Systematic review of screening and treatment of thyroid dysfunction in asymptomatic, nonpregnant, communitydwelling

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1 Update Appendix A1. Search Strategies Screening Database(s): Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE(R) and Ovid OLDMEDLINE(R) 1946 to Present 1 thyroid diseases/ or hyperthyroidism/ or hypothyroidism/ (thyroid and disease$).mp (hypothyroid$ or hyperthyroid$).mp or/ Mass Screening/ and Pregnancy/ (pediatric$ or newborn or neonat$ or child$ or infan$).mp not (7 or 8) limit 9 to (abstracts and english language and humans) (201407$ or $ or $ or $ or $ or $ or 2015*).dc,ed and remove duplicates from Database(s): COCHRANE LIBRARY Search Strategy as searched in 1 [Thyroid Diseases] explode all (thyroid and disease$) all text (hypothyroid$ or hyperthyroid$) all text #1 or #2 or # [Mass Screening] screen$ all text #5 or # #4 and #7 471

2 9 #4 and #7 Limit=Online Publication Date from Jul 2014 to Nov

3 Treatment Database(s): Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE(R) and Ovid OLDMEDLINE(R) 1946 to Present 1 Thyroid Diseases/ Hyperthyroidism/ Hypothyroidism/ (hyperthyroid$ or hypothyroid$).ti (thyroid deficien* or thyroid insufficien* or thyroid failure).mp or/ exp Antithyroid Agents/ (anti-thyroid or methimazole or propylthiouracil or radioiodine or radioactive iodine).ti,ab exp Thyronines/ exp Thyroxine/ (t3 or t4 or thyroxine or levothyroxine or triiodothyronine or liothyronine or thyrolar or liotrix).ti,ab or/ and and pc.fs and dt.fs and th.fs or/ or Pregnancy/ (child$ or pediatric$ or infan$ or newborn or neonat$ or toddler).mp grave's.ti not (19 or 20 or 21) limit 22 to (abstracts and english language and humans) limit 23 to (clinical trial, all or comparative study or controlled clinical trial or meta analysis or randomized controlled trial or systematic reviews) 1337

4 25 (201407$ or $ or $ or $ or $ or $ or 2015*).dc,ed and remove duplicates from Database(s): COCHRANE LIBRARY Search Strategy as searched in 1 [Thyroid Diseases] [Hyperthyroidism] [Hypothyroidism] (hyperthyroid$ or hypothyroid$):ti 17 5 ("thyroid deficien*" or "thyroid insufficien*" or "thyroid failure") all text 6 #1 or #2 or #3 or #4 or # [Antithyroid Agents] explode all (anti-thyroid or methimazole or propylthiouracil or radioiodine or "radioactive iodine"):ti,ab [Thyronines] explode all [Thyroxine] explode all (t3 or t4 or thyroxine or levothyroxine or triiodothyronine or liothyronine or thyrolar or liotrix):ti,ab #7 or #8 or #9 or #10 or # #6 and # [Pregnancy] (child$ or pediatric$ or infan$ or newborn or neonat$ or toddler) all text 16 grave's:ti #13 not (#14 or #15 or #16) #13 not (#14 or #15 or #16) Limit=Online Publication Date from Jul 2014 to Nov

5 All Key Questions Database(s): Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE(R) and Ovid OLDMEDLINE(R) 1946 to Present 1 Thyroid Diseases/ Hyperthyroidism/ Hypothyroidism/ (hyperthyroid$ or hypothyroid$).ti (thyroid deficien* or thyroid insufficien* or thyroid failure).mp or/ exp Antithyroid Agents/ exp Thyronines/ exp Thyroxine/ (t3 or t4 or thyroxine or levothyroxine or triiodothyronine or liothyronine or thyrolar or liotrix).ti,ab or/ and not (pregnan$ or pediatric$ or newborn or neonat$ or child$ or infan$).ti limit 13 to systematic reviews (201407$ or $ or $ or $ or $ or $ or 2015*).dc,ed and remove duplicates from Database(s): COCHRANE LIBRARY Search Strategy as searched in 1 (thyroid or hypothyroid$ or hyperthyroid$) :ti pregnan$.ti 8 3 #1 not #2 Reviews 19 4 #1 not #2 Limit=Online Publication Date from Jul 2014 to Nov

6 Search strategy history Topic #1: Thyroid Dysfunction Screening Patient preference and values Database(s): Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE(R) and Ovid OLDMEDLINE(R) 1946 to Present 1 exp Thyroid Diseases/co, di, pc, px, us [Complications, Diagnosis, Prevention & Control, Psychology, Ultrasonography] Thyroid Function Tests/ (hyperthyroid* or hypothyroid* or hyperthyroxinemia or thyrotoxicos*).mp. (thyroid adj3 (dysfunct* or dysgenes* or disorder* or deficien* or abnormal* or disease*)).mp or/ *patient satisfaction/ or *patient preference/ *Patient Compliance/px, sn [Psychology, Statistics & Numerical Data] exp *Attitude to Health/ (patient adj3 (prefer* or value* or attitude or compliance or satisf* or response*)).mp or/ *Mass Screening/ (thyroid adj10 (screen* or test*)).mp or/ and 10 and (pregnan* or infant or newborn).mp not limit 16 to (english or french) remove duplicates from 17 59

