6279). Continuous variables are reported as mean with 95% confidence interval and categorical values
More informationChanges in bread consumption and 4-year changes in adiposity in Spanish subjects at high cardiovascular risk
, page 1 of 10 q The Authors 2012 doi:10.1017/s000711451200476x Changes in bread consumption and 4-year changes in adiposity in Spanish subjects at high cardiovascular risk I. Bautista-Castaño 1,2, A.
More informationHeart Disease Genesis
Heart Disease Genesis The Ultimate Lecture on CAD origins Petr Polasek MD FRCPC FACC Copyright 2017 by Sea Courses Inc. All rights reserved. No part of this document may be reproduced, copied, stored,
More informationThe Mediterranean Diet decreases LDL atherogenicity in high cardiovascular risk
The Mediterranean Diet decreases LDL atherogenicity in high cardiovascular risk individuals: a randomized controlled trial Álvaro Hernáez 1,2,3, Olga Castañer 1,3, Alberto Goday 1,3, Emilio Ros 3,4, Xavier
More informationTable S1. Characteristics associated with frequency of nut consumption (full entire sample; Nn=4,416).
Table S1. Characteristics associated with frequency of nut (full entire sample; Nn=4,416). Daily nut Nn= 212 Weekly nut Nn= 487 Monthly nut Nn= 1,276 Infrequent or never nut Nn= 2,441 Sex; n (%) men 52
More informationDepok-Indonesia STEPS Survey 2003
The STEPS survey of chronic disease risk factors in Indonesia/Depok was carried out from February 2003 to March 2003. Indonesia/Depok carried out Step 1, Step 2 and Step 3. Socio demographic and behavioural
More informationPREDIMED STUDY MEDITERRANEAN DIET IN THE PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE
1 PREDIMED STUDY MEDITERRANEAN DIET IN THE PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE Research Protocol 2 INDEX A. BACKGROUND. SPECIFIC AIMS. 4 1. Primary Aims. 5 2. Other Aims. 5 B. BACKGROUND AND SIGNIFICANCE..
More informationCardiovascular Complications of Diabetes
VBWG Cardiovascular Complications of Diabetes Nicola Abate, M.D., F.N.L.A. Professor and Chief Division of Endocrinology and Metabolism The University of Texas Medical Branch Galveston, Texas Coronary
More informationCentral pressures and prediction of cardiovascular events in erectile dysfunction patients
Central pressures and prediction of cardiovascular events in erectile dysfunction patients N. Ioakeimidis, K. Rokkas, A. Angelis, Z. Kratiras, M. Abdelrasoul, C. Georgakopoulos, D. Terentes-Printzios,
More informationEstablished Risk Factors for Coronary Heart Disease (CHD)
Getting Patients to Make Small Lifestyle Changes That Result in SIGNIFICANT Improvements in Health - Prevention of Diabetes and Obesity for Better Health Maureen E. Mays, MD, MS, FACC Director ~ Portland
More informationTraditional Asian Soyfoods. Proven and Proposed Cardiovascular Benefits of Soyfoods. Reduction (%) in CHD Mortality in Eastern Finland ( )
Proven and Proposed Cardiovascular Benefits of Soyfoods Mark Messina, PhD, MS Soy Nutrition Institute Loma Linda University Nutrition Matters, Inc. markjohnmessina@gmail.com 1000 80 20 60 40 40 60 20 80
More informationKnow Your Number Aggregate Report Single Analysis Compared to National Averages
Know Your Number Aggregate Report Single Analysis Compared to National s Client: Study Population: 2242 Population: 3,000 Date Range: 04/20/07-08/08/07 Version of Report: V6.2 Page 2 Study Population Demographics
More informationFasting or non fasting?
