Ontario Institute of Technology (UOIT) and Canadian Memorial Chiropractic College (CMCC), 6100 Leslie Street, Toronto, ON M2H 3J1, Canada.

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1 Article Title: Are Work Disability Prevention Interventions Effective for the Management of Neck Pain or Upper Extremity Disorders? A Systematic Review by the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration Journal Name: Journal of Occupational Rehabilitation Authors: Sharanya Varatharajan 1,2, Pierre Côté 1,3,4, Heather M. Shearer 1,2, Patrick Loisel 2,5, Jessica J. Wong 1,6, Danielle Southerst 1,6, Hainan Yu 1,2, Kristi Randhawa 1,2, Deborah Sutton 1,2, Gabrielle van der Velde 7,8,9, Silvano Mior 2,4, Linda J. Carroll 10, Craig Jacobs 1,11, and Anne Taylor-Vaisey 1 1 UOIT-CMCC Centre for the Study of Disability Prevention and Rehabilitation, University of Ontario Institute of Technology (UOIT) and Canadian Memorial Chiropractic College (CMCC), 6100 Leslie Street, Toronto, ON M2H 3J1, Canada. 2 Division of Graduate Education and Research, Canadian Memorial Chiropractic College (CMCC), 6100 Leslie Street, Toronto, ON M2H 3J1, Canada. 3 Canada Research Chair in Disability Prevention and Rehabilitation, University of Ontario Institute of Technology (UOIT), Oshawa, ON, Canada. 4 Faculty of Health Sciences, University of Ontario Institute of Technology (UOIT), Oshawa, ON, Canada. 5 Division of Occupational and Environmental Health, Dalla Lana School of Public Health, University of Toronto, ON, Canada 6 Division of Undergraduate Education, Canadian Memorial Chiropractic College (CMCC), 6100 Leslie Street, Toronto, ON M2H 3J1, Canada. 7 Toronto Health Economics and Technology Assessment (THETA) Collaborative, ON, Canada. 8 Faculty of Pharmacy, University of Toronto, ON, Canada. 9 Institute for Work and Health, Toronto, ON, Canada. 10 Department of Public Health Sciences and Alberta Centre for Injury Prevention and Research, School of Public Health, University of Alberta, Edmonton, AB, Canada. 11 Division of Clinical Education, Canadian Memorial Chiropractic College (CMCC), 6100 Leslie Street, Toronto, ON M2H 3J1, Canada. Corresponding Author: Sharanya Varatharajan, UOIT-CMCC Centre for the Study of Disability Prevention and Rehabilitation, 6100 Leslie Street, Toronto, ON M2H 3J1, Canada; sharanya.varatharajan@uoit.ca; telephone: (416) ext. 170

2 Online Resource 1 MEDLINE Search Strategy Search Terms for Neck Pain and Associated Disorders, Whiplash-Associated Disorders and Work Disability Prevention Interventions 1. exp Whiplash Injuries/ 2. exp Neck Injuries/ 3. exp Neck Pain/ 4. Neck Muscles/in [Injuries] 5. exp Cervical Vertebrae/in [Injuries] 6. exp Radiculopathy/ 7. exp Brachial Plexus Neuropathies/ 8. exp Torticollis/ 9. Headache/ 10. whiplash.ab,ti. 11. "neck injur*".ab,ti. 12. "neck pain*".ab,ti. 13. "cervical pain*".ab,ti. 14. "neck ache*".ab,ti. 15. "neckache*".ab,ti. 16. "cervicalgia*".ab,ti. 17. "cervicodynia*".ab,ti. 18. "radiculopath*".ab,ti. 19. "brachial plexus neuropath*".ab,ti. 20. torticollis.ab,ti. 21. "headache*".ab,ti. 22. or/ exp guideline/ 24. Practice Guidelines as Topic/ 25. Guideline Adherence/

3 26. Randomized Controlled Trials as Topic/ 27. exp Controlled Clinical Trials as Topic/ 28. exp consensus development conferences as topic/ 29. "Review Literature as Topic"/ 30. meta-analysis/ 31. exp case-control studies/ 32. exp Cohort Studies/ 33. Double-Blind Method/ 34. single-blind method/ 35. Placebos/ 36. randomized controlled trial.pt. 37. controlled clinical trial.pt. 38. guideline.pt. 39. practice guideline.pt. 40. consensus development conference.pt. 41. "systematic review*".ab,ti. 42. (meta analys* or meta-analys* or metaanalys*).ab,ti. 43. (cohort adj4 (study or studies or analys*)).ab,ti. 44. (random* adj4 (control* or clinical or allocat*)).ab,ti. 45. "guideline*".ab,ti. 46. (case adj control*).ab,ti. 47. ((double or single) adj3 blind*).ab,ti. 48. "placebo*".ab,ti. 49. or/ Workplace/ 51. Workload/ 52. Occupational Diseases/

