Alcohol Biomarkers by UHPLC-MS/MS
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1 Alcohol Biomarkers by UHPLC-MS/MS Application #AN9 ACE Excel. C8 x. mm EXL--U A: mm ammonium fluoride B: MeCN ml/ µl C AB SCIEX triple quad Negative ESI MRM Source temperature: C IonSpray voltage: - V Transitions. Ethyl glucuronide (EtG) Quantifiers EtS EtG 8 Qualifiers EtS.8 9 EtG Fluoride counter-ion thought to enhance negative ESI response Detection limit ~ ng/ml in oral fluid Reproduced with permission of Biotage GB Ltd, UK Australia & New Zealand contact: info@winlab.com.au or call + 9. Ethyl sulphate (EtS)
2 Fast Analysis of β-blockers at High ph Application #AN ACE Excel. SuperC8 x. mm EXL--U A:.% ammonia in HO B:.% ammonia in MeCN.... Post time s ml/. µl C UV, nm. Atenolol. Acebutalol. Pindolol. Metoprolol 8. Oxprenolol. Carvedilol. Propranolol Australia & New Zealand contact: info@winlab.com.au or call + 9
3 Thyroid Hormones by LC-MS/MS (II) Application #AN8 ACE Excel. C8-AR x. mm EXL-9-U A: mm ammonium acetate,.% formic acid in HO B: mm ammonium acetate,.% formic acid in MeOH.... ml/ µl C XEVO TQS triple quad MS Desolvation temperature: C Ion source temperature: C Positive mode ESI, MRM TIC Analyte T. T (Tri-iodothyronine) Q (Da) Q (Da).8.8 (.8) (.8) (.8) (8.9) rt.8.8 (.8) (.8) (.8) (8.9) T/rT-d I.S. T (.) (). T (Thyroxine) (.) (.8). rt (Reversed tri-iodothyronine) Reproduced with permission of Biotage GB Ltd, UK Australia & New Zealand contact: info@winlab.com.au or call + 9
4 Drugs of Abuse Screen by UHPLC-MS/MS Application #AN9 Page of ACE Excel. C8 x. mm EXL--U A: mm ammonium acetate in HO B: mm ammonium acetate in MeOH ml/ µl C MS Quattro Premier XE triple quad MRM, positive and negative ESI mode Desolvation temperature: C Ion source temperature: C Collision gas pressure:. x - mbar Reproduced with permission of Biotage GB Ltd, UK Australia & New Zealand contact: info@winlab.com.au or call + 9
5 Drugs Of Abuse Screen By UHPLC-MS/MS Application #AN9 Page of Peak Analyte Oxymorphone Morphine-d Morphine Hydromorphone Amphetae-d Amphetae Dihydrocodeine 8 MDA 9 MDMA Methamphetae Oxycodone MDEA BZE-d BZE -MAM Codeine Norfentanyl 8 -Ao-clonazepam 9 Hydrocodone -Ao-flunitrazepam Cocaine Norbuprenorphine PCP Zaleplon EDDP Norketae Rt Q (Da) Q (Da) Peak Analyte 98. Bromazepam. 8 Ketae. 9 Clonazepam 8. Nitrazepam.9 Alpha-hydroxytriazolam 8.9 Flunitrazepam 99. Alpha-hydroxyalprazolam. Estazolam. Zolpidem 9.9 Triazolam. -Hydroxyethylflurazepam. 8 Lorazepam. 9 Oxazepam 8. Alprazolam. Methadone. Temazepam 8. Nordiazepam. Midazolam 99. Diazepam-d. Diazepam 8. Flurazepam. 8 Fentanyl THC-COOH-d. THC-COOH. Buprenorphine.9 Rt Reproduced with permission of Biotage GB Ltd, UK Australia & New Zealand contact: info@winlab.com.au or call + 9 Q (Da) Q (Da)
6 Fast Separation of Organic Acids Application #AN ACE C8-Amide ACE Excel. C8-Amide x. mm x. mm x. mm (EXL--U), x mm (EXL--U) mm HPO in MeOH/HO (: v/v). ml/ ( x. mm).8 ml/ ( x. mm) µl ( x. mm) µl ( x. mm) C UV, nm. Sinapic acid. Ferulic acid ACE C8-Amide I.,-Dimethoxycinnamic acid. Cinnamic acid ACE Excel. C8-Amide I. -Methoxycinnamic acid Australia & New Zealand contact: info@winlab.com.au or call + 9
