EVALUATION OF EFFERVESCENT FLOATING TABLETS. 6.7 Mathematical model fitting of obtained drug release data
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2 EVALUATION OF EFFERVESCENT FLOATING TABLETS 6.1 Technological characteristics of floating tablets 6.2 Fourier transform infrared spectroscopy (FT-IR) 6.3 Differential scanning calorimetry (DSC) 6.4 In vitro buoyancy studies 6.5 Water uptake studies 6.6 In vitro drug release studies 6.7 Mathematical model fitting of obtained drug release data 6.8 In vivo studies 6.9 Stability studies Formulation & Evaluation of Floating DDS for some selected drugs 118
3 6.1 Technological characteristics of floating tablets The hardness of prepared floating tablets ranged between 4.1 ± 1.23 to 6.1 ± Kg depending upon the mixture of the polymer used. The friability of the tablet formulation varied between 0.3 ± to 0.59 ± %. The weight variation of prepared tablet formulation complies with USP limits. The thickness was found to be in the range of 4.1 ± 0.48 to 4.2 ± 0.76 mm. The assay for drug content varied between ± 0.36 to ± 0.52%. The results of these parameters are given in Table Table 6.01: Physical properties of effervescent floating tablets of Verapamil hydrochloride Batch Content Floating Max Weight Hardnes Friability Thickness* Uniformity* lag* swelling* Variation s* (Kg) * (%) (mm) (%) time(s) (%) B 1 Passes 4.6± ± ± ± ± ±6.5 B 2 Passes 6.1± ± ± ± ± ±5.9 B 3 Passes 5.5± ± ± ± ± ±4.6 B 4 Passes 5.8± ± ± ± ± ±5.8 B 5 Passes 4.8± ± ± ± ± ±8.6 B 6 Passes 4.6± ± ± ± ± ±9.5 B 7 Passes 4.2± ± ± ± ± ±8.3 B8 Passes 4.1± ± ± ± ± ±5.5 B 9 Passes 4.5± ± ± ± ± ±4.6 B 10 Passes 3.2± ± ± ± ± ±4.9 B 11 Passes 3.7± ± ± ± ± ±2.3 B 12 Passes 3.1± ± ± ± ± ±3.5 B 13 Passes 3.1± ± ± ± ± ±5.1 *Standard deviation, n=3 Formulation & Evaluation of Floating DDS for some selected drugs 119
4 6.2 Fourier transform infrared spectroscopy (FT-IR) The spectrum was measured in the solid state as Potassium bromide dispersion. The bands were recorded using the FT-IR technique. FT-IR spectral study revealed that similar characteristic peaks appear with minor differences, for the pure drug and drug formulation, as shown in figure Hence it was confirmed that no chemical interaction had taken place between the drug and the polymer used. The data for the same is given in table Table 6.02: FT-IR Spectral data of effervescent floating tablet of Verapamil hydrochloride (B1) and Verapamil hydrochloride pure drug Functional groups C-H Stretching vibrations of methyl and methylene groups C-H stretching vibrations of the methoxy group C-O stretching vibrations of the aromatic ethers sharp weak bond due to C=N stretching vibrations of the alkyl nitrile skeletal stretching vibrations of the benzene ring Frequency of pure drug (cm -1 ) Frequency of formulation (cm -1 ) , , 1518 Formulation & Evaluation of Floating DDS for some selected drugs 120
5 Figure 6.01: FT-IR Spectra of effervescent floating tablet of Verapamil hydrochloride (B1) and Verapamil hydrochloride pure drug Formulation & Evaluation of Floating DDS for some selected drugs 121
6 6.3 Differential scanning calorimetry (DSC) DSC is a fast and reliable method to screen drug and excipient compatibility, and to provide maximum information about the possible interactions. DSC study was carried out for Verapamil hydrochloride and its formulation B1. Thermogram of pure drug shows a sharp endothermic peak at o C, which corresponds to its melting point. Matrix tablet formulation B1 also showed endothermic peak at o C, which corresponds to the melting point of the drug. The evaluation of thermograms obtained from DSC revealed no interaction between the drug and the excipients. From the thermograms, it was evident that melting point of Verapamil hydrochloride had not changed when it was formulated as a floating matrix tablet. The thermograms obtained are presented in figure 6.02 and the data is given in table Formulation & Evaluation of Floating DDS for some selected drugs 122
7 Table 6.03: DSC thermogram data of effervescent floating tablet of Verapamil hydrochloride (B1) and Verapamil hydrochloride pure drug Drug and formulation T O ( C) T m ( C) T c ( C) Melting range( C) Verapamil Hydrochloride Formulation B T o - Onset of melt, T m - Melting point, T c - Completion of melt, DSC data obtained at 10 C/min Figure 6.02: DSC thermograms of effervescent floating tablet of Verapamil hydrochloride (B1) and Verapamil hydrochloride pure drug Formulation & Evaluation of Floating DDS for some selected drugs 123
