Complexity of lifetime occupation and cognitive performance in old age
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1 Occupational Medicine 2013;63: Advance Access publication 9 November 2013 doi: /occmed/kqt115 Complexity of lifetime occupation and cognitive performance in old age P. C. Correa Ribeiro 1, C. S. Lopes 1 and R. A. Lourenço 2 1 Department of Epidemiology, Institute of Social Medicine, State University of Rio de Janeiro, Rio de Janeiro , Brazil, 2 Department of Internal Medicine, Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro , Brazil. Correspondence to: P. C. Correa Ribeiro, Serviço de Geriatria Prof. Mario A. Sayeg, Policlínica Piquet Carneiro, Universidade do Estado do Rio de Janeiro, Av. Marechal Rondon 381, 2º andar, Rio de Janeiro, Rio de Janeiro , Brazil. Tel: ; fax: ; priccr@gmail.com Background Occupation is recognized as a modifiable factor related to cognitive reserve in older adults. Aims Methods Results To examine the association between levels of complexity in lifelong occupations and cognitive performance in later life. A cross-sectional study of older adult users (aged 65 or more) of a private health care plan, resident in the north zone of Rio de Janeiro City, Brazil, and participating in the Rio de Janeiro section of the Study of Fragility in Brazilian Older Adults (FIBRA-RJ). Cognitive performance scores were obtained using the Mini-Mental State Examination. The level of complexity of their work was assessed in three domains: work with data, persons and things. Associations between the complexity of work in each domain and cognitive performance were evaluated using multivariate linear regression, adjusted for socio-demographic variables and duration of occupation. A total of 624 older adults (94% of the study group) performed lifelong work activities. Among those working with data, the high complexity group had cognitive performance scores 1.08 points higher (P < 0.05) than low complexity. In work with things, scores in the intermediate complexity group were 0.53 points higher (P < 0.05) than low complexity. There was no statistically significant difference in the cognitive performance between levels of complexity of work with people. Conclusions Complexity in work with data and things was associated with better cognitive performance in later life, independent of age, schooling, income and duration of occupation. Key words Introduction Ageing; cognitive performance; occupation; older adults. Occupation, the activities performed day to day by individuals at work, is recognized as a source of mental stimulation and its effects on cognitive function in later life have been explained by the hypotheses of environmental complexity and cognitive reserve. These ideas suggest that daily exposure to cognitively stimulating activities can modify the pattern of brain use in mediating tasks, making it more efficient and resilient with regard to cerebral pathologies [1,2]. Although most people spend a substantial portion of their time in adult life on work activities [3], the possible effects of these activities on cognitive performance in later life are little investigated, particularly in lowand middle-income countries where research has been limited to examining the effects of occupation in terms of the professional qualifications required for work [4 6]. Studies in developed countries have shown a positive relationship between greater mental demands in the work environment and improved cognitive performance in later life [7 9]. In addition to the intellectual demands of occupation, human interactions constitute another dimension of work activities where high complexity has been associated with improved cognitive performance [10] and with lower risk of dementia in later life [11 13]. On the other hand, no association between occupation and cognitive performance and/or dementia in later life has been found in some studies [14 16]. These researchers point to other factors, such as education in early life and the pursuit of other mental activities, as sources of cognitive reserve explaining good cognitive function in The Author Published by Oxford University Press on behalf of the Society of Occupational Medicine. All rights reserved. For Permissions, please journals.permissions@oup.com
