KYORITSU CHEMICAL-CHECK Lab., Corp. Revised 2016/05/20 No.3506 Titration Test Kit: (P) Acidity 1/7. Safety Data Sheet

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1 1/7 Safety Data Sheet Reference No Issue: 9 th January 2001 Revision: 20 th May Chemical product and company identification Product name Titration Test Kit: (P) Acidity Model WAD-AC-P Company name KYORITSU CHEMICAL-CHECK Lab., Corp. Address 37-11, Den-enchofu 5-chome, Ota-ku, Tokyo , Japan Tel Fax Person in charge Manabu KAITA Recommended uses and restrictions Reagent for water quality measurement 2. Hazards identification [GHS Classification] Physical hazards: Flammable liquids: Category 3 For those physical hazards not listed above are not classified or classification not possible (no data for GHS classification available) Health hazards: Skin corrosion/irritation: Category 1 (applicable R-2 (C) and R-2 (D) reagents) Serious eye damage/eye irritation: Category 1 (applicable R-2 (C) and R-2 (D) reagents) Category 2A Germ cell mutagenicity: Category 1B Toxic to reproduction Category 1A Specific target organ toxicity (single exposure): Category 3 (respiratory irritation, narcotic effects) (applicable only R-1 reagent) Specific target organ toxicity (repeated exposure): Category 1 (liver) Category 2 (nervous system) For those health hazards not listed above are not classified or classification not possible (no data for GHS classification available) Environmental hazards: Not classified or classification not possible (no data for GHS classification available) [GHS labeling elements] [Signal word] Danger [Hazard statements] Flammable liquid and vapor. Causes severe skin burns and eye damage. Causes serious eye damage. Causes serious eye irritation. May cause genetic defects. May damage fertility or the unborn child. May cause respiratory irritation. May cause drowsiness or dizziness. (applicable R-2 (C) and R-2 (D) reagents) (applicable R-2 (C) and R-2 (D) reagents)

2 2/7 Cause damage to liver through prolonged or repeated exposure. May cause damage to nervous through prolonged or repeated exposure. [Precautionary statements] Keep out of reach of children and store in the cool, dry, and dark place. Carefully read instructions before use and do not use for other purposes. Wear personal protective equipment if necessary. Do not inhale reagents. Wash contaminated clothing. Wash hands well before and after handling. Avoid release to the environment. 3. Composition/ information on ingredients Discrimination of single substance or mixture: Mixture Reagent name R-1 reagent R-2 (C) reagent R-2 (D) reagent Chemical name Phenolphthalein Ethanol Water Sodium hydroxide Water Sodium hydroxide Water Content < 0.2% < 49.9% > 49.9% < 1% > 99% < 0.1% > 99.9% Chemical formula METI No. (reference number under CSCL in Japan) C 20 H 14 O 4 C 2 H 6 O H 2 O NaOH H 2 O NaOH H 2 O (9)-1152 (2)-202 (1)-410 (1)-410 CAS No First-aid measures If reagents or test solutions; Enter in eyes: Immediately rinse with water for more than 15 minutes followed by the treatment from an ophthalmologist. Contact with skin: Immediately wash out contaminated site with plenty of water. Enter into mouth: Immediately rinse mouth with plenty of water. If any symptoms appear after above measures, immediately get medical advice or treatment. Especially in case ingested reagents or test solutions, drink plenty of milk or water and immediately get medical advice or treatment. 5. Fire-fighting measures Extinguishing methods: Suitable extinguishing media: Cut off ignition sources and extinct by a suitable media. Powder, carbon dioxide, and dry sand. 6. Accidental release measures In case of outdoor use: avoid spill of reagents or waste solutions. In case of indoor use: if spilled on a table or floor, wipe off immediately spilled reagents and dispose of them. Concentrated waste solutions should not be released into sewer or rivers. 7. Handling and storage Handling: Do not inhale or ingest the reagent. Avoid contacting the reagent with eyes and skin. Since the ph of R-2(C) and R-2(D) reagents are higher than or equal to 13, respectively, special care should be made so that contact with eyes, skin or inhalation will not occur. Storage: Avoid direct sunlight and store in a well-ventilated, cool, dry, and dark place.