8 6.4 In vitro buoyancy studies To provide in vitro buoyancy, an effervescent approach was adopted. Sodium bicarbonate was added as a gas-generating agent. As the dissolution medium (0.1 N HCl) got imbibed into the tablet matrix, the acidic fluid interacted with Sodium bicarbonate resulting in the generation of CO 2. The generated gas was entrapped and protected within the gel, formed by the hydration of polymer and Karaya gum, and thereby decreased the density of the tablet. As the density of the tablet fell below 1g/ml, the tablet became buoyant. Karaya gum with HPMC produced tablets with good gel strength, entrapping CO 2 gas within and thereby imparting stable and persistent buoyancy. The system need to float in a few minutes after contact with gastric fluid, to prevent the dosage form from being pushed into the small intestine together with food. The results demonstrated that the time taken by the system to float in the medium, decreased with increasing amount of effervescent agent and increased with increasing levels of Karaya gum, which was true in B13. The higher amount of effervescent agent caused faster and higher CO 2 generation. Thus, Sodium bicarbonate was essential to achieve optimum buoyancy. In general, gastric emptying time was 4 h. The extended gastric residence time of the drug in the stomach caused increased absorption due to the fact that the proximal part of the intestine was the main absorption site for Verapamil hydrochloride. Moreover, during formation of the floating tablets, evolving gas permeated through the matrix leaving gas bubbles or pores, which also increased the release rate of the active ingredient from the matrix. The amount of sodium bicarbonate also played an important role in floating lag time of tablets, the higher the amount the lesser the floating lag time, and vice versa. Figure 6.03 shows the effect of concentration of Sodium bicarbonate on floating lag time, Formulation & Evaluation of Floating DDS for some selected drugs 124
9 Floating lag time (s) C h a p t e r 6 duration of floating and floating behaviour and concentration of the tablet is shown in the table 6.03 and figures Table 6.04: Effect of Sodium bicarbonate on onset and duration of floatation of effervescent floating tablet of Verapamil hydrochloride (B1) Amount of sodium bicarbonate (mg) Onset of floating (s) Duration of floating (h) 10 92± ± ± ± ± ± ± ±0.75 *Standard deviation, n= Amount of Sodium bicorbonate (mg) Figure 6.03: Effect of amount Sodium bicarbonate on floating lag time of effervescent floating tablet of Verapamil hydrochloride (B1) Formulation & Evaluation of Floating DDS for some selected drugs 125
10 At initial time At 18 th Sec At 8 th h Figure 6.04: Photographs of in vitro floating behaviour of effervescent floating tablet at different time intervals Formulation & Evaluation of Floating DDS for some selected drugs 126
11 6.5 Water uptake studies The swelling of the polymers used could be determined by water uptake of the tablet. The percent swelling of the tablet was determined at different time intervals. The complete swelling was achieved by the end of 8 h, so percent swelling was determined at the end of 8 h for all the developed formulations. The maximum percentage of swelling of B8 was found to be higher, when compared to other formulations, and least percentage of swelling was found in B3. Water uptake data is presented in table 6.05 and figure 6.05 shows effect of various ingredients on dynamic water uptake of formulations at the end of 8 h. There was rapid increase in percentage swelling of the B4, B6, and B7 at 1 h. B8 showed a gradual increase in percentage of swelling at the end of 8 h. The increase in the concentration of Karaya gum retarded the water uptake during the first hour. B2, B3, and B5 showed a decrease at the end of 8 h. There was no significant difference observed in the swelling property by varying the concentration of Sodium bicarbonate, but less concentration of lactose in B8 showed maximum swelling (p 0.05). As described by Seipmann and Peppas 116 diffusion of drug significantly depends on the water content of the tablet. This may be because the mobility of the polymer chains strongly depends on the water content of the system. At high water content, polymer chain relaxation takes place with volume expansion giving high swelling to the system. Also, this higher water content could predict the higher penetration of the gastric fluid into the tablet, leading to faster carbon dioxide gas generation, and thus reduction in the floating lag time. Consequently, faster and higher swelling of the tablet led to an increase in the dimensions of the tablet, leading to increasing the gel barrier and thus decreasing diffusion rates. So the drug release was found to be high initially and then gradually decreased, this was true especially in B8. The swelling behaviour of tablet from 0 min Formulation & Evaluation of Floating DDS for some selected drugs 127
