HEAVY AND TOXIC METALS, AND DECHELATION

Transcription

1 HEAVY AND TOXIC METALS, AND DECHELATION by Dr. Christian Daniel ASSOUN (August 2007) HEAVY AND TOXIC METALS, TOXICS AND ASSIMILATED ELEMENTS This category of metals includes also metalloids such as Selenium (Se), Arsenic (As) or Beryllium (Be), as well as metals from the group of precious metals (Pt, Ir, Os, Ru, Rh, Pd ). Although this subject would well deserve a thorough and extensive study, we will now tackle this subject in a simplified way. Firstly, it has to be underlined that some metals used in therapy such as Selenium, Chromium, have dosages in therapy that are very close to toxic dosages. WHY DO THOSE ELEMENTS REPRESENT RISK FACTOR FOR OUR BIOLOGY AND INTIMATE MECHANISMS SUCH AS THE PROTEIC SYNTHESIS? Indeed, heavy and toxics metals are considered as such, because they are strong competitors to Calcium, Magnesium and Phosphorus; This does concern specifically Mercury (Hg), Cadmium (Cd), Thallium (Th), Lead (Pb), Osmium (Os), Selenium (Se), etc When the Calcium sites and the energetic sites linked to the ATP-Mg mechanisms are disturbed by toxic elements, the synaptic and energetic exchanges are considerably diminished, thus enhancing complex situations (molecular pathologies) and may favor symptomatologies that are often irreversible on a cerebral level. Dechelation therapies have to be applied with great precautions because of its side effects, thus the urine analysis (Urinary Atomic Metallogram) will allow good harmonization as well as the application of dechelation therapies which, on a scientific level are considered to be equal as chemotherapies. As a matter of fact, it appears that there is no deficiency situation or deficiency index with regard to heavy and toxic metals and assimilated. The ideal would be to show the lowest rate possible for these toxic for these toxic elements because they are competitors of major or minor vital biocatalysors. Our experience with the Zinc complexes (Zn) shows that the use of these products, allows a natural elimination without any side effects shown by heavy and toxic metals. Glycan Group Page 1

2 Certain medicinal plants may also be used in synergy with the Zinc complexes, but present legislation, very often forbids the use of some of them. The depletion out of range of the normal values of specific elements such as Boron (B), Silicon (Si), Lanthanides (La 3t ), and Molybdenum (Mo) contribute to increase the risk of immuno-depression. Therefore, it is essential to thoroughly know the major and minor electrolytic and oligoelementary resources from the patient in order to understand the evolutions, but also to appreciate in a scientific way the medications that have been administered to the patients and thus prevent the side effects from numerous therapies and treatments. COMPARAISON BETWEEN DIFFERENT METALLOGRAMS BLOOD-URINE-HAIR The Hair Analysis has been the subject of numerous studies in the hospital sector as well as of researchers in the private sector. It appears that the Hair Analysis, if the sampling is possible, reveals anomalies in the distribution of macro-elements (Na, K, Mg, P, Ca) and when the deficiencies are serious; it is referred to as an analysis as posteriori. This means that it does not allow us to establish reasonable etiopathology, and consequently does not present a major bio-medical interest. In addition, several American studies, published in the MEDLINE and JAMAS on thousands of samplings done for specific pathologies seem not to give credit to these tests. Furthermore, the capillar tegument is not a place where a sufficient significant metabolic exchange takes place, to allow to state if we are in presence of a deficiency or of an excess. In addition, electro chemical and catalytical flows are not important enough to determine a precise origin (physiological, immunitarian, or hormonal origin). With regard to the significant analytic level, the variation of depletions compared to the norms, are not scientifically significant with respect to the trace-elements (Oligo-elements) that are present in biological liquids and substrats (0.05 à 0.10 mg/l). In addition, the pollution caused by the environment, for example from heavy metals (Cd, Hg, Pb, Sn,Se) or by transition metals (V, Fe, Co, Ni), distort considerably the results of the measures of these trace-elements. Trace elements as important as Lanthanides (Ln 3+ ) or rare earths (14 elements + the precursor Yttrium) are not properly present in the hair. Moreover, especially in a woman, the use of shampoo or dyes may go against the credibility of this exam. It is interesting to note that each specialized Metallogram has its place in predictive or curative medicine according to a recent axiom that postulates that we cannot measure electric current with a gas counter, except with a radiation counter!... The Hair Metallogram must therefore not only be considered as an exam that reflects our existing metabolism, but more as an indication of the level of toxic elements absorbed by the capillary tegument over a period of 3 to 6 months. The atomic mass spectrometry (ICP-MS) for the hair from an analytical stand point is the only one that is credible; all other methods do not appear reliable due to the numerous interferences, the matrix effects and sensitivity limits. Glycan Group Page 2

