Page 1 of 5 7/24/2013. YI-NING (WINNIE) WU, PH.D. Assistant Professor Department of Physical Therapy

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1 7/24/2013 Page 1 of 5 YI-NING (WINNIE) WU, PH.D. Assistant Professor Department of Physical Therapy yining_wu@uml.edu EDUCATION Doctor of Philosophy in Biomedical Engineering National Cheng Kung University, Tainan, Taiwan (Nov. 2007) Bachelor of Science in Physical Therapy National Cheng Kung University, Tainan, Taiwan (Sep. 2000) HONORS AND AWARDS Sarah Baskin Award for Excellence in Research, 1st place. Rehabilitation Institute of Chicago, Student Travel Scholarship in 61th AACPDM Annual Meeting, 2007 Li Foundation Fellowship, 2005 Podium Paper Award for the paper entitled Velocity-dependent ankle torque combined with electroneurography in animal model at the Biomedical Engineering Society Annual Symposium, Taipei, Taiwan, 2003 Winner of the Design of Assistive Devices for the Disabled at the Fourth TIC100 Technology Innovation Competition, 2002 RESEARCH EXPERIENCE Post-doctoral Research Associate Neuroscience department, Brown University (Aug Aug. 2013) Developed home-based therapy system using video games for upper extremity training Investigating efficacy of home-based massed practice and its neural correlates using clinical measures, quantitative measures and fmri Post-doctoral Research Associate Sensory Motor Performance Program, Rehabilitation Institute of Chicago (June July 2010) Planed and carried out the laboratory pilot study for clinical trial on pediatric robotics rehabilitation Robotic-elliptical machine training in preventing sport-injury Developed in-vivo system to investigate the mechanisms of muscle adaptation at the cellular level using animal model systems Pre-doctoral fellow Northwestern University (Dec May 2008) Investigated abnormal muscle tone in stroke survivors and children with cerebral palsy and designed quantification tools for muscle tone evaluation Investigated the neurectomy and BOTOX effect in muscle cell adaptation to lengthening in the Rat model Research Assistance Institute of Biomedical Engineering, National Cheng Kung University, Taiwan (Sep Nov. 2005) Investigated the pharmacological effects of botulinum toxin type A on the hypertonic muscle in stroke patients Developed muscle tone measurement system for animal use Characterized abnormal muscle tone using biomechanical and neurological approaches

2 Page 2 of 5 Investigated physiological regulation of muscle tone in rat models Designed animal experiment platform to validate neural implanted electrodes for sensing neural signal Research Assistance Department of Physical Therapy, National Cheng Kung University, Taiwan (Sep Aug. 2001) Assisted in studies on the training effect of stationary cycling and treadmill training in stroke patients and balance deficiency in elderly population Trained and monitored patients during intensive exercising program Conducted data collection using Vicon motion capture system and Kistler force plates INVITED TALK Invited Speaker, Home-based technology for children with impaired upper extremity. The Rehabilitation Institute of Chicago, Chicago, IL, Feb 15 th, Guest lecturer of Neuroengineering (BME468), Technology for Neuro-rehabilitation, Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island. South Kingstown, RI. April 24 th, 2012 Invited Speaker, Play for neurorehabilitation, Department of Biomedical Engineering, Marquette University, Milwaukee, WI, Dec 2 nd, 2011 Invited Speaker, Combined passive stretching and active movement rehabilitation of limb impairment in cerebral palsy, Motion Analysis Center, the Children s Memorial Hospital, Chicago, IL, November 2009 PUBLICATIONS Peer-review article 1. Wu, Y-N, Saliu, V., Donoghue, N.D., Donoghue, J.P., and Kerman, K.L. A Home-based massed practice system for pediatric neurorehabilitation. (accepted by Journal of Accessibility and Design for All) 2. Wu, Y-N and Kerman, K.L,Towards home-based massed practice: children s response to using tailored game-play for hemiparetic arm rehabilitation (in preparation) 3. Ren, Y., Kang, S.H., Park, H-S., Wu, Y-N., Zhang, L-Q. (2012) Developing a Multi-Joint Upper Limb Exoskeleton Robot for Diagnosis, Therapy and Outcome Evaluation in Neurorehabilitation. Neural Systems and Rehabilitation Engineering, IEEE Transactions on (in press) 4. Drobyshevsky, A., Derrick, M., Luo, K., Zhang, L-Q., Wu, Y-N., Takada, SH., Yu, L., Tan, S. (2012) Near-term fetal hypoxia-ischemia in rabbits: MRI can predict muscle tone abnormalities and deep brain injury. Stroke, 43(10), Wu, Y-N., Wilcox, B., Donoghue, J.P., Crisco, J., Kerman, K.L. (2012) The impact of massed practice on children with hemiplegic cerebral palsy: Pilot study of home-based toy play therapy. Journal of Medical and Biological Engineering, 32(5), Peng, Q., Park, H-S., Shah, P, Wilson, N., Ren, Y., Wu, Y-N., Liu, J., Gaebler-Spira, D.J., Zhang, L-Q. (2011) Quantitative evaluations of ankle spasticity and stiffness in neurological disorders using manual spasticity evaluator. Journal of Rehabilitation Research and Development, 48(4), Zhao, H., Wu, Y-N., Hwang, M., Ren, Y., Gao, F., Gaebler-Spira, D., Zhang, L-Q. (2011) Changes of Calf Muscle-Tendon Biomechanical Properties Induced by Passive Stretching and Active Movement Training in Children with Cerebral Palsy. Journal of Applied Physiology, 111(2), (PMCID: PMC )

