At any time, an abnormal test result or organ dysfunction could lead to further investigations and more intensive follow-up not depicted here
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1 March 17, 2012 Minimum follow-up guidelines for screening of late complications after treatment with NOPHO ALL 2008 SR/IR At any time, an abnormal test result or organ dysfunction could lead to further investigations and more intensive follow-up not depicted here Revaccination program according to national policies. The Swedish vaccination program could be found at Please apply the 9 th follow-up program until the visit when transition to adult health care will be performed. No screening program is recommended for age above 18.
2 SR/IR 3 rd 4 th 5 th 6 th 7 th 8 th 9 th Transition Psychosocial fct: History Growth: Height and weight Metabolic fct: BMI, B- lipids, waist and hip circumference Pubertal develop: Tanner, testes volume, menarche School,spare time, relations, work Or more frequent At least once during follow-up Or more frequent Fertility: sperm exam. Menstruation history Assessment on demand Heart: electrocardiogram echocardiography (within 6 mo of last dose Blood pressure + early puberty, +pregnancy, +top level sports Lungs: history Physical fct: history
3 SR/IR 3 rd 4 th 5 th 6 th 7 th 8 th 9 th Transition Kidneys: dip stick, creatinine, GFR Liver: ALAT, bil, ALP, hepatitis serol Neurologic fct: examination Hearing: history Vision: history Neuropsychological fct: history Skeletal/soft tissue: history, fractures, pain Mouth, teeth: history Skin: examination
4 Minimum follow-up guidelines for screening of late complications after treatment with Stem cell transplantation excluded. NOPHO ALL 2008 HR At any time, an abnormal test result or organ dysfunction could lead to further investigations and more intensive follow-up not depicted here Revaccination program according to national policies. The Swedish vaccination program could be found at Please apply the 9 th follow-up program until the visit when transition to adult health care will be performed. For the adult patient who received HR treatment in childhood, further follow-up is warranted: Echocardiogram + echocardiography every 5 th during life-time. See also the special situations, ie pregnancies and top level sports. Any dysfunction noted during follow-up should be persistently followed after transitioning to adult health care. Special follow-up for those who entered the liposomal cytarabin (DepoCyte) study: Clinical neurological examination, neuropsychological testing, MRI imaging of brain and spinal cord, and motor evoked potentials by magnetic stimulation (MEP) are all done 6 months after end of, i.e. 3 s from diagnosis. (see in the protocol).
5 HR 3 rd 4 th 5 th 6 th 7 th 8 th 9 th Transition Psychosocial fct: History Growth: Height and weight Metabolic fct: BMI, B- lipids, waist and hip circumference Pubertal develop: Tanner, testes volume, menarche School, spare time, relations, work Or more frequent Or more frequent Fertility: Sperm exam. Menstruation history Assessment on demand Heart: electrocardiogram echocardiography (within 6 mo of last dose Blood pressure + early puberty, +pregnancy, +top level sports Lungs: history Physical fct: history
6 HR 3 rd 4 th 5 th 6 th 7 th 8 th 9 th Transition Kidneys: dip stick, creatinine, GFR Liver: ALAT, bil, ALP, hepatitis serol Neurologic fct: examination For DepoCyte study, see above Hearing: history Vision: history Neuropsychological fct: history Skeletal/soft tissue: history, fractures, pain Mouth, teeth: history For DepoCyte study, see above Skin: examination
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