Vascular harmony Robert Chilton Professor of Medicine University of Texas Health Science Center Director of Cardiac Catheterization labs Director of clinical proteomics Which is best to measure Lower continues
More informationWaist-to-Height Ratio and Cardiovascular Risk Factors in Elderly Individuals at High Cardiovascular Risk
Factors in Elderly Individuals at High Cardiovascular Risk Marta Guasch-Ferré 1,2,Mònica Bulló 1,2, Miguel Ángel Martínez-González 3, Dolores Corella 4, Ramon Estruch 2,5, María-Isabel Covas 6, Fernando
More informationThe Diabetes Link to Heart Disease
The Diabetes Link to Heart Disease Anthony Abe DeSantis, MD September 18, 2015 University of WA Division of Metabolism, Endocrinology and Nutrition Oswald Toosweet Case #1 68 yo M with T2DM Diagnosed DM
More informationOverview of effects of alcohol intake on cardiovascular disease
Beverage specific effects Overview of effects of alcohol intake on cardiovascular disease Dr. Ramon Estruch Department of Internal Medicine, Barcelona University, Spain. CIBER OBN Institute of Health Carlos
More informationProven and Proposed Cardiovascular Benefits of Soyfoods
Proven and Proposed Cardiovascular Benefits of Soyfoods Mark Messina, PhD, MS Soy Nutrition Institute Loma Linda University Nutrition Matters, Inc. markjohnmessina@gmail.com Alpro Foundation 20 years symposium
More informationJohn J.P. Kastelein MD PhD Professor of Medicine Dept. of Vascular Medicine Academic Medial Center / University of Amsterdam
Latest Insights from the JUPITER Study John J.P. Kastelein MD PhD Professor of Medicine Dept. of Vascular Medicine Academic Medial Center / University of Amsterdam Inflammation, hscrp, and Vascular Prevention
More informationFigure S1. Comparison of fasting plasma lipoprotein levels between males (n=108) and females (n=130). Box plots represent the quartiles distribution
Figure S1. Comparison of fasting plasma lipoprotein levels between males (n=108) and females (n=130). Box plots represent the quartiles distribution of A: total cholesterol (TC); B: low-density lipoprotein
More informationSupplemental Table S2: Subgroup analysis for IL-6 with BMI in 3 groups
Supplemental Table S1: Unadjusted and Adjusted Hazard Ratios for Diabetes Associated with Baseline Factors Considered in Model 3 SMART Participants Only Unadjusted Adjusted* Baseline p-value p-value Covariate
More information300 Biomed Environ Sci, 2018; 31(4):
300 Biomed Environ Sci, 2018; 31(4): 300-305 Letter to the Editor Combined Influence of Insulin Resistance and Inflammatory Biomarkers on Type 2 Diabetes: A Population-based Prospective Cohort Study of
More informationMercury exposure and risk of cardiovascular disease: a nested casecontrol study in the PREDIMED (PREvention with MEDiterranean Diet) study
Downer et al. BMC Cardiovascular Disorders (2017) 17:9 DOI 10.1186/s12872-016-0435-8 RESEARCH ARTICLE Mercury exposure and risk of cardiovascular disease: a nested casecontrol study in the PREDIMED (PREvention
More informationTotal risk management of Cardiovascular diseases Nobuhiro Yamada
Nobuhiro Yamada The worldwide burden of cardiovascular diseases (WHO) To prevent cardiovascular diseases Beyond LDL Multiple risk factors With common molecular basis The Current Burden of CVD CVD is responsible
More informationMarshall Tulloch-Reid, MD, MPhil, DSc, FACE Epidemiology Research Unit Tropical Medicine Research Institute The University of the West Indies, Mona,
Marshall Tulloch-Reid, MD, MPhil, DSc, FACE Epidemiology Research Unit Tropical Medicine Research Institute The University of the West Indies, Mona, Jamaica At the end of this presentation the participant
More informationLow Fat vs. Low Carbohydrate Diet: Coronary Artery Disease. Christina Light Craigo MSN ACNP AACC Los Angeles Cardiology Associates January 27, 2018
Low Fat vs. Low Carbohydrate Diet: Coronary Artery Disease Christina Light Craigo MSN ACNP AACC Los Angeles Cardiology Associates January 27, 2018 Diet and Cardiovascular Risk The rise in extreme obesity
More informationThe Metabolic Syndrome: Is It A Valid Concept? YES
The Metabolic Syndrome: Is It A Valid Concept? YES Congress on Diabetes and Cardiometabolic Health Boston, MA April 23, 2013 Edward S Horton, MD Joslin Diabetes Center Harvard Medical School Boston, MA
More informationSponsor Novartis. Generic Drug Name Fluvastatin. Therapeutic Area of Trial Dyslipidemia
Page 1 Sponsor Novartis Generic Drug Name Fluvastatin Therapeutic Area of Trial Dyslipidemia Approved Indication Therapeutic area and approved indications in Germany: Hypercholesterolemia (HC), combined
More informationJUPITER NEJM Poll. Panel Discussion: Literature that Should Have an Impact on our Practice: The JUPITER Study
Panel Discussion: Literature that Should Have an Impact on our Practice: The Study Kaiser COAST 11 th Annual Conference Maui, August 2009 Robert Blumberg, MD, FACC Ralph Brindis, MD, MPH, FACC Primary
More informationControversies in Preventative Cardiology
Controversies in Preventative Cardiology Francisco Lopez-Jimenez, M.D., M.Sc, FACC, FAHA Professor of Medicine, Mayo Medical School Chair, Division of Preventive Cardiology Co-Director, Artificial Intelligence
More informationDyslipidemia: Lots of Good Evidence, Less Good Interpretation.