3 3/7 8. Exposure controls and personal protection Administrative control level Working environment standard: Not established Occupational exposure limits Japan Society for Occupational health: 2 mg/m 3 ACGIH (TLVs): Ceiling, 2 mg/m 3 (only for Sodium hydroxide) OSHA(PEL): 8H, TWA, 2 mg/m 3 (only for Sodium hydroxide) ACGIH (TLVs): TWA 1000 ppm (only for 100% Ethanol) OSHA(PEL): air TWA, 1000 ppm, 1900 mg/m 3 (only for 100% Ethanol) Protective equipment: Recommended to wear protective glasses and gloves 9. Physical and chemical properties Physical state: R-1: Liquid reagent 10 ml x 1 poly-bottle in poly bag R-2 (C): Liquid reagent 15 ml x 1 poly-bottle in poly bag R-2 (D): Liquid reagent 15 ml x 1 poly-bottle in poly bag Color: R-1: colorless, R-2 (C), R-2 (D): colorless Odor: R-1: no odor, R-2 (C), R-2 (D): no odor ph: R-1: 7, R-2 (C),R-2 (D): 13, test solution after measurement: 8 Melting point, boiling point, flash point, ignition point, lower explosion limit, vapor pressure, density, specific gravity, solubility, Log Pow, kinematic viscosity : not available as a mixture Note that ethanol has a flash point of 13 ºC and a boiling point of 78.5 ºC and is classified as flammable liquid Category 2 (Danger, Highly flammable liquid and vapor) by NITE. This product is classified as flammable liquid Category 3 (Warning, flammable liquid and vapor) because more than or equal to 10%of ethanol is contained in this product and 0.04% Phenolphthalein ethanol solution (40) manufactured by Wako Pure Chemical Industries Ltd., which has a similar composition to R-1 reagent, is classified as Category 3 in MSDS No. JW (revised ). 10. Stability and reactivity Avoid leaving in a place where high temperature, humid or under direct sunlight. No data on flash point, ignition point, explosion limits and dangerous/hazardous decomposition product is available. Although ethanol vapor generates explosive mixed gas with air, stable under normal handling conditions and no dangerous reaction is expected to occur under specific conditions. 11. Toxicological information No data on mixture is available. Data on R-1, R-2, R-2 (C) and R-2 (D) reagents are shown below. R-1 reagent Phenolphthalein (no data on solution): Acute toxicity (Oral): Classification is not possible because of data lack; Oral-rat LD 50 > 1,000 mg/kg (RTECS, Access in Aug 2007) and no other data is available. Skin corrosion/ irritation: Classified as Category 2 based on data; it is reported that severe edema in palpebra and echymotic hemorrhages in conjunctiva in humans (HSDB, 2004). Respiratory or skin sensitization Classified as Category 1 because it is reported that Causes allergic skin reaction in humans (HSDB 2004, IARC ). Germ cell mutagenicity: Classified as Category 2 based on data; Negative in vitro reverse mutation study and in vitro sister chromosome exchange study (HSDB 2004, NTP TR465, 1996). Although in an Ames and in vitro sister chromosome exchange studies are negative, in vivo mouse micronucleus study in peripheral blood and in vitro chromosome aberration studies are positive (IARC ). Carcinogenicity: Classified as Category 2 because of facts that IARC Group 2B (Possibly carcinogenic to humans) (IARC 76, 2000) and NTP-R (NTP, 2005). Reproductive toxicity: Classified as Category 2 based on data; In a mouse reproductive toxicity study by oral exposure, decreased weight of testes and decreased sperms number, decreased

