Supplementary Online Content

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1 Supplementary Online Content Ribe AR, Laursen TM, Charles M, et al. Long-term risk of dementia in persons with schizophrenia: a Danish population-based cohort study. JAMA Psychiatry. Published online October 7, doi: /jamapsychiatry etable 1. Information on Schizophrenia Obtained From the Danish Psychiatric Central Research Register etable 2. Information on Dementia Obtained From the Danish Psychiatric Central Research Register, the Danish National Patient Register, and the Danish National Prescription Registry etable 3. Information on Comorbidity (ie, Other Risk Factors for Dementia) Obtained From the Danish National Patient Register, the Danish National Diabetes Register and the Danish Psychiatric Central Register etable 4. Information on Diabetes Obtained From the Danish National Diabetes Register etable 5. Information on Substance Abuse Disorders Obtained From the Danish National Patient Register and the Danish Psychiatric Central Research Register This supplementary material has been provided by the authors to give readers additional information about their work 2015 American Medical Association. All rights reserved. 1

2 etable 1. Information on Schizophrenia Obtained From the Danish Psychiatric Central Research Register Schizophrenia 295 (excluding ) F20 Schizoaffective disorders , F25 Persons with other psychiatric diseases, such as depression or bipolar affective disorder were not excluded from the study and were thus part of the group of persons without schizophrenia American Medical Association. All rights reserved. 2

3 etable 2. Information on Dementia Obtained From the Danish Psychiatric Central Research Register, the Danish National Patient Register, and the Danish National Prescription Registry A diagnosis of dementia was identified if at least one of the following criteria was met: 1. Registration of a diagnosis of dementia in the Danish Psychiatric Central Register or the Danish National Patient Register. And/or 2. Registration of at least one prescription of anti-dementia drug redeemed in the Danish National Prescription Registry. Diagnosis according to a record of dementia in the Danish Psychiatric Central Register or the Danish National Patient Register. AD (Alzheimer s disease) F00.0, F00.1, F00.2, F00.9, G30.0, G30.1, G30.8, G30.9 VaD (vascular dementia) F01.0, F01.1, F01.2, F01.3, F01.8, F01.9 FTD (frontotemporal dementia) F02.0 Dementia without specification F03.9 Diagnosis according to a record of prescriptions for anti-dementia drugs in the Danish National Prescription Registry: Name Drug name ATC-codes Anticholinesterases Tacrine N06DA01 Donepezile N06DA02 Rivastigmine N06DA03 Other anti-dementia drugs Galantamine Donepezile and Memantine Memantine N06DA04 N06DA52 N06DX American Medical Association. All rights reserved. 3

4 etable 3. Information on Comorbidity (ie, Other Risk Factors for Dementia) Obtained From the Danish National Patient Register, the Danish National Diabetes Register and the Danish Psychiatric Central Register Ischemic heart disease I20 I25 Congestive heart failure , , , , , I50, I11.0, I13.0, I13.2 Atrial fibrillation or flutter , I48 Peripheral vascular disease 440, 441, 442, 443, 444, 445 I70, I71, I72, I73, I74, I77 Cerebrovascular disease I60-I69, G45, G46 Diabetes See Appendix 4 Substance abuse disorder See Appendix American Medical Association. All rights reserved. 4

5 etable 4. Information on Diabetes Obtained From the Danish National Diabetes Register Algorithm: Individuals were classified as having diabetes on the date when at least one of the following six criteria was met: 1. A diagnosis of diabetes made at any Danish hospital registered in the Danish National Patient Register (:249, 250; :E10-14, H36.0, O24, excluding O24.4). 2. A referral to chiropody of diabetic patients as registered in the Danish National Health Service Register. 3. Five blood glucose measurements within one year registered in the Danish National Health Service Register. 4. Two blood glucose measurements per year for five consecutive years registered in the Danish National Health Service Register. 5. Two redemptions of oral anti-diabetic drugs within six months registered in the Danish National Prescription Registry. 6. Two redemptions of prescribed insulin registered in the Danish National Prescription Registry American Medical Association. All rights reserved. 5

6 etable 5. Information on Substance Abuse Disorders Obtained From the Danish National Patient Register and the Danish Psychiatric Central Research Register Drug-related abuse Opioids , F11.0 F11.9 Cannabinoids F12.0 F12.9 Sedatives/hypnotics , F13.0 F13.9 Cocaine F14.0 F14.9 Other stimulants F Hallucinogens F16.0 F16.9 Other and multiple drugs , F18.0 F19.9 Alcohol-related abuse Alcohol psychosis and abuse syndrome F10.0 F Cirrhosis and steatosis of the liver , , K70.0 K70.9 Esophageal varices , , I85.0 I American Medical Association. All rights reserved. 6