Dyslipidemia: Lots of Good Evidence, Less Good Interpretation. G Michael Allan Evidence & CPD Program, ACFP Associate Professor, Dept of Family, U of A. CFPC CoI Templates: Slide 1 Faculty/Presenter Disclosure
More informationInsulin resistance influences 24h heart rate and blood pressure variabilities and cardiovascular autonomic modulation in normotensive healthy adults
Insulin resistance influences 24h heart rate and blood pressure variabilities and cardiovascular autonomic modulation in normotensive healthy adults Ochoa JE 1, Correa M 2, Valencia AM 2, Gallo J 2, McEwen
More informationClinical Trial: PREDIMED Trial. Mediterranean Diet Reduces 24-Hour Ambulatory Blood Pressure, Blood Glucose, and Lipids
Mediterranean Diet Reduces 24-Hour Ambulatory Blood Pressure, Blood Glucose, and Lipids One-Year Randomized, Clinical Trial Mónica Doménech, Pilar Roman, José Lapetra, Francisco J. García de la Corte,
More informationCorrelation of novel cardiac marker
Correlation of novel cardiac marker and mortality in EGAT population. Soluble ST2 hscrp Poh Chanyavanich, MD SukitYamwong, MD Piyamitr Sritara, MD Ramathibodi hospital Background hscrp - the most widely
More informationAndrew Cohen, MD and Neil S. Skolnik, MD INTRODUCTION
2 Hyperlipidemia Andrew Cohen, MD and Neil S. Skolnik, MD CONTENTS INTRODUCTION RISK CATEGORIES AND TARGET LDL-CHOLESTEROL TREATMENT OF LDL-CHOLESTEROL SPECIAL CONSIDERATIONS OLDER AND YOUNGER ADULTS ADDITIONAL
More informationScreening Results. Juniata College. Juniata College. Screening Results. October 11, October 12, 2016
Juniata College Screening Results Juniata College Screening Results October 11, 2016 & October 12, 2016 JUNIATA COLLEGE The J.C. Blair Hospital CARES team screened 55 Juniata College employees on October
More informationA replacement KAMUT khorasan wheatbased diet improves the risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized cross-over trial
A replacement KAMUT khorasan wheatbased diet improves the risk profile of patients with type 2 diabetes mellitus (T2DM): a randomized cross-over trial Whittaker A 1, Dinu M 2, Cesari F 2, Gori AM 2, Fiorillo
More informationORIGINAL INVESTIGATION. Effect of a Mediterranean Diet Supplemented With Nuts on Metabolic Syndrome Status
ORIGINAL INVESTIGATION Effect of a Mediterranean Diet Supplemented With Nuts on Metabolic Syndrome Status One-Year Results of the PREDIMED Randomized Trial Jordi Salas-Salvadó, MD, PhD; Joan Fernández-Ballart,
More informationMediterranean Diet is an Effective Method for Treating Type 2 Diabetes in Adults
Sacred Heart University DigitalCommons@SHU Health Sciences Undergraduate Publications Health Sciences 12-2013 Mediterranean Diet is an Effective Method for Treating Type 2 Diabetes in Adults Amy Bois Sacred
More informationPrevention of Diabetes With Mediterranean Diets A Subgroup Analysis of a Randomized Trial
Annals of Internal Medicine Original Research Prevention of Diabetes With Mediterranean Diets A Subgroup Analysis of a Randomized Trial Jordi Salas-Salvadó, MD, PhD*; Mònica Bulló, PhD; Ramón Estruch,
More informationInflammation and and Heart Heart Disease in Women Inflammation and Heart Disease
Inflammation and Heart Disease in Women Inflammation and Heart Disease What is the link between een inflammation and atherosclerotic disease? What is the role of biomarkers in predicting cardiovascular
More informationGALECTIN-3 PREDICTS LONG TERM CARDIOVASCULAR DEATH IN HIGH-RISK CORONARY ARTERY DISEASE PATIENTS
GALECTIN-3 PREDICTS LONG TERM CARDIOVASCULAR DEATH IN HIGH-RISK CORONARY ARTERY DISEASE PATIENTS Table of Contents List of authors pag 2 Supplemental figure I pag 3 Supplemental figure II pag 4 Supplemental
More informationImpact of Physical Activity on Metabolic Change in Type 2 Diabetes Mellitus Patients
2012 International Conference on Life Science and Engineering IPCBEE vol.45 (2012) (2012) IACSIT Press, Singapore DOI: 10.7763/IPCBEE. 2012. V45. 14 Impact of Physical Activity on Metabolic Change in Type
More informationStatin therapy in patients with Mild to Moderate Coronary Stenosis by 64-slice Multidetector Coronary Computed Tomography
