Scientific Program. Tissue Repair, IsASL Annual Conference. June 16th 18th 2016 לתקצירים נא סרקו את הקוד: The Dan Hotel Eilat (Red Sea) Sponsored by:

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1 Tissue Repair, IsASL Annual Conference June 6th 8th 206 The Dan Hotel Eilat (Red Sea) Scientific Program Sponsored by: Platinum Gold Silver Bronze לתקצירים נא סרקו את הקוד:

2 Thursday 6/6/206 0:00-0:30 Light breakfast & exhibition 0:30-3:0 SESSION : THE JUNE LIVER FORUM Moderator: Yoav Lurie & Rifaat Safadi 0:30-:00 Case Presentation & Discussion, Rambam, Haifa :00-:0 Case Presentation & Discussion 2, Bnei Zion, Haifa :0-:40 Case Presentation & Discussion 3, Kaplan, Rehovot :40-2:0 Case Presentation & Discussion 4, Hadassah, Jerusalem 2:0-2:40 Case Presentation & Discussion 5, Barzilay, Ashkelon 2:40-3:0 Case Presentation & Discussion 6, Rambam, Haifa Sponsored by 3:0-3:45 Light Lunch & Exhibition PARALLEL SESSION 3:45-4:00 TISSUE REPAIR OPENING IsASL Chairman: Rifaat Safadi 4:00-5:4 SESSION 2: THE 206 CHALLENGES IN VIRAL HEPATITIS Chairs: Amir Shlomai & Michal Carmiel 4:00-4:20 Translating molecular virology into novel antiviral therapies Jeffrey Glenn, Associate Professor of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Director, Center for Hepatitis and Liver Tissue Engineering, Stanford University School of Medicine 4:22-4:30 Hepatitis B virus antagonizes sorafenib in hepatoma cells through indirect induction of the Raf-Mek-Erk pathway Amir Shlomai,2, Dvora Witt-Kehati 2, Romy Zemel 2 Department of Medicine D, Beilinson hospital, 2 Felsenstein Medical Research Center, The Faculty of Medicine, Tel-Aviv University

3 4:32-4:36 Regression of Liver Fibrosis assessed by non-invasive methods in Patients with Chronic Hepatitis C who Achieved Sustained Virologic Response after DAAs Treatment Davidov Yana, Klienboum Yoram 2, Cohen-Ezra Oranit,3, Veitsman Ella, Berdichevsky Tanya, Weiss Perez, Katerginsky Sima 2, Hassid Avishag, Tzaraf Keren, Ben-Ari Ziv,3 Liver Disease Center, 2 Department of Radiology Sheba Medical Center, Tel Hashomer, Ramat Gan, 3 Sackler School of Medicine, Tel Aviv University 4:37-4:4 Beneficial outcomes of DAA s on post SVR liver stiffness Saleh Daher, Nadav Ilani, Tawfik Khouri, Mina Rowe, Rifaat Safadi The Liver Unit, Institute of Gastroenterology and hepatology, Hadassah-Hebrew University Medical Center, Jerusalem 4:42-4:46 Hepatitis C virus induces oncogenic signatures that are not fully reverted following treatment with DAAs Shira Perez,2, Antony Kaspi 3, Ateret Davidovich, Assy Nimer 4, Izhak Haviv 2, Meital Gal-Tanamy Molecular Virology Lab, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, 2 Cancer Personalized Medicine and Diagnostic Genomics Lab, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, 3 Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart & Diabetes Institute, Melbourne, 4 Galilee, Medical Centre, Nahariya 4:47-4:5 The Efficacy and Safety of Different Direct-Acting Antiviral Agents in Liver Transplant Recipients with Recurrent Hepatitis C: A Single Center Study Ella Weitzman, Lichter Maria, Keren Tsaraf, Ardita Jonuzi, Peretz Weiss, Orna Mor 2,3, Ziv Ben-Ari,3 Center for liver diseases, Sheba Medical Center, 2 Central Virology Laboratory, Ministry of Health, Ramat Gan, 3 Sackler School of Medicine, Tel Aviv University, Tel Aviv, 4:52-5:2 Harvoni Real Life German Data Peter Buggisch, Head of Liver Center Hamburg, IFI at the Asklepiosklinik St. Georg Haus L Sponsored by

