(anisotropic diffusion) (fractional anisotropy FA)
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1 Alzheimer(AD) 3). AD PETSPECTstatistical parametric mapping (SPM) 4), 56) PETMRI (anisotropic diffusion) (fractional anisotropyfa) 710) PETMRI (rcbf)(rcmr0 2 ) (roef) NINCDS-ADRDA AD MRI
2 1 AD FAST HDS-R() IV V VI FASTfunctional assessment staging HDS-R MRISIGNA3.0TVH/IGESPGR T1 TR/TE:12/3)T2 (SETR/TE:2800/100) EPI TR/TE:3000/84b:2000sec/mm 2 Fractional anisotropy (FA) map T2 20mm 2 (ROI) FA
3 PET(-),steady-stateC 15 O 2 rcbf 15 O 2 rcmro 2 roefroi rcbfrcmro 2 roeffa rcbfrcmro 2 roeffa( 2) (r=0.50p0.05) (r=0.50p0.05)(r=0.48p0.05) rcbf FA (r=0.48p0.05)(r=0.47p0.05) rcbf FA (r=0.49p0.05) (r=0.63p0.01)(r=0.59p0.05)rcmro 2 FA(r=0.69p0.01) (r=0.69p0.01)(r=0.72p 0.005) rcmro 2 FA FA FA (r) (r) rcbf rcmro 2 rcbf rcmro * 0.503* 0.492* * 0.685** * 0.629** ** * 0.587** * 0.719*** *:P<0.05**:P<0.01***P<0.005
4 roef FA rcbfrcmro 2 roeffa
5 2 MRI FA 7~10) FA 11~13) AD ) PETAD MRIFA ROIPETMRIFA AD 14~18)
6 FAAD PET FA rcmro 2 FArCBF FA FAFA rcbfrcmro 2 FAFA 2 16) ADFA 16) 17 rcbf rcmro 2 1~3) AD SPM 4~6) AD AD PET rcbfrcmro 2 roeffa ROI AD MRIAD 17,18) AD FA
7 1) Frackowiak RS. Pozzilli C. Legg NJ. Du Boulay GH. Marshall J. Lenzi GL. Jones T. Regional cerebral oxygen supply and utilization in dementia. A clinical and physiological study with oxygen-15 and positron tomography. Brain. 104:753-78, ) Cutler NR. Haxby JV. Duara R. Grady CL. Kay AD. Kessler RM. Sundaram M. Rapoport SI. Clinical history, brain metabolism, and neuropsychological function in Alzheimer's disease. Annals of Neurology. 18(3): , 1985 Sep Abstract Complete Reference 3) Friedland RP. Brun A. Budinger TF. Pathological and positron emission tomographic correlations in Alzheimer's disease. Lancet. 1(8422):228, 1985 Jan Complete Reference 4) Minoshima S. Foster NL. Kuhl DE. Posterior cingulate cortex in Alzheimer's disease. Lancet. 344(8926):895, 1994 Sep 24. 5) Ishii K. Sasaki M. Yamaji S. Sakamoto S. Kitagaki H. Mori E. Demonstration of decreased posterior cingulate perfusion in mild Alzheimer's disease by means of H215O positron emission tomography. European Journal of Nuclear Medicine. 24(6):670-3, ) Kogure D. Matsuda H. Ohnishi T. Asada T. Uno M. Kunihiro T. Nakano S. Takasaki M. Longitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT. Journal of Nuclear Medicine. 41(7): , ) Basser PJ, Pierpaoli C.Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J Magn Reson B ;111(3): ) Basser PJ, Pierpaoli C. Related Articles A simplified method to measure the diffusion tensor from seven MR images. Magn Reson Med.;39(6): ) Pierpaoli C, Basser PJ. Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med;36: , ) Prayer D. Barkovich AJ. Kirschner DA. Prayer LM. Roberts TP. Kucharczyk J. Moseley ME. Visualization of nonstructural changes in early white matter development on diffusion-weighted MR images: evidence supporting premyelination anisotropy. Ajnr:. 22:1572-6, ) Pfefferbaum A. Sullivan EV. Hedehus M. Lim KO. Adalsteinsson E. Moseley M. Age-related decline in brain white matter anisotropy measured with spatially corrected echo-planar diffusion tensor imaging. Magnetic Resonance in Medicine. 44:259-68, ) Nusbaum AO. Tang CY. Buchsbaum MS. Wei TC. Atlas SW. Regional and global changes in cerebral diffusion with normal aging. American Journal of Neuroradiology. 22:136-42, ) Rose SE. Chen F. Chalk JB. Zelaya FO. Strugnell WE. Benson M. Semple J. Doddrell DM. Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging. Journal of Neurology, Neurosurgery & Psychiatry. 69:528-30, ) Hanyu H. Asano T. Sakurai H. Imon Y. Iwamoto T. Takasaki M. Shindo H. Abe K. Diffusion-weighted and magnetization transfer imaging of the corpus callosum in Alzheimer's disease. Journal of the Neurological Sciences. 167(1):37-44, ) Bozzali M. Franceschi M. Falini A. Pontesilli S. Cercignani M. Magnani G. Scotti G. Comi G. Filippi M. Quantification of tissue damage in AD using diffusion tensor and magnetization transfer MRI. Neurology. 57:1135-7, 2001
8 16) Takahashi S, Yonezawa H, Takahashi J, Kudo M, Inoue T, Tohgi H. Selective reduction of diffusion anisotropy in white matter of Alzheimer disease brains measured by 3.0 Tesla magnetic resonance imaging. Neurosci Lett. 332:45-8, ) Jack CR. Petersen RC. Xu YC. Waring SC. O'Brien PC. Tangalos EG. Smith GE. Ivnik RJ. Kokmen E. Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease.,. Neurology. 49(3):786-94, ) Vogt BA. Vogt LJ. Vrana KE. Gioia L. Meadows RS. Challa VR. Hof PR. Van Hoesen GW. Multivariate analysis of laminar patterns of neurodegeneration in posterior cingulate cortex in Alzheimer's disease. Experimental Neurology. 153:8-22, 1998
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