Ergot Alkaloids. International Workshop on Ergot Alkaloids Rome, December 6 7, Editors P.F. Spai'.o and M. Trabucchi, Milan

Transcription

1 Ergot Alkaloids

2 International Workshop on Ergot Alkaloids Rome, December 6 7, 1976 Ergot Alkaloids Editors P.F. Spai'.o and M. Trabucchi, Milan 140 figures and 46 tables, 1978 S. Karger Basel München Paris London New York Sydney

3 Pharmacology Vol. 16, Suppl. 1, 1978 The organization of the International Workshop on Ergot Alkaloids was under the sponsorship of the Italian Brain Research Foundation and the publication of the proceedings was carried out with the support and assistance of Sandoz Ltd. Cataloging in Publication International Workshop on Ergot Alkaloids, Rome 1976 Ergot alkaloids / editors, P.F. Spano and M. Trabucchi Basel; New York : Karger, (Pharmacology ; v. 16, suppl. 1) Temporary cataloging. Workshop held under the sponsorship of the Italian Brain Research Foundation. 1. Ergot Alkaloids - congresses 1. Spano, P.F., ed. 11. Trabucchi, M., ed. W1 PH283 v. 16 suppl. 1 QV c 1976 ISBN Copyright 1978 by S. Karger AG 4011 Basel (Switzerland), Arnold-Böcklin-Strasse 25 Printed in Switzerland by Thür AG Offsetdruck, Prat teln ISBN All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

4 Contents Preface...VII Hofmann, A. (Burg i.l.): Historical View on Ergot A lkaloids... 1 Boissier, J.R. (Paris): General Pharmacology of Ergot Alkaloids McConnachie, R. IV. (Chesterfield): The Clinical Assessment of Brain Failure in the Elderly Samorajski, T.; Rolsten, C., and Pratte, K.A. (Houston, Tex.): Dihydroergotoxine (Hydergine ) and Ethanol-Induced Aging of C57BL/6J Male Mice Meier-Ruge, W.; Emmenegger, H.; Enz, A.; Gygax, P.; Iwangoff, P., and Wiernsperger, N. (Basel): Pharmacological Aspects of Dihydrogenated Ergot Alkaloids in Experimental Brain R esearch Müller, E.E.; Cocchi, D.; Panerai, A.E.; Gil-Ad, I.; Locatelli, V., and Mantegazza, P. (Milan): Pituitary Hormones and Ergot Alkaloids Silvestrini, F.; Liuzi, A., and Chiodini, P.G. (Milan): Effect of Ergot Alkaloids on Growth Hormone and Prolactin Secretion in Humans Handy, K. and Schneider, F.H. (Bedford, Mass.): Effects of Hydergine on Aging Neuroblastoma Cells in Culture Cools, A.R. (Nijmegen): Ergometrine and its Biphasic Action at Dopaminergic Receptors in the Nucleus Accumbens of Rats Fuxe, K.; Fredholm, B.B.; Agnati, L.F.; Ogren, S.-O.; Everitt, B.J.; Jonsson, G., and Gustafsson, J.-À. (Stockholm): Interaction of Ergot Drugs with Central Monoamine Systems. Evidence for a High Potential in the Treatment of Mental and Neurological Disorders Di Chiara, G.; Porceddu, M.L.; Vargiu, L., and Gessa, G.L. (Cagliari): Stimulation of Regulatory Dopamine Receptors by Bromocriptine (CB-154) Goldstein, M.; Lieberman, A.; Battista, A.F.; Lew, J.Y., and Hata, F. (New York, N.Y.): Bromocriptine, Lergotrile: The Antiparkinsonian Efficacy and the Interaction with Monoaminergic Receptors Trabucchi, M.; Hofmann, M.; Montefusco, 0., and Spano, P.F. (Brescia): Ergot Alkaloids and Cyclic Nucleotides in the CNS Vigouret, J.M.; Bürki, H.R.; Jaton, A.L.; Züger, P.E., and Loew, D.M. (Bern): Neurochemical and Neuropharmacological Investigations with Four Ergot Deriv-

5 Contents V) atives: Bromocriptine, Dihydroergotoxine, CF and CM Agnoli, A.; Ruggieri, S., and Casacchia, M. (L Aquila): Restatement and Prospectives of Ergot Alkaloids in Clinical Neurology and Psychiatry Longo, V.G. and Loizzo, A. (Rome): Evaluation of the Central Effects of Ergot Alkaloids by Means of Electroencephalography Rossi, G.L. (Bern): Effects of 2-Bromo-aergocryptine on the Ultrastructure of Anterior Pituitaries in Different Experimental Conditions Pepeu, G. and Mantovani, P. (Florence): Effect of Bromocriptine on Acetylcholine Output from the Cerebral C o rtex Portaleone, P. (Turin): Bromocriptine and Hydergine: a Comparison on Striatal or Hypothalamic Adenylate Cyclase Activity Author Index Subject Index...211

6 Preface The major aim of the International Workshop on Ergot Alkaloids, which was held in Rome in December 1976 under the sponsorship of the Italian Brain Research Foundation, was to provide an integrated overview of the current knowledge of the basic and clinical aspects of classic and new ergot derivatives. The topics have been selected to encompass all aspects related to an understanding of the regulation and control of brain functions by this class of drugs. This volume is intended to survey the large number of significant experimental and clinical data dealing with ergot drugs which were reported at the Rome meeting. In particular, the contributors to this book have drawn on the salient literature, as well as on their own work, with the aim of clarifying the different modes of action of ergot derivatives and the various possible utilization in abnormal clinical conditions, depending on brain disfunctions. The combined efforts of research workers in different areas of neurochemistry and of experimental therapeutics offer good hope for a better understanding on the mechanism of action of these compounds and consequently new opportunities for successful treatment of a variety of disorders. The Editors P.F. Spano and M. Trabucchi