ORTHOPAEDICS. Component position alignment with patient-specific jigs in total knee arthroplasty. Introduction. ANZJSurg.com
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1 ORTHOPAEDICS ANZJSurg.com Component position alignment with patient-specific jigs in total knee arthroplasty Terence R. Moopanar,* Jeevaka E. Amaranath* and Rami M. Sorial *Department of Orthopaedics, Nepean Public Hospital, Penrith, New South Wales, Australia and Nepean Public Hospital/Nepean Private Hospital, University of Sydney, Penrith, New South Wales, Australia Key words alignment in TKA, patient-specific jigs, total knee arthroplasty. Correspondence Dr Terence R. Moopanar, Department of Orthopaedics, Nepean Public Hospital, Coonara Avenue, West Pennant Hills, NSW 15, Australia. T. R. Moopanar MBBS; J. E. Amaranath MBBS; R. M. Sorial MBBS, FRACS, FAOrthoA. Accepted for publication 1 April 1. doi: /ans.17 Abstract Background: The failure to restore mechanical alignment and appropriate rotational axis intraoperatively has been described as one of the most common causes of implant failure in total knee arthroplasty (TKA). Both conventional and computer-assisted TKA have their limitations. Patient-specific jigs (PSJ) offer a possible alternative method for TKA. The aim of this study was to investigate if the use of PSJ offers reproducible and accurate orientation of the components in TKA compared with conventional and computer-assisted surgery. Methods: We conducted a prospective case series looking at 1 consecutive patients undergoing TKA for osteoarthritis using the Signature Patient Specific System (Biomet, North Ryde, NSW, Australia). Each patient underwent a preoperative magnetic resonance imaging for planning. Using a computer software program, specialized femoral and tibial pin placement jigs were generated. Post-operative femoral and tibial component alignment was measured using computed tomography. Results: Of patients, 9.% achieved femoral rotational alignment ±3 degrees of the transepicondylar axis. Tibial coronal alignment showed 9.7% of cases were 9 ± 3 degrees to the tibial medullary axis. Implant measurements of the posterior tibial slope demonstrated 7.% of cases were within our accepted to 7 degrees slope and 1.% of patients had an overall mechanical axis within ±3 degrees of neutral. We also recorded femoral coronal alignment of the last 9 patients of our group and found that 99% were within 9 ± 3 degrees. Conclusion: PSJ for TKA shows good accuracy in alignment when compared with conventional TKA. However, improvements in the development of the tibial alignment cutting guides will aid in further increasing its overall accuracy and reproducibility. Introduction Since its inception in the 195s, total knee arthroplasty (TKA) has been regarded as a very successful orthopaedic procedure. 1 Throughout this time, there have been dramatic advancements in knowledge of knee mechanics that have led to modifications of technique and design, which aid in making the prosthesis more durable and long lasting.,3 Ultimately, such research aims to reduce the risk of implant failure. The failure to restore mechanical alignment and appropriate rotational axis intraoperatively, has been described as one of the most common causes of implant failure. Previous studies have clearly demonstrated the correlation between implant alignment and clinical outcome. Internal rotation of the femoral component is associated with patella femoral complications including anterior knee pain, patella subluxation/dislocation and component failure. 5, Excessive external rotation of the femoral component has been shown to cause an increased medial flexion gap and symptomatic flexion instability. 7, Deviations in excess of the accepted 3 degrees of varus or valgus in the coronal mechanical axis have been shown to increase polyethylene load contributing to increased wear and decreased survival of the prosthesis More recently, it has been shown that the margin of error in implant placement is narrow and implant failure is statistically appreciable when components are marginally malaligned. 1 Conventional TKA relies on visual references and identifying bony landmarks as critical points for restoration of mechanical alignment and component placement. Studies have shown that the ANZ J Surg (1) 3
2 Component position alignment 9 accuracy and reproducibility of identifying these landmarks can be variable and will have an effect on overall alignment. 13 Computer navigation appeared to present one answer to improving accuracy of implant placement intraoperatively. A number of studies have shown that computer navigation offers a better rate of accuracy and fewer outliers with regard to prosthetic implant placement than the use of standard instrumentation. 