4 4/7 pregnancy dates and number of new born child, decreased body weight in child animals were observed where no maternal toxicity was reported (IARC ). Specific target organ toxicity (repeated exposure): Classified as Category 1 (digestive organs, kidneys and nervous system) based on data; stomach ache and abnormality in digestive organs in humans after chronic exposure, effects on kidneys and central nervous system were caused by chronic exposure in humans (IARC ). Ethanol (no data on solution): Acute toxicity (oral): Rat-oral LD 50 = g/kg-bw, 5g/kg-bw (DFGOT vol.7 (1996, p148) and Patty 5th, (2005, p385)). Acute toxicity (inhalation: vapor): Rat-inhalation LC 50 = 20,000ppm/10H (RTECS (2004)) on which data can be considered as a vapor inhalation test because saturated vapor concentration of ethanol at 20 ºC is 56,580ppm. Furthermore, 20,000ppm/10H * 10/ 4 = 31,600ppm/4h > 12,500 ppm (gas 5,000 ppm (category 4) * 2.5). Acute toxicity (inhalation: dust-mist): Rat-inhalation LC 50 (4h) = ca 63,000ml/m 3 = 63,000ppm (definition by DFG, DFGOT (1996)) exceeds saturated vapor concentration of ethanol at 20 ºC of 56,580ppm and is classified as a mist inhalation test. Skin corrosion/ irritation: Not irritating in an OECD TG 404 and American Guideline tests (DFGOT (1996)). Serious eye damage/ eye irritation: Classified as moderate according to OECD TG 405 and Draize tests (DFGOT (1996), and it is reported that disorder of cornea epithelium and conjunctival congestion in human have been recovered in 1-2 days (ACGIH (2001)). Germ cell mutagenicity: Positive in rats and mice dominant lethal tests and induction of heteroploidy in mice germ cell (DFG (1999) and IARC (1988)). Carcinogenicity: IARC classifies as a Group 1 alcohol beverages is human carcinogen. This is based on the fact that there is a relationship of cancer in liver and esophagus and alcohol beverages which can be concluded from large numbers of epidemiological studies regarding regular intake of alcohol beverages (DFGOT (1996)). On the other hands, ACGIH classifies ethanol A4 (not classifiable as a human carcinogen) as a toxicant in occupational settings (ACGIH, 1996). In this MSDS, it is evaluated that not classified based on the classification made by ACGIH and according to the technical guidance manual because classification should not be made on hazards of alcohol beverages but focused on hazards of ethanol. Reproductive toxicity: Large number of teratogenicity in human child or other adverse effects are reported which are caused by heavy drinking of alcohol beverages (DFGOT (1996)). Specific target organ toxicity (single exposure): Ingestion of ethanol causes disorder of central nervous system, headache, tiredness, loss of concentration in humans (ICSC (2000)) and acute poisoning may cause death (DFGOT (1996)) and inhalation of 5,000ppm (9.4 mg/l) caused respiratory irritation, lethargy and sick sleep in humans (ACGIH (2001)). Specific target organ toxicity (repeated exposure): Classified as Category 1 (liver system) based on data; Chronic and large amount of consumption of alcohols cause systemic toxicity in almost all organs in humans and the target organ is liver. Disorder may initiates from fatty degeneration and results in necrosis, fibrosis and liver cirrhosis. (DFGOT (1996)) Classified as Category 2 (nervous system) based on data; Withdrawal symptoms of alcoholism: tremor, epilepsia and distraction. (HSDB (2003)) Water: Acute toxicity: Oral-rat LD 50 >90 ml/kg (used 90g/kg for the calculation of ATEmix below) R-2 (C) and R-2 (D) reagents Sodium hydroxide (no data on solution): Acute toxicity: Interperioneal-mouse LD 50 = 40 mg/kg, Oral-human LDLo = 1.57 mg/kg, Oral-rabbit LDLo = 500 mg/kg Skin corrosion/ irritation: 0.5% and higher solution is irritating (SIDS, 2002), severe corrosion to human skin (DFGOT vol.12, 1999). 8% and higher solution causes corrosion to pig skin (SIDS, 2002). 5% and 4 hours administration causes severe necrosis to rabbit skin (ACGIH 7th, 2001;

