Developments in Ophthalmology
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1 Intermediate Uveitis
2 Developments in Ophthalmology Vol. 23 Series Editor W. Straub, Marburg a. d. Lahn KARGER Basel München Paris London. NewYork New Delhi Bangkok Singapore. Tokyo. Sydney
3 International Workshop on Intermediate Uveitis, Gütersloh, July 5-6, 1990 Intermediate Uveitis Volume Editors W.R.F. Böke, Kiel K.F. Manthey, Bordesholm R.B. Nussenblatt, Washington, D.C. 49 figures and 56 tables, 1992 KARG ΕR Bertelsmann Foundation Basel München Paris London NewYork New Delhi Bangkok Singapore. Tokyo. Sydney
4 Developments in Ophthalmology Continuation of `Bibliotheca Ophthalmologica', `Advances in Ophthalmology', and `Modem Problems in Ophthalmology'. Founded 1926 as `Abhandlungen aus der Augenheilkunde und ihren Grenzgebieten' by C. Behr, Hamburg and J. Meldet; Wien Former Editors: A. Brücknet; Basel ( ); H.J.M. Weave, Utrecht ( ); H.M. Dekking, Groningen ( ); E.B. Streiff, Lausanne ( ); ]. François, Gand ( ); J. van Doesschate, Utrecht ( ); M.J. Roper-Hall, Birmingham ( ); H. Sautter, Hamburg ( ). Bibliographic Indices This publication is listed in bibliographic servicies, including Current Contents and Index Medicus. Drug Dosage The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequent employed drug. All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storate and retrieval sysem, without permission in writing from the publisher. Copyright 1992 by Bertelsmann Foundation, Moltkestrasse 10, D-W-4830 Gütersloh 1 (FRG) S. Karger AG, P.O. Box, CH-4009 Basel (Switzerland) has the sole distribution rights for all countries. Printed in Switzerland on acid-free paper by Merkur Druck AG, Langenthal ISBN
5 Contents Bloch-Michel, E. (Paris): Opening Address: Intermediate Uveitis 1 Clinical Aspects Dinning, W.J. (St. Louis. Mo.): Intermediate Uveitis: History, Terminology, Definition. Pars Planitis: Systemic Disease Associations 3 Althaus, Ch.; Sundmacher, R. (Dusseldorf): Intermediate Uveitis: Epidemiology, Age and Sex Distribution 9 Arocker-Hettinger, E.; Georgiew, L.; Grabner, G. (Vienna): Mayr, W.R. (Aachen): Intermediate Uveitis: Do HLA Antigens Play a Role? 15 Böke, W. (Kiel): Clinical Picture of Intermediate Uveitis 20 Slezak, H. (Vienna): Biomicroscopy in Intermediate Uveitis 28 Vadot, E. (Chambéry): Epidemiology of Intermediate Uveitis: A Prospective Study ín Savoy 33 Davis, J.L. (Miami, Fla.); Mittal, K.K.; Nussenblatt, R.B. (Bethesda, Md.): HLA in Intermediate Uveitis 35 Martenet, A.-C. (Zurich): Diseases Masquerading Intermediate Uveitis Zierhut, M. (Boston, Mass./Tubingen); Foster, C.S. (Boston, Mass.): Multiple Sclerosis, Sarcoidosis and Other Diseases in Patients with Pars Planitis Smith, R.E. (Los Angeles, Calif.): Intermediate Uveitis: What Is the Significance of the Pars Plana Exudate in `Pars Planitis`? A Summary 48 Etiology and Pathogenesis Lütjen-Drecoll, E. (Erlangen): Morphology of the Pars Plana Region 50 Poser, S.L.; Forster, D.J.; Rao, N.A. (Los Angeles, Calif.): Pathology of Intermediate Uveitis 60 Davis, J.L. (Miami, Fla.); Chan, Ch.-Ch.; Nussenblatt, R.B. (Bethesda, Md.): Immunology of Intermediate Uveitis 71