2 P. C. Correa Ribeiro et al.: Cognitive Performance in Old Age 557 later life. These apparent contradictions need to be clarified, because identification of modifiable factors influencing cognitive reserve in later life may contribute to more effective interventions to prevent cognitive impairment and dementia among older adults. This study examined the association between levels of complexity in lifelong work activities involving data, people and things and global cognitive performance in late adulthood. Methods The study was conducted using data from the Rio de Janeiro section of a study of fragility in Brazilian older adults, Estudo da Fragilidade em Idosos Brasileiros Seção Rio de Janeiro (FIBRA-RJ). The FIBRA-RJ study evaluated a sample of clients of a private health care and social protection foundation with widespread population coverage in Rio de Janeiro State (approximately elderly). The criteria for inclusion in the FIBRA-RJ study were being a client of the health care operator for at least 12 months, at least 65 years old and resident in one of the districts of the North Zone of Rio de Janeiro City. A total of 9769 individuals met these criteria and, in order to select the study population, were stratified by sex and age group, the total sample in each stratum being obtained by inverse random sampling to produce a planned 900 completed questionnaires. For men and women over 95 years old, a full census was taken with no selection. The actual sample size in each stratum was a random variable dependent not only on the number of individuals making up the stratum, but on the non-response rate, the number of refusals and the number of individuals identified as outside the scope of the study (because of institutionalization, change of address or death prior to start of the study). Each unit of the sample was attributed an expansion factor termed a weighting, defined from a basic weight, plus a correction factor combining an adjustment for non-response and an adjustment for individuals who died during the study or refused to participate. The FIBRA-RJ study interviewed 847 individuals, representing an expanded sample of 9197 units of analysis. These participants were contacted and underwent a semi-structured interview concerning work activities over the course of their lives. Individuals with impaired ability to communicate, e.g. because of dementia or severe hearing deficit (n = 25), were excluded from this procedure. In addition to these, 78 refused to respond to the questionnaire on occupation and another 73 died or were lost to contact after the first stage of the study. Accordingly 671 individuals from the FIBRA-RJ study database were interviewed in full. Of these, five were excluded for not returning performance test results so that the study included 666 individuals, corresponding to an expanded sample of 7298 units of analysis. The study was authorized by the Research Ethics Committee of the Pedro Ernesto University Hospital (1850-CEP/HUPE). All participants signed consent forms. The data on cognitive performance, socioeconomic and demographic characteristics used were taken from the FIBRA-RJ baseline information obtained in face-toface interviews by specifically trained university students and health personnel, conducted in a home or outpatient setting. The survey of occupational activities was carried out later by telephone. The dependent variable examined was global cognitive performance as indicated by overall score in the Mini-Mental State Examination (MMSE) [17,18]. This instrument, which is widely used to screen for cognitive impairment in older adults, evaluates the following domains: (i) orientation to time (day of the month, day of the week, month, year, hour); (ii) orientation to place (specific place, general place, neighbourhood, city, state); (iii) immediate memory and evocation (registration and recall of three words); (iv) attention and calculation (successive subtractions starting with ); (v) follow a three-stage command ( Take a paper in your right hand, fold it in half, and throw it on the floor ); (vi) language (name a watch and pen, repeat neither here, nor there, nor over there, write a sentence, read and obey the following: Close your eyes ) and (vii) visual constructive ability (copy a figure). Total scores for this instrument range from 0 to 30. Independent variables examined included the level of complexity of subjects lifelong occupation, in three dimensions: working with data, people and things. Information on occupation was obtained using a questionnaire of semi-structured questions on subjects lifelong work activities, including Have you performed any lifelong work activity? What was (is) your main occupation? and Describe the activities you perform in your day-to-day work. In order to provide a detailed description of activities performed during the working day, participants chose a primary occupation, i.e. the one to which they had devoted most time over their lifetime. In cases where various activities had been performed for equal lengths of time a maximum of three were chosen and the one with the greatest level of complexity was examined. The primary occupation was subjected to content analysis in order to categorize it according to the Dictionary of Occupational Titles (DOT) [19]. Once the occupation was categorized, it was assigned a score determined by the criteria for complexity given by the dictionary, which classifies all activities into three parallel domains: work with data, people and things. Each of these domains is organized into vertical levels of complexity ranging from 0 to 6 points for work