4 SESSION 3: NURSES WORKSHOP I, DAA S ADHERENCE Chairman: Matthias Carlebach & Rimma Kramsky 3:45-4:00 פתיחת שירותי כבד בבי ח העמק אלכס שטרקמן, בי ח העמק 4:00-4:5 מהכנה להשתלה, מנקודות המבט של המטופל והצוות רימה קראמסק, רמב ם 4:5-4:30 חוליו בורמן עמותת חץ - עמותת חץ, הווה ועתיד בפעילויות בארץ Sponsored by 5:4-6:30 SESSION 4: ABSTRACTS PRESENTATION & DEBATE: ANTICOAGULATION AND CHIROSSIS Chairman: Assy Nimmer & Tarek Saadi 5:4-5:24 Debate: Pro - Amir Shlomai Con - Michal Carmiel 5:25-5:33 Genomic signatures of Hepatitis viruses in liver cancer Shira Perez,2, Anat Lavi-Izkovitz 3, Gur Yaari 3, Ana Tover 4, Salomon M Stemmer 4, Izhak Haviv 2, Meital Gal-Tanamy Molecular Virology Lab, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, 2 Cancer Personalized Medicine and Diagnostic Genomics Lab, Faculty of Medicine in the Galilee, Bar- Ilan University, Safed, 3 Systems computational biology, Faculty of Engineering, Bar-Ilan University, Ramat-Gan 4 Davidoff Center, Tel-Aviv University, Rabin Medical Center, Beilinson Campus, Petach Tikva 5:34-5:42 Sortilin deficiency reduces ductular reaction, hepatocyte apoptosis and liver fibrosis in cholestatic-induced liver injury Isabel Zvibel * Einav Hubel, Ashish Saroha 2, Woo-Jae Park 3, Yael Pewzner-Jung 2, Elise G Lavoie 4, Anthony H Futerman 2, Rafael Bruck, Sigal Fishman, Jonathan A Dranoff 4, Oren Shibolet # The Research Center for Digestive Tract and Liver Diseases, Tel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 2 Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, 3 Department of Biochemistry, School of Medicine, Gachon University, 4 Division of Gastroenterology & Hepatology, University of Arkansas for Medical Sciences

5 5:43-5:55 NK cells from homozygous NLG4-/- (KO) mice inhibit liver fibrosis through PI3K/AKT/mTOR pathway and decreased interleukin-4 Rifaat Safadi, Johnny Amer, Ahmad Salhab, Liver Unit, Gastroenterology and Liver Diseases, Hadassah- Hebrew University Medical Center,Jerusalem 5:56-6:04 Improvement in Non-Invasive Hepatic Parameters of Nonalcoholic Fatty Liver Disease in Obese Uncontrolled T2DM Patients who underwent Endoscopic Duodenal Jejunal Bypass Liner (Endobarrier) Implantation Oranit Cohen-Ezra, G Segal-Liberman 2, A Lang 3, M Lahav 3, Y Kleinbaum 4, Y Inbar 4, S Katscherginsky 4, E Veitsman, T Bradichevsky, P Weiss, K Tsaraf, Z Ben-Ari liver disease center, sheba medical center, Ramat Gan 2 Endocrine institute, sheba medical center, Ramat Gan 3 Gastroenterology institute, sheba medical center, Ramat Gan 6:04-6:08 Effects of anti-hypertensive and triglyceride lowering agents on hepatic copper concentrations in rats with fatty liver disease Zvi Ackerman, Galina Skarzinski 2, Maria Grozovski 3, Mor Oron- Herman 4, Ben-Ami Sela 4 Department of Medicine, Hadassah-Hebrew University Medical Center, 2 Department of Pathology, Hadassah-Hebrew University Medical Center, 3 Department of Human Nutrition and Metabolism, Hebrew University- Hadassah Medical School, 4 Biotechnology, Ort Braude College of Engineering, Karmiel 6:09-6:3 The effects of iron overload on acetaminophen hepatotoxicity in rats Zvi Ackerman, Galina Skarzinski 2, Gabriela Link 3, Maya Glazer, Orit Pappo 2, Maria Grozovski 4 Department of Medicine, Hadassah-Hebrew University Medical Center, 2 Department of Pathology, Hadassah-Hebrew University Medical Center, 3 Department of Human Nutrition and Metabolism, Hebrew University- Hadassah Medical School, 4 Biotechnology, Ort Braude College of Engineering, Karmiel