1,15 Although this may be considered the current gold standard, the limitations of computer-navigated surgery include high set-up costs, pin site complications and increased operative time. A few case reports and small studies have recently advocated image based patient-specific instrumentation when performing TKA. 1,17 These jigs are produced after a preoperative magnetic resonance imaging (MRI) of the limb is taken and anatomical landmarks for alignment are identified. Coronal, sagittal and rotational positioning of the prosthesis is then fashioned using a propriety software program with the surgeons input to restore mechanical alignment. Pin guides to position the femoral and tibial cutting blocks are then manufactured for the surgical procedure. We adopted the use of patient-specific jigs (PSJ) looking for a more accurate and reproducible prosthetic implant alignment, while reducing the limitations associated with computer navigation TKA mentioned earlier. The aim of this study was to investigate whether our use of a PSJ system offers reproducible and accurate orientation of the components in TKA. We also assessed the short-term clinical outcomes of patients undergoing TKA using PSJ. The results of our cohort group were then compared with published results for standard instrumentation and computer navigation. Materials and methods We conducted a prospective case series looking at patients undergoing TKA by a single surgeon. The first 1 patients from June 9 to December 1 to have surgery using this method and then assessed by CT were included in this study. All patients underwent TKA using the Signature TM patient-specific system (Biomet, North Ryde, NSW, Australia). using the cementless Vanguard knee replacement prosthesis (Biomet). Awritten informed consent was taken from every patient and ethics approval confirmed (Nepean Hospital, Kingswood, NSW, Australia) to review and report data. Preoperative workup included documentation of age, sex and range of motion. The majority of patients were imaged preoperatively by MRI (except for 1 patients who required CT imaging because of presence of pacemaker or claustrophobia). The MRI images were taken by a 1.5-T scanner (GE Medical Systems, Mansfield, QLD, Australia). A knee MRI scanning protocol consisting of four imaging sequences was followed. The images data file was then forwarded to the manufacturer for segmentation and the production of 3-D reconstructions to determine preoperative mechanical alignment, anatomical landmarks, implant sizes and ultimately implant placement. Using specialized computer software analysing anatomical landmarks and surgeon s input (on alignment, rotation and any additional femoral resection based on preoperative flexion deformity), specialized femoral and tibial pin placement jigs were generated uniquely for each patient. Alignment was defined by the mechanical axis and rotation by the transepicondylar axis. TKA was carried out in the supine position with a tourniquet inflated to 3 mm Hg using a medial para-patella approach. All patients in the study underwent either a posterior cruciate ligament (PCL) retaining or PCL substituting TKA (Vanguard, Biomet). After meticulous soft tissue clearance the patient-specific guides, Signature Patient Guide System (Biomet), were placed directly on the bony and chondral surfaces for pin placement. Osteophytes were left intact as the PSJ accommodated for them as a means of improving accuracy of fit for each patient. Jig placement intraoperatively was compared and referenced to the MRI-generated model of the proximal tibia and distal femur in an effort to reproduce accurate placement outlined in the preoperative surgical plan. A removable drop rod allowed visual confirmation of coronal and sagittal positioning. Following pin placement, the standard tibial and femoral cutting blocks were then utilized over the pins and osteotomies performed. This is a measured resection technique followed with appropriate soft tissue balancing as needed. With the pins still in situ if the extension space is tight a further mm can be resected from the distal femur using the standard cutting blocks. Following implantation of the components, wounds were closed in layers over a drain with surgical staples to the skin, which were removed on Day 7. After the first weeks patients had a CT scan of the operated knee using a modified Perth CT protocol 1 to determine the accuracy of implant placement. All scans were performed and read by the same senior radiographer. Measured parameters for the whole cohort included femoral component rotation, tibial component coronal alignment, tibial component posterior slope and overall mechanical limb alignment (centre of femoral head to centre of knee to centre of ankle). Femoral component coronal alignment was measured for the last 9 patients in this cohort. Statistical analysis was performed using Microsoft Excel and used the Excel ToolPak for basic data analysis including summary statistics and the generation of tables and figures. Student s t-test was performed with mean and standard deviation recorded. We used P <.5 as threshold of significance. Results The first consecutive 1 patients (159 women, 1 men) undergoing TKA using PSJ and assessed by CT are reported on in our study. The average age was. ±. years, with 5.9% being left. Preoperative alignment measures showed that % of knees were in valgus, 3% in neutral and 7% in varus as referenced to the mechanical axis. The average preoperative deformity was 3.9 degrees of varus. With respect to rotation of the femoral component in the axial plane, the transepicondyllar axis (TEA) was used as the reference line for our CT measurements of component alignment. The angular rotation of the femoral component with respect to the TEA to be on average. ± 1.1 of external rotation (range from. degrees internal rotation. degrees external rotation). Femoral components in 9.% of patients were within 3 degrees of the TEA reference line. Internal rotation of the femoral component occurred in less than % of our patient population (Fig. 1). Femoral component coronal alignment to mechanical axis was also recorded for the last 9 patients of the cohort and 99% of patients had alignment measures of 9 ± 3 degrees.