Statin therapy in patients with Mild to Moderate Coronary Stenosis by 64-slice Multidetector Coronary Computed Tomography Hyo Eun Park 1, Eun-Ju Chun 2, Sang-Il Choi 2, Soyeon Ahn 2, Hyung-Kwan Kim 3,
More informationKnow Your Number Aggregate Report Comparison Analysis Between Baseline & Follow-up
Know Your Number Aggregate Report Comparison Analysis Between Baseline & Follow-up... Study Population: 340... Total Population: 500... Time Window of Baseline: 09/01/13 to 12/20/13... Time Window of Follow-up:
More informationDiabetes and Heart Disease. Sarah Alexander, MD, FACC Assistant Professor of Medicine Rush University Medical Center
Diabetes and Heart Disease Sarah Alexander, MD, FACC Assistant Professor of Medicine Rush University Medical Center No conflicts of interest or financial relationships to disclose. 2 What s the problem??
More information7/6/2012. University Pharmacy 5254 Anthony Wayne Drive Detroit, MI (313)
University Pharmacy 5254 Anthony Wayne Drive Detroit, MI 48202 (313) 831-2008 Be able to identify the signs of a heart attack or stoke Identify what puts you at a higher risk for cardiovascular disease,
More informationCase Presentation. Rafael Bitzur The Bert W Strassburger Lipid Center Sheba Medical Center Tel Hashomer
Case Presentation Rafael Bitzur The Bert W Strassburger Lipid Center Sheba Medical Center Tel Hashomer Case Presentation 50 YO man NSTEMI treated with PCI 1 month ago Medical History: Obesity: BMI 32,
More informationTest5, Here is Your My5 to Health Profile with Metabolic Syndrome Insight
Test5, Here is Your My5 to Health Profile with Metabolic Syndrome Insight Quest, Quest Diagnostics, the associated logo, and all associated Quest Diagnostics marks are the registered trademarks of Quest
More informationWhite Blood Cell Counts as Risk Markers of Developing Metabolic Syndrome and Its Components in the Predimed Study
White Blood Cell Counts as Risk Markers of Developing Metabolic Syndrome and Its Components in the Predimed Study Nancy Babio 1,2,Núria Ibarrola-Jurado 1,2,Mònica Bulló 1,2, Miguel Ángel Martínez-González
More informationAntihypertensive Trial Design ALLHAT
1 U.S. Department of Health and Human Services Major Outcomes in High Risk Hypertensive Patients Randomized to Angiotensin-Converting Enzyme Inhibitor or Calcium Channel Blocker vs Diuretic National Institutes
More informationSupplementary table 1 Demographic and clinical characteristics of participants by paraoxonase-1 (PON-1) gene polymorphisms
Supplementary table 1 Demographic and clinical characteristics of participants by paraoxonase-1 (PON-1) gene polymorphisms QQ QR/RR n = 36 n = 80 Men (%) 20 (55) 54 (67) 0.216 Age (years) 57 ± 10 56 ±
More informationA bs tr ac t. n engl j med 368;14 nejm.org april 4,
The new england journal of medicine established in 1812 april 4, 2013 vol. 368 no. 14 Primary Prevention of Cardiovascular Disease with a Diet Ramón Estruch, M.D., Ph.D., Emilio Ros, M.D., Ph.D., Jordi
More informationPREDIMED. A five year Mediterranean and mixed nuts diet study from Spain
PREDIMED A five year Mediterranean and mixed nuts diet study from Spain Updated March 2017 WHAT IS THE PREDIMED STUDY? A long term study undertaken by 16 research groups in seven communities in Spain over
More informationDiabetes and Cardiovascular Risk Management Denise M. Kolanczyk, PharmD, BCPS-AQ Cardiology
Diabetes and Cardiovascular Risk Management Denise M. Kolanczyk, PharmD, BCPS-AQ Cardiology Disclosures In compliance with the accrediting board policies, the American Diabetes Association requires the
More informationEffect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial
Effect of the Mediterranean diet on blood pressure in the PREDIMED trial: results from a randomized controlled trial Toledo et al. Toledo et al. BMC Medicine 2013, 11:207 Toledo et al. BMC Medicine 2013,
More informationCardiovascular Risk Assessment and Management Making a Difference
Cardiovascular Risk Assessment and Management Making a Difference Norman Sharpe March 2014 Numbers and age-standardised mortality rates from all causes, by sex, 1950 2010 Death rates halved Life expectancy
More informationLipid Management 2013 Statin Benefit Groups
Clinical Integration Steering Committee Clinical Integration Chronic Disease Management Work Group Lipid Management 2013 Statin Benefit Groups Approved by Board Chair Signature Name (Please Print) Date