7 Database(s): Embase 1974 to 2015 November 18 1 exp thyroid disease/co, di, pc [Complication, Diagnosis, Prevention] exp thyroid function test/ (hyperthyroid* or hypothyroid* or hyperthyroxinemia or thyrotoxicos*).mp. (thyroid adj3 (dysfunct* or dysgenes* or disorder* or deficien* or abnormal* or disease*)).mp or/ exp *patient satisfaction/ exp *patient preference/ *patient compliance/ or *mental compliance/ exp *attitude to health/ (patient adj3 (prefer* or value* or attitude or compliance or satisf* or response*)).mp or/ *mass screening/ (thyroid adj10 (screen* or test*)).mp or/ and 11 and (pregnan* or infant or newborn).mp not limit 17 to (english or french) remove duplicates from Database(s): ProQuest Public Health Set# Searched for Databases Results S1 (mesh.exact("thyroid Diseases") OR mesh.exact("thyroid Function Tests") OR ALL(hyperthyroid* OR hypothyroid* OR hyperthyroxinemia OR thyrotoxicos*) OR ALL(thyroid NEAR/3 (dysfunct* OR dysgenes* OR disorder* OR deficien* OR abnormal* OR disease*))) AND ProQuest Public Health 55

8 (mesh.exact("patient Preference" OR "Patient Satisfaction" OR "Attitude to Health" OR "Patient Compliance") OR (patient NEAR/3 (prefer* OR value* OR attitude OR compliance OR satisf* OR response*))) AND (mesh.exact("mass Screening") OR ALL(thyroid NEAR/10 (screen* OR test*))) NOT ALL(pregnan* OR infant OR newborn) AND PEER(yes) Database(s): Scopus (TITLE-ABS(thyroid w/3 (dysfunct* OR dysgenes* OR disorder* OR deficien* OR abnormal* OR disease* OR screen* OR test*)) OR TITLE-ABS(hyperthyroid* OR hypothyroid* OR hyperthyroxinemia OR thyrotoxicos*)) AND ALL(inciden* OR "new* diagnosis") AND TITLE-ABS-KEY(patient w/3 (prefer* or value* or attitude or compliance or satisf* or response*)) AND TITLE(screen* OR test*) AND NOT (TITLE-ABS- KEY(pregnan* OR infant OR newborn)) AND (LANGUAGE(English OR French)) AND (LIMIT-TO(DOCTYPE,"ar" ) OR LIMIT-TO(DOCTYPE,"re" )) 19 Results

9 Topic #2: Thyroid Dysfunction Screening Cost-effectiveness and/or resources Database(s): Ovid MEDLINE(R) In-Process & Other Non-Indexed Citations, Ovid MEDLINE(R) Daily, Ovid MEDLINE(R) and Ovid OLDMEDLINE(R) 1946 to Present 1 exp Thyroid Diseases/co, di, pc [Complications, Diagnosis, Prevention & Control] Thyroid Function Tests/ (hyperthyroid* or hypothyroid* or hyperthyroxinemia or thyrotoxicos*).mp. (thyroid adj3 (dysfunct* or dysgenes* or disorder* or deficien* or abnormal* or disease*)).mp or/ *Mass Screening/ (thyroid adj10 (screen* or test*)).mp or/ exp *"Costs and Cost Analysis"/ec, mt, sn [Economics, Methods, Statistics & Numerical Data] (cost adj3 (effective* or benefi* or analysis)).ti,ab Quality-Adjusted Life Years/ *Health Resources/ec, sn, sd, ut [Economics, Statistics & Numerical Data, Supply & Distribution, Utilization] or/ and 8 and (pregnan* or infant or newborn).mp not limit 16 to (english or french) remove duplicates from

10 Database(s): Embase 1974 to 2015 November 18 1 exp thyroid disease/co, di, pc [Complication, Diagnosis, Prevention] exp thyroid function test/ (hyperthyroid* or hypothyroid* or hyperthyroxinemia or thyrotoxicos*).mp. (thyroid adj3 (dysfunct* or dysgenes* or disorder* or deficien* or abnormal* or disease*)).mp or/ *mass screening/ (thyroid adj10 (screen* or test*)).mp or/ exp *"cost benefit analysis"/ exp *"cost effectiveness analysis"/ (cost adj3 (effective* or benefi* or analysis)).ti,ab *quality adjusted life year/ or/ and 8 and (pregnan* or infant or newborn).mp not limit 16 to (english or french) remove duplicates from Database(s): ProQuest Public Health Set# Searched for Databases Results S2 (mesh.exact("thyroid Diseases") OR mesh.exact("thyroid Function Tests") OR ALL(hyperthyroid* OR hypothyroid* OR hyperthyroxinemia OR thyrotoxicos*) OR ALL(thyroid NEAR/3 (dysfunct* OR dysgenes* OR disorder* OR deficien* OR abnormal* OR disease*))) AND (MJMESH.EXACT("Costs and Cost ProQuest Public Health 9

11 Analysis") OR MJMESH.EXACT("Health Resources") OR MJMESH.EXACT("Quality- Adjusted Life Years") OR ALL(cost NEAR/10 (effective* OR benefi* OR analysis))) AND (mesh.exact("mass Screening") OR ALL(thyroid NEAR/10 (screen* OR test*))) NOT ALL(pregnan* OR infant OR newborn) Database(s): Scopus (TITLE-ABS(thyroid w/3 (dysfunct* OR dysgenes* OR disorder* OR deficien* OR abnormal* OR disease* OR screen* OR test*)) OR TITLE-ABS(hyperthyroid* OR hypothyroid* OR hyperthyroxinemia OR thyrotoxicos*)) AND TITLE-ABS-KEY(cost w/3 (effective* or benefi* or analysis)) AND TITLE(screen* OR test*) AND NOT (TITLE-ABS- KEY(pregnan* OR infant OR newborn)) AND (LANGUAGE(English OR French)) AND ( LIMIT-TO(DOCTYPE,"ar" ) OR LIMIT-TO(DOCTYPE,"re" ) OR LIMIT- TO(DOCTYPE,"sh" ) ) 78 Results

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