Lisuride and Other Dopamine Agonists
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1 Lisuride and Other Dopamine Agonists Basic Mechanisms and Endocrine and Neurological Ejfects Editors Donald B. Calne, D.M., F.R.C.P. Division of Neurology Department of Medicine University of British Columbia Vancouver, British Columbia, Canada Reinhard Horowski, Dr. Med. Department of Neuroendocrinology and Neuropsychopharmacology Schering AG Berlin, Federal Republic of Germany Richard J. McDonald, Ph.D. Department of Neuroendocrinology and Neuropsychopharmacology Schering AG Berlin, Federal Republic of Germany Wolfgang Wuttke, Prof. Dr. Med. Department of Neurobiology Max-Planck-Institute for Biophysical Chemistry Gottingen Federal Republic of Germany Raven I n
2 Contents Introduction 1 Dopaminergic Ergot Compounds: An Overview E. Fliickiger, U. Briner, A. Enz, R. Markstein, andj. M. Vigouret Receptor Pharmacology \f\ 11 Heterogeneity of Brain Dopamine Systems: Possible Discrimination of Different Types of Dopamine Systems and Receptors by Ergot Drugs K. Fuxe, L. F. Agnati, C. Kohler, K. Andersson, P. Eneroth, L. Calza, and S.-O. Ogren ^ 33 Ergot-Induced Inhibition of Dopamine Synthesis in Striatal Synaptosomes: A D-2 DA Receptor-Mediated Mechanism A. H. Tissari and G. L. Gessa X 45 Actions of Lisuride on Adrenoceptors and Dopamine Receptors T. E. Cote, R. L. Eskay, E. A. Frey, C. W. Grewe, M. Munemura, K. Tsuruta, E. M. Brown, and J'. W. Kebabian \ 55 Estrogen Modulation of Dopaminomimetic Actions: Implications for Autoreceptor Regulation M. P. Piccardi, F. Bernardi, A. Bocchetta, and G. U. Corsini Behavioral Pharmacology 65 Behavioral Pharmacology of Ergot Derivatives Michele O. Carruba and Paolo Mantegazza 79 Lisuride-Induced Mounting Behavior and Effects on the Monoaminergic System in Rat Brain H. H. Keller, E. P. Bonetti, L. Pieri, and M. Da Prada 89 Behavioral, Neurochemical, and Electrophysiological Effects of Lisuride and LSD in Animals L. Pieri, H. H. Keller, J.-P. Laurent, W. P. Burkard, M. Pieri, E. P. Bonetti, and M. Da Prada vu
3 viii CONTENTS \f\ 97 Effect of Chronic Lisuride Treatment on Stereotypical and Myoclonic Jumping Behavior in Guinea Pigs Paul M. Carvey and Harold L. Klawans 109 Central Dopaminergic and Antidopaminergic Effects of Ergot Derivatives Structurally Related to Lisuride Helmut Wachtel 127 Pharmacological Effects of Lisuride and Their Potential Role in Further Research R. Horowski Pharmacokinetics 141 Pharmacokinetics of Lisuride in Animal Species and Humans Michael Hiimpel 153 Disposition of Dopaminergic Ergot Compounds Following Oral Administration R. Stanley Burns and Donald B. Calne 161 Neuroendocrine Effects of Lisuride and Its 9,10-Dihydrogenated Analog in Healthy Volunteers R. Dorow, M. Breitkopf, K.-J. Graf, and R. Horowski Endocrinologic Pharmacology \f i 175 Neuroendocrine Effects of Dopamine in the Hypothalamus and i Pituitary Gland \ W. Wuttke, E. Duker, K. Honma, M. Demajo, S. A. de Lira, M. Lohse, and T. Mansky \{tylj 199 ^ 187 Effect of Lisuride on Spontaneous Pituitary Tumors in Female Rats M. F. El Etreby, D. Dehne, S. H. Hasan, R. Horowski, K. Kovacs, and D. McComb Effects of Dopamine Agonists on Prolactin, Growth Hormone, and Cortisol Secretion in Animals and Humans K.-J. Graf and I. Ktirten 213 Dopamine Agonists and Prolactinomas: Clinical and Basic Considerations of the Mechanisms of Action Michael O. Thorner, Jose A. Burdman, Maria T. Calabrese, Carlos A. Valdenegro, Mary L. Vance, and Robert M. MacLeod