3 Furthermore, the analysis of Sulfur (S) in the hair is absolutely unnecessary because sulfured bridges (S-S) exist in nearly all biological materials as well as also, Oxygen, Nitrogen, Hydrogen or water. From a toxicological point of view, the hair analysis may provide important information on the everyday life habits or environmental customs of the patients and we can appreciate the accumulations every three months. In addition, toxic elements such as Selenium (Se) or Beryllium (Be) can be easily absorbed by the face skin as well as by the capillary tegument; the same applies for elements as Strontium (Sr) and Cesium (Cs) that result from accidental nuclear human known or unknown activities. On the same level, The exo-toxicological appreciation is complemetary to endo-toxicological appreciation of the Urinary Atomic Metallogram TM or Urine Global Evaluation TM. Multi-elementary analysis established in total blood, plasma, and other specialized fractions (serum) present an interesting approach to the amount of trace- elements contained in the blood. The blood represents the advantage to mix extra-cellular medium: red globules, leucocytes, erythrocytes platelets. Indeed, the produced image by a multi-elementary Metallogram in the blood is linked to the cinetic distribution. It represents a constitutional image which has to be considered with great bio-medical cautiousness. Plasmatic concentration variation from one given trace-element does not logically imply the same variation in other mediums. For example, normal plasmatic Zinc does not always correspond to normal erythrocytary Zinc. Some elements, such as Rubidium (Rb) essentially belong to the intra-cellular medium, as a consequence, the plasma is thus not the most significative medium to appreciate the variation of concentration for certain elements. In conclusion, the total blood analysis represents a constitutional image of the circulation of the medium that must be correlated together with a pathological urine image (depletion). Since major concerns are being focused towards preventive medicine, this does explain the urine depletion choice. For the therapist, it can be of a bio-medical interest as long as it is possible to control the drug administration delivered to the patients, with the help of several urinary metallograms, regardless whether or not these medications are of chemical nature (homeopathy, phytotherapy, oligotherapy, etc ), physical (electrotherapy) or energetical (acupuncture, auricular medecine ). The only serious recommendations of prescription of a Metallogram for hair or for known dermoskeletons (nails) are linked to Menke s disease where depletion deficiency of Zinc and Copper are equitably noticed (but then it is already too late). With regard to severe professional intoxications due to heavy metals, the hair and dermoskeletons, analysis is scientifically justified. Glycan Group Page 3

4 It has to be underlined that the hair analysis done in hospitals, have been undertaken by non-professionals, at a medical and analytic level, and therefore these analysis have greatly contributed to create an analytical fashion. This phenomenon has delayed numerous other more serious studies referring to biological liquids (blood, urine, sperm ). In conclusion, the hair metallogram or M.A.C (Atomic Capillar Metallogram) takes its place within the biotoxicologic control, associated with MAU TM or BGU TM. On the level of trace elements distribution within the fractioning of the blood and thus the serum, our analysis has mainly focused on the Lanthanides pool and Yttrium which distribution seems comparable to one that is present in urine. Finally, serious exams cannot be excluded from preventive medicine, but must be complementary for the patient s interest. Only thorough knowledge of electrolytic resources within the complementary biologic liquids such as blood, serum and urines may allow in accordance with a toxicological analysis of the hair, to elaborate a reasonable nutritional program. The MAST (Atomic Metallogram Total Blood) as we mentioned, represents a very interesting analytical research in a complete toxicological and nutritional context. The possibility of setting up very specialized metallogram does exist such as for example, the one of saliva or sperm, but these studies are reserved to aspects that are linked to teratogenesis and spermatogenesis where only some isotopes elements are being considered. This study belongs to specific areas that are heavily contaminated or at risks to different levels. PROTOCOL QUELATORR TM GENERAL INFORMATION ON DECHELATION BY HEAVY, TOXIC METALS AND ASSIMILATED. Heavy and/or toxic metals cause alterations in various channels of the command of metabolic, proteinic, neurologic, immunologic or genetic reactions. The importance of those alterations, reversible or irreversible syndromes, is directly proportional to the quantity of heavy or toxic metals, which have been ingested or assimilated by external tissues (skin) or internal tissues (pulmonary alveolus, liver, kidneys or pancreas). The encountered issue on heavy metals is directly linked to acute or chronic toxicology caused by direct intake, through oral or atmospherical ways, of dosages considered to be toxic. Heavy metals are found in countless environments and mediums that surround us : water, air, ground aliments, amalgams and dental prosthesis, plaques from internal bones prosthesis etc.. Some shampoos and strong detergents like bleach as well, manufactured with poor quality raw material, may contain toxic metals. Glycan Group Page 4