More informationDyslipidaemia. Is there any new information? Dr. A.R.M. Saifuddin Ekram
Dyslipidaemia Is there any new information? Dr. A.R.M. Saifuddin Ekram PhD,FACP,FCPS(Medicine) Professor(c.c.) & Head Department of Medicine Rajshahi Medical College Rajshahi-6000 New features of ATP III
More informationIschemic Heart and Cerebrovascular Disease. Harold E. Lebovitz, MD, FACE Kathmandu November 2010
Ischemic Heart and Cerebrovascular Disease Harold E. Lebovitz, MD, FACE Kathmandu November 2010 Relationships Between Diabetes and Ischemic Heart Disease Risk of Cardiovascular Disease in Different Categories
More informationEffects of whole grain intake on weight changes, diabetes, and cardiovascular Disease
Effects of whole grain intake on weight changes, diabetes, and cardiovascular Disease Simin Liu, MD, ScD Professor of Epidemiology and Medicine Director, Center for Global Cardiometabolic Health Brown
More informationCVD Prevention, Who to Consider
Continuing Professional Development 3rd annual McGill CME Cruise September 20 27, 2015 CVD Prevention, Who to Consider Dr. Guy Tremblay Excellence in Health Care and Lifelong Learning Global CV risk assessment..
More informationBlood Pressure Targets in Diabetes
Stockholm, 29 th August 2010 ESC Meeting Blood Pressure Targets in Diabetes Peter M Nilsson, MD, PhD Department of Clinical Sciences University Hospital, Malmö Sweden Studies on BP in DM2 ADVANCE RCT (Lancet
More informationHypertension with Comorbidities Treatment of Metabolic Risk Factors in Children and Adolescents
Hypertension with Comorbidities Treatment of Metabolic Risk Factors in Children and Adolescents Stella Stabouli Ass. Professor Pediatrics 1 st Department of Pediatrics Hippocratio Hospital Evaluation of
More informationZhengtao Liu 1,2,3*, Shuping Que 4*, Lin Zhou 1,2,3 Author affiliation:
Dose-response Relationship of Serum Uric Acid with Metabolic Syndrome and Non-alcoholic Fatty Liver Disease Incidence: AMeta-analysis of Prospective Studies Zhengtao Liu 1,2,3*, Shuping Que 4*, Lin Zhou
More informationJanet B. Long, MSN, ACNP, CLS, FAHA, FNLA Rhode Island Cardiology Center
Primary and Secondary Prevention of Coronary Artery Disease: What is the role of non statin drugs (fenofibrates, fish oil, niacin, folate and vitamins)? Janet B. Long, MSN, ACNP, CLS, FAHA, FNLA Rhode
More informationBritish Journal of Nutrition
(2015), 113, 984 995 q The Authors 2015 doi:10.1017/s0007114514004401 Dietary inflammatory index and anthropometric measures of obesity in a population sample at high cardiovascular risk from the PREDIMED
More informationSupplementary Online Content
Supplementary Online Content Larsen JR, Vedtofte L, Jakobsen MSL, et al. Effect of liraglutide treatment on prediabetes and overweight or obesity in clozapine- or olanzapine-treated patients with schizophrenia
More informationMediterranean Diet Pattern and Health
NUTRI-BITES Webinar Series Mediterranean Diet Pattern and Health will begin at the top of the hour Audio for today s presentation is being broadcast over your computer speakers, so be sure they are turned
More informationNew Antihypertensive Strategies to Improve Blood Pressure Control
New Antihypertensive Strategies to Improve Blood Pressure Control Antonio Coca, MD, PhD,, FRCP, FESC Hypertension and Vascular Risk Unit Department of Internal Medicine. Hospital Clínic (IDIBAPS) University
More informationORIGINAL INVESTIGATION. Effect of a Traditional Mediterranean Diet on Lipoprotein Oxidation
ORIGINAL INVESTIGATION Effect of a Traditional Mediterranean Diet on Lipoprotein Oxidation A Randomized Controlled Trial Montserrat Fitó, MD, PhD; Mònica Guxens, MD; Dolores Corella, DPharm, PhD; Guillermo
More informationPrevenzione cardiovascolare e cambiamento degli stili di vita. Gian Franco Gensini
Prevenzione cardiovascolare e cambiamento degli stili di vita Gian Franco Gensini Main causes of death worldwide at all ages (year:: 2005) 17.5 milion Preventing Chronic Diseases A vital investiment. WHO
More information2003 World Health Organization (WHO) / International Society of Hypertension (ISH) Statement on Management of Hypertension.