3 Patent Page 3 of 5 8. Wu, Y.-N., Hwang, M., Ren, Y., Gaebler-Spira, D., Zhang, L.Q (2011) Combined passive stretching and active movement rehabilitation of lower-limb impairments in children with cerebral palsy using a portable robot. Neurorehabilitation and Neural Repair, 25(4), Khan, N., Levin, S., Domont, Z.B., Wu, Y-N., Ren, Y, Zhang, L-Q. (2011) Strian effects of placing an arthroscopic portal through the subscapularis tendon. Journal of Shoulder and Elbow Surgery, 20(1), Wu, Y-N., Ren, Y., Goldsmith, A., Gaebler-Spira, D., Liu, S., Zhang, L-Q. (2010) Characterization of spasticity in cerebral palsy: dependence of catch angle on velocity. Developmental Medicine and Child Neurology, 52(6), Hsieh, T.H., Tsai, J.Y., Wu, Y-N., Hwang, I.S., Chen, T.I., Chen, J.J. (2010) Time-Course Quantification of Spastic Hypertonia Following Spinal Hemisection in Rats. Neuroscience, 167(1), Wu, Y-N., Chen J-J., Zhang L-Q., Hyland B.I. (2009) Regulation of hind-limb tone by adenosine A2A receptor in rats. Neuroscience, 159(4), Zhao, H., Ren, Y., Wu, Y-N., Liu, S.Q., Zhang L-Q. (2009) Ultrasonic evaluations of Achilles tendon mechanical properties poststroke. Journal of Applied Physiology, 106(3), Lee, H-M., Chen, J-J., Wu, Y-N., Wang, Y-L., Huang, S-C., Piotrkiewicz, M. (2008) Time course analysis of the effects of botulinum toxin type A on elbow spasticity based on biomechanic and electromyographic parameters. Archive of Physical Medicine and Rehabilitation, 89(4), Wu, Y-N., Hyland, B.I., Chen, J-J. (2007) Biomechanical and electromyogram characterization of neuroleptic-induced rigidity in the rat. Neuroscience, 147(1), Chen, J-J., Wu, Y-N., Huang, S-C., Lee, H-M., Wang, Y-L. (2005) The use of a portable muscle tone measurement device to measure the effects of botulinum toxin type a on elbow flexor spasticity. Archive of Physical Medicine and Rehabilitation, 86(8), Lin, S-I., Tsai, T-T., Lee, I-H., Wu, Y-N. (2002) Perception of unsteadiness in patients with dizziness: association with handicap and imbalance. Journal of Biomedical Science, 9(5), Zhang, L.-Q., Wu, Y-N. and Ren, Y. System and method of microscopic imaging and soft tissue tension measurements US Patent Aug Book section Ren, Y., Park, H.S., Wu, Y-N., Geiger, F., Zhang, L.Q., Off-axis Neuromuscular Training for Knee Ligament Injury Prevention and Rehabilitation in New Developments in Biomedical Engineering edited by Domenico Campolo. Wu, Y-N, Saliu, V., Donoghue, N.D., Donoghue, J.P., and Kerman, K.L. A Home-based massed practice system for pediatric neurorehabilitation. Pons, J.L. et al. (Eds.): Converging Clinical & Engi. Research on NR, BIOSYSROB 1, pp , Springer-Verlag Berlin Heidelberg Conference Proceedings 1. Wu, Y-N., Hwang, M., Ren Y., Gaebler, D., Zhang, L-Q. (2010) Efficacy of robotic rehabilitation of ankle impairments in children with cerebral palsy. Conf Proc IEEE Eng Med Biol Soc., Wu, Y-N., Ren Y., Zhang, L-Q. (2010) In vivo sarcomere imaging and fiber tension measurements. Conf Proc IEEE Eng Med Biol Soc., Ren, Y., Park, H., Wu, Y-N., Geiger, F., Zhang, L.-Q. (2008) Training for knee injury prevention using a pivoting elliptical machine. Conf Proc IEEE Eng Med Biol Soc.,