3 3 Moopanar et al. Femoral Rota on (Degrees) Femoral Rota on Pa ent number Fig. 1. The rotation of the femoral component in the axial plain for the first 1 patients. The shaded area depicts the acceptable margin of alignment (±3 degrees). The negative values represent internal rotation of the component. The positive values represent external rotation of the component. Posterior Slope (Degrees) Posterior Tibial Slope Fig. 3. The scatter plot of the component posterior tibial slope plotted against patient number shows the distribution of tibial slopes within the range of to 7 degrees (shaded area). The negative values represent an anterior slope. Tibial Alignment (degrees) Tibial Coronal Alignment Fig.. The tibial component coronal alignment plotted against the first 1 patients. The shaded area depicts the acceptable margin of alignment (±3 degrees). Mechanical Axis (Degrees) Mechanical Axis Fig.. The component mechanical axis plotted for each patient. The negative values represent varus alignment, positive values represent valgus alignment and neutral alignment is at degrees. For the coronal alignment of the tibial component, the desired implant placement is at 9 degrees to the longitudinal axis of the tibia (neutral). On average, tibial component placement was measured at 9.7 degrees (range 95 degrees). Tibial components in 9.7% of patients were aligned within 3 degrees of the neutral position. Varus alignment outliers (<7 degrees) was seen in 1.5% of patients and valgus alignment outliers (>93 degrees) was seen in 5.% (Fig. ). The posterior slope of the tibial component was placed at.9 ±.7 degrees (range anterior slope degrees posterior slope) on average. 7.% of patients had tibial components aligned within the range of to 7 degrees. Anterior slope outliers were noted in less than % of patients (Fig. 3). Finally, the overall mechanical axis averaged at 1.1 ±. degrees (valgus) (range degrees varus to 7 degrees valgus) postoperatively. 1.% of patients to have a mechanical axis within 3 degrees of neutral alignment. Of the remaining outliers 1.5% had >3 degrees of valgus alignment and.3% had >3 degrees of varus alignment (Fig. ). Discussion The success of a total knee replacement can depend primarily on the restoration of the patient s mechanical and rotational alignment.,5 This paper has shown that signature PSJ produce very accurate
4 Component position alignment 31 results for femoral component alignment as measured on coronal (99%) and axial (9.%) CT scans of the femoral prosthesis. But tibial component alignment does not match this same high level of accuracy on coronal (91.7%) and sagittal (7.%) CT scans of the tibial prosthesis. The additive result is an overall mechanical alignment for the group that has 1.% in the neutral ±3 degree range. The authors believe this can only be improved further by modifying the tibial pin guides to ensure more enhanced capture of the patient s tibial articular and anterior cortical surfaces. Although not specifically measured, it was noted throughout the series that the femoral guides always had an accurate and secure fit to the femoral surface, but the tibial guides occasionally had a few degrees of play that required the drop rod attachment to double check alignment along the anterior tibial anterior crest visually. Improving the security of this fit by increasing anterior cortical contact with the tibia and further posterior articular extension of the guide is needed to improve tibial prosthetic alignment further. Restoration of the femoral rotational axis is universally recognized as important in reducing implant failure. 5 We found that 9.