6 6:4-6:22 Batf3 Dependent Dendritic cells are crutial for Primary Bilary Cholangitis Ehud Zigmond, Debby Reuveni, Yael Gore, Patrick Leung 2, Eli Brazowski, Zamir Halpern, Oren Shibolet, Eric Gershwin 2 Research Center for Digestive Diseases, Sourasky Medical Center and Sackler Faculty of Medicine, Tel-Aviv, 2 Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis 6:23-6:3 Detected HCV RNA at the end of treatment with DAAs deos not reduce the possibility to achieve SVR Tarek Saadi, Rawi Hazzan 2, Yelena Yermenko 2, Michal Carmiel 3, Matthias Carlebach 4, Rimma Kramskay, Vered Ben-Hakoon, Bella Smolen, Hisham Sholy, Johad Khoury, Yaacov Baruch Liver Units, Rambam-Health Care Campus, Haifa; 2 Liver Unit, HaEmek Medical Center, Afula; 3 Liver Unit, Western Galilee Hospital, Nahariya; 4 Bnai-Zion, Medical Center, Haifa. 6:32-7:00 Coffee Break & Exhibition 7:00-8:0 SESSION 5: ACUTE AND / ON CHRONIC LIVER FAILURE Chairman: Yoram Menachem & Marius Braun 7:00-7:8 Hepatic decompensation during DAAs therapy in advanced HCV cirrhosis Ziv Ben Ari, Director Liver Disease Center, Sheba Medical Center, Tel Hashomer 7:20-7:24 Acute Coronary Syndromes in patients with Non-alcoholic Fatty Liver Disease (NAFLD) Yaakov Maor, Dan Haberman 2, Ehud Melzer, Jacob George 2 Institute of Gastroenterology and Hepatology, Kaplan Medical Center, Rehovot, 2 Heart Center, Kaplan Medical Center, Affiliated to the Hebrew university, Jerusalem, Rehovot 7:25-7:29 Non-alcoholic Fatty Liver Disease in Young Adults-Epidemiologic Data from a Large Cohort Yaakov Maor, Salah Daher 2,3, Eran Israeli 3, Lior Katz 2,4 Institute of Gastroenterology and Hepatology, Kaplan Medical Center, Rehovot, 2 Israeli Defense Force,Israeli Defense Force, 3 Department of Gastroenterology and Hepatology, Hadassah Medical Center, Jerusalem, 4 Department of Gastroenterology, Sheba Medical Center, Tel-Hashomer

7 7:30-7:34 Unexpected diagnosis of Hepatocellular Carcinoma(HCC) soon after all oral (DAA) therapy for hepatitis C virus (HCV) Marius Braun,2, Michal Cohen Naftali,2, Yfaat Snir,2, Orly Sneh Arbib,2, Amir Shlomai,2, Ofer Beniaminov 2,3, Salomon Stemer 2,4, Ran Tur Kaspa,5 Liver Institute, Beilinson Hospital, Petah Tikva, Israel 2 Sackler School of Medicine, Tel Aviv University, Israel 3 Imaging department, Beilinson Hospital, Petah Tikva, Israel 4 Oncology department, Beilinson Hospital, Petah Tikva, Israel 5 Faculty of Medicine of Bar-Ilan University in the Galilee, Safed 7:35-7:39 The role of hepatic microenvironment in growth and metastasis of hepatitis c virus - induced hepatocellular carcinoma Abraham Nissani, Liat Ninio, Ateret Davidovich, Mark Shlapobersky 2, Anastasia Malek 3, Izhak Haviv 2, Hava Gil- Henn 3, Meital Gal-Tanamy Laboratory of molecular virology, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, 2 Laboratory of cancer research, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, 3 Laboratory of cell migration and invasion, Faculty of Medicine in the Galilee, Bar-Ilan University, Safed 7:40-7:44 The interplay between Hepatitis C virus infection, changes in higher chromatin organization and cancer Meital Gal-Tanamy, Michael Gevor, Shira Perez, Antony Kaspi 2, Ateret Davidovich, Izhak Haviv, Itay Onn, Faculty of Medicine in the Galilee, Bar-Ilan University, 2 Epigenetics in Human Health and Disease Laboratory, Baker IDI Heart & Diabetes Institute 7:45-8:0 Acute Liver Failure: Causes and Consequences Adrian Reuben, Medical University of South Carolina (MUSC), Charleston SC, USA 9:30 Dinner