4 Page 4 of 5 4. Park, H.-S., Wu, Y-N., Ren Y., Zhang, L.-Q. (2007) A Tele-Assessment System for Evaluating Elbow Spasticity in Patients with Neurological Impairments. Rehabilitation Robotics, 2007 IEEE 10th International Conference on, Wu, Y-N., Park, H-S., Ren, Y., Gaebler-Spira, D., Chen, J-J., Zhang, L-Q. (2006) Measurement of elbow spasticity in stroke patients using a manual spasticity evaluator. Conf Proc IEEE Eng Med Biol Soc Selected Conference Presentation 1. Wu, Y-N., Saliu, V., Donoghue, N.D, Donoghue, J.P., and Kerman, K.L. A Home-based Massed Practice System for Pediatric Neurorehabilitation. International conference on Neurorehabilitation. Toledo, Spain. November 14-16, Wu, Y-N., Khan-Williams, S., and Kerman, K.L. Figure 8 paradigm for quantitative wrist evaluation with motion sensor systems, 66 th Annual Meeting of the AACPDM. Toronto Canada Waldman, G., Wu, Y-N., Ren, Y., Li, Y., Guo, X., Roth, E.J., Wang, L., and Zhang, L-Q. Stroke Rehabilitation using a portable robot improves biomechanical and clinical outcome measures. International Stroke Conference, Los Angles, USA Wu, Y-N., Hwang, M., Ren Y., Gaebler, D., Zhang, L.-Q., Biomechanical and Gait improvements after passive stretching and active movement training in children with cerebral palsy. 34th Annual Meeting of the American Society of Biomechanics, Providence, Rhode Island, August, Wu, Y-N., Hwang, M., Ren Y., Gaebler, D., Zhang, L.-Q., Portable intelligent stretching combined with active movement training for children with cerebral palsy. Australasian Academy of Cerebral Palsy and Developmental Medicine 5 th Biennial Conference, Christchurch, New Zealand, March, (selected as podium presentation) 6. Wu, Y-N., Ren, Y., Gaebler, D., Zhang, L.-Q., Combined passive stretching and active movement training on children with CP- a pilot study. 63rd AACPDM Annual Meeting, Scottsdale, AZ, September Wu, Y-N., Zhang, L-Q., Ren, Y., Intra-surgery Setup for in vivo Sarcomere Length and Tension Measurements. 55 th ORS annual meeting, Las Vagas, NV, February Wu, Y-N., Swaroop, V., Sisson, G., Zhang, L.-Q., Evaluation of Sarcomeric Adaptation to Botulinum Toxin A Injection during Muscle Lengthening in Rats. 55 th ORS annual meeting, Las Vagas, NV, February Wu, Y-N., Ren, Y., Zhang L.-Q., In vivo sarcomere length and fiber tension measurements. North American Congress on Biomechanics, Ann Arbor, MI. August (selected as podium presentation) 10. Wu, Y-N., Park, H.-S., Gaebler, D., Chen, J.-J., Zhang, L.-Q., Reflex and nonreflex characterization of spasticity in children with cerebral palsy: dependence of catch angle on velocity. American society of Biomechanics Annual Conference, San Francisco, CA, August Wu, Y-N., Chung, S., Lin, A., Tan, R., Liu, S.Q., Zhang, L.-Q., Evaluation of Muscle Fiber- Sarcomere Property BMES Annual Fall Meeting, Chicago, IL, October Wu, Y.N., Chen, J.-J., Huang, S.-C., Evaluation of BOTOX Effect on Upper Limb of Stroke Patients by Portable Stretching Device Combined with EMG. XV th Congress of the International Society of Electrophysiology and Kinesiology, Boston, MA, June 2004.(Podium presentation) PROFESSIONAL AFFILIATIONS Member of American Academy of Cerebral Palsy and Developmental Medicine Member of American Society of Neurorehabilitation

5 Page 5 of 5 FUNDING SUPPORT Completed grant The effectiveness of intelligent-stretching followed by Active movement in children with cerebral palsy founded by National Institute on Disability and Rehabilitation Research, U.S. Department of Education Role: PI ~ USD 65,000 Under review grant The impact of Massed-practice AT Home (MATH) on children with cerebral palsy Role: PI USD 275,000 (NIH R21)