% of all our cases were ±3 degrees of neutral. The majority of these were externally rotated. The accuracy of femoral rotation alignment is higher than conventional TKR and within range or better than computer-assisted TKR. 19 These results demonstrate that PSJ instrumentation can reduce the variability in femoral rotational alignment seen previously with conventional and navigated TKAs principally because it utilizes an image-based selection of the anatomical landmarks rather than relying on surgeon selection of these landmarks intraoperatively. The tibial component placement in the coronal plane showed that 9.7% of cases reached an alignment of 9 ± 3 degrees. Furthermore, the outliers were mainly in valgus and not varus. This is significant as studies show that a tibial component alignment of greater than 3 degrees of varus is associated with implant failure and revision surgery. 1 A large retrospective study by Ritter et al. 1 reviewing 7 TKR found a high failure rate (.7%) was associated with patients that had varus (<9 degrees relative to the tibial axis) malalignment of their tibial component compared with those that had neutral orientation (.%). The study also commented on the importance of obtaining neutral alignment in both the tibial and femoral components, as compensatory alignment of one for the malalignment of another in order to produce a neutrally aligned knee was reported to increase the risk of failure (3.% for varus tibial alignment and 7.% for valgus femoral malalignment). This shows that achieving neutrality in each separate alignment plane aims to maximize the survival of TKR. The posterior tibial slope in 7.% was within the range of to 7 degrees. The majority of the remaining cases showed a slightly increased slope while only very few cases cut anteriorly (less than degrees). Many studies have shown that an accurate tibial slope cut within an acceptable range of to 7 degrees reproduces good knee range of motion and limits failure by tibial component subsidence.,3 This study is one of the largest reporting on CT measured postoperative alignment in TKA surgery using PSJ. Multiple studies have shown the importance of restoring the mechanical axis within ±3 degrees to neutral in order to reduce the failure of the implants and increase the success of a TKA. 9 11,1 A study by Choong et al. looking at conventional versus computer-assisted surgery (CAS) TKA found CAS TKA achieved a higher accuracy of mechanical alignment within 9 ± 3 degrees at % compared with 1% for conventional TKAs. Furthermore, patients with a mechanical alignment within ±3 degrees of neutral (9 degrees) had better functional scores at 3, and 1 months follow. This suggests accurate mechanical alignment can be a factor in a more successful outcome following TKA. Our study showed that 1.% of cases had a mechanical axis restored to within ±3 degrees of neutral. These results are lower than previous results for CAS TKA, 5 but superior to alignment for conventional instruments. Our data in regards to femoral component coronal alignment to mechanical axis post-operatively, found that 99% of these cases had an alignment measure of 9 ± 3 degrees. This high level of accuracy in the femoral component shows that as the mechanical axis alignment incorporates the additive errors in the femoral and tibial implant alignment from a neutral position, the reduced accuracy in the mechanical axis can be attributed to the relative reduced accuracy of the tibial cutting guides and subsequent alignment of the tibial component. This study had some limitations that need to be considered. Firstly, the study was a single-surgeon prospective case series and did not compare the PSJ TKA with a cohort of conventional instrument TKA done by the same surgeon. It relied on the surgeon s individual degree of experience and learning curve. Regarding coronal alignment, the tibial component was measured to assess varus and valgus alignment of the implants initially with an assumption that the femoral component would always be parallel. However, this is not always the case, so we are now collecting data independently for femoral component alignment and this will become a source for analysis to allow identification of cases of compensatory malalignment. We did not record factors such as blood loss or complications as the aim of this study was to report on the reproducibility and accuracy of component alignment in PSJ TKA. In conclusion, these results show that PSJ implant alignment shows improved accuracy when compared with published results for conventional instrumented TKA. However, we believe the overall mechanical axis of the limb can be reproduced more accurately with continued development of the tibial pin cutting guides to further improve tibial implant positioning and overall alignment. References 1. Shiers LG. 