3 558 OCCUPATIONAL MEDICINE with data, 0 to 8 for work with people and 0 to 7 for work with things. The lower the score, the greater the complexity of the occupation. Complexity scores were divided into three categories (low, intermediate and high), according to percentiles. The co-variables (all self-reported) were gender, age, schooling (in years of study), family income (the sum of the personal incomes of the respondent and other individuals in the same household) and duration of occupation, from the age when work began to that at which all work activity ceased. For individuals who were still working the variable, duration of occupation was calculated using the participant s age at interview. The co-variables were categorized as follows: age (65 74, and 85 years), schooling (illiterate, 1 4, 5 8, 9 12, 13 years of school), family income (0 1, 1.1 2, 2.1 5, , , >20 times minimum wage) and duration of occupation (<20, and 40 years working). The dependent variable was analysed as a continuous variable. The independent variables and co-variables were categorized because when treated as continuous in preliminary analyses, no linearity was observed in the relationship between them and the dependent variable (data not shown). Linear regression models were used to compare the global cognitive performance scores of the groups exposed to work with high, intermediate and low levels of complexity. The models were analysed for each domain of occupational complexity and unadjusted and adjusted estimates for age, sex, schooling, family income and duration of occupation were obtained (stepwise method). In all analyses, low levels of complexity were the reference categories. The analyses were performed using the software Statistical Package for the Social Sciences (SPSS), version 17.0, and R, version All estimates were weighted and statistical procedures incorporated sample design [20]. Results Of the 666 individuals studied, 624 (94%) had performed lifelong work activities, representing 100% of the men and 90% of the women. Of the respondents who had worked, two were excluded from the complexity analyses due to lack of precision in the description of the day-to-day work activities performed. Participants and non-respondents (due to loss or refusal) had similar distributions of socio-demographic characteristics and cognitive performance. However, the excluded group consisting of homemakers and individuals with severe cognitive impairment was a significantly older and predominantly female sample. Socio-demographic, occupational and cognitive performance characteristics of the study population are given in Table 1. Of the women and men, respectively, 19 and 30% had worked as graduate professionals; 28 and 23% as technical/ mid-level personnel; 11 and 3% as manual workers (manufacturing/industrial services) and <1 and 2% in repair and maintenance work. The distribution of complexity in the population in each occupational domain is shown in Table 2. In the bivariate analyses, associations were observed between all the socio-demographic variables and cognitive performance (Table 3). As regards the effects of complexity of the work, associations were observed between cognitive performance and high complexity of work with data and people, but there were no significant associations between cognitive performance and the complexity of work with things. In the multiple linear models, the associations between the complexity of work with people and with things and cognitive performance were adjusted for age, schooling, income and duration of occupation and both reached Table 1. Demographic and occupational characteristics of participants and MMSE scores n (%) Sex (% female) Female 436 (67) Male 188 (33) Age group (years) (35) (48) (17) Schooling Illiterate 18 (3) (15) (19) (33) (30) Family income a (1) (3) (19) (39) (28) >20 48 (10) Years worked in lifetime (11) (42) (47) Mean SD Age of starting working Age of stopping working Total years worked in lifetime Level of complexity of work with data Level of complexity of work with people Level of complexity of work with things Total MMSE score n (%): number of individuals in the unweighted sample (percentage weighted by the sampling weight), where missing values were imputed from the mean. a Income in minimum wages; minimum wage = R$ from January 2009 to January 2010.
