NANOS 2018 Literature Review Clinical Papers Neurology. Caroline Tilikete, MD, PhD Hospices Civils de Lyon, University Lyon I Lyon, France

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1 NANOS 2018 Literature Review Clinical Papers Neurology Caroline Tilikete, MD, PhD Hospices Civils de Lyon, University Lyon I Lyon, France

2 Nystagmus Effect of Gabapentin/Memantine on the Infantile Nystagmus Syndrome in the Zebrafish Model Bogli SY, Afthinos M, Huang MY. Invest Ophthalmol Vis Sci. 2017;58(7):

3 Nystagmus Magnetic Oculomotor Prosthetics for Acquired Nystagmus. Nachev P, Rose GE, Verity DH, Manohar SG, MacKenzie K, Adams G, et al. Ophthalmology. 2017;124(10):

4 Nystagmus Resolution of periodic alternating nystagmus with amantadine. Lee SH, Lee SY, Choi SM, Kim BC, Kim MK, Kim JS. J Neurol Sci. 2016;364:65-7.

5 Vestibular testing in INO Vestibulo-ocular reflex deficits with medial longitudinal fasciculus lesions. Aw ST, Chen L, Todd MJ, Barnett MH, Halmagyi GM. J Neurol. 2017;264(10): Impaired vestibular responses in internuclear ophthalmoplegia: Association and dissociation. Choi SY, Kim HJ, Kim JS. Neurology Nov 15 Severe deficit of contralesional posterior semicircular canal (SCC) function

6 MOG associated optic neuritis Clinical presentation and prognosis in MOG-antibody disease: a UK study. Jurynczyk M, Messina S, Woodhall MR, Raza N, Everett R, Roca-Fernandez A, et al. Brain. 2017;140(12): Clinical presentation isolated optic neuritis : 55%, bilateral in almost half transverse myelitis: 18% acute disseminated encephalomyelitis-like presentations : 18% Pronostic 16% patients of bad visual acuity (<6/36) in at least 1 eye 7% EDSS > 4 ; 5% EDSS > 6 28% bladder issues, 20% bowel dysfunction and 21% erectile dysfunction Annualized relapse rate 0,2 Decreased with immunosuppression > 3 months

7 MOG associated optic neuritis Etiologies of acute demyelinating optic neuritis: an observational study of 110 patients. Deschamps R, Lecler A, Lamirel C, Aboab J, Gueguen A, Bensa C, et al. Eur J Neurol. 2017;24(6):875 10% ON-MOG What proportion of AQP4-IgGnegative NMO spectrum disorder patients are MOG-IgG positive? Hamid SHM, Whittam D, Mutch K, Linaker S, Solomon T, Das K, et al. J Neurol. 2017;264(10): % MOG-IgG positive

8 MOG associated optic neuritis Optic neuritis in patients with anti-mog antibodies spectrum disorder: MRI and clinical features from a large multicentric cohort in France. Biotti D, Bonneville F, Tournaire E, Ayrignac X, Dalliere CC, Mahieu L, et al. Journal of Neurology. 2017;264(10): optic nerve head swelling Extensive optic nerve T2 hyperintensity with gadolinium enhancement

9 MOG associated optic neuritis MOG-ab as potential markers of severe optic neuritis and subclinical retinal axonal degeneration. Havla J, Kumpfel T, Schinner R, Spadaro M, Schuh E, Meinl E, et al. J Neurol. 2017;264(1): MOG-ab>AQP4-ab Retinal Nerve Fiber Layer May Be Better Preserved in MOG-IgG versus AQP4-IgG Optic Neuritis: A Cohort Study. Stiebel-Kalish H, Lotan I, Brody J, Chodick G, Bialer O, Marignier R, et al. PLoS One. 2017;12(1):e AQP4-ab>MOG-ab

10 Diagnostic MRI criteria for NMOSD Brain lesion distribution criteria distinguish MS from AQP4-antibody NMOSD and MOG-antibody disease. Jurynczyk M, Tackley G, Kong Y, Geraldes R, Matthews L, Woodhall M, et al. J Neurol Neurosurg Psychiatry. 2017;88(2): lesion adjacent to the body of the lateral ventricle and in the inferior temporal lobe 2. subcortical U-fibre lesion 3. Dawson s finger-type lesion sensitivity 90.9% specificity 89.7%

11 Paraneoplastic NMOSD Clinical profile of patients with paraneoplastic neuromyelitis optica spectrum disorder and aquaporin-4 antibodies. Sepulveda M, Sola-Valls N, Escudero D, Rojc B, Baron M, Hernandez-Echebarria L, et al. Multiple sclerosis. 2017: In NMOSD, the risk for cancer is higher in patients who present with brainstem involvement, mainly nausea and vomiting patients older than 45 years, usually male, presenting with extensive transverse myelitis

12 PLEX treatment of NMOSD Short delay to initiate plasma exchange is the strongest predictor of outcome in severe attacks of NMO spectrum disorders. Bonnan M, Valentino R, Debeugny S, Merle H, Ferge JL, Mehdaoui H, et al. J Neurol Neurosurg Psychiatry. 2017

13 Posterior cerebral atrophy (PCA) Consensus classification of posterior cortical atrophy. Crutch SJ, Schott JM, Rabinovici GD, Murray M, Snowden JS, van der Flier WM, et al. Alzheimers Dement. 2017;13(8):870-84

14 Multiple Sclerosis Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, et al. Lancet Neurol In a patient with a typical clinical isolated syndrome (CIS) and fulfilment of clinical or MRI criteria for "dissemination in space" and no better explanation for the clinical presentation, demonstration of CSF-specific oligoclonal bands allows an MS diagnosis to be made without the previously required "dissemination in time. 2. Both symptomatic and asymptomatic MRI lesions can be used for fulfilling MRI criteria for dissemination in space or dissemination in time. 3. In addition to juxtacortical lesions, cortical lesions can also be used to demonstrate dissemination in space requirements. 4. The group also declined to include the presence of optic neuritis pathology in the revised criteria

15 MS Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial. Cadavid D, Balcer L, Galetta S, Aktas O, Ziemssen T, Vanopdenbosch L, et al. Lancet Neurol. 2017;16(3):189-99