2003 World Health Organization (WHO) / International Society of Hypertension (ISH) Statement on Management of Hypertension Writing Group: Background Hypertension worldwide causes 7.1 million premature
More informationThe role of physical activity in the prevention and management of hypertension and obesity
The 1 st World Congress on Controversies in Obesity, Diabetes and Hypertension (CODHy) Berlin, October 26-29 2005 The role of physical activity in the prevention and management of hypertension and obesity
More informationORIGINAL INVESTIGATION. C-Reactive Protein Concentration and Incident Hypertension in Young Adults
ORIGINAL INVESTIGATION C-Reactive Protein Concentration and Incident Hypertension in Young Adults The CARDIA Study Susan G. Lakoski, MD, MS; David M. Herrington, MD, MHS; David M. Siscovick, MD, MPH; Stephen
More informationOlea europaea in hypertension & metabolic syndrome
Olea europaea in hypertension & metabolic syndrome Cardio 017 The Hotel - 13-05-2017 Michel P. HERMANS MD (UCL) PhD (UCL & Oxford, UK) Dip. Natural Sciences (Open University, Milton Keynes, UK) Dip. Earth
More informationElevated Serum Levels of Adropin in Patients with Type 2 Diabetes Mellitus and its Association with
Elevated Serum Levels of Adropin in Patients with Type 2 Diabetes Mellitus and its Association with Insulin Resistance Mehrnoosh Shanaki, Ph.D. Assistant Professor of Clinical Biochemistry Shahid Beheshti
More informationSupplementary Appendix
Supplementary Appendix This appendix has been provided by the authors to give readers additional information about their work. Supplement to: Schauer PR, Kashyap SR, Wolski K, et al. Bariatric surgery
More informationYuqing Zhang, M.D., FESC Department of Cardiology, Fu Wai Hospital. CAMS & PUMC, Beijing, China
What Can We Learn from the Observational Studies and Clinical Trials of Prehypertension? Yuqing Zhang, M.D., FESC Department of Cardiology, Fu Wai Hospital. CAMS & PUMC, Beijing, China At ARIC visit 4
More informationHypertension and obesity. Dr Wilson Sugut Moi teaching and referral hospital
Hypertension and obesity Dr Wilson Sugut Moi teaching and referral hospital No conflict of interests to declare Obesity Definition: excessive weight that may impair health BMI Categories Underweight BMI
More informationCARE PATHWAYS. Allyson Ashley
CARE PATHWAYS Allyson Ashley WHAT IS A CARE PATHWAY? An explicit statement of the goals and key elements of care based on evidence, best practice, and patient s expectations and their characteristics The
More informationA: Epidemiology update. Evidence that LDL-C and CRP identify different high-risk groups
A: Epidemiology update Evidence that LDL-C and CRP identify different high-risk groups Women (n = 27,939; mean age 54.7 years) who were free of symptomatic cardiovascular (CV) disease at baseline were
More informationSerum levels of galectin-1, galectin-3, and galectin-9 are associated with large artery atherosclerotic
Supplementary Information The title of the manuscript Serum levels of galectin-1, galectin-3, and galectin-9 are associated with large artery atherosclerotic stroke Xin-Wei He 1, Wei-Ling Li 1, Cai Li
More information