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5 3 Moopanar et al.. Matsuda S, Miura H, Nagamine R, Urabe K, Hirata G, Iwamoto Y. Effect of femoral and tibial component position on patellar tracking following total knee arthroplasty: 1-year follow-up of Miller Galante I knees. Am. J. Knee Surg. 1; 1: Olcott CW, Scott RD. The Ranawat Award. Femoral component rotation during total knee arthroplasty. Clin. Orthop. Relat. Res. 1999; 37: 39.. Hanada H, Whiteside LA, Steiger J, Dyer P, Naito M. Bone landmarks are more reliable than tensioned gaps in TKA component alignment. Clin. Orthop. Relat. Res. 7; : Jeffery RS, Morris RW, Denham RA. Coronal alignment after total knee replacement. J. Bone Joint Surg. Br. 1991; 73: Ritter MA, Davis KE, Meding JB, Pierson JL, Berend ME, Malinzak RA. The effect of alignment and BMI on failure of total knee replacement. J. Bone Joint Surg. Am. 11; 93: Perillo-Marcone A, Barrett DS, Taylor M. The importance of tibial alignment: finite element analysis of tibial malalignment. J. Arthroplasty ; 15: Ritter MA, Albohm MJ, Keating EM, Faris PM, Meding JB. Comparative outcomes of total joint arthroplasty. J. Arthroplasty 1995; 1: Jenny JY, Boeri C. Low reproducibility of the intra-operative measurement of the transepicondylar axis during total knee replacement. Acta Orthop. Scand. ; 75: Dutton AQ, Yeo SJ. Computer-assisted minimally invasive total knee arthroplasty compared with standard total knee arthroplasty. Surgical technique. J. Bone Joint Surg. Am. 9; 91 (Suppl. Pt): Sparmann M, Wolke B, Czupalla H, Banzer D, Zink A. Positioning of total knee arthroplasty with and without navigation support. A prospective, randomised study. J. Bone Joint Surg. Br. 3; 5: Chan KY, Teo YH. Patient-specific instrumentation for total knee replacement verified by computer navigation: a case report. J. Orthop. Surg. (Hong Kong) 1; : Bali K, Walker P, Bruce W. Custom-fit total knee arthroplasty: our initial experience in 3 knees. J. Arthroplasty 1; 7: Chauhan SK, Clark GW, Lloyd S, Scott RG, Breidahl W, Sikorski JM. Computer-assisted total knee replacement. A controlled cadaver study using a multi-parameter quantitative CT assessment of alignment (the Perth CT Protocol). J. Bone Joint Surg. Br. ; : Matziolis G, Krocker D, Weiss U, Tohtz S, Perka C. A prospective, randomized study of computer-assisted and conventional total knee arthroplasty. Three-dimensional evaluation of implant alignment and rotation. J. Bone Joint Surg. Am. 7; 9: Siston RA, Patel JJ, Goodman SB, Delp SL, Giori NJ. The variability of femoral rotational alignment in total knee arthroplasty. J. Bone Joint Surg. Am. 5; 7: Berend ME, Ritter MA, Meding JB et al. Tibial component failure mechanisms in total knee arthroplasty. Clin. Orthop. Relat. Res. ; : 3.. Hofmann AA, Bachus KN, Wyatt RW. Effect of the tibial cut on subsidence following total knee arthroplasty. Clin. Orthop. Relat. Res. 1991; 9: Malviya A, Lingard EA, Weir DJ, Deehan DJ. Predicting range of movement after knee replacement: the importance of posterior condylar offset and tibial slope. Knee Surg. Sports Traumatol. Arthrosc. 9; 17: 91.. Choong PF, Dowsey MM, Stoney JD. Does accurate anatomical alignment result in better function and quality of life? Comparing conventional and computer-assisted total knee arthroplasty. J. Arthroplasty 9; : Zamora LA, Humphreys KJ, Watt AM, Forel D, Cameron AL. Systematic review of computer-navigated total knee arthroplasty. ANZ J. Surg. 13; 3: 3.
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