8 Friday 7/6/206 07:30 Breakfast with Visitors, F:F meeting 08:00-09:00 SESSION 6: NURSES WORKSHOP II, DAA'S ADHERENCE Chairman: Alice Herskovic & Orly Azulay 08:00-08:5 אפקטים סיעודיים בטיפול בחולי NASH מרינה ליבשיץ איכילוב 08:5-08:30 חווית המטפל בחולים קשים והשפעתה על תפקודו יעל חריף בלינסון 08:30-08:45 תוצאות סקר מטופלי HCV בישראל בהשוואה לאוכלוסיה באירופה קרן צארף, המרכז למחלות כבד תל השומר 08:45-09:00 תפקיד האחות בעידן הטיפולים החדשים בהפטיטיס C ד ר גל ניצן גיליאד Sponsored by 08:00-0:00 SESSION 7: PEDIATRIC HEPATOLOGY: METABOLIC DISORDERS Chairman: Tania Berdichevski & Rifaat Safadi 08:00-08:8 Pediatric liver transplantations Indications and outcome Dr. Yael Mozer, Schneider Children's Hospital 08:20-08:28 Challenging the current normal range of serum alanine aminotransferase in the elderly - a need for reevaluation Schmilovitz-Weiss Hemda,2, Rachel Gingold-Belfer,2, Yichayaou Beloossesky,2, Joseph Meirovitch 2, Nira Koren- Morag 2, Avraham Weiss,2 Gastroenterology, Rabin Medical Center, Petach-Tiqwa 2 Sackler faculty of medicine, Tel Aviv University, Tel Aviv 08:30-08:38 The association of ALT levels with myocardial perfusion imaging and cardiovascular morbidity. David Yardeni, Ohad Etzion,4, Ronen Toledano 2, Victor Novack 2, Aryeh Shalev 3, Arik Wolak 3, Yaron Rotman 4 Gastroenterology and Liver Disease Institute, Soroka University Medical Center, 2 Clinical Research Center, Soroka University Medical Center, 3 Cardiology Section, Soroka University Medical Center, 4 Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, USA

9 08:40-08:58 The role of Whole Exome Sequencing in diagnosis of liver diseases Orli El Peleg, Hadassah Medical Center 09:00-09:04 Thiopurine Metabolite Assessment in children with Autoimmune Hepatitis Eyal Shteyer, Jahjah Elias, Orit Pappo 2, Ledder Oren, Raffi Lev-Tzion Pediatric Gastroenterology institute, Shaare Zedek Medical Center, Jerusalem, 2 Departement of Pathology, Hebrew University-Hadassah Medical Center, Jerusalem 09:05-09:09 New ultrasonographic protocol for early diagnosis of cystic fibrosis liver disease Eyal Shteyer 5, Or Steg Saban, Michael Wilschanski, Moti Menachem, Natasha Simanovski 2, Eitan Kerem, Deirdre Kelly 4, Louis Stewart 4 Pediatric Gastroenterology Unit, 2 Radiology Department, 3 Department of Pediatrics, Hebrew University-Hadassah Medical Center, Jerusalem, 4 Liver Unit, Birmingham Children s Hospital, Birmingham, 5 Pediatric Gastroenterology institute, Shaare Zedek Medical Center, Jerusalem 09:0-09:28 MiRNA tools in diagnosis and treatment of liver diseases Shimon Reif, Hadassah Medical Center 09:30-09:34 ADAR knockdown HepG2 cells directly affect the activation of primary HSCs via the up-regulation of IL-6 Michal Safran, Polina Kagan,4, Shirley Oren 2,4, Maya Sultan, Ziv Ben-Ari,3,4 Liver Research Laboratory, Chaim Sheba Medical Center, Ramat Gan, 2 Cancer Research Center, Chaim Sheba Medical Center, Ramat Gan, 3 Liver Disease Center, Chaim Sheba Medical Center, Ramat Gan, 4 The Sackler School of Medicine, Tel Aviv University, Tel-Aviv 09:35-09:39 CD49a- CD49b+ NK. cells in C57/BL fibrotic livers are distinct from peripheral NK cells in their neurologin4/cd07a activatory marker Johnny Amer, Ahmad Salhab, Rifaat Safadi Liver Unit, Gastroenterology and Liver Diseases, Hadassah- Hebrew University Medical Center,Jerusalem