5 5/7 PATTY 5th 2001). Serious eye damage/ eye irritation: Human severe, serious hazard (ACGIH 7th 2001, DFGOT vol , PATTY 5th 2001). Rabbit corrosive 1.2% and higher (SIDS 2002). Respiratory or Skin sensitization: Not classified because it is reported no skin sensitization in a human sensitization test (SIDS 2002; IUCLID). Germ cell mutagenicity: Negative in vivo mouse bone marrow micronucleus study and in vitro Ames study (SIDS 2002, DFGOT vol ). Not Classified. Specific target organ toxicity (single exposure): Irritating to respiratory organs and airways in humans. Causes lung edema. (SIDS 2002, ACGIH 7th 2001, DFGOT vo , PATTY 5th 2001). GHS classification results of R-1, R-2 (C) and R-2 (D) reagents as mixtures are shown below. [Skin corrosion/ irritation] R-2 (C) and R-2 (D) reagents: Classified as Category 1 (Danger, Causes severe skin burns and eye damage.) because ph of mixture is higher than or equal to [Serious eye damage/ eye irritation] R-2 (C) and R-2 (D) reagents: Classified as Category 1 (Danger, Causes serious eye damage.) because ph of mixture is higher than or equal to R-1 reagent: Classified as Category 2A (Warning, Causes serious eye irritation.) because Category 2A is contained more than or equal to 10%. [Skin sensitization] R-1 reagent: Not classified because Category 1 is contained less than 1.0%. [Germ cell mutagenicity] R-1 reagent: Classified as Category 1B (Danger, May cause genetic defects.) because Category 1B is contained more than or equal to 0.1%. [Reproductive toxicity] R-1 reagent: Classified as Category 1A (Danger, May damage fertility or the unborn child.) because Category 1A is contained more than or equal to 0.3%. [Carcinogenicity] R-1 reagent: Not classified because Category 2 is contained less than 1.0%. [Specific target organ toxicity (single exposure)] R-1 reagent: Classified as Category 3 (Warning, May cause respiratory irritation, May cause drowsiness or dizziness.) because Category 3 is contained more than or equal to 20%. [Specific target organ toxicity (repeated exposure)] R-1 reagent: Classified as Category 1 (Danger, Cause damage to liver through prolonged or repeated exposure.) and Category 2 (Warning, May cause damage to nervous through prolonged or repeated exposure.) because Category 1 and Category 2 are contained more than 10%. R-1 reagent: [Acute toxicity (oral)], [Skin corrosion/ irritation] and R-2 (C) and R-2 (D) reagents: [Acute toxicity (oral)], [Specific target organ toxicity (single exposure)] are not classified based on data of ingredients. R-1 reagent: [Acute toxicity (dermal)], [Aspiration hazard] and R-2 (C) and R-2 (D) reagents: [Acute toxicity (dermal)], [Respiratory or skin sensitization], [Germ cell mutagenicity], [Carcinogenicity], [Reproductive toxicity], [Specific target organ toxicity (repeated exposure)], [Aspiration hazard] Classifications are not possible because of data lack. 12. Ecological information No data on mixture is available. Data on R-1, R-2(C) and R-2(D) reagents are shown below. R-1 reagent Ethanol: Hazardous to aquatic environment Acute: Crustacea (Daphnia magna): 48-h EC 50 = mg/l (ECETOC TR91, 2003) Hazardous to the aquatic environment Chronic: Not classified. Not poorly soluble (water solubility = 1.00 x 10 6 mg/l (PHYPROP Database, 2005) and low acute toxicity. Phenolphthalein, Water: No eco-toxicological information available.