4 53. Occupational Therapy/ 54. Work/ 55. Occupational Health/ 56. Sick Leave/ 57. Workers' Compensation/ 58. Occupations/ 59. Occupational Injuries/ 60. Work Capacity Evaluation/ 61. Rehabilitation, Vocational/ 62. Employment/ 63. Occupational Health Services/ 64. Human Engineering/ 65. Occupational Therapy/ 66. (return* adj2 work).ab,ti. 67. RTW.ab,ti. 68. (workplace or (work adj place)).ab,ti. 69. (worksite or (work adj site)).ab,ti. 70. (occupational adj disease*).ab,ti. 71. (occupational adj health).ab,ti. 72. "workers* compensation".ab,ti. 73. (sick adj leave*).ab,ti. 74. (work adj3 (hardening or conditioning)).ab,ti. 75. (graded adj activit*).ab,ti. 76. "ergonomic*".ab,ti. 77. or/ and 49 and limit 78 to (english language and yr="2006 -Current")

5 Search Terms for Upper Extremity Disorders and Work Disability Prevention Interventions 1. exp guideline/ 2. Practice Guidelines as Topic/ 3. Guideline Adherence/ 4. Randomized Controlled Trials as Topic/ 5. exp Controlled Clinical Trials as Topic/ 6. exp consensus development conferences as topic/ 7. "Review Literature as Topic"/ 8. meta-analysis/ 9. exp case-control studies/ 10. exp Cohort Studies/ 11. Double-Blind Method/ 12. single-blind method/ 13. Placebos/ 14. randomized controlled trial.pt. 15. controlled clinical trial.pt. 16. guideline.pt. 17. practice guideline.pt. 18. consensus development conference.pt. 19. "systematic review*".ab,ti. 20. (meta analys* or meta-analys* or metaanalys*).ab,ti. 21. (cohort adj4 (study or studies or analys*)).ab,ti. 22. (random* adj4 (control* or clinical or allocat*)).ab,ti. 23. "guideline*".ab,ti. 24. (case adj control*).ab,ti. 25. ((double or single) adj3 blind*).ab,ti. 26. "placebo*".ab,ti.

6 27. or/ Workplace/ 29. Workload/ 30. Occupational Diseases/ 31. Occupational Therapy/ 32. Work/ 33. Occupational Health/ 34. Sick Leave/ 35. Workers' Compensation/ 36. Occupations/ 37. Occupational Injuries/ 38. Work Capacity Evaluation/ 39. Rehabilitation, Vocational/ 40. Employment/ 41. Occupational Health Services/ 42. Human Engineering/ 43. Occupational Therapy/ 44. (return* adj2 work).ab,ti. 45. RTW.ab,ti. 46. (workplace or (work adj place)).ab,ti. 47. (worksite or (work adj site)).ab,ti. 48. (occupational adj disease*).ab,ti. 49. (occupational adj health).ab,ti. 50. "workers* compensation".ab,ti. 51. (sick adj leave*).ab,ti. 52. (work adj3 (hardening or conditioning)).ab,ti. 53. (graded adj activit*).ab,ti.

7 54. "ergonomic*".ab,ti. 55. exp Upper Extremity/ 56. Shoulder Pain/ 57. exp "Sprains and Strains"/ 58. exp Cumulative Trauma Disorders/ 59. exp Median Neuropathy/ 60. Shoulder Impingement Syndrome/ 61. exp Arm Injuries/ 62. exp Hand Injuries/ 63. Rotator Cuff/in [Injuries] 64. exp Tendinopathy/ 65. Radial Neuropathy/ 66. exp Ulnar Neuropathies/ 67. exp Brachial Plexus/ 68. Bursitis/ 69. Thoracic Outlet Syndrome/ 70. carpal tunnel syndrome.ab,ti. 71. (medial adj (epicondylitis or epicondylosis or epicondylopathy)).ab,ti. 72. (lateral adj (epicondylitis or epicondylosis or epicondylopathy)).ab,ti. 73. (shoulder adj (sprain* or strain*)).ab,ti. 74. tennis elbow.ab,ti. 75. (forearm adj4 (injur* or pain)).ab,ti. 76. (wrist adj4 (injur* or pain)).ab,ti. 77. peritendinitis.ab,ti. 78. (rotator cuff adj (injur* or disorder*)).ab,ti. 79. (median adj neuropath*).ab,ti. 80. (radial adj neuropath*).ab,ti.

8 81. "De Quervain s tenosynovit*".ab,ti. 82. (shoulder adj3 (tendonitis or impingement or capsulitis)).ab,ti. 83. frozen shoulder.ab,ti. 84. "thoracic outlet syndrome*".ab,ti. 85. brachial plexus.ab,ti. 86. bursitis.ab,ti. 87. "shoulder impingement syndrome*".ab,ti. 88. "upper extremit* injur*".ab,ti. 89. ((radial or ulnar) adj neuropath*).ab,ti. 90. (hand adj injur*).ab,ti. 91. (arm adj4 (injur* or pain)).ab,ti. 92. "cumulative trauma disorder*".ab,ti. 93. or/ or/ and 93 and limit 95 to (english language and yr="1990 -Current")

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