12 to 8 h is shown in figure All the tablets showed better radial and axial swelling, but maximum was shown by B8. Formulation & Evaluation of Floating DDS for some selected drugs 128
13 Table 6.05: % Water uptake of effervescent floating tablets of Verapamil hydrochloride formulations in ph 1.2 hydrochloric acid buffer Time (h) % Water uptake B1 B2 B3 B4 B5 B6 B7 B8 B9 B10 B11 B12 B ± ± ± ± ± ± ± ± ± ± ±2.9 77± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±5.1 *Standard deviation, n=3 Formulation & Evaluation of Floating DDS for some selected drugs 129
14 Figure 6.05: Effect of various concentrations of ingredients on swelling index of floating tablets of Verapamil hydrochloride at the end of 8 h Figure 6.06: Swelling behavior of effervescent floating tablet of Verapamil hydrochloride subjected to dissolution testing from 0-8 h. Formulation & Evaluation of Floating DDS some selected d drugs 130
15 6.6 In vitro drug release studies It has been reported that floating drug delivery systems can prolong the gastric retention time and thus increase the overall bioavailability of drug like Verapamil hydrochloride that shows better absorption at the proximal part of the intestine. The concentration of gum, polymer, and diluent had a remarkable influence on the drug release. Increase in the concentration of gum with decrease in lactose concentration, decreased the drug release. This may be due to the formation of thick gel barrier. The in vitro drug release data is presented in table 6.06 and 6.07 and profile is presented in figures 6.07 and The B1, B5, B6, B9, and B10 exhibited more than 75% drug release at 12 h. The B1 exhibited a maximum of 30 % drug release in the 1 st hour and constant release for almost upto 12 h. B8 showed the least drug release among all other formulations; this may be due to the formation of a thick gel barrier on the tablet. As the thickness of the gel barrier increased, the drug took more time to diffuse through it; this was observed in other formulations which showed higher swelling index. However, this was not true in case of B1 because of the presence of higher concentration of lactose. The controlled release of drug from the formulations might be because of the diffusion of release medium into the matrix, which in turn would have caused drug diffusion out of the tablets. The ideal controlled drug delivery systems should release the drug in a pre-determined manner. The objectives of the systems were to ensure safety and efficacy of the drugs, as well as improve patient compliance. The results showed that the karaya gum could be used for the preparation of gastric floating controlled delivery systems. Formulation & Evaluation of Floating DDS some selected d drugs 131
16 Table 6.06: In vitro drug release data of effervescent floating tablets of Verapamil hydrochloride in ph 1.2 Hydrochloric acid buffer(b1-b6) Time (h) % Cumulative drug release* B1 B2 B3 B4 B5 B ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±0.35 *Standard deviation, n=3 Formulation & Evaluation of Floating DDS some selected d drugs 132
17 Table 6.07: In vitro drug release data of effervescent floating tablets of Verapamil hydrochloride in ph 1.2 Hydrochloric acid buffer (B7-B13) Time (h) % Cumulative drug release* B7 B8 B9 B10 B11 B12 B ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±0.60 *Standard deviation, n=3 Formulation & Evaluation of Floating DDS some selected d drugs 133
18 % Cumulative Drug Release % Cumulative Drug Release C h a p t e r B1 B2 B3 B4 B5 B Time (h) Figure 6.07: In vitro drug release profiles of Verapamil hydrochloride effervescent floating tablets (B1-B6) Time (h) B7 B8 B9 B10 B11 B12 B13 Figure 6.08: In vitro drug release profiles of Verapamil hydrochloride effervescent floating tablets (B7-B13) Formulation & Evaluation of Floating DDS some selected d drugs 134