6 6/7 R-2(C) and R-2(D) reagents Sodium hydroxide: Hazardous to aquatic environment Acute: Crustacea (Ceriodaphnia sp.): 48-h EC 50 = 40.4 mg/l (SIDS, 2004) Hazardous to the aquatic environment Chronic: Toxicity may be caused because solutions become strong acid however it should be lowered in the environment due to buffering effects. Water: No eco-toxicological information available. GHS classification results of R-1, R-2(C) and R-2(D) reagents as mixtures are shown below. Every reagent [Hazardous to aquatic environment- Acute] and [Hazardous to aquatic environment- Chronic]: Classifications are not possible because of data lack. Every reagent [Harmful effects on the ozone layer]: Classifications are not possible because each of the substances is not described in Annex to Montreal Protocol. 13. Disposal considerations The ph level of remaining solution R-2(C),(D) reagents are higher than or equal to 13, respectively. Always dispose of in accordance with local regulations. 14. Transport information In addition to precautionary measures regarding handling and storage, avoid rough handling so as not to break containers. It is recommended to ship by air because under high temperature for long period may lead to deterioration. UN number 3316 Proper shipping name: Chemical Kit (Chemical measurement kit) UN classification: Class 9 (miscellaneous dangerous substances and articles) Packing group: II Civil Aeronautics Act: Same as above. Applicable as a Limited Quantities of Dangerous Goods. Poisonous and Deleterious Substances Control Act: Not applicable. (Not considered as a deleterious substance under the law because the product is a preparation.) Fire Service Act: Not applicable Total weight of the product: ca.160 g/kit 15. Regulatory information PRTR Act: Not applicable. (Concentration of Phenolphthalein in this product is lower than 1.0%.) Industrial Safety and Health Act: Applicable R-1 reagent contains more than 0.1% of ethanol. : Cabinet order, article 18, shall be notified the Name of the substances, #2 : Cabinet order, article 18-2, shall be indicated the Name of the substances, #2 Waste Disposal and Cleaning Act: Applicable Since the ph of remaining solution of R-2(C) and R-2(D) reagents are higher than 12.5, respectively, applicable as a Special Controlled Industrial Waste under the Act. 16. Other information Reference literature 15,911 no Kagaku Shouhin, The Chemical Diary Co., Ltd. (2011) Material Safety Data Sheet No.JW160107, Wako Pure Chemical Industries, Ltd. ( ) NITE, GHS Classification, ID662 Ethanol ( , ) NITE, GHS Classification, ID8 Phenolphthalein ( ) Material Safety Data Sheet No.JW050044, Wako Pure Chemical Industries, Ltd. ( ) Material Safety Data Sheet No.JW041678, Wako Pure Chemical Industries, Ltd. ( ) NITE, GHS Classification, ID599 Sodium hydroxide ( , ) Material Safety Data Sheet No.JW190212, Wako Pure Chemical Industries, Ltd. ( ) Koukuu Kikenbutsu Yusou Houreisyu, Ed. MLIT, HOUBUN SHORIN CO., LTD. (2015) JIS Z 7252:2014 Classification of chemicals based on Globally Harmonized System of Classification and Labelling

7 7/7 of Chemicals (GHS) (Japanese Industrial Standards Committee) JIS Z 7253:2012 Hazard communication of chemicals based on GHS-Labelling and Safety Data Sheet (SDS) (Japanese Industrial Standards Committee) UN GHS (tentative translation, forth revised version), GHS Kankei Syocho Renraku Kaigi (2011) Ministry of Economy, Trade and Industry, GHS Classification Guidance for Enterprises 2013 Revised Edition (2013) NOTE) This information is not always exhaustive and use with care. This data sheet only provides information but any description cannot be warranted. Descriptions may possibly be changed because of new findings or modification of the current knowledge. Precautions only cover normal handling. This English SDS is prepared in the cooperation with the Chemicals Evaluation and Research Institute (CERI), Japan.