Date of transplant for which this form is being completed: Month Day Year. Date of report: Month Day Year. Pretransplant Information
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1 INSERT XXVII Langerhans Cell Histiocytosis (LCH) 1. Date of diagnosis of primary disease: 32. Did patient develop diabetes insipidus at any time prior to conditioning? 1 Yes 0 No (Institutional Unique Blood or Marrow Transplant Identification Number) Date of transplant for which this form is being completed: Pretransplant Information FOR REGISTRY USE ONLY: I.D. Date received: Registry (circle one): IBMTR ABMTR EBMT Date of report: * If this is a report of a second (or subsequent) transplant, check here, and go to Q.158 Organ involvement at diagnosis (check all that apply): If confirmed by biopsy, Histologic Diagnosis Confirmed by biopsy? (see codes below) Yes No Unknown Yes No Unknown Presumptive Designated Definitive Bone Bone marrow Central nervous system Gastrointestinal Liver Lung Lymph node(s) Skin Spleen Other, specify: If Biopsy Report is available check here, attach copy and reference Qs.3-31 P Histologic Diagnosis Codes 1 = Presumptive diagnosis (light microscopy only) 2 = Designated diagnosis (LM+ at least 2 supplemental stains: ATPase, S100, alpha-d-mannosidase, Peanut lectin) 3 = Definitive diagnosis (CD1a and/or Birbeck granules on electronmicroscopy) IBMTR/ABMTR Reporting Form 095-LCH (1/01) Page 1 of 6
2 33. Was patient treated for LCH prior to conditioning? 1 Yes 0 No Go to Q.158 Line of Therapy 1st 2nd Date started: Date stopped: SURGICAL RESECTION/CURETTAGE: Yes 0 No 8 Unk Yes 0 No 8 Unk Site of Surgery: If Surgery Report is available, check here, attach copy and reference Q.37 and/or 68 RADIATION THERAPY: Yes 0 No Yes 0 No Total cgy (rads) Total cgy (rads) Bone: Yes 0 No Yes 0 No CNS: Yes 0 No Yes 0 No Gastroinestinal tract: Yes 0 No Yes 0 No Liver: Yes 0 No Yes 0 No Lung: Yes 0 No Yes 0 No Lymph nodes: Yes 0 No Yes 0 No Skin: Yes 0 No Yes 0 No Spleen: Yes 0 No Yes 0 No Other: Yes Yes Specify: Fractionation schedule: Single 3 Multiple daily Single 3 Multiple daily CHEMOTHERAPY: Yes 0 No Yes 0 No # of cycles: Unknown Unknown Treatment: 2 CdA: Yes 0 No Yes 0 No Chlorambucil: Yes 0 No Yes 0 No Cyclosporin-A (CsA): Yes 0 No Yes 0 No Etoposide (VP-16): Yes 0 No Yes 0 No Steroids: Yes 0 No Yes 0 No Vinblastine (Velban): Yes 0 No Yes 0 No 6-mercaptopurine (6-MP): Yes 0 No Yes 0 No Other: Yes, specify: Yes, specify: Other: Yes, specify: Yes, specify: Best response (see pg 4): CR 2 PR CR 2 PR (check one only) 3 SD 4 MX 5 PROG 3 SD 4 MX 5 PROG 7 NE 8 Unknown 7 NE 8 Unknown Specify: Date response evaluated: Did patient relapse or progress? following this line of therapy? Yes 0 No Yes 0 No Date of relapse/progression: Continued on next page IBMTR/ABMTR Reporting Form 095-LCH (1/01) Page 2 of 6
3 Continued from previous page Copy this page for recording more than 4 instances Line of Therapy 3rd 4th Date started: Date stopped: SURGICAL RESECTION/CURETTAGE: Yes 0 No 8 Unk Yes 0 No 8 Unk Site of Surgery: If Surgery Report is available, check here, attach copy and reference Q.99 and/or 130 RADIATION THERAPY: Yes 0 No Yes 0 No Total cgy (rads) Total cgy (rads) Bone: Yes 0 No Yes 0 No CNS: Yes 0 No Yes 0 No Gastroinestinal tract: Yes 0 No Yes 0 No Liver: Yes 0 No Yes 0 No Lung: Yes 0 No Yes 0 No Lymph nodes: Yes 0 No Yes 0 No Skin: Yes 0 No Yes 0 No Spleen: Yes 0 No Yes 0 No Other: Yes Yes Specify: Fractionation schedule: Single 3 Multiple daily Single 3 Multiple