7 Fast Analysis of Paracetamol and Related Substances (I) Application #AN ACE Excel. C8 x. mm EXL--U A: mm ammonium acetate ph. in HO B: mm ammonium acetate ph. in MeOH/HO (9: v/v) ml/. µl ( x. mm) C UV, nm For enhanced resolution of paracetamol and related compounds, see AN. Australia & New Zealand contact: info@winlab.com.au or call + 9 -Aophenol Hydroquinone Paracetamol -Acetamidophenol Phenol -Nitrophenol -Nitrophenol -Chloroacetanilide
8 Enhanced Resolution of Paracetamol and Related Substances Application #AN ACE Excel. C8 x. mm EXL--U A: mm ammonium acetate ph. in HO B: mm ammonium acetate ph. in MeOH/HO (9: v/v) ml/. µl C UV, nm For enhanced speed of paracetamol and related compounds, see AN. Australia & New Zealand contact: info@winlab.com.au or call + 9 -Aophenol Hydroquinone Paracetamol -Acetamidophenol Phenol -Nitrophenol -Nitrophenol -Chloroacetanilide
9 Fast Separation of Vanillin Compounds Application #AN ACE Excel. C8-Amide x. mm EXL--U A:.% formic acid in HO B:.% formic acid in MeCN ml/ µl C UV, nm. Vanillic acid. -Hydroxybenzoic acid. Vanillin. -Hydroxybenzaldehyde. Guaicol. o-vanillin Ethyl vanillin 8. Eugenol Australia & New Zealand contact: info@winlab.com.au or call + 9
10 Perfluorinated Compounds in Water by LC-MS/MS Application #AN ACE Excel. C8 x. mm EXL--U A: mm ammonium acetate,.% formic acid/mecn (9: v/v) B: mm ammonium acetate,.% formic acid in MeCN (:9 v/v) ml/ µl C AB SCIEX triple quad Negative ESI MRM Source temperature: C IonSpray voltage: - V XIC of -MRM (9 pairs): Exp,.9/8.9 amu Expected RT:. ID: HFBA from Sample (PFA8 ng/ml) of _standards.wiff (... Max..8e cps. Transitions. Perfluorohexanoic acid 8.e 8.e (m/z. 8.9).e. Perfluorobutanesulfonic acid.e (m/z ).e.e In te n s ity, c p s. Perfluorooctanoic acid.e.e (m/z. 8.9).e.e.e (m/z. 9.).e. Perfluorodecanoic acid.e.e (m/z. 9.).e.e (m/z ). Perfluorononanoic acid.e.. Perfluorohexanesulfonic acid. Perfluorooctanesulfonic acid (m/z ) Time, s Time, Reproduced with permission of Biotage GB Ltd, UK. For extraction conditions see Biotage Application Note AN89 Australia & New Zealand contact: info@winlab.com.au or call + 9
11 Ultra Resolution Separation of the Natural Product Ginkgo Biloba Application #AN ACE Excel. C8-PFP x x. mm (coupled) x EXL--U A:.% formic acid in HO B:.% formic acid in MeCN ml/ µl 8 C UV, nm. Ginkgo Biloba - 8 Australia & New Zealand contact: info@winlab.com.au or call + 9
12 Separation of Aspirin and Related Substances Application #AN8 ACE Excel. CN-ES x. mm EXL--U A:.% formic acid in HO B:.% formic acid in MeCN.. ml/. µl C UV, nm Acetamidophenol. -Hydroxyisophthalic acid. Acetanilide. Salicylamide. Aspirin. Phenacetin. Salicylic acid 8. Acetylsalicylsalicylic acid 9. Salsalate 9 8 In Australia and New Zealand WINLAB PTY LTD PO Box, Brendale, QLD, Australia Ph: info@winlab.com.au Web:
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