4 P. C. Correa Ribeiro et al.: Cognitive Performance in Old Age 559 Table 2. Distribution of level of complexity of work with data, people and things among the participants who worked throughout their lifetime (n = 622) Complexity level Data n (%) People n (%) Things n (%) High 0 Synthesizing 24 (4) 0 Mentoring 50 (8) 0 Setting up 1 Coordinating 169 (28) 1 Negotiating 17 (3) 1 Precision working 86 (14) 2 Analysing 51 (8) 2 Instructing 57 (9) 3 Supervising 13 (2) 4 Diverting 2 (0) 5 Persuading 11 (2) Intermediate 3 Compiling 242 (39) 6 Speaking/signalling 268 (44) 2 Operating 247 (40) 4 Computing 22 (4) 3 Driving/operating 17 (3) Low 5 Copying 14 (2) 7 Serving 74 (11) 4 Manipulating 66 (10) 6 Comparing 100 (15) 8 Taking instructions 130 (21) 5 Tending 5 (1) 6 Feeding/offbearing 1 (0) 7 Handling 200 (32) Data: Activities described vertically by levels of complexity of work with data, score ranging from 0 to 6 points. People: Activities described vertically by levels of complexity of work with people, score ranging from 0 to 8 points. Things: Activities described vertically by levels of complexity of work with things, score ranging from 0 to 7 points. n (%): Number of individuals in the unweighted sample (percentage weighted by the sampling weight). Table 3. β coefficient and estimated error of the simple linear regression for the association between socio-demographic characteristics and cognitive performance score Variables β (SE) P-value Sex Female 0 Male 0.60 (0.26) <0.05 Age group (0.25) < (0.47) <0.001 Schooling Illiterate (1.15) < (1.11) < (1.09) < (1.08) <0.001 Family income a (2.07) NS (1.79) NS (1.77) < (1.78) <0.05 > (1.81) <0.01 NS, not significant. a Income in minimum wages; minimum wage = R$ from January 2009 to January R 2 adj of The variable sex, although significant in the crude analysis, showed no association in the presence of the other variables and did not yield any improvement in R 2 in the multivariate models for work with people and things (data not shown). The multiple linear models for the complexity of work with data and cognitive performance were also adjusted 2 for sex (Table 4) resulting in R adj of In the model for complexity of work with data it was observed that Table 4. Crude and adjusted β coefficients and estimated errors for the association between levels of complexity by occupation domain and cognitive performance score Complexity of occupation Crude β (SE) Adjusted β (SE) Work with data a Intermediate versus low 1.49 (0.43) 0.30 (0.50) 95% CI to 1.28 High versus low 2.65 (0.42) 1.08 (0.52) 95% CI to 2.11 Work with people b Intermediate versus low 1.60 (0.33) 0.61 (0.35) 95% CI to 1.29 High versus low 2.22 (0.37) 0.72 (0.41) 95% CI to 1.53 Work with things b Intermediate versus low 0.14 (0.29) 0.53 (0.26) 95% CI to 1.05 High versus low 0.12 (0.47) 0.08 (0.36) 95% CI to 0.62 a Model adjusted for age, schooling, income, duration of occupation and sex. b Model adjusted for age, schooling, income and duration of occupation. the group that had performed high complexity work returned cognitive performance scores 1.08 higher (95% CI = ) than the low complexity group. For work with things, an increased cognitive performance score was found for the group with intermediate complexity, which was statistically significant (P < 0.05) after controlling for socio-demographic variables. However work with people showed no significant difference in cognitive performance between the complexity levels. Discussion This study found that greater complexity of work with data and things was associated with higher global
5 560 OCCUPATIONAL MEDICINE cognitive performance scores in later life, independently of the effects of age, schooling, income and duration of the occupation. The cognitive reserve resulting from occupational mental stimulation may explain these results. The same mechanism is used to explain how high levels of education represent a source of cognitive maintenance in later life [14,15]. Singh-Manoux et al. [21] showed that measures of cognition were more strongly associated with occupation than with level of education. They argue that this effect can be attributed to the impact of practice and reinforcement of cognitive capacities induced by work activities. Therefore, cognitive reserve is regarded not as fixed but as continuous and shaped by life experience. This study corroborates other studies regarding the effects of the complexity of work with data and cognitive function in older adults [3,9]. On the other hand, its findings differ from the same studies regarding an association with complexity in work with things and with people. Other studies [22,23] indicate that only work activities of an intellectual nature are associated with improved cognitive performance in older adults. Our results also show an association between intermediate complexity of work involving manual activities and improved global cognitive performance, compared with individuals with work of low complexity, but no association with high complexity work of this kind. The lack of objective instruments to assess the type of work performed can make it difficult to measure the complexity of occupation, particularly in work with things, entailing limited accuracy in gauging complexity in the use of machinery and equipment. The difficulty of measuring the complexity of