19 6.7 Mathematical model fitting of obtained drug release data The in vitro drug dissolution profiles were fitted to various models and release data was analyzed on the basis of Korsmeyer-Peppas equation and Higuchi kinetics. The diffusion exponent ranges from The release rates k and n values of each model were calculated by PCP disso v2.08 software. Co-efficients of correlation (R 2 ) were used to evaluate the accuracy of the model fitting. The R 2, k, and n values are given in table On calculating and comparing R 2 values for, Korsmeyer-Peppas, Matrix, and other models, B4, B5, B7, and B12 gave a good fit to the Matrix model, and the remaining formulations best fitted the Korsmeyer-Peppas model. B1, B4 and B7 exhibited Fickian release and other formulations showed non- Fickian or anomalous release. B4 and B7 best fitted to the matrix model with Fickian release; B5 and B12 best fitted to the matrix model with non-fickian release. If the value of n in Korsmeyer-Peppas is 0.5 or less, the release mechanism follows a Fickian diffusion, and for anomalous or non-fickian, release the release is mainly by diffusion with n values between This model was used to analyze the release of pharmaceutical polymeric dosage forms, when the release mechanism is not wellknown or, when more than one type of release phenomenon could be involved. The fundamental of diffusion is based on Fick s laws, which describes the macroscopic transport of molecules by a concentration gradient. Formulation & Evaluation of Floating DDS some selected d drugs 135
20 Table 6.08: Kinetic treatment of dissolution profile of tablets (Values of r 2, k, and n for tablets) and mechanism of drug release Batch Korsmeyer Peppas Matrix Mechanism of drug n R 2 k R 2 k release Release kinetics B Fickian Peppas B Non-Fickian Peppas B Non-Fickian Peppas B Fickian Matrix B Non-Fickian Matrix B Non-Fickian Peppas B Fickian Matrix B Non-Fickian Peppas B Non-Fickian Peppas B Non-Fickian Peppas B Non-Fickian Peppas B Non-Fickian Matrix B Non-Fickian Peppas Formulation & Evaluation of Floating DDS some selected d drugs 136
21 6.8 In vivo studies The gastric retention property of the matrix tablet formulation B1 was examined in rabbit. Barium sulphate was used as a radio opaque marker. After the administration of tablet to a fasted rabbit, X-ray pictures were taken at different intervals which are represented in the figure The X-ray image of rabbit with empty stomach, prior to administration of tablet formulation, is as shown in figure A. X-ray images taken at 2 nd and 8 th h (Figure B and C) have shown the presence of tablet in the stomach region, which indicated its retention in the stomach. X-ray image at 12 th h (Figure D) indicated that the tablet is partially disintegrated but still remained in the stomach. This experiment clearly showed that Matrix tablets could prolong the gastric retention time for more than 12 h. Formulation & Evaluation of Floating DDS some selected d drugs 137
22 A) At 0 h (Empty stomach) B) At 2 h C) At 8 h D) At 12 h Figure 6.09: X-ray images showing gastric retention of effervescent floating tablet (B1)in a rabbit model at different time intervals Formulation & Evaluation of Floating DDS some selected d drugs 138
23 6.9 Stability studies Stability studies were performed for the optimized formulation B1to determine the effect of formulation additives on the stability of the drug and also to determine the physical stability of the formulation. The stability studies were carried out at 25ºC/60% RH, 30ºC/65% RH for 12 months and 40ºC/75% RH for 6 months. There was no significant change in the physical appearance and drug content during the study period. The results of drug content determination during stability testing period are reported in table The drug content in the formulation in long-term storage conditions and accelerated storage conditions along with 95% confidence interval was plotted using Sigmaplot software The observations of long-term storage conditions and accelerated conditions are shown in the figures 6.10, 6.11 and Results showed that changes in the parameters evaluated, were very small and were not significant. Formulation & Evaluation of Floating DDS some selected d drugs 139
24 Table 6.09: Stability study data of effervescent floating tablet formulation (B1) of Verapamil hydrochloride Stability condition 25 o ±2 o C/60±5% RH 30 o ±2 o C/65±5% RH 40º±2 o C/75±5% RH *Standard deviation, n=3 Sampling interval (months) Physical appearance % Drug content B1 (mean ± S.D*) 0 No change ± No change ± No change ± No change ± No change ± No change ± No change ± No change ± No change ± No change ± No change ± 0.26 Figure 6.10: % Drug content in the effervescent floating tablet of Verapamil hydrochloride (B1) when stored at 25 ± 2 C & 60 ± 5 % RH for 12 months Formulation & Evaluation of Floating DDS some selected d drugs 140
25 Figure 6.11: % Drug content in the effervescent floating tablet of Verapamil hydrochloride (B1) when stored at 30 ± 2 o C/65 ± 5 % RH for 12 months Figure 6.12: % Drug content in the effervescent floating tablet of Verapamil hydrochloride (B1) when stored at 40 ± 2 o C/75 ± 5 % RH for 06 months Formulation & Evaluation of Floating DDS some selected d drugs 141
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