The Danish Twin Registry - a National and International Research Ressource for 65 Years

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1 The Danish Twin Registry - a National and International Research Ressource for 65 Years

2 Alder The Danish Twin Registry (1953-) Twins born in Denmark ,398 pairs included 105,000 twins alive 1-2% of all births År

3 Human Databases - with focus on data available at SDU REGISTERS SURVEYS 5% random sample of DK pop. First degree relatives Biobank 3.6 million individuals

4 Co-Twin Lifespan Monozygotic Dizygotic Twin 2 (years) Twin 2 (years) Herskind et al., Hum Genet 1996

5 Twin Design Heritability Life span 25% Functioning 50% Alzheimer 70% Parkinson 35%

6 Co-Twin Control Design Dokkedal et al. Anesthesiology 2016

7 Leukocyte Telomere Length Inversely correlated with age Shorter in men than in women Associated with aging-related diseases Associated with mortality? Kimura et al. AM J Epidemiol, 2008

8 Telomeres and Survival Intrapair comparisons Kimura et al. AM J Epidemiol, 2008

Sex, chronological age, perceived age and mortality N Hazard ratios (95% CI) Sex 1826 0.60 (0.52-0.70) Chronological age 1.11 (1.10-1.13) Sex 1826 0.67 (0.

9 Sex, chronological age, perceived age and mortality N Hazard ratios (95% CI) Sex ( ) Chronological age 1.11 ( ) Sex ( ) Perceived age 1.15 ( ) Sex ( ) Chronological age 1.08 ( ) Perceived age 1.08 ( ) Christensen et al, BMJ, 2009

11 Twins, the epigenetic clock and survival Christiansen et al. Aging Cell, 2016

12 von Dongen et al., 2012 MZ discordant SNPs, CNV, epigenetics, omics

13 Frost et al., Diabetologia, 2012

14 Mucci et al. JAMA 2016 The Nordic Twin Cancer Study

1895-1979 1886-2008 Cancer since 1943 1953

15 The Nordic Twin Cancer Study Denmark Finland Norway Sweden Total Birth Cancer since Twins 110,482 24,438 26, , ,212

16 GenomEUTwin

17 Am J Clin Nutr Aug;106(2):

18 Age of participants The 1895, 1905, 1910 and 1915 Danish Birth Cohorts Survey methods indicated by colour Green: Medical doctor and research nurse Red: Trained lay interviewers cohort cohort 273 West East cohort 1905-cohort Rasmussen et al. Int J Epidemiol, Survey Year

19 The 1905 Cohort in 1998 (N = 2262) versus the 1915 Cohort in 2010 (N = 1584) 22.8*** *** *** *** Christensen et al. Lancet, 2013 *** = p<0.001

20 A Success of Success 30% more made it to their 90 s in the 1915-Cohort compared with the 1905-Cohort Still, 95-year olds from 1915 have better cognition and mental health than 93 year-olds from 1905 Christensen et al, Lancet 2013

21 5-COOP study of 100-year olds

INSERM U988, Paris, France EPHE, Paris, France INSERM U1198,

of Geriatric Medicine, School of Medicine, Keio University,

Science, Osaka University, Osaka, Japan Dept.

Japan Nihon University Advanced Research Institute for the

Center, University of Southern Denmark, Odense, Denmark Dept.

of Internal Medicine, Rehabilitation and Geriatrics, Geneva

22 INSERM U988, Paris, France EPHE, Paris, France INSERM U1198, Montpellier, France INSERM-UVSQ UMR 1168, Paris, France Dept. of Geriatric Medicine, School of Medicine, Keio University, Tokyo, Japan Clinical Thanatology and Geriatric Behavioral Science, Osaka University, Osaka, Japan Dept. of Human Welfare, Okinawa International University, Okinawa, Japan Nihon University Advanced Research Institute for the Sciences and Humanities, Tokyo, Japan Danish Aging Research Center, University of Southern Denmark, Odense, Denmark Dept. of Geriatrics, Odense University Hospital, Odense, Denmark Dept. of Internal Medicine, Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Switzerland Aging Research Center, Karolinska Institute & Stockholm University, Sweden

23 Probability of surviving to age 100 Male probability of surviving to age Japan France Switzerland Sweden Denmark Female probability of surviving to age Japan France Switzerland Sweden Denmark Robine et al and 2017

24 VELUX FONDEN

25 Contributors University of Southern Denmark James W Vaupel Bernard Jeune University of Copenhagen: Merete Osler, Erik Lykke Mortensen, Lene Christiansen Tan Qihua Rikke Lund Jacob B Hjelmborg Rune Lindahl-Jacobsen Aarhus University: Tinna Stevnsner, Vilhelm Bohr, Jørn Olsen Matt McGue Karen Andersen-Ranberg Odense University Hospital: Torben Kruse Jonas Mengel-From Dorthe Almind Pedersen University of Minnesota: Matt McGue Mette Sørensen Axel Skytthe Duke University: Anatoli Yashin Marianne Nygaard Mikael Thinggaard Peking University: Yi Zeng Ulrich Halekoh Signe Høi Rasmussen Colombia University: Nicole Schupf Birgit Debrabant Jacob Krabbe Pedersen Pittsburgh University: Anne Newman Gunhild Tidemann Christensen Unni Dokkedal Washington University: Michael Province Lisbeth Aagaard Larsen Mette Wod Nihon University: Yasuhiko Saito Paul Bingley Laura Ekstrøm Løkkegaard Leiden: Eileen Slagboom, Bas Heijmans, Rudolph P Talens Frans Bødker Kirsten Gauthier Kiel: Almut Nebel Susanne Knudsen Lars Hvidberg MPI Rostock: Anna Oksuzyan Ulla Iversen Gitte Bay-Christensen Universität Rostock: Roland Rau Jette Martens Jørgensen Jakob Mortensen University of Helsinki: Jaakko Kaprio Anders Svendsen Nuno Nielsen Karolinska, Sweden: Nancy Pedersen, Stefan Fors Susanne Kløjgaard Kirsten Rasmussen Norwegian Institute of Public Health: Jennifer Harris

Research Article Power Estimation for Gene-Longevity Association Analysis Using Concordant Twins

Genetics Research International, Article ID 154204, 8 pages http://dx.doi.org/10.1155/2014/154204 Research Article Power Estimation for Gene-Longevity Association Analysis Using Concordant Twins Qihua