6 Contents VI Streilein, J.W. (Miami, Fla.): Role of Anterior-Chamber-Associated Immune Deviation in the Pathogenesis of Uveitis 86 Nölle, B. (Kiel): Antiretinal Autoantibodies in Intermediate Uveitis 94 Association with Other Diseases Wagemans, M.A.J.; Breebaart, A.C. (Amsterdam): Association between Intermediate Uveitis and Multiple Sclerosis 99 Graham, E.M.; Edelsten, C. (London): Intermediate Uveitis and Sarcoidosis Kraus-Mackiw, E.; Alexandridis, E. (Heidelberg): Intermediate Uveitis and Multiple Sclerosis: Considerations and Necessary Consequences for Treatment Nölle, B. (Kiel): Serological Evidence of an Association between Lyme Borreliosis and Intermediate Uveitis 115 Dernouchamps, 7.P. (Brussels): Intermediate Uveitis and Focal Infection. 118 Invasive Diagnostic Procedures Davis, J.L. (Miami, Fla.); Chan, Ch.-Ch.; Nussenblatt, R.B. (Bethesda, Md.): Diagnostic Vitrectomy in Intermediate Uveitis 120 Nussenblatt, R.B.; Davis, J.L.; Palestine, A.G. (Bethesda, Md.): Chorioretinal Biopsy for Diagnostic Purposes in Cases of Intraocular Inflammatory Disease. 133 Schmidt, F. (Kiel): Fluorescein Angiography in Intermediate Uveitis 139 Nölle, B.; Eckardt, C. (Kiel): Cellular Phenotype of Vitreous Cells in Intermediate Uveitis 145 Cousins, S.W. (Miami, Fla.): T Cell Activation within Different Intraocular Compartments during Experimental Uveitis 150 Medical Treatment Foster, C.S. (Boston, Mass.): Medical Treatment of Intermediate Uveitis Manthey, K.F. (Kiel): Nonsteroid Anti-Inflammatory Drugs in the Treatment of Intermediate Uveitis 158 Forster, D.J.; Rao, N.A.; Smith, R.E. (Los Angeles, Calif.): Corticosteroids in the Treatment of Intermediate Uveitis 163 Belfort, R., Jr.; Toledo de Abreu, M.; Petrílli, A.M.; Kim, M.K.; Martins, M.C.; Lottemberg, C.; Neves, R.A.; Pavesin, C.E. (Sao Paolo): Cytotoxic Drugs in Intermediate Uveitis 171 Nussenblatt, R.B.; Palestine, A.G. (Bethesda, Md.): Ciclosporin (Sandimmun ) Therapy: Experience in the Treatment of Pars Plantis and Present Therapeutic Guidelines 177
7 Contents VII Surgical Treatment Kaplan, H.J. (St. Louis, Mo.): Surgical Treatment of Intermediate Uveitis Mieler, W.F. (Milwaukee, Wisc.); Aaberg, T.M. (Atlanta, Ga.): Further Observations on Cryotherapy of the Vitreous Base in the Management of Peripheral Uveitis 190 Heimann, K; Schmanke, L.; Brunner, R.; Amerian, B. (Cologne): Pars Plana Vitrectomy in the Treatment of Chronic Uveitis 196 Forster, D.J.; Rao, N.A.; Smith, R.E. (Los Angeles, Calif.): Cataract Extraction in Intermediate Uveitis 204 Foster, C.S. (Boston, Mass.): Cataract Surgery and Intraocular Lens Implantation in Patients with Intermediate Uveitis 212 Berg, P.; Kroll, P. (Marburg): Cryotherapy in Uveitis 219 Brinkman, C.J.J.; Otto, A.J. (Amsterdam): Role of the Vitreous in Experimental Uveitis 226 Eckardt, C.; Bacskulin, A. (Kiel): Vitrectomy in Intermediate Uveitis 232 Mieler, W.F. (Milwaukee, Wise.); Aaberg, Th.M. (Atlanta, Ga.): Vitreous Surgery in the Management of Peripheral Uveitis 239 Franklin, R.M. (New Orleans, La.): Laser Photocoagulation of Retinal Neovascularization in Intermediate Uveitis 251 Further Aspects of Treatment Streilein, J.W. (Miami, Fla.): Immune Modulation by Ultraviolet Light Manthey, K.F. (Kiel): Light as Alternative Treatment of Intermediate Uveitis and Chronic Iridocyclitis 271 Brunner, R.; Borberg, H.; Kadar, J.; Hoffmann, A.; Konen, W.; Heidel, M.; Heidner, K. (Cologne): Plasma Exchange and Immunglobulins in the Treatment of Intermediate Uveitis 275 Subject Index 285
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