daily CHEMOTHERAPY: Yes 0 No Yes 0 No # of cycles: Unknown Unknown Treatment: 2 CdA: Yes 0 No Yes 0 No Chlorambucil: Yes 0 No Yes 0 No Cyclosporin-A (CsA): Yes 0 No Yes 0 No Etoposide (VP-16): Yes 0 No Yes 0 No Steroids: Yes 0 No Yes 0 No Vinblastine (Velban): Yes 0 No Yes 0 No 6-mercaptopurine (6-MP): Yes 0 No Yes 0 No Other: Yes, specify: Yes, specify: Other: Yes, specify: Yes, specify: Best response (see pg 4): CR 2 PR CR 2 PR (check one only) 3 SD 4 MX 5 PROG 3 SD 4 MX 5 PROG 7 NE 8 Unknown 7 NE 8 Unknown Specify: Date response evaluated: Did patient relapse or progress? following this line of therapy? Yes 0 No Yes 0 No Date of relapse/progression: IBMTR/ABMTR Reporting Form 095-LCH (1/01) Page 3 of 6
4 158. Patient's disease status immediately prior to conditioning (check one only): 1 CR 2 PR 3 SD 4 MX 5 PROG 7 NE, specify: See Response Codes below Organs involved at time of transplant (check all that apply): Yes No Unknown Bone Bone marrow Central nervous system Gastrointestinal Liver Lung Lymph node(s) Skin Spleen Hematologic findings immediately prior to conditioning: Other, specify: Specify Units Unknown Differential 169. Monocytes: % 8 Definition of Disease State: Response Codes CR = Complete Response: Absence of all signs and/or symptoms of disease. PR = Partial Response: Regression of signs and/or symptoms of disease without appearance of new lesions. SD = Stable Disease: Persistence of signs and/or symptoms of disease without appearance of new lesions. MX = Mixed Response: Regression of some signs and/or symptoms of disease with appearance of new lesions. PROG = Progressive Disease: Progression of signs and/or symptoms of disease initially detected and/or reappearance of old and/or appearance of new lesions. NE = Not Evaluable: Not evaluable, specify. IBMTR/ABMTR Reporting Form 095-LCH (1/01) Page 4 of 6
5 Posttransplant Information* * To be completed 100 days posttransplant, or at time of death if death occurred <100 days posttransplant, or immediately prior to start of high-dose therapy (conditioning) for second tranplant if second transplant done <100 days after first transplant 170. Best response posttransplant not including posttransplant therapy (check one only): 1 CR 2 PR 3 SD 4 MX 5 PROG 7 NE, specify: 171. Did patient relapse posttransplant? 1 Yes 0 No 172. Date of relapse: See Response Codes on pg 4 Specify organs involved (check all that apply): Yes No Unknown Bone Bone marrow Central nervous system Gastrointestinal Liver Lung Lymph node(s) Skin Spleen Other, specify: IBMTR/ABMTR Reporting Form 095-LCH (1/01) Page 5 of 6
6 183. Did patient receive additional therapy specifically for LCH after transplant? 1 Yes 0 No 184. Date treatment started: 8 Unknown 203. Date current disease determination first established: 204. Patient's disease status at time of last contact or at time of death (check one only): 1 CR 2 PR 3 SD 4 MX 5 PROG 7 NE, specify: 185. Still receiving additional therapy? 1 Yes 0 No 8 Unknown Treatments: Yes No Unknown CdA Cyclosporin-A (CsA) Etoposide (VP-16) Steroids Vinblastine (Velban) Other, specify: Radiation See Response Codes on pg 4 Total cgy (rads) Bone: Yes 0 No CNS: Yes 0 No Gastroinestinal tract: Yes 0 No Liver: Yes 0 No Lung: Yes 0 No Lymph nodes: Yes 0 No Skin: Yes 0 No Spleen: Yes 0 No Other: 201. Specify: Fractionation schedule: Yes 1 Single 3 Multiple daily See Date on pg 1 of 095CORE IBMTR/ABMTR Reporting Form 095-LCH (1/01) Page 6 of 6
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