Arg-ADNI. Gustavo E. Sevlever, Silvia Vázquez, Deborah R. Gustafson, Salvador M. Guinjoan, Ricardo F. Allegri(*) and Arg-ADNI group.
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1 Arg-ADNI Gustavo E. Sevlever, Silvia Vázquez, Deborah R. Gustafson, Salvador M. Guinjoan, Ricardo F. Allegri(*) and Arg-ADNI group. Memory and Aging Center Institute for Neurological Research (FLENI) Buenos Aires, Argentina *speaker WW-ADNI update: Copenhagen, July 11, 2014
2 Argentine ADNI Background 2. Work-Plan 3. Results 4. AAIC and other meetings 5. Publications 6. New Projects
3 Worldwide Life Expectancy 78a 62a 70a 81a 79a 79a 75a 74a Argentina 76a 72a 68a 73a 81a 76a Buenos Aires 78a 78a 77a 76a Font: CIA World Factbook / INDEC
4 Argentina
5 Institute for Neurological Research Memory and Aging Center Institute for Neurological Research FLENI Buenos Aires Argentina Institute for Neurological Rehabilitation
6 Argentine ADNI Background 2. Work-Plan 3. Results 4. AAIC and other meetings 5. Publications 6. New Projects
7 Arg-ADNI 1 st Arg-ADNI: FLENI Cohort ( ) Single-Center, Pilot Study-60pts Main Project 2 nd Arg-ADNI: Multicenter Cohort ( )
8 Arg-ADNI Management Committee Sevlever G, Allegri RF, Guinjoan S, Gustafson D, Vazquez S. Clinical Stream Neurologists Ricardo Allegri (*) Jorge Campos Alejandra Amengual Gabriela Cohen Neuroimaging Stream Silvia Vazquez S (*) Esteban Obenaus German Falasco Leandro Urrutia Fernando Ventrice Laboratory Stream Gustavo Sevlever (*) Horacio Martinetto Ezequiel Surace Miguel Riudavetz Epidemiological Stream Deb Gustafson (*) Marcos Fernández Suárez Patricio Chrem Julieta Russo Psychiatrists Salvador Guinjoan Griselda Russo Pablo Bagnati Lucas Drucaroff Neuropsychologists Liliana Sabe María Eugenia Martín Florencia Clarens Lucía Crivelli Paula Harris (*) Stream Chair
9 Arg-ADNI 1 st Cohort (FLENI) Study Timelines 11/20/2013 Last patient / first visit 1 06/08/2014 Copenhagen Study report 2 01/19/2012 First patient / first visit 02/10/2011 FLENI Review Board approval 1. Recruitment: 24 months 2. Follow-up: 24 months
10 Patients Invited to ADNI Nº= 73 Arg-ADNI 1st Cohort (FLENI) Patients Flowchart Patients Screened at FLENI Nº= 60 Screening Failure Nº= 7 2 Claustrophobia 1 Psychiatric Disease 1 Cancer 1 Adult ADHD 2 without informant Patients Followed (1 st year) Nº= 50 Dropout Nº= 3 2 removed inform.cons 1 by distance/caregiver Healthy Controls Nº= 10 Early MCI Nº=15 Late MCI Nº= 16 Dementia AD Nº=9
11 Arg-ADNI 1 st Cohort (FLENI) Table 1: Demographic Data Healthy Controls Early MCI Late MCI Dementia AD Age (years) Education (years) Sex (%fem) 70% 40% 68.8% 44.4% MMSE
12 Arg-ADNI 1 st Cohort (FLENI) Methods: ADNI 1. Demographic and Neurological Exams 2. Neuropsychological Assessment 3. Cognitive Reserve Inventory 4. Blood sampling including DNA banking 5. Cerebro Spinal Fluid (AB42, tau and f-tau) 6. MRI (3.0T) 7. FDG PET-CT scan C-PiB PET-CT scan
13 Argentine ADNI Background 2. Work-Plan 3. Results 4. AAIC and other meetings 5. Publications 6. New Projects
14 Arg-ADNI 1 st Cohort (FLENI) Results Baseline Follow-up Follow-up Total Nº NPS Ass MRI CSF Aβ-tau PET FDG PET PiB Follow-up 1 year Healthy Controls Follow-up 2 year Early MCI Late MCI Dementia AD TOTAL (76%) 49 (98%) 43 (86%) 23
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16 Brain 18 FDG PET scan Brain 11 C-PiB PET scan Uptake Map AD Healthy Hypometabolism Map AD
17 Arg-ADNI 1 st Cohort (FLENI) Results Table 3: PET Scanning as of June 2014 FDG-PET Normal FDG-PET Pathol PiB-PET Negative PiB-PET Possitive Healthy Control s Early MCI Late MCI Dementia AD Total
18 Brain Bank. FLENI houses the only brain bank in Argentina. ADNI participants are being asked to consent brain donation at the time of death. Brain banking: opportunities, challenges and meaning for the future Hans Kretzschmar Nature Reviews Neuroscience 10, (January 2009)
19 Argentine ADNI Background 2. Work-Plan 3. Results 4. AAIC and other meetings 5. Publications 6. New Projects
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21 April 2014
22 POSTER in AAIC>14 Alzheimer s Imaging Consortium (AIC) pre-conference 1. Discrepancy between PiB amyloid imaging in typical and atypical clinical diagnosis. (nº: IC-P-005) 2. Hippocampal atrophy. Automated volumetry vs visual examination: Arg-ADNI cohort analysis (nº: IC-P-006)
23 Argentine ADNI Background 2. Work-Plan 3. Results 4. AAIC and other meetings 5. Publications 6. New Projects
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28 Papers submitted 1. Concordance between C 11 -PiB amyloid imaging and clinical diagnosis in a memory clinic. American Journal of Alzheimer s Disease and other Dementias. 2. Discriminability and Response bias Indices in recognition memory performance in amnestic mild cognitive impairment and Alzheimer s disease. Alzheimer & Dementia 3. Hippocampal atrophy. Automated volumetry vs visual examination: an ARG ADNI cohort analysis
29 Argentine ADNI Background 2. Work-Plan 3. Results 4. AAIC and other meetings 5. Publications 6. New Projects
30 Future Tasks Arg-DIAN (Dominantly Inherited Alzheimer Network) National grant application (CONICET) June 2014 to study an Argentine DIAN cohort of 40 participant. Start-up October 2014
31 Future Tasks Arg-ADNI 2 nd Cohort (Argentine Multicenter Study) National grant application ( ) to study larger Argentina ADNI 2 cohort of 180pts involving at least 8 new sites (AD Centers). Mendoza 9.-Univ. Mendoza Mar del Plata 7.- CEMA Córdoba 8.- Instituto Neuropsiquiátrico Kremer Buenos Aires 1.- FLENI 2.- Hospital Zubizarreta (GCBA) 3.- INEBA 4.- Hospital Fernandez (GCBA) 5.- Hospital Borda (GCBA) La Plata 6.- Instituto Neuropsiquiátrico Luria
32 Thank you ADNI Argentina
Arg-ADNI. WW-ADNI update, Boston, July 12, 2013
Arg-ADNI Silvia Vázquez, Gustavo E. Sevlever, Ricardo Allegri, Deborah R. Gustafson, Salvador M. Guinjoan(*) Depts. of Neuroimaging, Neuropathology, and Cognitive Neurology and Neuropsychiatry, FLENI,
AAIC Satellite Symposium: Buenos Aires, Argentina April 17-18, 2018 Sheraton Libertador Hotel Grand Bourg Ballroom
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