occupations has previously been discussed, suggesting that indicating work with things is the least reliable and least representative element of the overall complexity of work [2,24]. Confounders such as involvement with other activities and/or genetic factors not controlled for in this study may explain the relationship encountered between complexity in working with things and cognitive performance in this study sample. In our study, higher complexity of work with people was not associated with better cognitive performance. This may be because the stimulation resulting from dealing with people is present not only in occupation but also in any social activity, so that even those working with people at lower levels of complexity may be exposed to similar levels of stimulation as in high complexity of work with people. The benefits of human interactions for cognitive performance have been described in studies that investigated support networks and participation in social activities among older adults [25 27]. In the Brazilian context, studies conducted with populations of older adults have shown that not performing work activities [28] and doing work requiring fewer qualifications was associated with worse cognitive functioning and the development of dementia in later life [5,6,22]. However, these studies do not permit comparisons in terms of occupational complexity because the variable work was examined either as a dichotomous variable (having or not having an occupation) or in categories that discriminated only by the qualification (formal education) necessary to perform the work activity. No Brazilian standards exist for measuring and classifying levels of occupational complexity. Consequently the US classification of occupations was used [19] because it allows complexity scores to be assigned independently of schooling. Use of a classification originating in another socio-cultural context may lead to inaccurate measurement of complexity levels for unusual activities or those that differ from one context to another. The US format is used in international studies [9,11,12], which have approximated their classification for occupations to the DOT format. Nonetheless limitations occur in the measurement of occupational complexity using the DOT. The arbitrary nature of measurement of levels of occupational complexity can for instance underestimate the complexity of occupations when performed in a real environment and underrate their effects. Another limitation is possible memory bias when self-reporting reports are used to measure lifelong work activities. Although often used by virtue of being a quick and inexpensive way to obtain long-term information, it may not furnish accurate descriptions of activities performed by older adults in earlier periods of their lives. An objective instrument constructed to measure occupation has been presented as an appropriate means of representing mentally complex activities [29]. Although the objective is to reduce imprecision in measuring older adults engagement in lifelong activities, this format is still subject to memory bias [30]. Therefore, the impossibility of measuring occupational complexity directly still constitutes a limitation on evaluations of the level of cognitive stimulation individuals are actually exposed to in their day-to-day work. The sample was limited to subjects without severe cognitive impairment, since there were no other available sources of information regarding occupation. The reports of other informants (e.g. child or spouse) were regarded as prone to information bias because the data required detailed knowledge of the activities performed in daily work. In this study, the cross-sectional design limits the conclusions that can be drawn regarding the effect of lifelong occupation on cognitive decline, although it is possible to point to associations with cognitive functioning at a given point in the ageing process. Furthermore, cross-sectional and longitudinal studies of samples drawn particularly from developing countries need to be conducted in order to confirm this association in those populations. Given the associations found between cognitive performance in later life and occupation pursued, we believe that detailed description of occupation constitutes an additional mechanism that can help screen for
6 P. C. Correa Ribeiro et al.: Cognitive Performance in Old Age 561 individuals at heightened risk of cognitive impairment and dementia. In addition, we suggest that in future preventive interventions for groups lacking in occupationally derived cognitive stimulation should be developed and tested. Key points Complexity of work with data and work with things was associated with better cognitive performance in later life, independent of age, schooling, income and duration of the occupation. Complexity of work with people was not associated with cognitive performance in later life. Detailed description of occupation could be an additional mechanism to assist in screening individuals at increased risk of cognitive impairment and dementia. Funding National Research Council Brazil (CNPq /2006-9), Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro, Brazil (FAPERJ E-26/ /2006, E-26/ /2007). Conflicts of interest None declared. References 1. Schooler C. 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