10 09:40-09:58 Characteristics of Cholestatic liver disease in Pediatrics. Efrat Broide, Assaf Harofe Medical Center 0:00-0:30 Coffee Break & Exhibition 0:30-:45 SESSION 8: NUTRITION AND LIVER DISEASE Chairman: Eli Zuckerman & Rafi Bruck 0:30-0:48 Nutrition in Cirrhosis Shibolet Oren, Director of the Liver Unit, Department of Gastroenterology, Tel-Aviv Medical Center and Tel-Aviv University 0:50-:08 Nutrition & Acute Liver States Rifaat Safadi, Liver & Gastroenterology Units, Hadassah-Hebrew University Hospital :0-:8 Baseline and treatment failure resistance analysis in HCV GT patients treated with first and second generation direct acting antivirals Yael Gozlan, Ziv Ben Ari 2,3, Rachel Shirazi, Roy Moscona, Avia Rakovsky, Ella Weitzman 2,3, Tania Bradichevsky 2,3, Peretz Weiss 2,3, Avishag Hassid 2, Keren Tsaraf 2, Yoav Luria 4, Oren Shibolet 3,5, Eli Zuckerman 6,7, Marius Brown 3,8, Michal Cohen- Naftali 3,8, Ofer Peleg 9, Ella Mendelson,0, Orna Mor Central Virology Laboratory, Ministry of Health, 2 Liver Disease Center, Sheba Medical Center, 3 Faculty of Medicine, Sackler faculty of Medicine, Tel Aviv University, 4 Liver unit, Shaare Zedek Medical Center, 5 Department of Gastroenterology, Tel- Aviv Medical Center, 6 Liver Unit, Carmel Medical Center, 7 Rappaport Faculty of Medicine, The Technion, 8 Liver Institute, Rabin Medical Center, 9 Genaphora, Genaphora, 0 School of Public Health, Tel Aviv University :20-:24 Unique clinical features of Non Alcoholic Steato Hepatitiis (NASH)-related hepatocellular carcinoma (HCC) Yoram Menachem, Oren Shibolet, Izhar Levy 2, Rifaat Safadi 2, Eli Zuckerman 3 Tel Aviv Sourasky Medical Center, 2 Hadassah University Hospital Jerusalem, 3 Carmel Hospital, Haifa