5 Toxic and/or heavy metals cause irreversible or reversible alterations because they are strong competitors to elementary biochemical reactions. These reactions from our biology are conducted by proteins, enzymes and metalo-enzymes that constitute a Enzym-Metal-Substrat reaction (E-M-S), which forms our cellular motor and specifically the one from major organs like the liver, the brains or pancreas. The Cadmium, Mercury, Thallium can stop the energetic mechanisms from neural transmission where intervene the Calcium in ionic form Ca 2+. These metals may compete with Calcium in ionic form and prevent the good functioning of the synapses within the acetylcholine cycle. They, then interfere in the elementary nervous transmission and may cause substantial disorders within basic functions dictated by the brain, like for example, the speech, the sight, the smell and cause locomotor system disturbances, balance alterations, shakings or difficulties of concentration. The noticeable changes seem to be directly proportional with the quantity of heavy metals and active toxics that are found within our biological system and that act as invaders and competitors (cytotoxicity and DL50) in vitro and vivo studies. Heavy and toxic metals may cause at first molecular changes, therefore a change as far as proteinic synthesis is concerned and finally they can cause changes on nucleic acids ADN and ARN (the later acts as enzyme). It is proven that heavy or toxic metals also depend on the chemical shape of the metal salt : for example, the metal Mercury is not toxic enough at normal body temperature (37 ) ; therefore, there is no irreversible intoxication in case of accidental Mercury ingestion from a broken thermometer. On the other hand, organic-metallic derivatives from Mercury like radical Methyl CH3- Mercury form a very powerful complex that can cause neuron permanent injuries as well as DNA desamination or its methylation ; consequently, a purine base loses one function NH2 that is being replaced by methyl radical CH3 enhancing substantial defaults within the proteinic synthesis and genetical defaults since whilst losing functions as NH2, the transformation of cytosine base takes place into uracycle basis and the later counter altered DNA. EXISTING NATURAL METHODS AND DECHELATIONS SYNTHESIS OF HEAVY AND TOXIC METALS There is an increasing preoccupation and important sensibilisation from the populations facing continuous pollutions within our biosphere. Understandably, the human activities are responsible for their own diseases. Moreover, the non-respect of in vigor laws or the importation of dodgy raw materials are responsible in great extend for induced pollutions. (Accidental pollutions are not taken into consideration in the current presentation of Quelatorr TM protocol). Analytics techniques (ICP-MS, AES-AAS and GC-MS, AN) permit to measure with extreme precision (ppt) 2 within all biological liquids and tissues, for the last 10 years, toxicological grounds of heavy and toxic metals. It is difficult to stay immune to environmental and alimentary pollutions. Glycan Group Page 5

6 On the molecular and scientific side, there is no existing substance synthesis that has proved as dechelation without causing side effects (from minute nausea to teratogene effects). In serious scientific environments (toxico-pharmacology), we found that thousands of references and studies on synthesis substances such as (DMPS, DMSA, DMSO, EDTA) and derived agents do exist. Most of those organic acids and mercaptans are strong dechelators in vitro and vivo. ; None of those substances have been approved up to today by FDA (USA) or by the agencies of European Medications. The highest risk with regard to these substances, for which studies still remain incomplete as far as toxico-pharmacology is concerned, is to dechelate the metals that are indispensable for biological balance, such as Zinc and Calcium that act like main managing agents of 300 metallo-enzymatic reactions, necessary for our biological and energetic life. So, during the mentioned synthetic quelation process, a strong chemical reaction does not resolve any serious problem at ponderal delequation level. The risks of modifying EMS formulas (Enzyme-Metal-Substrat) and ferric pools are possible and can be considered as part of clinical observations The pediatric administration of such synthesis substances is not advisable according to some studies. Moreover, the use of them must be affiliated to a rigid control of heavy metals contents and other essential excreted metals from urine, to avoid disturbances caused by side effects. With regard to synthesis dechelatric therapies, we have the same problem as chemotherapeutic methods, to which are systematically associated urine and seric check up and also the administration of mineral dietetic, pharmaceutics or neutracetics supplements. The old saying remedy is worse than illness must be avoided furthermore, the fairest established research of therapy does not imply systematically the intake of unnecessary risks. Furthermore, a passive attitude along with axiom self-defense organism virtues are insufficient or also with time it will all come into places cannot be contemplated. The therapists, doctors and health professionals must be fully informed on the type of synthesis molecules that they chose to dechelate but also they must control the amounting reached results in urines, mainly through atomic and spectroscopic techniques that are used in the medical, hospital or private environment. A recent controversial on the possible intoxication by some heavy metals, that are found in vaccine injections has been resolved due to the withdrawal of some components that might be toxics or problematic, which has been decided by vaccine manufacturers. It is necessary to remember that mercaptans DMPS and derivatives have been mainly developed following Tchernobyl nuclear accident, during which some radioactive isotopes from heavy metals needed to be promptly eliminated by severe chemical methods due to the fact, that isotopic radioactive risk of some heavy elements are worse than the toxicological risk of the same metals at stable status (non radioactive). Most of the natural elements from the Mendelieff chart (Periodic classification of elements) have isotopes even Z (number of electrons) but a different atomic mass we count several hundred of radioactive isotopes the conditions were exceptional and emergencies were different. We can also state sino-sovietic experiments, using them as curative or prevention title with mining populations the scientific and medical verification of such experiments remains unknown. Glycan Group Page 6

