.. Mini-Mental State Examination MMSE TPQ

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1 Cloninger Tridimensional Personality Questionnaire TPQ Cloninger.... Mini-Mental State Examination MMSE Tridimensional Personality Questionnaire TPQ : U=., p<. : U=., p<. dopamine norepinephrine TPQ This study sought to evaluate the personality traits of aged patients with dementia by applying Cloninger s tridimensional personality theory. Using Mini-Mental State Examination MMSE and Tridimensional Personality Questionnaire TPQ, aged patients with mild cognitive impairment MCI and aged patients with Alzheimer s disease AD were individually tested for cognitive function. Findings show a decrease in general cognitive function of AD patients in comparison with MCI patients. In addition, the study shows a decline in personality traits such as novelty-seeking and reward-dependence behaviours. The results may indicate that decreased secretion of dopamine and norepinephrine is more remarkable among AD patients compared to MCI patients. Key words : Mild Cognitive Impairment, Alzheimer s Disease, Tridimensional personality theory, Tridimensional Personality Questionnaire Cloninger Tridimensional Personality TDP monoamine dopamine Novelty Seeking NS serotonin

2 Cloninger 1 Cloninger Tridimensional Personality TDP, Harm Avoidance HA norepinephrine Reward Dependence RD NS HA RD Tridimensional Personality Questionnaire TPQ TPQ NS HA HA Young, HA RD Osher, HA Hansenne, HA Goel, HA HA Richter, Ettelt, NS HA NS HA Kleifield, HA Berg, RD Cannon, NS HA NS RD Pomerleau, NS RD Ko, HA RD Kurs, Herrán, NS HA Fujii, TPQ Mild Cognitive Impairment MCI Alzheimer s Disease AD Tridimensional Personality Questionnaire TPQ amnestic MCI amnestic MCI probable AD probable AD amnestic MCI Petersen

3 probable AD National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer s Disease and Related Disorders Association NINCDS- ADRDA McKhann, Mini- Mental State Examination MMSE Folstein,,,,, Alzheimer s Disease Assessment Scale ADAS Mohs,, Kohs Block-design Test Kohs,, TPQ Cloninger,, ADAS ADAS-cognition part ADAS-non cognition part ADAS-Japanese version cognition part ADAS-Jcog. t MMSE ADAS-Jcog. Kohs Block-design Test TPQ Mann-Whitney U SPSS version. J amnestic MCI.. probable AD.. t=-., ns U MMSE U=., p<.u=., p<. U=., p<. serial s U=., p<. amnestic MCI probable AD ADAS- Jcog. U=., p<. U=., p<.u=., p<. U=., p<.u=., p<. U=., p<. amnestic MCI probable AD ADAS-Jcog. Kohs Block-design Test U=., p<. amnestic MCI probable AD TPQ NSb U=., p<. NSd U=., p<. NS U=., p<.nstl U=., p<.rd U=., p<.rdtl U=., p<. amnestic MCI 2 ns=no significant

4 Cloninger 3 U ns=no significant, p<., *p<., **p<. probable AD 1 MCI AD amnestic MCI probable AD MMSE serial s amnestic MCI probable AD ADAS-Jcog. amnestic MCI probable AD ADAS-Jcog. Kohs Block-design Test amnestic MCI probable AD

5 serial s single photon emission computed tomography SPECT early AD Kogure, Matsuda, Matsuda,, 2 MCI AD TPQ NSb NSd NSNSTLRD RDTL amnestic MCI probable AD amnestic MCI probable AD dopamine norepinephrine probable AD Fujii Control.. Fujii Control.. amnestic MCI.. Aspin-Welch t=., p<. Control.. probable AD.. Aspin-Welch t=., p<. TPQ Fujii Control U NSTL control amnestic MCI probable AD amnestic MCI probable AD HATL amnestic MCI probable AD control RDTL control amnestic MCI probable AD 4 TPQ Fujii 2000 Control U ns=no significant, p<., *p<.

6 Cloninger amnestic MCI probable AD TPQ control amnestic MCI HA amnestic MCI serotonin amnestic MCI probable AD NS RD dopamine norepinephrine control Fujii Control control MCI AD TPQ Cloninger MCI AD SPECT early AD MCI AD NSTL RDTL MCI AD dopamine norepinephrine AD TPQ MCI serotonin MCI AD dopamine norepinephrine control control TPQ - - F, TEL --, FAX --, URL Berg ML, Crosby RD, Wonderlich SA, Hawley D Relationship of temperament and perceptions of

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8 Cloninger assessing treatment efficacy Psychopharmacology Bulletin - Osher Y, Cloninger CR, Belmaker RH TPQ in euthymic manic-depressive patients. Journal of Psychiatric Research -, Petersen RC Mild cognitive impairment as a diagnostic entity Journal of Internal Medicine - Pomerleau CS, Pomerleau OF, Flessland KA, Basson SM Relationship of Tridimensional Personality Questionnaire scores and smoking variables in female and male smokers. Journal of Substance Abuse -, Richter MA, Summerfeldt LJ, Joffe RT, Swinson RP The Tridimensional Personality Questionnaire in obsessive-compulsive disorder. Psychiatry Research -, Cloninger TDP Tridimensional Personality Questionnaire TPQ - Young LT, Bagby RM, Cooke RG, Parker JD, Levitt AJ, Joffe RT A comparison of Tridimensional Personality Questionnaire dimensions in bipolar disorder and unipolar depression. Psychiatry Research -,