11 :25-:29 HBV down regulates the expression levels of vitamin d receptor in hepatocellular carcinoma transfected cells thereby preventing inhibition of viral replication by Vitamin D Michal Safran, Neta Gotlieb, Irina Tachlytski, Lena Lapidot,3, Maya Sultan, Ziv Ben Ari,2,3 Liver Research Laboratory, Sheba Medical Center, Ramat Gan, 2 Liver Disease Center, Sheba Medical Center, Ramat Gan 3 The Sackler School of Medicine, Tel Aviv University :30-:34 Enhancing patients` knowledge and accessibility to healthcare services increase implementation of hepatitis C virus therapy in methadone maintenance treatment patients Einat Peles, Miriam Adelson, Anat Sason, Helena Katchman 2, Stella Levit 2, Shaul Schreiber, Oren Shibolet 2 and Rafael Bruck 2 Dr. Miriam & Sheldon G. Adelson Clinic for Drug Abuse Treatment & Research, 2 Liver Unit, Department of Gastroenterology, Tel-Aviv Medical Center & Sackler Faculty of Medicine, Tel Aviv University :35-:39 Israeli s and global lessions extracted from the HCV Quest Global Patient Survey Ziv Ben-Ari,3,4, Hulio Burman 2, Keren Tsaraf, Charles Gore 3 :40-:44 Autoimmune hepatitis: a single center experience with a long follow-up Eli Zuckerman, Yulia Kovalev, Eyal Ashkenasie :45-4:00 SESSION 9: THE 206 CHALLENGES IN VIRAL HEPATITIS Chairman: Dani Shoval & Yaacov Maor :45-2:0 HCV treatment in special populations Didier Samuel, Professor of Hepatology and Gastroenterology at Université Paris-Sud, Villejuif, France Sponsored by 2:2-2:32 The HCV real life in Israel Prof. Eli Zuckerman

12 2:34-2:42 Hepatitis E in Israel Orna Mor, Daniela Ram, Yossi Manor, Yael Gozlan, Eli Schwartz 2, Ziv Ben-Ari 3, Ella Mendelson, Shaul Possi 4 Central Virology Laboratory, Ministry of Health, 2 Center for Geographic Medicine and Tropical Diseases, Chaim Sheba Medical Center, 3 Liver Diseases Center, Chaim Sheba Medical Center 2:43-2:5 Hepatitis E in haematological patients in Israel Rasha Daniel,4,5, Tsila Zuckerman 2, Shira Zelber-Sagi 3,5, Mira Barak 4, Orly Azulay, Eli Zuckerman Liver Unit, Carmel Medical Center, Haifa, Haifa and Western Galilee District, 2 BMT Unit, Department of Hematology, Rambam Medical Center, Haifa, 3 Department Gastroenterology, Tel-Aviv Medical Center, 4 Nesher Central Laboratories, CHS, Haifa and Western Galilee District, 5 Faculty of Public Health, Haifa University 2:52-2:56 The Prevalence Of Hepatitis E Virus Antibodies In Israel Rasha Daniel,3,4, Shira Zelber-Sagi 2,4, Mira Barak 3, Orly Azulay, Eli Zuckerman Liver Unit, Carmel Medical Center, 2 Department Gastroenterology, Tel-Aviv Medical Center, 3 Nesher Central Laboratories, CHS, Haifa and Western Galilee District, 4 Faculty of Public Health, Haifa University 2:57-3:0 Patients age rather than their Model of End-stage Liver Disease (MELD) score predicts long-term survival after liver transplantation Yaara Leibovici-Weissman,2, Moshe Leshno 3, Amir Shlomi,2,4 Sackler Faculty of Medicine, Tel-Aviv University, 2 Department of Medicine D, Beilinson hospital, 3 School of Management, Tel-Aviv University, 4 The Liver Institute, Beilinson hospital 3:02-3:22 Prenylation inhibitors for treating delta hepatitis Jeffrey Glenn, Associate Professor of Medicine and Microbiology & Immunology, Division of Gastroenterology and Hepatology, Director, Center for Hepatitis and Liver Tissue Engineering, Stanford University School of Medicine 3:30-3:40 IsASL Business Meeting: IsASL Governing Board Rifaat Safadi, Chairman Tania Berdichevski, Treasurer Matthias Carlebach, Observer 3:40 Closing Remarks: Rifaat Safadi, IsASL Chairman 4:00 Lunch

Treatment of HCV IFN-free DAAs: The Israeli real-life experience 2016

Treatment of HCV IFN-free DAAs: The Israeli real-life experience 2016 Eli Zuckerman, Ella Veitzman, Oren Shibolet, Eyal Ashkenazi, ulia Kovalev, Ran Tur-Kaspa, Marius Braun, Michal Cohen, Amir Shlomai