7 With regard to the present dechelation problematic, we currently experience daily contamination linked to our environment or to our food habits, or in relation with amalgams. The diffusion of heavy and toxics metals inside of our organism has lasted for years; a part is regularly eliminated by substances that are found in our alimentation, mainly Zinc, vitamin C and some natural phytoquelators that are found in vegetables, fruits, plants, aromas, mushrooms and spices. Referring to possible dechelation with the seaweeds (marine or continental), they must be used with care because they have a natural content of heavy and toxics metals, since their main function is mainly to accumulate and trap heavy and toxics metals. We feel that the best forms of Zinc than can dechelate the heavy metals are organo-metallic presentations, as they do exist in natural mentioned projects, for instance under form of Zinc associated to the Fructose molecule, sugar (C6) that has the specificity to present a carbonyle radical (C=0). It seems that carbonyle function linked to Zinc atom offers the possibility to set up bivalents atom as Mercury, Cadmium, Lead and others like Titanium and Osmium This concerns a problem of quantum chemistry. Whilst observing the nature and its complicated phenomena, in the specific case of dechelation, we can submit a protocol that is adapted and without incurring risk of biological integrity. A protocol that adhered to a rigorous scientific control, elaborated in the frame of clinical analysis laboratory that would measure the urine excretions and the effects from the natural dechelators supplementation like the Zinc associated with Fructose. To resume anterior developments, the protocol Quelatorr TM presents itself as follow: 1. Urinary Atomic Metallogram TM or (UAM) 1 ST control : Analysis of heavy and toxics metals or equivalent as well as Calcium and Zinc status; Zn, Hg, Cd, Tb, Th, Tl, Pd, Ni, Cr, Au, Rh, Pt, As, Os, Sb, Sn, Pb, B, Mo, Si). 2. Supplementation by Zinc complex (ZnFLNT4) and Organic Silicon G5 during three months nd control: after the three months of supplementation; toxics distribution study and conclusion. OBSERVATIONS: During the duration of the Zinc and Silicon supplementation, it is recommended to the patient to not take additional related forms of Zinc or any other dechelators. (The patient ought to take further advice from his assigned General Practitioner). If eventual intake of other dechelators occurs, it is suggested to check toxic distribution before and after, with the help of the UAM, along with Zinc, Boron and Molybdenum. Glycan Group Page 7

8 NOTA BENE The terms of Urinary Atomic Metallogram and Global Urine Exam as well as Atomic Matrices Imagery and Memorial Urine Exam are registered international trade marks and their use must be submitted to the preliminary authorization of the owner Prof. Dr. Christian Daniel ASSOUN, CEO of Glycan Group. Ten years ago, spectrometric techniques did not permit to obtain the limits of very low detections (ppt) within biological materials. Thanks to the Atomic Technique ICP-MS, Inductive Coupled Plasma, (Mass Spectroscopy), those grounds (ppt) may be attained and allow us to qualify biological material as contaminated material or contaminating material. These new Atomic Techniques, are most efficient and precise ones; they enable Laboratories to elaborate irreproachable work as far as precision is concerned. In conclusion, all actions in preventive medicine in relation with acts such as dechelation must be submitted to ICP-MS analysis application (before during after). Following this, the treatment with natural dechelation agents (or chemical ones) should avoid to lower the pool of the essential protectors of the immunity system such as the elements Zinc (Zn), Treatment established along with naturals or chemical dechelation agents in order to avoid to lower the pool of the essential protectors of the immunity system such as the elements Zinc (Zn), Molybdenum (Mo), Boron (B) and Silicon (Si). Glycan Group Page 8