4 CONTENTS ix 231 Medical Treatment of Pituitary Adenomas: Effects on Hormonal Secretion and Tumor Size A. Liuzzi, P. G. Chiodini, G. Oppizzi, D. Dallabonzana, B. Spelta, F. Silvestrini, E. Rainer, and R. Horowski Hormonal and Clinical Effects of Dopamine Agonists G. M. Besser, J. A. H. Wass, A. Grossman, P. J. A. Moult, and P. Bouloux 255 Dopamine Agonists and Prolactinomas: Clinical and Therapeutic Aspects Klaus von Werder, Rudolf Fahlbusch, and Hanns-Kristian Rjosk 271 Comparison of Effects of Dopamine Agonists and Microsurgery in GH- and PRL-Secreting Adenomas D. K. Ludecke, H.-D. Herrmann, C. Hormann, U. Desaga, and W. Saeger 291 Dopaminergic Ergots in Lactation and Cycle Disturbances Luigi De Cecco, Pier Luigi Venturini, Nicola Ragni, Mario Valenzano, Sergio Costantini, and Reinhard Horowski 301 Suppression of Lactation M. Schmidt-Gollwitzer 313 Prolactin and the Inadequate Corpus Luteum H. P. G. Schneider, R. Goeser, and U. Cirkel 325 Effect of Bromocriptine on LH Secretion in the Polycystic Ovary Syndrome Paolo Falaschi and Emilio del Pozo 111 Lisuride and Female Fertility W. H. F. Schneider 337 Effects of Prolactin-Lowering Agents in the Treatment of Disorders of Fertility M. Carstensen, R. Sohnchen, W. Braendle, and G. Bettendorf 345 EEG and Psychological Effects of Lisuride in Women with Premenstrual Tension M. Schwibbe, D. Becker, and W. Wuttke Neurological Pharmacology 357 Ergot Derivatives and Extrapyramidal Disease Donald B. Calne
5 x CONTENTS 363 Theoretical and Practical Issues in Assessment of Deficits and Therapy in Parkinsonism T. Andreo Larsen, Peter A. LeWitt, and Donald B. Calne 375 Desensitization of Striatal Spiperone-Binding Sites by Dopaminergic Agonists in Parkinson's Disease P. Riederer, G. P. Reynolds, W. Danielczyk, K. Jellinger, and D. Seemann 383 Intravenous Lisuride in Extrapyramidal Disorders N. Quinn, C. D. Marsden, M. Schachter, C. Thompson, A. E. Lang, and J. D. Parkes 395 Treatment of the Shy-Drager Syndrome with Dopaminergic Ergots A. J. Lees and Roger Bannister 407 Dopaminergic Ergots in Parkinsonism Alessandro Agnoli, Stefano Ruggieri, Massimo Baldassarre, Fabrizio Stocchi, Alessandro Denaro, and Paolo Falaschi 419 Lisuride in Parkinson's Disease and Related Disorders Abraham N. Lieberman, Menek Goldstein, Govindan Gopinathan, Andreas Neophytides, Morton Leibowitz, Russell Walker, and Emil Hiesiger 431 New Ergot Derivatives in the Treatment of Parkinson's Disease U. K. Rinne 443 Pergolide Treatment in Parkinsonism Joyce Ilson, Stanley Fahn, Richard Mayeux, and Lucien Cote 453 Effects of Lisuride on Motor Function, Psychomotor Activity, and Psychic Behavior in Parkinson's Disease W. Birkmayer and P. Riederer 463 Experience with Lisuride in the Treatment of Parkinson's Disease Gudrun Ulm 473 Experience with Dopamine Agonists in Parkinson's Disease and Related Disorders Peter A. LeWitt and Donald B. Calne 481 Dopamine as an Agonist in Opiate and Endogenous Opioid (Migraine) Abstinence Federigo Sicuteri and Marcello Fanciullacci
6 CONTENTS * Pharmacology of Aging 489 Regulation of Monoamine Metabolism in Young and Old Rats: Effects of Ergot Derivatives Wolfgang Kehr 503 Role of Lisuride and Other Dopamine Agonists in Memory Retrieval Processes David Quartermain, Martin E. Judge, and Eitan Friedman 515 Effects of Lisuride on Psychomotor Functions and Recall Memory in Elderly Healthy Volunteers Richard J. McDonald and Aloysius Rohloff 529 Clinical Effects of Dopamine Agonists in Elderly Patients Irmgard H. Suchy 543 Subject Index
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